Acsl3 (acyl-CoA synthetase long-chain family member 3) - Rat Genome Database

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Gene: Acsl3 (acyl-CoA synthetase long-chain family member 3) Rattus norvegicus
Analyze
Symbol: Acsl3
Name: acyl-CoA synthetase long-chain family member 3
RGD ID: 70552
Description: Enables arachidonate-CoA ligase activity. Involved in fatty acid biosynthetic process; long-chain fatty acid metabolic process; and response to nutrient. Predicted to be located in Golgi apparatus and perinuclear region of cytoplasm. Predicted to be active in endoplasmic reticulum; lipid droplet; and plasma membrane. Human ortholog(s) of this gene implicated in asthma; breast cancer; and prostate cancer. Orthologous to human ACSL3 (acyl-CoA synthetase long chain family member 3); PARTICIPATES IN fatty acid beta degradation pathway; eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; fatty acid metabolic pathway; INTERACTS WITH 1-benzylpiperazine; 1-naphthyl isothiocyanate; 1-nitropropane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Acs3; arachidonate--CoA ligase; arachidonate--CoA ligase Acsl3; brain acyl-CoA synthetase II; Facl3; fatty acid CoA ligase Acsl3; fatty acid Coenzyme A ligase, long chain 3; LACS 3; long-chain acyl-CoA synthetase 3; long-chain-fatty-acid--CoA ligase 3; medium-chain acyl-CoA ligase Acsl3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8987,563,601 - 87,613,078 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl987,563,601 - 87,613,097 (+)EnsemblGRCr8
mRatBN7.2980,115,164 - 80,164,636 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl980,115,112 - 80,164,627 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx988,544,917 - 88,594,391 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0993,660,348 - 93,709,510 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0992,056,362 - 92,105,840 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0984,569,601 - 84,593,565 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl984,569,597 - 84,593,565 (+)Ensemblrn6Rnor6.0
Rnor_5.0984,301,912 - 84,351,516 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4978,083,239 - 78,106,933 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera977,647,726 - 77,671,370 (+)NCBICelera
RGSC_v3.1978,266,656 - 78,290,352 (+)NCBI
Cytogenetic Map9q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-benzylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
1-nitropropane  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-diaminotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-nitro-p-phenylenediamine  (EXP)
2-nitropropane  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-acetylaminofluorene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nitro-1,2-phenylenediamine  (EXP)
5-aza-2'-deoxycytidine  (ISO)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
alpha-pinene  (ISO)
amiodarone  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (EXP,ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
buspirone  (EXP)
caffeine  (ISO)
calcitriol  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP,ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
daidzein  (ISO)
daidzein 7-O-beta-D-glucoside  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
difenoconazole  (ISO)
dimethyl sulfoxide  (ISO)
dipentyl phthalate  (EXP)
diquat  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenofibrate  (EXP)
flavonoids  (EXP)
fluoranthene  (ISO)
fluoxetine  (ISO)
flutamide  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
furfural  (ISO)
genistein  (ISO)
genistein 7-O-beta-D-glucoside  (ISO)
glycitein  (ISO)
glycitin  (ISO)
graphene oxide  (ISO)
GW 4064  (ISO)
GW 7647  (ISO)
haloperidol  (ISO)
indole-3-methanol  (EXP)
iron atom  (EXP)
iron(0)  (EXP)
isoflavones  (EXP,ISO)
isoniazide  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (ISO)
methyl methanesulfonate  (ISO)
methylseleninic acid  (ISO)
mitomycin C  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
Muraglitazar  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
quinolin-8-ol  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
senecionine  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP,ISO)
Soman  (EXP)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP,ISO)
thiram  (ISO)
topotecan  (ISO)
Trapidil  (EXP)
triadimefon  (EXP)
tributylstannane  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (EXP,ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Up-regulation of fatty acid metabolizing-enzymes mRNA in rat spinal cord during persistent peripheral local inflammation. Benani A, etal., Eur J Neurosci. 2003 Oct;18(7):1904-14.
2. Elevated expression of liver X receptor alpha (LXRα) in myocardium of streptozotocin-induced diabetic rats. Cheng Y, etal., Inflammation. 2011 Dec;34(6):698-706. doi: 10.1007/s10753-010-9281-5.
3. Molecular characterization and expression of rat acyl-CoA synthetase 3. Fujino T, etal., J Biol Chem 1996 Jul 12;271(28):16748-52.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Targeted exome sequencing of Korean triple-negative breast cancer reveals homozygous deletions associated with poor prognosis of adjuvant chemotherapy-treated patients. Jeong HM, etal., Oncotarget. 2017 Jun 27;8(37):61538-61550. doi: 10.18632/oncotarget.18618. eCollection 2017 Sep 22.
6. Common variation in fatty acid genes and resuscitation from sudden cardiac arrest. Johnson CO, etal., Circ Cardiovasc Genet. 2012 Aug 1;5(4):422-9. doi: 10.1161/CIRCGENETICS.111.961912. Epub 2012 Jun 1.
7. Long-chain acyl-CoA synthetase isoforms differ in preferences for eicosanoid species and long-chain fatty acids. Klett EL, etal., J Lipid Res. 2017 May;58(5):884-894. doi: 10.1194/jlr.M072512. Epub 2017 Feb 16.
8. Diets high in selenium and isoflavones decrease androgen-regulated gene expression in healthy rat dorsolateral prostate. Legg RL, etal., Reprod Biol Endocrinol. 2008 Nov 24;6:57.
9. Rat long-chain acyl-CoA synthetase mRNA, protein, and activity vary in tissue distribution and in response to diet. Mashek DG, etal., J Lipid Res. 2006 Sep;47(9):2004-10. Epub 2006 Jun 13.
10. Gene Data Set MGD Curation, June 12, 2002
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Targeting Oct1 genomic function inhibits androgen receptor signaling and castration-resistant prostate cancer growth. Obinata D, etal., Oncogene. 2016 Dec 8;35(49):6350-6358. doi: 10.1038/onc.2016.171. Epub 2016 Jun 6.
14. [Long-term results of prolonged dicoumarol anticoagulant therapy in 327 peipheral arteriopathic subjects] Papadia F, etal., Chir Ital 1976 Dec;28(6):817-30.
15. Very long-chain acyl-CoA synthetase 3: overexpression and growth dependence in lung cancer. Pei Z, etal., PLoS One. 2013 Jul 23;8(7):e69392. doi: 10.1371/journal.pone.0069392. Print 2013.
16. Relation of DNA methylation of 5'-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma. Perera F, etal., PLoS One. 2009;4(2):e4488. doi: 10.1371/journal.pone.0004488. Epub 2009 Feb 16.
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Comprehensive gene review and curation RGD comprehensive gene curation
21. Epigenetic alterations by DNA methylation in house dust mite-induced airway hyperresponsiveness. Shang Y, etal., Am J Respir Cell Mol Biol. 2013 Aug;49(2):279-87. doi: 10.1165/rcmb.2012-0403OC.
22. Lipid metabolism genes in contralateral unaffected breast and estrogen receptor status of breast cancer. Wang J, etal., Cancer Prev Res (Phila). 2013 Apr;6(4):321-30. doi: 10.1158/1940-6207.CAPR-12-0304. Epub 2013 Mar 19.
23. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. Watkins PA, etal., J Lipid Res. 2007 Dec;48(12):2736-50. Epub 2007 Aug 30.
Additional References at PubMed
PMID:9276691   PMID:14741744   PMID:18003621   PMID:19737935   PMID:19946888   PMID:20219900   PMID:20605918   PMID:21498505   PMID:22633490  


Genomics

Comparative Map Data
Acsl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8987,563,601 - 87,613,078 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl987,563,601 - 87,613,097 (+)EnsemblGRCr8
mRatBN7.2980,115,164 - 80,164,636 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl980,115,112 - 80,164,627 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx988,544,917 - 88,594,391 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0993,660,348 - 93,709,510 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0992,056,362 - 92,105,840 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0984,569,601 - 84,593,565 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl984,569,597 - 84,593,565 (+)Ensemblrn6Rnor6.0
Rnor_5.0984,301,912 - 84,351,516 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4978,083,239 - 78,106,933 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera977,647,726 - 77,671,370 (+)NCBICelera
RGSC_v3.1978,266,656 - 78,290,352 (+)NCBI
Cytogenetic Map9q34NCBI
ACSL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382222,861,036 - 222,944,639 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2222,860,942 - 222,944,639 (+)Ensemblhg38GRCh38
GRCh372223,725,754 - 223,809,357 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362223,433,976 - 223,516,363 (+)NCBIBuild 36Build 36hg18NCBI36
Celera2217,493,969 - 217,573,566 (+)NCBICelera
Cytogenetic Map2q36.1NCBI
HuRef2215,580,012 - 215,659,429 (+)NCBIHuRef
CHM1_12223,732,626 - 223,813,632 (+)NCBICHM1_1
T2T-CHM13v2.02223,346,613 - 223,427,414 (+)NCBIT2T-CHM13v2.0
Acsl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39178,635,600 - 78,685,462 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl178,635,542 - 78,685,460 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38178,657,825 - 78,707,743 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl178,657,825 - 78,707,743 (+)Ensemblmm10GRCm38
MGSCv37178,654,400 - 78,704,318 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36178,536,898 - 78,586,011 (+)NCBIMGSCv36mm8
Celera179,126,781 - 79,177,063 (+)NCBICelera
Cytogenetic Map1C4NCBI
cM Map140.84NCBI
Acsl3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545310,913,786 - 10,947,963 (-)Ensembl
ChiLan1.0NW_00495545310,916,423 - 10,963,986 (-)NCBIChiLan1.0ChiLan1.0
ACSL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213125,473,216 - 125,554,533 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B125,488,197 - 125,569,501 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B110,100,210 - 110,181,277 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B228,706,141 - 228,759,882 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B228,706,142 - 228,759,882 (+)EnsemblpanPan2panpan1.1
ACSL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13728,882,264 - 28,929,451 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3728,864,147 - 28,938,866 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3729,699,888 - 29,765,386 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03728,889,472 - 28,955,180 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3728,888,886 - 28,955,178 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13728,798,984 - 28,864,540 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03728,730,857 - 28,796,337 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03728,744,094 - 28,809,662 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Acsl3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303178,431,793 - 178,500,065 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365694,774,542 - 4,844,494 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365694,774,602 - 4,842,906 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACSL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15124,765,854 - 124,816,960 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115124,741,986 - 124,816,955 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215138,663,708 - 138,712,406 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACSL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110108,787,341 - 108,867,523 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10108,787,061 - 108,869,042 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604090,486,570 - 90,576,665 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acsl3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248232,324,345 - 2,381,420 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248232,323,939 - 2,387,213 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Acsl3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14151,871,582 - 151,918,959 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Acsl3
257 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:80
Count of miRNA genes:56
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000020161
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)986720043110356905Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)986720043121768150Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)98672213292642305Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)985262459109044727Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)985262459118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat

Markers in Region
SHGC-36164  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2980,164,446 - 80,164,553 (+)MAPPERmRatBN7.2
Rnor_6.0984,593,376 - 84,593,482NCBIRnor6.0
Rnor_5.0984,351,324 - 84,351,430UniSTSRnor5.0
RGSC_v3.4978,106,744 - 78,106,850UniSTSRGSC3.4
Celera977,671,181 - 77,671,287UniSTS
Cytogenetic Map9q33UniSTS
RH138650  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2980,164,527 - 80,164,648 (+)MAPPERmRatBN7.2
Rnor_6.0984,593,457 - 84,593,577NCBIRnor6.0
Rnor_5.0984,351,405 - 84,351,525UniSTSRnor5.0
RGSC_v3.4978,106,825 - 78,106,945UniSTSRGSC3.4
Celera977,671,262 - 77,671,382UniSTS
RH 3.4 Map9727.2UniSTS
Cytogenetic Map9q33UniSTS
RH80004  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2980,164,414 - 80,164,601 (+)MAPPERmRatBN7.2
Rnor_6.0984,593,344 - 84,593,530NCBIRnor6.0
Rnor_5.0984,351,292 - 84,351,478UniSTSRnor5.0
RGSC_v3.4978,106,712 - 78,106,898UniSTSRGSC3.4
Celera977,671,149 - 77,671,335UniSTS
Cytogenetic Map9q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000020161   ⟹   ENSRNOP00000020161
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl980,120,613 - 80,164,616 (+)Ensembl
Rnor_6.0 Ensembl984,569,597 - 84,593,565 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108973   ⟹   ENSRNOP00000091017
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl987,563,601 - 87,613,097 (+)Ensembl
mRatBN7.2 Ensembl980,115,112 - 80,164,627 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110563   ⟹   ENSRNOP00000078357
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl980,115,164 - 80,164,455 (+)Ensembl
RefSeq Acc Id: NM_057107   ⟹   NP_476448
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8987,563,601 - 87,613,075 (+)NCBI
mRatBN7.2980,115,164 - 80,164,636 (+)NCBI
Rnor_6.0984,569,601 - 84,593,565 (+)NCBI
Rnor_5.0984,301,912 - 84,351,516 (+)NCBI
RGSC_v3.4978,083,239 - 78,106,933 (+)RGD
Celera977,647,726 - 77,671,370 (+)RGD
Sequence:
RefSeq Acc Id: XM_063266533   ⟹   XP_063122603
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8987,569,058 - 87,613,078 (+)NCBI
Protein Sequences
Protein RefSeqs NP_476448 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122603 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA06340 (Get FASTA)   NCBI Sequence Viewer  
  EDL75474 (Get FASTA)   NCBI Sequence Viewer  
  EDL75475 (Get FASTA)   NCBI Sequence Viewer  
  EDL75476 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000091017
GenBank Protein Q63151 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_476448   ⟸   NM_057107
- UniProtKB: Q63151 (UniProtKB/Swiss-Prot),   A6JW67 (UniProtKB/TrEMBL),   A0A8L2UJF0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020161   ⟸   ENSRNOT00000020161
Ensembl Acc Id: ENSRNOP00000078357   ⟸   ENSRNOT00000110563
Ensembl Acc Id: ENSRNOP00000091017   ⟸   ENSRNOT00000108973
RefSeq Acc Id: XP_063122603   ⟸   XM_063266533
- Peptide Label: isoform X1
- UniProtKB: Q63151 (UniProtKB/Swiss-Prot),   A0A8L2UJF0 (UniProtKB/TrEMBL),   A6JW67 (UniProtKB/TrEMBL)
Protein Domains
AMP-dependent synthetase/ligase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63151-F1-model_v2 AlphaFold Q63151 1-720 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70552 AgrOrtholog
BioCyc Gene G2FUF-27021 BioCyc
BioCyc Pathway FAO-PWY [fatty acid beta-oxidation I (generic)] BioCyc
  PWY-5143 [long-chain fatty acid activation] BioCyc
  PWY-5972 [stearate biosynthesis I (animals)] BioCyc
  PWY-6000 [gamma-linolenate biosynthesis II (animals)] BioCyc
  PWY-7049 [icosapentaenoate biosynthesis II (6-desaturase, mammals)] BioCyc
  PWY-8181 [2-methyl-branched fatty acid beta-oxidation] BioCyc
  PWY3DJ-11470 [sphingosine and sphingosine-1-phosphate metabolism] BioCyc
  PWY66-387 [3-methyl-branched fatty acid alpha-oxidation] BioCyc
  PWY66-388 [ceramide degradation by alpha-oxidation] BioCyc
  PWY66-389 [phytol degradation] BioCyc
  PWY66-391 [fatty acid beta-oxidation VI (mammalian peroxisome)] BioCyc
BioCyc Pathway Image FAO-PWY BioCyc
  PWY-5143 BioCyc
  PWY-5972 BioCyc
  PWY-6000 BioCyc
  PWY-7049 BioCyc
  PWY-8181 BioCyc
  PWY3DJ-11470 BioCyc
  PWY66-387 BioCyc
  PWY66-388 BioCyc
  PWY66-389 BioCyc
  PWY66-391 BioCyc
Ensembl Genes ENSRNOG00000014718 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000108973 ENTREZGENE
Gene3D-CATH 3.40.50.12780 UniProtKB/Swiss-Prot
InterPro AMP-binding_CS UniProtKB/Swiss-Prot
  AMP-dep_Synth/Lig UniProtKB/Swiss-Prot
  ANL_N_sf UniProtKB/Swiss-Prot
KEGG Report rno:114024 UniProtKB/Swiss-Prot
NCBI Gene 114024 ENTREZGENE
PANTHER LONG-CHAIN-FATTY-ACID--COA LIGASE UniProtKB/Swiss-Prot
  LONG-CHAIN-FATTY-ACID--COA LIGASE 3 UniProtKB/Swiss-Prot
Pfam AMP-binding UniProtKB/Swiss-Prot
PhenoGen Acsl3 PhenoGen
PROSITE AMP_BINDING UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014718 RatGTEx
Superfamily-SCOP Acetyl-CoA synthetase-like UniProtKB/Swiss-Prot
UniProt A0A8I6AC39_RAT UniProtKB/TrEMBL
  A0A8L2UJF0 ENTREZGENE
  A6JW66_RAT UniProtKB/TrEMBL
  A6JW67 ENTREZGENE, UniProtKB/TrEMBL
  ACSL3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Acsl3  acyl-CoA synthetase long-chain family member 3  Facl3  fatty acid Coenzyme A ligase, long chain 3  Symbol and Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function catalyzes the first reaction in the acyl-CoA metabolism 70280
gene_function catalyzes the first reaction in the acyl-CoA metabolism 70808
gene_process plays a key role in lipid synthesis and in fatty acid degradation 70280
gene_process plays a key role in lipid synthesis and in fatty acid degradation 70808
gene_product member of the firefly luciferase family 70280
gene_product member of the firefly luciferase family 70808
gene_protein predicted 720 amino acids, 80 kDa 70280
gene_protein predicted 720 amino acids, 80 kDa 70808