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Gene: Brinp2 (BMP/retinoic acid inducible neural specific 2) Rattus norvegicus

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Symbol:

Brinp2

Name:

BMP/retinoic acid inducible neural specific 2

RGD ID:

708419

Description:

Involved in negative regulation of cell cycle and nervous system development. Located in dendrite and neuronal cell body. Human ortholog(s) of this gene implicated in oral squamous cell carcinoma. Orthologous to human BRINP2 (BMP/retinoic acid inducible neural specific 2); INTERACTS WITH 1,3-dinitrobenzene; 17alpha-ethynylestradiol; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

BMP/retinoic acid-inducible neural-specific protein 2; bone morphogenetic protein/retinoic acid inducible neural-specific 2; bone morphogenic protein/retinoic acid inducible neural-specific 2; Fam5b; family with sequence similarity 5, member B

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	72,964,498 - 73,065,312 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	72,964,502 - 73,065,294 (-)	Ensembl				GRCr8
mRatBN7.2	13	70,431,006 - 70,532,766 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	70,431,010 - 70,531,810 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	73,009,747 - 73,110,601 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	74,307,588 - 74,408,329 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	71,567,679 - 71,668,362 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	75,948,679 - 76,049,363 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	75,948,679 - 76,049,363 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	80,863,780 - 80,964,493 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	73,541,992 - 73,644,517 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	70,246,465 - 70,347,212 (-)	NCBI		Celera
RGSC_v3.1	13	73,556,179 - 73,658,705 (-)	NCBI
Cytogenetic Map	13	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

oral squamous cell carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

1,3-dinitrobenzene (EXP)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-palmitoylglycerol (ISO)

4,4'-sulfonyldiphenol (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

alpha-Zearalanol (EXP)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bromobenzene (EXP)

Butylbenzyl phthalate (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

CGP 52608 (ISO)

copper atom (EXP)

copper(0) (EXP)

diazinon (EXP)

dieldrin (EXP)

dimethylarsinic acid (EXP)

ethanol (ISO)

fenvalerate (EXP)

fipronil (ISO)

gentamycin (EXP)

ketamine (EXP)

methapyrilene (ISO)

methoxychlor (EXP)

N,N-diethyl-m-toluamide (ISO)

nickel dichloride (EXP)

paracetamol (EXP)

perfluorohexanesulfonic acid (ISO)

perfluorooctanoic acid (EXP)

pirinixic acid (ISO)

potassium dichromate (ISO)

raloxifene (ISO)

rotenone (ISO)

Soman (EXP)

trichloroethene (EXP)

triclosan (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to retinoic acid (IBA,IEA,ISO)

central nervous system neuron differentiation (IBA,IEA,ISO)

locomotion (ISO)

multicellular organism growth (ISO)

negative regulation of cell cycle (IEA,IMP)

negative regulation of mitotic cell cycle (IBA,IEA,ISO)

nervous system development (IEP,ISO)

positive regulation of neuron differentiation (IEA)

regulation of cell cycle (IEA)

Cellular Component

cytoplasm (IBA)

dendrite (IBA,IDA)

extracellular region (IEA)

neuronal cell body (IBA,IDA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal circadian regulation of systemic arterial blood pressure (IMP)

salt-sensitive hypertension (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Genetic alterations in oral squamous cell carcinoma progression detected by combining array-based comparative genomic hybridization and multiplex ligation-dependent probe amplification.	Cha JD, etal., Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 May;111(5):594-607. doi: 10.1016/j.tripleo.2010.11.020. Epub 2011 Feb 22.
2.	Characterization of biological pathways associated with a 1.37 Mbp genomic region protective of hypertension in Dahl S rats.	Cowley AW, etal., Physiol Genomics. 2014 Jun 1;46(11):398-410. doi: 10.1152/physiolgenomics.00179.2013. Epub 2014 Apr 8.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Identification and characterization of novel developmentally regulated neural-specific proteins, BRINP family.	Kawano H, etal., Brain Res Mol Brain Res 2004 Jun 18;125(1-2):60-75.
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:20025061

Genomics

Comparative Map Data

Brinp2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	72,964,498 - 73,065,312 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	72,964,502 - 73,065,294 (-)	Ensembl				GRCr8
mRatBN7.2	13	70,431,006 - 70,532,766 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	70,431,010 - 70,531,810 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	73,009,747 - 73,110,601 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	74,307,588 - 74,408,329 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	71,567,679 - 71,668,362 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	75,948,679 - 76,049,363 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	75,948,679 - 76,049,363 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	80,863,780 - 80,964,493 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	73,541,992 - 73,644,517 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	70,246,465 - 70,347,212 (-)	NCBI		Celera
RGSC_v3.1	13	73,556,179 - 73,658,705 (-)	NCBI
Cytogenetic Map	13	q22	NCBI

BRINP2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	177,170,958 - 177,282,422 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	177,170,890 - 177,282,422 (+)	Ensembl			hg38	GRCh38
GRCh37	1	177,140,094 - 177,251,558 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	175,407,256 - 175,518,181 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	1	150,250,704 - 150,361,628 (+)	NCBI		Celera
Cytogenetic Map	1	q25.2	NCBI
HuRef	1	148,367,642 - 148,478,577 (+)	NCBI		HuRef
CHM1_1	1	178,564,624 - 178,675,569 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	176,525,633 - 176,637,111 (+)	NCBI		T2T-CHM13v2.0

Brinp2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	158,072,835 - 158,185,096 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	158,072,839 - 158,183,896 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	158,245,265 - 158,356,528 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	158,245,269 - 158,356,326 (-)	Ensembl			mm10	GRCm38
MGSCv37	1	160,175,400 - 160,286,391 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	160,081,948 - 160,193,003 (-)	NCBI		MGSCv36	mm8
Celera	1	160,640,225 - 160,749,398 (-)	NCBI		Celera
Cytogenetic Map	1	H1	NCBI
cM Map	1	68.27	NCBI

Brinp2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	16,748,824 - 16,844,093 (+)	Ensembl
ChiLan1.0	NW_004955406	16,748,824 - 16,840,924 (+)	NCBI	ChiLan1.0	ChiLan1.0

BRINP2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	72,437,118 - 72,547,910 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	72,107,317 - 72,218,106 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	152,694,667 - 152,806,085 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	156,391,436 - 156,502,742 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	156,450,411 - 156,502,742 (+)	Ensembl			panPan2	panpan1.1

BRINP2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	22,332,465 - 22,449,295 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	22,339,056 - 22,448,854 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	21,865,088 - 21,973,700 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	22,086,726 - 22,195,881 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	22,072,721 - 22,195,861 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	21,992,092 - 22,101,532 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	22,092,409 - 22,201,467 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	22,235,542 - 22,344,318 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Brinp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	93,512,083 - 93,615,246 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936481	11,356,608 - 11,455,125 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936481	11,358,832 - 11,455,104 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BRINP2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	118,975,719 - 119,095,336 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	9	118,967,670 - 119,095,345 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	130,733,801 - 130,820,039 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

BRINP2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	51,993,095 - 52,114,569 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	51,993,135 - 52,105,212 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666055	53,564,202 - 53,676,022 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Brinp2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624771	4,924,750 - 4,972,097 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624771	4,926,187 - 5,021,454 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Brinp2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	10	37,575,518 - 37,681,593 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Brinp2
1029 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	34
Count of miRNA genes:	33
Interacting mature miRNAs:	34
Transcripts:	ENSRNOT00000007455
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1298066	Bp159	Blood pressure QTL 159		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	48639634	93639634	Rat
10755495	Bp387	Blood pressure QTL 387	3.78		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	37216241	90057603	Rat
1354655	Bp241	Blood pressure QTL 241	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	38975045	103588154	Rat
8655951	Rf63	Renal function QTL 63	12.2		blood urea nitrogen amount (VT:0005265)	plasma urea nitrogen level (CMO:0000586)	13	71610804	109350286	Rat
70220	Bp55	Blood pressure QTL 55	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	39924693	84924693	Rat
8655945	Rf61	Renal function QTL 61	3.6		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	13	71610804	89333251	Rat
71119	Thym2	Thymus enlargement QTL 2	3.8		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	13	48749814	87285480	Rat
4889861	Pur29	Proteinuria QTL 29	13.8	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	39968211	83286298	Rat
1331783	Bp221	Blood pressure QTL 221	3.72886		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	71610804	89333251	Rat
8655959	Pur32	Proteinuria QTL 32	8.4		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	72984506	99745408	Rat
2293687	Bss26	Bone structure and strength QTL 26	4.6	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	13	67635937	109350286	Rat
1300166	Kidm6	Kidney mass QTL 6	3.93		kidney mass (VT:0002707)	single kidney wet weight to body weight ratio (CMO:0000622)	13	71610804	89333251	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	7421791	87286911	Rat
61340	Bp25	Blood pressure QTL 25	4.2	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	37087983	82087983	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
1549897	Stresp12	Stress response QTL 12	3.35		stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	13	40983585	85983585	Rat
724564	Uae11	Urinary albumin excretion QTL 11	5.7		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	13	47354258	94285672	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	21120177	109350286	Rat
738027	Lnnr6	Liver neoplastic nodule remodeling QTL 6	3.3		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	65613454	109350286	Rat
7387280	Uae43	Urinary albumin excretion QTL 43	5.69	0.4174	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	68983334	109350286	Rat
738026	Lnnr5	Liver neoplastic nodule remodeling QTL 5	3.29		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	62424592	88113509	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	13	33794096	78794096	Rat
2293702	Bss34	Bone structure and strength QTL 34	4.61	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	13	67635937	109350286	Rat
61349	Bp31	Blood pressure QTL 31	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	39924693	84924693	Rat
1576318	Schws5	Schwannoma susceptibility QTL 5		0.0351	nervous system integrity trait (VT:0010566)	post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)	13	64497900	109350286	Rat
2303563	Bw89	Body weight QTL 89	6		body mass (VT:0001259)	body weight (CMO:0000012)	13	34834947	79834947	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	11081740	103588154	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
12879477	Bp401	Blood pressure QTL 401			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	39814726	84814726	Rat
1331750	Bp220	Blood pressure QTL 220	2.98		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	39968211	84968211	Rat
12879475	Bp400	Blood pressure QTL 400			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	64375743	109350286	Rat
11530006	Niddm72	Non-insulin dependent diabetes mellitus QTL 72		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	38286298	83286298	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	103588154	Rat
2293341	Glom15	Glomerulus QTL 15	9.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	13	67635937	109350286	Rat

Markers in Region

RH143402

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	70,431,248 - 70,431,370 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	75,948,918 - 75,949,039	NCBI	Rnor6.0
Rnor_5.0	13	80,864,019 - 80,864,140	UniSTS	Rnor5.0
RGSC_v3.4	13	73,542,231 - 73,542,352	UniSTS	RGSC3.4
Celera	13	70,246,704 - 70,246,825	UniSTS
Cytogenetic Map	13	q22	UniSTS

AU046789

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	70,441,637 - 70,441,813 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	75,959,309 - 75,959,484	NCBI	Rnor6.0
Rnor_5.0	13	80,874,410 - 80,874,585	UniSTS	Rnor5.0
RGSC_v3.4	13	73,553,232 - 73,553,407	UniSTS	RGSC3.4
Celera	13	70,257,093 - 70,257,268	UniSTS
Cytogenetic Map	13	q22	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
13	12	67	165	56	55	24	35	24	6	242	135	11	137	62	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_173115	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090411	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090412	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090413	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272059	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB077853	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000007455 ⟹ ENSRNOP00000007455

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	72,964,502 - 73,065,294 (-)	Ensembl
mRatBN7.2 Ensembl	13	70,431,010 - 70,531,810 (-)	Ensembl
Rnor_6.0 Ensembl	13	75,948,679 - 76,049,363 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000075865 ⟹ ENSRNOP00000068294

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	13	75,948,679 - 76,049,363 (-)	Ensembl

RefSeq Acc Id:

NM_173115 ⟹ NP_775138

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	72,964,502 - 73,065,294 (-)	NCBI
mRatBN7.2	13	70,431,010 - 70,531,810 (-)	NCBI
Rnor_6.0	13	75,948,679 - 76,049,363 (-)	NCBI
Rnor_5.0	13	80,863,780 - 80,964,493 (-)	NCBI
RGSC_v3.4	13	73,541,992 - 73,644,517 (-)	RGD
Celera	13	70,246,465 - 70,347,212 (-)	RGD

Sequence:

show sequence

GGCAGGGCAGCATTGTTATCTTAAGACACTCATCTGGTGTCTGAGTCTGCAGGTGACACTGGTT
AGGTACGGAGCGTGAAGTCGGAGTGGGGACGCACCGGGCTGCAGCTCTAGGATGGAATCCGCCT
GCCTGCCAAGCGGCTCGCGGCTCAACCCGCAGCGCCTCCTCTGAGCTCGGCGGGTTCCGGAGGA
CTTGGGAAATGCACCTGCCGCGCGCTCAGAGGACACCAGCAGGTCCTCAGGCAGCCGAAGGAGC
CCAGACGCCCGAGGAACCGTTTCTGACCACGTACAAGGCACAGATTTCGGATGACAGGGCGGGT
GAGTCTCTTTAGAGTTGGGGGAAAAAAAGGCAAGATCTTTGGTTTCACCTCGGTCGAGGGACAG
GGGACTTCTCAGTTGGCCTCCCACTTTCCTCACCTCTCCCACGCCGCGTGCGACCCAGCCTAGC
GCTGATCCCACTTCACAGATGCTGTGGGTGCCTGGGATGCTCGCTGCTCCGTGGCAAGGCAGCA
GGCAAGTGGTCTAAACGCCGCCGCCGCCGCCGCCGCCACCGCCGCCGCCGCGGCAACAGCAAAG
CCCAGAACAGGAGAATTTGAAAAGAGACATCCGTTCCCTCTCACAAGCTGAGGGGGGGAGGCAT
TCGCATTTCCCCAAAGGAGAAAGAGCCACAAGAAATCATGAAGTAAAAACTTTGGAAGGCTGCC
ACTGGAGATGTTGCACAAAAACTGGGCGTCTTTTAGGAGTCTCCTCGCAGTCCTTGGTGTTTTG
GGGAGCAGCTGATACAGCAAGAAGGGCTCTTACAAGGATTCAAGTTTGGAGCCCTGGAGGAGCA
GCACGGAGTGGGAGAGCTTGGCGAGAGAATGAAGACACTAACCGCCTGGGAGAAGCATGAGGTG
GCCGTGCAGCTCTCGGTTTAGAGGGCTTTGGCCGGAGGCCGCCCCATGGGCAGTCCTGCTGGCA
CTAGGCGTGCCCGGGTGGGTGCTGGCTGTCTCGGCCACGGTGGCCGCTGTGGTCCCGGAACAGC
ATGTCTCCTCGGCTGGTCAGGCTCCCCTGGACTGGCTGCTCACAGACCGAGGCCCCTTCCACCG
TGCCCAGGAGTATGCTGATTTCATGGAGCGTTACCGCCAGGGGTTCACTACCAGATACAGGATC
TACAGGGAGTTTGCCCGATGGAAAGTGAACAACTTGGCCCTAGAAAGGAAAGACTTCTTCAGTT
TGCCCCTGCCTCTCGCCCCAGAGTTTGTCCGCAACATCCGCCTCCTTGGAAGGAGACCCAACCT
GCAGCAGGTCACTGAAAACCTCATCAAAAAGTACGGCACTCATTTCTTACTTTCTGCCACTCTT
GGAGGAGAAGAGTCCCTGACCATTTTTGTGGACAAGAGGAAACTAAGCAGAAAGTCAGAAACAC
TAGGAGGTGTTCCTGTAGTGGGGGGCACTGGGAACAGCTCTGCTGTGTCTCTGGAAACCCTGCA
CCAGCTGGCAGCCTCCTACTTCATTGACAGAGAGAGCACACTGCGAAGACTTCACCATATCCAA
ATAGCCACAGGGGCCATAAAGGTCACAGAGACCAGGACCGGTCCACTGGGCTGCAGCAACTATG
ACAATCTGGACTCTGTCAGCTCTGTCCTGGTTCAGAGTCCAGAGAACAAAGTGCAGTTATTGGG
CCTGCAGGTGCTGCTCCCTGAACACCTGCGTGAGCGGTTTGTGGCTGCAGCACTCAGCTACATC
ACATGCAGCTCTGAGGGTGAGCTTGTCTGCAGGGAGAATGACTGCTGGTGCAAGTGCAGCCCCA
CGTTCCCAGAATGCAACTGTCCTGATGCTGACATTCAAGCTATGGAAGACAGCTTGCTGCAGAT
CCAAGACTCCTGGGCCACTCACAACAGGCAGTTTGAAGAGTCAGAAGAATTCCAGACCCTGCTG
AAGAGGCTCCCCAGCGACCGATTCCTGAACTCCACAGCCATCTCCCAGTACTGGACCATGGACG
CCAACCTCCAGCACCGTTATCAGCAGCTGGGAGCCAGCTTGAAAGTCCTGTTAAAGAAGATGCA
CCGGATCGTCCGCCGCCTCTTCAATCTCTGCAAGCGCTGCCATCGGCAGCCTCGCTTCCGCCTG
CCCAAGGAGAGATCCTTGTCTTTCTGGTGGAACCGAATCCAGTCCCTTCTCTACTGTGGAGAAA
GCACCTTCCCTGGGACATTCCTGGAACAGAGCCACAGCTGCACCTGTCCCTATGACCAATCTTC
CTGCCAGGGCCCCATTCCATGTGCCCTGGGGGAAGGGCCTGCATGTGCCCACTGTGCTTCAGAC
AATACCACGCGCTGTGGGAGTTGTAACCCTGGTTATGTGCTAGCCCAGGGACTGTGCCGGCCAG
AGGTAGCCGAGTCCCTGGAGAACTTTCTTGGGCTGGAGACAGACCTGCAGGACCTTGAGCTGAA
GTACCTGCTGCAGAAGCGAGATAGCCGCATTGAGGTGCACTCCATCTTTATCAGCAATGACATG
CGTCTGGGCAGCTGGTTTGACCCTTCCTGGAGGAAGCGGATGCTCCTCACTTTGAAGAGTAACA
AGTACAAGCCGGGCCTGGTGCATGTGATGTTAGCCTTGTCCTTGCAGATCTGCCTCACTAAGAA
CAGCACCCTGGAGCCCGTCATGGCCATCTATGTGAACCCCTTCGGGGGCAGCCACTCTGAGAGC
TGGTTCATGCCTGTAAACGAGGGCAGCTTTCCAGACTGGGAAAGGACTAACGTGGATGCAGCTG
CCCAGTGCCAAAACTGGACTATCACTTTGGGGAACAGGTGGAAGACTTTTTTTGAGACAGTCCA
TGTTTACCTACGGAGCCGAATCAAGTCCCTGGATGACAGCTCCAACGAGACAATCTACTATGAG
CCCCTGGAGATGACTGATCCCTCCAAGAATTTGGGCTACATGAAAATCAACACTTTGCAGGTCT
TTGGCTACAGCCTGCCCTTTGACCCGGATGCTATCCGAGACTTAATTCTCCAGCTGGACTACCC
GTACACTCAAGGTTCCCAGGACTCTGCACTCTTACAACTCATTGAGCTTAGAGACCGGGTGAAC
CAACTCTCTCCCCCTGGCAAAGTCCGGCTTGATCTTTTCTCCTGCTTGCTCCGCCATAGGCTCA
AGCTGGCCAACAACGAGGTGGGCAGGATCCAGTCCTCCCTGAGAGCTTTCAATTCCAAGCTGCC
AAATCCTGTGGAGTATGAGACAGGCAAACTCTGTAGCTAATGGGGGAACTACCCCAGTGCTGGT
CAGAGAGTTGATCCACACATTCAGGGTGCAAAGATAATCCAAGCCCTCACCTCAGTGCCAACAG
AGTGCTTCTAAGAGACTTTTAGCACCTGGGAGATAGGAGCTCAAGGCTTGGACTGAAGCAGGCG
AAAAACAATGAAACAGCCACTGCACACATGCACAAGTGCATATAACACCCTACCACACACACTC
ACAGGGAGGCCACAGCCCAGCCACCTCGAATCTGTAAAGTTGGTGCTCTCTAAAATGAATGCAG
TTGAAGAAGAACCAAGGAAGAGATAAAAGAGCTGGCTAAACCAGGAAAGAAATGACTGAAAAAA
ATACATTTCAAAGTGATTCTTGTCATCTAGGATAGCAAGAGGGACAGAAGTGGGAGGGACAGGA
GACCTCCCCTCTGTGGAGTCACTTTTGTATTCTTTTTAACCAGATTTCTTAAAATGTCATTGTT
CTGTGACTCCCTGCACTGCTTCTTACTCTGTACAGTGCCTCCCTGCACCCTGGAGGCCTTGGTG
TCCTTGGAAAGTGTGTGCAGTGCTAAAGCAGAGGAGCTCACGCTAAGGGCAGGTCACGGCCTCT
TTGCTCCCTCCCCCACTTCTTCCTCCTGCCAGCTCCCTCACTTTCTTGGCCTCCCCAGTTTCAG
AGTTTTGACTTGTTCCAAGAGCCCCTCACAGTTCATCCAGAGCCCTCTTCCCACAGCACCCATC
TGTTCAAGGAAGCAGTTTTGTCAAGTTAGAGAGACAACATATATGGAAATGTTCTTTTTAAAAA
AAAACAACAAAACAAAAAATATTTATTTTGTGATTGTTTTCTTGTCAACCTGCTCCAGTCACAT
GAACCTCTGAGTAAAGTTTTACTTGGTTTAAAGC

hide sequence

RefSeq Acc Id:

XM_039090411 ⟹ XP_038946339

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	72,964,498 - 73,065,312 (-)	NCBI
mRatBN7.2	13	70,431,006 - 70,532,766 (-)	NCBI

RefSeq Acc Id:

XM_039090412 ⟹ XP_038946340

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	72,964,498 - 73,065,312 (-)	NCBI
mRatBN7.2	13	70,431,006 - 70,532,765 (-)	NCBI

RefSeq Acc Id:

XM_039090413 ⟹ XP_038946341

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	72,964,498 - 73,065,312 (-)	NCBI
mRatBN7.2	13	70,431,006 - 70,532,765 (-)	NCBI

RefSeq Acc Id:

XM_063272059 ⟹ XP_063128129

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	72,964,498 - 73,012,334 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_775138	(Get FASTA)	NCBI Sequence Viewer
	XP_038946339	(Get FASTA)	NCBI Sequence Viewer
	XP_038946340	(Get FASTA)	NCBI Sequence Viewer
	XP_038946341	(Get FASTA)	NCBI Sequence Viewer
	XP_063128129	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAC03099	(Get FASTA)	NCBI Sequence Viewer
	EDM09460	(Get FASTA)	NCBI Sequence Viewer
	EDM09461	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000007455
	ENSRNOP00000007455.8
GenBank Protein	Q8K1M8	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_775138 ⟸ NM_173115
- Peptide Label:	precursor
- UniProtKB:	Q8K1M8 (UniProtKB/Swiss-Prot), A6ID37 (UniProtKB/TrEMBL), F1MA15 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRWPCSSRFRGLWPEAAPWAVLLALGVPGWVLAVSATVAAVVPEQHVSSAGQAPLDWLLTDRGP FHRAQEYADFMERYRQGFTTRYRIYREFARWKVNNLALERKDFFSLPLPLAPEFVRNIRLLGRR PNLQQVTENLIKKYGTHFLLSATLGGEESLTIFVDKRKLSRKSETLGGVPVVGGTGNSSAVSLE TLHQLAASYFIDRESTLRRLHHIQIATGAIKVTETRTGPLGCSNYDNLDSVSSVLVQSPENKVQ LLGLQVLLPEHLRERFVAAALSYITCSSEGELVCRENDCWCKCSPTFPECNCPDADIQAMEDSL LQIQDSWATHNRQFEESEEFQTLLKRLPSDRFLNSTAISQYWTMDANLQHRYQQLGASLKVLLK KMHRIVRRLFNLCKRCHRQPRFRLPKERSLSFWWNRIQSLLYCGESTFPGTFLEQSHSCTCPYD QSSCQGPIPCALGEGPACAHCASDNTTRCGSCNPGYVLAQGLCRPEVAESLENFLGLETDLQDL ELKYLLQKRDSRIEVHSIFISNDMRLGSWFDPSWRKRMLLTLKSNKYKPGLVHVMLALSLQICL TKNSTLEPVMAIYVNPFGGSHSESWFMPVNEGSFPDWERTNVDAAAQCQNWTITLGNRWKTFFE TVHVYLRSRIKSLDDSSNETIYYEPLEMTDPSKNLGYMKINTLQVFGYSLPFDPDAIRDLILQL DYPYTQGSQDSALLQLIELRDRVNQLSPPGKVRLDLFSCLLRHRLKLANNEVGRIQSSLRAFNS KLPNPVEYETGKLCS hide sequence

Ensembl Acc Id:

ENSRNOP00000068294 ⟸ ENSRNOT00000075865

Ensembl Acc Id:

ENSRNOP00000007455 ⟸ ENSRNOT00000007455

RefSeq Acc Id:	XP_038946339 ⟸ XM_039090411
- Peptide Label:	isoform X1
- UniProtKB:	Q8K1M8 (UniProtKB/Swiss-Prot), A6ID37 (UniProtKB/TrEMBL), F1MA15 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038946341 ⟸ XM_039090413
- Peptide Label:	isoform X1
- UniProtKB:	Q8K1M8 (UniProtKB/Swiss-Prot), A6ID37 (UniProtKB/TrEMBL), F1MA15 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038946340 ⟸ XM_039090412
- Peptide Label:	isoform X1
- UniProtKB:	Q8K1M8 (UniProtKB/Swiss-Prot), A6ID37 (UniProtKB/TrEMBL), F1MA15 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063128129 ⟸ XM_063272059
- Peptide Label:	isoform X2

Protein Domains

MACPF

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8K1M8-F1-model_v2	AlphaFold	Q8K1M8	1-783	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:708419	AgrOrtholog
BioCyc Gene	G2FUF-17781	BioCyc
Ensembl Genes	ENSRNOG00000005592	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000007455	ENTREZGENE
	ENSRNOT00000007455.8	UniProtKB/Swiss-Prot
InterPro	BRINP	UniProtKB/Swiss-Prot
	MACPF	UniProtKB/Swiss-Prot
KEGG Report	rno:286895	UniProtKB/Swiss-Prot
NCBI Gene	286895	ENTREZGENE
PANTHER	BMP/RETINOIC ACID-INDUCIBLE NEURAL-SPECIFIC PROTEIN 2	UniProtKB/Swiss-Prot
	PTHR15564	UniProtKB/Swiss-Prot
Pfam	BRINP	UniProtKB/Swiss-Prot
	EGF_BRNP1-3	UniProtKB/Swiss-Prot
	MACPF	UniProtKB/Swiss-Prot
PhenoGen	Brinp2	PhenoGen
RatGTEx	ENSRNOG00000005592	RatGTEx
SMART	MACPF	UniProtKB/Swiss-Prot
UniProt	A6ID36_RAT	UniProtKB/TrEMBL
	A6ID37	ENTREZGENE, UniProtKB/TrEMBL
	BRNP2_RAT	UniProtKB/Swiss-Prot
	F1MA15	ENTREZGENE, UniProtKB/TrEMBL
	Q8K1M8	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-01	Brinp2	BMP/retinoic acid inducible neural specific 2	Brinp2	bone morphogenetic protein/retinoic acid inducible neural-specific 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-08-14	Brinp2	bone morphogenetic protein/retinoic acid inducible neural-specific 2	Brinp2	bone morphogenic protein/retinoic acid inducible neural-specific 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-08-07	Brinp2	bone morphogenic protein/retinoic acid inducible neural-specific 2	Fam5b	family with sequence similarity 5, member B	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-05-15	Fam5b	family with sequence similarity 5, member B	Brinp2	BMP/retinoic acid-inducible neural-specific protein 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-07-08	Brinp2	BMP/retinoic acid-inducible neural-specific protein 2			Symbol and Name status set to approved	1299863	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Mammalian Phenotype