Fgd4 (FYVE, RhoGEF and PH domain containing 4) - Rat Genome Database

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Gene: Fgd4 (FYVE, RhoGEF and PH domain containing 4) Rattus norvegicus
Analyze
Symbol: Fgd4
Name: FYVE, RhoGEF and PH domain containing 4
RGD ID: 708357
Description: Enables actin filament binding activity. Involved in positive regulation of JNK cascade and regulation of cell shape. Acts upstream of or within positive regulation of JUN kinase activity. Predicted to be located in filopodium and lamellipodium. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4H. Orthologous to human FGD4 (FYVE, RhoGEF and PH domain containing 4); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: actin filament-binding protein frabin; actin-filament binding protein frabin; FGD1-related F-actin-binding protein; FYVE, RhoGEF and PH domain-containing protein 4; LOC108352368; uncharacterized LOC108352368
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81197,904,182 - 98,055,190 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1197,904,182 - 98,055,190 (+)EnsemblGRCr8
mRatBN7.21184,399,989 - 84,551,013 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1184,399,816 - 84,546,972 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1193,183,216 - 93,280,301 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01185,844,359 - 85,941,442 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01184,897,963 - 84,995,041 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01188,699,222 - 88,796,677 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1188,699,222 - 88,796,677 (+)Ensemblrn6Rnor6.0
Rnor_5.01191,755,139 - 91,851,321 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41186,700,118 - 86,767,928 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1183,195,465 - 83,292,853 (+)NCBICelera
RGSC_v3.11186,740,714 - 86,808,525 (-)NCBI
Cytogenetic Map11q23NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4,6-tribromophenol  (ISO)
2-palmitoylglycerol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
crotonaldehyde  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dorsomorphin  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
indometacin  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melphalan  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
nickel atom  (ISO)
ozone  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
succimer  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thiram  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
cytoskeleton  (IEA)
filopodium  (IEA,ISO)
lamellipodium  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Frabin, a novel FGD1-related actin filament-binding protein capable of changing cell shape and activating c-Jun N-terminal kinase. Obaishi H, etal., J Biol Chem 1998 Jul 24;273(30):18697-700.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10464238   PMID:11527409   PMID:12477932   PMID:17564959  


Genomics

Comparative Map Data
Fgd4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81197,904,182 - 98,055,190 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1197,904,182 - 98,055,190 (+)EnsemblGRCr8
mRatBN7.21184,399,989 - 84,551,013 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1184,399,816 - 84,546,972 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1193,183,216 - 93,280,301 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01185,844,359 - 85,941,442 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01184,897,963 - 84,995,041 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01188,699,222 - 88,796,677 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1188,699,222 - 88,796,677 (+)Ensemblrn6Rnor6.0
Rnor_5.01191,755,139 - 91,851,321 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41186,700,118 - 86,767,928 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1183,195,465 - 83,292,853 (+)NCBICelera
RGSC_v3.11186,740,714 - 86,808,525 (-)NCBI
Cytogenetic Map11q23NCBI
FGD4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381232,399,558 - 32,646,050 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1232,399,558 - 32,646,050 (+)Ensemblhg38GRCh38
GRCh371232,552,492 - 32,798,984 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361232,546,361 - 32,684,940 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341232,546,360 - 32,684,940NCBI
Celera1212,475,281 - 12,619,210 (+)NCBICelera
Cytogenetic Map12p11.21NCBI
HuRef1232,407,492 - 32,551,291 (+)NCBIHuRef
CHM1_11232,621,603 - 32,765,483 (+)NCBICHM1_1
T2T-CHM13v2.01232,275,797 - 32,522,311 (+)NCBIT2T-CHM13v2.0
Fgd4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391616,234,774 - 16,418,400 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1616,234,781 - 16,418,413 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381616,416,910 - 16,600,534 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1616,416,917 - 16,600,549 (-)Ensemblmm10GRCm38
MGSCv371616,422,071 - 16,560,289 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361616,335,541 - 16,473,759 (-)NCBIMGSCv36mm8
Celera1616,993,276 - 17,131,405 (-)NCBICelera
Cytogenetic Map16A2- A3NCBI
cM Map1610.18NCBI
Fgd4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555053,099,672 - 3,239,950 (-)Ensembl
ChiLan1.0NW_0049555053,108,131 - 3,314,040 (-)NCBIChiLan1.0ChiLan1.0
FGD4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21064,103,468 - 64,351,914 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11264,099,864 - 64,348,309 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01253,574,573 - 53,822,971 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11256,177,209 - 56,421,662 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1256,181,565 - 56,421,810 (-)EnsemblpanPan2panpan1.1
FGD4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12716,252,405 - 16,464,099 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2716,254,542 - 16,464,112 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2729,959,925 - 30,175,525 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02716,432,262 - 16,643,309 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2716,437,077 - 16,643,512 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12716,239,925 - 16,454,669 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02716,272,975 - 16,488,424 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02730,109,074 - 30,323,691 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fgd4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494576,841,846 - 77,044,093 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366073,679,887 - 3,877,470 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366073,675,217 - 3,796,329 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGD4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl541,680,452 - 41,879,062 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1541,683,265 - 41,879,197 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2544,933,765 - 44,960,137 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FGD4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11131,831,051 - 32,080,267 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660692,825,191 - 3,084,236 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fgd4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247783,498,436 - 3,743,312 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247783,509,546 - 3,743,213 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Fgd4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v141,663,821 - 1,798,557 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:150
Count of miRNA genes:126
Interacting mature miRNAs:136
Transcripts:ENSRNOT00000002491
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)117385089499753367Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)117330831599753367Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)117961851999753367Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 355 192 11 144 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000078367   ⟹   ENSRNOP00000072359
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1197,904,182 - 98,055,190 (+)Ensembl
mRatBN7.2 Ensembl1184,399,816 - 84,546,972 (+)Ensembl
Rnor_6.0 Ensembl1188,732,381 - 88,795,399 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000084177   ⟹   ENSRNOP00000074767
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1197,953,433 - 98,034,672 (+)Ensembl
mRatBN7.2 Ensembl1184,449,241 - 84,546,972 (+)Ensembl
Rnor_6.0 Ensembl1188,699,222 - 88,796,677 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100508   ⟹   ENSRNOP00000092594
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1197,934,897 - 98,055,190 (+)Ensembl
mRatBN7.2 Ensembl1184,430,398 - 84,546,972 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000145334   ⟹   ENSRNOP00000100627
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1197,940,821 - 98,055,190 (+)Ensembl
RefSeq Acc Id: NM_001415054   ⟹   NP_001401983
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,904,182 - 98,055,190 (+)NCBI
mRatBN7.21184,399,989 - 84,551,008 (+)NCBI
RefSeq Acc Id: NM_001415055   ⟹   NP_001401984
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,940,821 - 98,055,190 (+)NCBI
mRatBN7.21184,436,629 - 84,551,008 (+)NCBI
RefSeq Acc Id: XM_039087982   ⟹   XP_038943910
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,934,673 - 98,055,188 (+)NCBI
mRatBN7.21184,430,471 - 84,551,013 (+)NCBI
RefSeq Acc Id: XM_039087984   ⟹   XP_038943912
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,962,618 - 98,055,188 (+)NCBI
mRatBN7.21184,458,427 - 84,551,013 (+)NCBI
RefSeq Acc Id: XM_063270283   ⟹   XP_063126353
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,986,627 - 98,055,188 (+)NCBI
Ensembl Acc Id: ENSRNOP00000072359   ⟸   ENSRNOT00000078367
Ensembl Acc Id: ENSRNOP00000074767   ⟸   ENSRNOT00000084177
RefSeq Acc Id: XP_038943910   ⟸   XM_039087982
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GK89 (UniProtKB/TrEMBL),   A6JSP9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038943912   ⟸   XM_039087984
- Peptide Label: isoform X2
- UniProtKB: O88387 (UniProtKB/Swiss-Prot),   A6JSQ0 (UniProtKB/TrEMBL),   A0A0G2K8X0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000092594   ⟸   ENSRNOT00000100508
RefSeq Acc Id: NP_001401983   ⟸   NM_001415054
- Peptide Label: isoform 1
- UniProtKB: A0A0G2K2S8 (UniProtKB/TrEMBL),   A6JSP9 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001401984   ⟸   NM_001415055
- Peptide Label: isoform 2
- UniProtKB: O88387 (UniProtKB/Swiss-Prot),   A6JSQ0 (UniProtKB/TrEMBL),   A0A0G2K8X0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126353   ⟸   XM_063270283
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000100627   ⟸   ENSRNOT00000145334
Protein Domains
DH   FYVE-type   PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88387-F1-model_v2 AlphaFold O88387 1-766 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708357 AgrOrtholog
BioCyc Gene G2FUF-20553 BioCyc
Ensembl Genes ENSRNOG00000059491 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000078367 ENTREZGENE
  ENSRNOT00000084177.2 UniProtKB/Swiss-Prot
  ENSRNOT00000100508 ENTREZGENE
  ENSRNOT00000145334 ENTREZGENE
Gene3D-CATH 1.20.900.10 UniProtKB/Swiss-Prot
  2.30.29.30 UniProtKB/Swiss-Prot
  3.30.40.10 UniProtKB/Swiss-Prot
InterPro DBL_dom_sf UniProtKB/Swiss-Prot
  DH-domain UniProtKB/Swiss-Prot
  FDG4_N_PH UniProtKB/Swiss-Prot
  FGD1-4_PH2 UniProtKB/Swiss-Prot
  FYVE_RhoGEF_PH UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  PH_domain UniProtKB/Swiss-Prot
  Znf_FYVE UniProtKB/Swiss-Prot
  Znf_FYVE-rel UniProtKB/Swiss-Prot
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot
NCBI Gene 246174 ENTREZGENE
PANTHER FACIOGENITAL DYSPLASIA PROTEIN UniProtKB/Swiss-Prot
  FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 4 UniProtKB/Swiss-Prot
Pfam FYVE UniProtKB/Swiss-Prot
  PF00169 UniProtKB/Swiss-Prot
  RhoGEF UniProtKB/Swiss-Prot
PhenoGen Fgd4 PhenoGen
PROSITE DH_2 UniProtKB/Swiss-Prot
  PH_DOMAIN UniProtKB/Swiss-Prot
  ZF_FYVE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000059491 RatGTEx
SMART FYVE UniProtKB/Swiss-Prot
  RhoGEF UniProtKB/Swiss-Prot
  SM00233 UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
  SSF48065 UniProtKB/Swiss-Prot
UniProt A0A0G2K2S8 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K8X0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GK89 ENTREZGENE, UniProtKB/TrEMBL
  A6JSP9 ENTREZGENE, UniProtKB/TrEMBL
  A6JSQ0 ENTREZGENE, UniProtKB/TrEMBL
  A6JSQ1_RAT UniProtKB/TrEMBL
  A6JSQ2_RAT UniProtKB/TrEMBL
  A6JSQ3_RAT UniProtKB/TrEMBL
  FGD4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Fgd4  FYVE, RhoGEF and PH domain containing 4  LOC108352368  uncharacterized LOC108352368  Data merged from RGD:11362447 737654 PROVISIONAL
2016-08-02 LOC108352368  uncharacterized LOC108352368      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-01-09 Fgd4  FYVE, RhoGEF and PH domain containing 4  LOC246174  actin-filament binding protein frabin  Symbol and Name updated to reflect Human and Mouse nomenclature 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology has similarity in domain organization to human FGD1, whose mutation causes faciogenital dysplasia or Aarskog-Scott syndrome 1299389