Camk2n1 (calcium/calmodulin-dependent protein kinase II inhibitor 1) - Rat Genome Database

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Gene: Camk2n1 (calcium/calmodulin-dependent protein kinase II inhibitor 1) Rattus norvegicus
Analyze
Symbol: Camk2n1
Name: calcium/calmodulin-dependent protein kinase II inhibitor 1
RGD ID: 708430
Description: Enables calcium-dependent protein kinase inhibitor activity and protein kinase binding activity. Involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus and positive regulation of systemic arterial blood pressure. Located in dendrite and neuronal cell body. Human ortholog(s) of this gene implicated in ovarian cancer; ovarian carcinoma; and prostate adenocarcinoma. Orthologous to human CAMK2N1 (calcium/calmodulin dependent protein kinase II inhibitor 1); PARTICIPATES IN calcium/calmodulin dependent kinase 2 signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: calcium/calmodulin-dependent protein kinase II inhibitor alpha; caM-KIINalpha; CaM-kinase II inhibitor alpha; caMKIINalpha; LOC287005
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Camk2n1em1Tja
Genetic Models: SHR-Camk2n1em1Tja-/-
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85155,958,116 - 155,959,897 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5155,957,878 - 155,961,058 (+)EnsemblGRCr8
mRatBN7.25150,674,819 - 150,676,600 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5150,673,507 - 150,676,600 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5153,371,504 - 153,373,282 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05155,145,792 - 155,147,571 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05155,127,794 - 155,129,574 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05156,876,706 - 156,878,486 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5156,876,706 - 156,878,486 (+)Ensemblrn6Rnor6.0
Rnor_5.05160,625,616 - 160,627,396 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45157,235,534 - 157,237,314 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5149,065,196 - 149,066,976 (+)NCBICelera
RGSC_v3.15157,245,572 - 157,247,353 (+)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
alcohol  (ISO)
all-trans-retinoic acid  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
DDE  (ISO)
dimethylarsinous acid  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
ethanol  (ISO)
fipronil  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
glycidol  (EXP)
Heptachlor epoxide  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
methapyrilene  (EXP)
methylmercury chloride  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nickel atom  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
PCB138  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thiram  (ISO)
titanium dioxide  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
XL147  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
dendrite  (IDA,IEA)
neuronal cell body  (IDA)
postsynaptic density  (IEA,ISO)
synapse  (IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Camk2n1 Is a Negative Regulator of Blood Pressure, Left Ventricular Mass, Insulin Sensitivity, and Promotes Adiposity. Alfazema N, etal., Hypertension. 2019 Sep;74(3):687-696. doi: 10.1161/HYPERTENSIONAHA.118.12409. Epub 2019 Jul 22.
2. Expression of EMT-Related Genes CAMK2N1 and WNT5A is increased in Locally Invasive and Metastatic Prostate Cancer. Carneiro I, etal., J Cancer. 2019 Oct 15;10(24):5915-5925. doi: 10.7150/jca.34564. eCollection 2019.
3. Calcium/calmodulin-dependent protein kinase II inhibitor protein: localization of isoforms in rat brain. Chang BH, etal., Neuroscience 2001;102(4):767-77.
4. Loss of control over the ethanol consumption: differential transcriptional regulation in prefrontal cortex. de Paiva Lima C, etal., J Neurogenet. 2017 Sep;31(3):170-177. doi: 10.1080/01677063.2017.1349121. Epub 2017 Jul 17.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. RUNX3 and CAMK2N1 hypermethylation as prognostic marker for epithelial ovarian cancer. Häfner N, etal., Int J Cancer. 2016 Jan 1;138(1):217-28. doi: 10.1002/ijc.29690. Epub 2015 Jul 28.
7. DNA microarray and miRNA analyses reinforce the classification of follicular thyroid tumors. Jacques C, etal., J Clin Endocrinol Metab. 2013 May;98(5):E981-9. doi: 10.1210/jc.2012-4006. Epub 2013 Apr 8.
8. miR-182-5p Promotes Growth in Oral Squamous Cell Carcinoma by Inhibiting CAMK2N1. Li N, etal., Cell Physiol Biochem. 2018;49(4):1329-1341. doi: 10.1159/000493411. Epub 2018 Sep 11.
9. Novel insights into CaMKII function and regulation during memory formation. Lucchesi W, etal., Brain Res Bull. 2011 Apr 25;85(1-2):2-8. doi: 10.1016/j.brainresbull.2010.10.009. Epub 2010 Nov 9.
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Patient-derived ovarian cancer xenografts re-growing after a cisplatinum treatment are less responsive to a second drug re-challenge: a new experimental setting to study response to therapy. Ricci F, etal., Oncotarget. 2017 Jan 31;8(5):7441-7451. doi: 10.18632/oncotarget.7465.
13. Regulation of Ca2+/calmodulin kinase II inhibitor alpha (CaMKIINalpha) in virus-infected mouse brain. Saha S, etal., Biochem Biophys Res Commun. 2006 Nov 17;350(2):444-9. doi: 10.1016/j.bbrc.2006.09.066. Epub 2006 Sep 22.
14. Controlling the cell cycle: the role of calcium/calmodulin-stimulated protein kinases I and II. Skelding KA, etal., Cell Cycle. 2011 Feb 15;10(4):631-9. Epub 2011 Feb 15.
15. Upregulation of T-cell factor-4 isoform-responsive target genes in hepatocellular carcinoma. Tomimaru Y, etal., Liver Int. 2013 Aug;33(7):1100-12. doi: 10.1111/liv.12188. Epub 2013 May 8.
16. The tumor suppressive role of CAMK2N1 in castration-resistant prostate cancer. Wang T, etal., Oncotarget. 2014 Jun 15;5(11):3611-21. doi: 10.18632/oncotarget.1968.
17. Polymorphic markers associated with severe oxaliplatin-induced, chronic peripheral neuropathy in colon cancer patients. Won HH, etal., Cancer. 2012 Jun 1;118(11):2828-36. doi: 10.1002/cncr.26614. Epub 2011 Oct 21.
Additional References at PubMed
PMID:12175859   PMID:17350603   PMID:23145145   PMID:24711999   PMID:32320502  


Genomics

Comparative Map Data
Camk2n1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85155,958,116 - 155,959,897 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5155,957,878 - 155,961,058 (+)EnsemblGRCr8
mRatBN7.25150,674,819 - 150,676,600 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5150,673,507 - 150,676,600 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5153,371,504 - 153,373,282 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05155,145,792 - 155,147,571 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05155,127,794 - 155,129,574 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05156,876,706 - 156,878,486 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5156,876,706 - 156,878,486 (+)Ensemblrn6Rnor6.0
Rnor_5.05160,625,616 - 160,627,396 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45157,235,534 - 157,237,314 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5149,065,196 - 149,066,976 (+)NCBICelera
RGSC_v3.15157,245,572 - 157,247,353 (+)NCBI
Cytogenetic Map5q36NCBI
CAMK2N1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38120,482,391 - 20,486,210 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl120,482,391 - 20,486,210 (-)Ensemblhg38GRCh38
GRCh37120,808,884 - 20,812,703 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36120,681,471 - 20,685,315 (-)NCBIBuild 36Build 36hg18NCBI36
Celera119,133,214 - 19,137,058 (-)NCBICelera
Cytogenetic Map1p36.12NCBI
HuRef119,055,013 - 19,058,818 (-)NCBIHuRef
CHM1_1120,919,287 - 20,923,131 (-)NCBICHM1_1
T2T-CHM13v2.0120,307,345 - 20,311,164 (-)NCBIT2T-CHM13v2.0
Camk2n1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394138,182,459 - 138,187,437 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4138,181,625 - 138,187,434 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384138,455,148 - 138,460,126 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4138,454,314 - 138,460,123 (+)Ensemblmm10GRCm38
MGSCv374138,011,063 - 138,016,041 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364137,725,651 - 137,730,594 (+)NCBIMGSCv36mm8
MGSCv364136,043,940 - 136,058,301 (+)NCBIMGSCv36mm8
Celera4140,239,091 - 140,244,093 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map470.3NCBI
Camk2n1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554521,043,459 - 1,046,669 (-)Ensembl
ChiLan1.0NW_0049554521,044,696 - 1,046,657 (-)NCBIChiLan1.0ChiLan1.0
CAMK2N1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21206,633,219 - 206,636,276 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11205,750,123 - 205,753,105 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0119,437,761 - 19,441,573 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1120,479,559 - 20,482,600 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl120,479,562 - 20,482,600 (-)EnsemblpanPan2panpan1.1
CAMK2N1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha274,928,874 - 74,931,940 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0278,981,714 - 78,984,779 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl278,980,444 - 78,983,830 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1275,800,282 - 75,803,341 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0276,812,085 - 76,815,128 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0277,815,680 - 77,818,746 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Camk2n1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505840,638,909 - 40,641,859 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364746,461,050 - 6,466,641 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364746,463,691 - 6,466,641 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAMK2N1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl678,730,206 - 78,733,740 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1678,730,204 - 78,734,232 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2672,919,019 - 72,922,690 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CAMK2N1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120112,064,718 - 112,068,505 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20112,065,581 - 112,067,256 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660334,148,834 - 4,152,590 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Camk2n1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247645,544,484 - 5,547,683 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247645,544,589 - 5,547,811 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Camk2n1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1119,761,568 - 19,765,025 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Camk2n1
19 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:122
Count of miRNA genes:101
Interacting mature miRNAs:113
Transcripts:ENSRNOT00000021864
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5149642129171146538Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5134369218156289444Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5149805999162987697Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5149661912166600247Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat


Genetic Models
This gene Camk2n1 is modified in the following models/strains:
SHR-Camk2n1em1Tja-/-    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 89 59 6 353 189 10 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000021864   ⟹   ENSRNOP00000021864
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5156,876,706 - 156,878,486 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093999   ⟹   ENSRNOP00000094278
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5150,673,507 - 150,676,600 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000154497   ⟹   ENSRNOP00000110819
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5155,957,878 - 155,961,058 (+)Ensembl
RefSeq Acc Id: NM_173337   ⟹   NP_775459
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85155,958,116 - 155,959,897 (+)NCBI
mRatBN7.25150,674,819 - 150,676,600 (+)NCBI
Rnor_6.05156,876,706 - 156,878,486 (+)NCBI
Rnor_5.05160,625,616 - 160,627,396 (+)NCBI
RGSC_v3.45157,235,534 - 157,237,314 (+)RGD
Celera5149,065,196 - 149,066,976 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_775459 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF75281 (Get FASTA)   NCBI Sequence Viewer  
  EDL80881 (Get FASTA)   NCBI Sequence Viewer  
  Q9JI15 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_775459   ⟸   NM_173337
- UniProtKB: Q9JI15 (UniProtKB/Swiss-Prot),   A6ITI0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021864   ⟸   ENSRNOT00000021864
Ensembl Acc Id: ENSRNOP00000094278   ⟸   ENSRNOT00000093999
Ensembl Acc Id: ENSRNOP00000110819   ⟸   ENSRNOT00000154497

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JI15-F1-model_v2 AlphaFold Q9JI15 1-78 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708430 AgrOrtholog
BioCyc Gene G2FUF-39453 BioCyc
Ensembl Genes ENSRNOG00000016322 Ensembl
  ENSRNOG00000067661 Ensembl
  ENSRNOG00000090010 Ensembl
InterPro Camk2n UniProtKB/Swiss-Prot
KEGG Report rno:287005 UniProtKB/Swiss-Prot
NCBI Gene 287005 ENTREZGENE
PANTHER CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE II INHIBITOR 1 UniProtKB/Swiss-Prot
  PTHR31007 UniProtKB/Swiss-Prot
Pfam CaM-KIIN UniProtKB/Swiss-Prot
PhenoGen Camk2n1 PhenoGen
RatGTEx ENSRNOG00000016322 RatGTEx
  ENSRNOG00000067661 RatGTEx
  ENSRNOG00000090010 RatGTEx
UniProt A0ABK0M5T4_RAT UniProtKB/TrEMBL
  A6ITI0 ENTREZGENE, UniProtKB/TrEMBL
  CK2N1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-11-17 Camk2n1  calcium/calmodulin-dependent protein kinase II inhibitor 1  LOC287005  CaM-kinase II inhibitor alpha  Symbol and Name updated 1299863 APPROVED
2005-10-12 LOC287005        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to cell bodies and dendrites of neurons 1299437
gene_expression expressed specifically in frontal cortex, hippocampus and inferior colliculus 1299437