Hsd17b6 (hydroxysteroid (17-beta) dehydrogenase 6) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Hsd17b6 (hydroxysteroid (17-beta) dehydrogenase 6) Rattus norvegicus
Analyze
Symbol: Hsd17b6
Name: hydroxysteroid (17-beta) dehydrogenase 6
RGD ID: 708343
Description: Enables steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in brexanolone catabolic process and retinol metabolic process. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human HSD17B6 (hydroxysteroid 17-beta dehydrogenase 6); PARTICIPATES IN steroid hormone biosynthetic pathway; INTERACTS WITH 1-nitropropane; 2,4-diaminotoluene; 2,6-diaminotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 17-beta-HSD 6; 17-beta-HSD6; 17-beta-hydroxysteroid dehydrogenase type 6; 3-alpha->beta-HSE; 3-alpha->beta-hydroxysteroid epimerase; Hsd17b9; hydroxysteroid (17-beta) dehydrogenase 9; hydroxysteroid 17-beta dehydrogenase 6; hydroxysteroid 17-beta dehydrogenase 6-like; LOC100362350; LOC286964; MGC108559; oxidative 17 beta hydroxysteroid dehydrogenase type 6; oxidative 3-alpha hydroxysteroid dehydrogenase
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87831,407 - 850,950 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7831,421 - 850,873 (-)EnsemblGRCr8
mRatBN7.27422,466 - 442,008 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7422,480 - 442,425 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx73,181,210 - 3,200,875 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,057,225 - 5,076,887 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,355,342 - 5,375,051 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,412,370 - 2,431,249 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13110,633,786 - 110,642,754 (-)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl72,412,363 - 2,431,197 (-)Ensemblrn6Rnor6.0
Rnor_5.072,390,308 - 2,409,187 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.471,118,183 - 1,137,670 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7310,880 - 321,035 (-)NCBICelera
RGSC_v3.171,270,995 - 1,274,641 (-)NCBI
Cytogenetic Map7q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(2E,4E)-hexa-2,4-dienoic acid  (ISO)
1,2-dichloroethane  (ISO)
1-nitropropane  (EXP)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-diaminotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-diaminotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-nitro-p-phenylenediamine  (EXP)
2-nitropropane  (EXP)
3-Benzylidene camphor  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-acetylaminofluorene  (EXP)
4-Hydroxybenzophenone  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitro-1,2-phenylenediamine  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
Benzyl parahydroxybenzoate  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Butylparaben  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
cetrorelix  (ISO)
chenodeoxycholic acid  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
cocaine  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP,ISO)
Enterolactone  (ISO)
entinostat  (ISO)
enzacamene  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP)
ethylparaben  (ISO)
fipronil  (ISO)
flutamide  (EXP)
formaldehyde  (ISO)
fructose  (ISO)
furan  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
indometacin  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
mifepristone  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
naphthalene  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
paracetamol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
Propiverine  (EXP)
propylparaben  (ISO)
quercetin  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
tauroursodeoxycholic acid  (EXP)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression cloning and characterization of oxidative 17beta- and 3alpha-hydroxysteroid dehydrogenases from rat and human prostate. Biswas MG and Russell DW, J Biol Chem 1997 Jun 20;272(25):15959-66.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Hsd17b6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87831,407 - 850,950 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7831,421 - 850,873 (-)EnsemblGRCr8
mRatBN7.27422,466 - 442,008 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7422,480 - 442,425 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx73,181,210 - 3,200,875 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,057,225 - 5,076,887 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,355,342 - 5,375,051 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,412,370 - 2,431,249 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13110,633,786 - 110,642,754 (-)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl72,412,363 - 2,431,197 (-)Ensemblrn6Rnor6.0
Rnor_5.072,390,308 - 2,409,187 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.471,118,183 - 1,137,670 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7310,880 - 321,035 (-)NCBICelera
RGSC_v3.171,270,995 - 1,274,641 (-)NCBI
Cytogenetic Map7q11NCBI
HSD17B6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381256,763,324 - 56,787,790 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1256,751,817 - 56,788,409 (+)Ensemblhg38GRCh38
GRCh371257,157,108 - 57,181,574 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361255,443,375 - 55,467,841 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1256,811,056 - 56,835,545 (+)NCBICelera
Cytogenetic Map12q13.3NCBI
HuRef1254,196,177 - 54,220,440 (+)NCBIHuRef
CHM1_11257,124,709 - 57,149,178 (+)NCBICHM1_1
T2T-CHM13v2.01256,720,359 - 56,755,674 (+)NCBIT2T-CHM13v2.0
Hsd17b6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910127,826,800 - 127,843,517 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10127,826,805 - 127,843,480 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3810127,990,931 - 128,007,648 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,990,936 - 128,007,611 (-)Ensemblmm10GRCm38
MGSCv3710127,427,992 - 127,444,564 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3610127,393,885 - 127,410,457 (-)NCBIMGSCv36mm8
Celera10130,386,654 - 130,402,718 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1076.39NCBI
HSD17B6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21037,532,580 - 37,570,667 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11237,529,349 - 37,567,436 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01232,117,696 - 32,155,740 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11232,371,489 - 32,409,079 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1232,371,489 - 32,408,860 (-)EnsemblpanPan2panpan1.1
HSD17B6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110948,982 - 1,016,651 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl101,000,199 - 1,016,420 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha101,013,547 - 1,081,648 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.010959,903 - 1,028,028 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl101,008,915 - 1,027,809 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110936,956 - 1,005,109 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0101,178,872 - 1,246,960 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0101,303,521 - 1,371,687 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
HSD17B6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl522,092,578 - 22,273,382 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1522,089,496 - 22,114,319 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2523,775,876 - 23,800,805 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HSD17B6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11152,710,903 - 52,736,645 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1152,710,758 - 52,736,629 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037193,238,228 - 193,265,612 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hsd17b6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480211,115,928 - 11,162,174 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462480211,125,544 - 11,162,914 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Hsd17b6
131 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:352
Count of miRNA genes:175
Interacting mature miRNAs:191
Transcripts:ENSRNOT00000003498, ENSRNOT00000029039
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat

Markers in Region
RH134999  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27422,564 - 422,752 (+)MAPPERmRatBN7.2
Rnor_6.013110,633,879 - 110,634,064NCBIRnor6.0
Rnor_6.072,412,469 - 2,412,655NCBIRnor6.0
Rnor_5.072,390,407 - 2,390,593UniSTSRnor5.0
Rnor_5.013115,193,898 - 115,194,083UniSTSRnor5.0
RGSC_v3.471,267,872 - 1,268,059UniSTSRGSC3.4
RGSC_v3.471,118,278 - 1,118,464UniSTSRGSC3.4
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
22 1 14 56 90 83 55 13 55 12 140 53 30 9 44 28

Sequence


Ensembl Acc Id: ENSRNOT00000003498   ⟹   ENSRNOP00000003498
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7831,421 - 850,134 (-)Ensembl
mRatBN7.2 Ensembl7422,480 - 441,958 (-)Ensembl
Rnor_6.0 Ensembl72,412,363 - 2,431,197 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000029039   ⟹   ENSRNOP00000031599
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl13110,633,786 - 110,642,754 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103179   ⟹   ENSRNOP00000094822
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7831,421 - 850,134 (-)Ensembl
mRatBN7.2 Ensembl7422,480 - 442,425 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000140501   ⟹   ENSRNOP00000099005
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7831,421 - 842,484 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000148163   ⟹   ENSRNOP00000110093
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7831,421 - 850,873 (-)Ensembl
RefSeq Acc Id: NM_173305   ⟹   NP_775427
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87831,407 - 850,950 (-)NCBI
mRatBN7.27422,466 - 442,008 (-)NCBI
Rnor_6.072,412,374 - 2,431,249 (-)NCBI
Rnor_5.072,390,308 - 2,409,187 (-)NCBI
RGSC_v3.471,118,183 - 1,137,670 (-)RGD
Celera7310,880 - 321,035 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594688   ⟹   XP_017450177
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87831,407 - 850,912 (-)NCBI
mRatBN7.27422,466 - 441,841 (-)NCBI
Rnor_6.072,412,370 - 2,431,219 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063263082   ⟹   XP_063119152
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87831,407 - 848,841 (-)NCBI
Protein Sequences
Protein RefSeqs NP_775427 (Get FASTA)   NCBI Sequence Viewer  
  XP_017450177 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119152 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH88104 (Get FASTA)   NCBI Sequence Viewer  
  AAH91114 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003498
  ENSRNOP00000094822
  ENSRNOP00000110093
GenBank Protein O54753 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_775427   ⟸   NM_173305
- UniProtKB: A0A8I6AMC0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450177   ⟸   XM_017594688
- Peptide Label: isoform X2
- UniProtKB: O54753 (UniProtKB/Swiss-Prot),   Q5M8C8 (UniProtKB/Swiss-Prot),   A0A8I6AMC0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000003498   ⟸   ENSRNOT00000003498
Ensembl Acc Id: ENSRNOP00000031599   ⟸   ENSRNOT00000029039
Ensembl Acc Id: ENSRNOP00000094822   ⟸   ENSRNOT00000103179
RefSeq Acc Id: XP_063119152   ⟸   XM_063263082
- Peptide Label: isoform X1
- UniProtKB: F1LYR5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000099005   ⟸   ENSRNOT00000140501
Ensembl Acc Id: ENSRNOP00000110093   ⟸   ENSRNOT00000148163

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O54753-F1-model_v2 AlphaFold O54753 1-317 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694917
Promoter ID:EPDNEW_R5442
Type:initiation region
Name:Hsd17b6_2
Description:hydroxysteroid (17-beta) dehydrogenase 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5443  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.072,431,055 - 2,431,115EPDNEW
RGD ID:13694918
Promoter ID:EPDNEW_R5443
Type:initiation region
Name:Hsd17b6_1
Description:hydroxysteroid (17-beta) dehydrogenase 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5442  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.072,431,186 - 2,431,246EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708343 AgrOrtholog
BioCyc Gene G2FUF-35403 BioCyc
Ensembl Genes ENSRNOG00000002597 Ensembl, ENTREZGENE
  ENSRNOG00000007758 Ensembl
Ensembl Transcript ENSRNOT00000003498 ENTREZGENE
  ENSRNOT00000103179 ENTREZGENE
  ENSRNOT00000148163 ENTREZGENE
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7321553 IMAGE-MGC_LOAD
  IMAGE:7326228 IMAGE-MGC_LOAD
InterPro NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot
  Sc_DH/Rdtase_CS UniProtKB/Swiss-Prot
  SDR_fam UniProtKB/Swiss-Prot
KEGG Report rno:286964 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108558 IMAGE-MGC_LOAD
  MGC:108559 IMAGE-MGC_LOAD
NCBI Gene 286964 ENTREZGENE
PANTHER 17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 6 UniProtKB/Swiss-Prot
  SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C UniProtKB/Swiss-Prot
Pfam adh_short UniProtKB/Swiss-Prot
PhenoGen Hsd17b6 PhenoGen
PRINTS GDHRDH UniProtKB/Swiss-Prot
  SDRFAMILY UniProtKB/Swiss-Prot
PROSITE ADH_SHORT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002597 RatGTEx
  ENSRNOG00000007758 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot
UniProt A0A8I6AMC0 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L4E8_RAT UniProtKB/TrEMBL
  A0ABK0LWW0_RAT UniProtKB/TrEMBL
  F1LYR5 ENTREZGENE, UniProtKB/TrEMBL
  H17B6_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5M8C8 ENTREZGENE
UniProt Secondary Q5M8C8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Hsd17b6  hydroxysteroid (17-beta) dehydrogenase 6  LOC100362350  hydroxysteroid 17-beta dehydrogenase 6-like  Data merged from RGD:2318336 737654 PROVISIONAL
2010-05-05 LOC100362350  hydroxysteroid 17-beta dehydrogenase 6-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-12-05 Hsd17b6  hydroxysteroid (17-beta) dehydrogenase 6  Hsd17b9  hydroxysteroid (17-beta) dehydrogenase 9  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2004-09-10 Hsd17b9  hydroxysteroid (17-beta) dehydrogenase 9  LOC286964  oxidative 17 beta hydroxysteroid dehydrogenase type 6  Symbol and Name updated 1299863 APPROVED