Pcyt1a (phosphate cytidylyltransferase 1A, choline) - Rat Genome Database

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Gene: Pcyt1a (phosphate cytidylyltransferase 1A, choline) Rattus norvegicus
Analyze
Symbol: Pcyt1a
Name: phosphate cytidylyltransferase 1A, choline
RGD ID: 70515
Description: Enables several functions, including calmodulin binding activity; choline-phosphate cytidylyltransferase activity; and phosphatidylcholine binding activity. Involved in CDP-choline pathway. Located in nuclear envelope. Human ortholog(s) of this gene implicated in congenital generalized lipodystrophy and spondylometaphyseal dysplasia with cone-rod dystrophy. Orthologous to human PCYT1A (phosphate cytidylyltransferase 1A, choline); PARTICIPATES IN glycerophospholipid metabolic pathway; lamivudine pharmacokinetics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CCT A; CCT-alpha; choline phosphate cytidylyltransferase 1 alpha; choline-phosphate cytidylyltransferase A; choline-phosphate cytidylyltransferase A-like; CT A; CTP; CTP:phosphocholine cytidylyl transferase; CTP:phosphocholine cytidylyltransferase A; CTP:phosphocholine cytidylyltransferase alpha; LOC100911343; MGC93248; phosphate cytidylyltransferase 1, choline, alpha; phosphate cytidylyltransferase 1, choline, alpha isoform; phosphorylcholine transferase A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81181,818,914 - 81,862,623 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1181,819,285 - 81,862,395 (-)EnsemblGRCr8
mRatBN7.21168,313,860 - 68,357,828 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1168,313,882 - 68,357,357 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1177,154,021 - 77,194,395 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01169,818,577 - 69,859,107 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01168,843,143 - 68,883,509 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01171,547,865 - 71,592,037 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1171,548,222 - 71,591,502 (-)Ensemblrn6Rnor6.0
Rnor_5.01174,632,576 - 74,676,227 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41170,133,325 - 70,173,686 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1167,749,599 - 67,789,957 (-)NCBICelera
RGSC_v3.11170,190,913 - 70,212,531 (-)NCBI
Cytogenetic Map11q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atorvastatin calcium  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
bromobenzene  (EXP)
buspirone  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
caffeine  (ISO)
carmustine  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
FR900359  (ISO)
furan  (EXP)
gentamycin  (EXP)
hydrogen cyanide  (ISO)
ivermectin  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methidathion  (ISO)
methotrexate  (EXP)
mevalonic acid  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
oxaliplatin  (EXP)
PCB138  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phosphatidylcholine  (ISO)
pirinixic acid  (ISO)
potassium cyanide  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tolcapone  (EXP)
topotecan  (EXP)
torcetrapib  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Interdomain and membrane interactions of CTP:phosphocholine cytidylyltransferase revealed via limited proteolysis and mass spectrometry. Bogan MJ, etal., J Biol Chem. 2005 May 20;280(20):19613-24. doi: 10.1074/jbc.M414028200. Epub 2005 Feb 15.
2. Calmodulin binds and stabilizes the regulatory enzyme, CTP: phosphocholine cytidylyltransferase. Chen BB and Mallampalli RK, J Biol Chem. 2007 Nov 16;282(46):33494-506. Epub 2007 Sep 5.
3. Functions of the C-terminal domain of CTP: phosphocholine cytidylyltransferase. Effects of C-terminal deletions on enzyme activity, intracellular localization and phosphorylation potential. Cornell RB, etal., Biochem J. 1995 Sep 1;310 ( Pt 2)(Pt 2):699-708. doi: 10.1042/bj3100699.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Identification of lysine 122 and arginine 196 as important functional residues of rat CTP:phosphocholine cytidylyltransferase alpha. Helmink BA, etal., Biochemistry 2003 May 6;42(17):5043-51.
7. Both acidic and basic amino acids in an amphitropic enzyme, CTP:phosphocholine cytidylyltransferase, dictate its selectivity for anionic membranes. Johnson JE, etal., J Biol Chem 2003 Jan 3;278(1):514-22.
8. Cloning and expression of rat liver CTP: phosphocholine cytidylyltransferase: an amphipathic protein that controls phosphatidylcholine synthesis. Kalmar GB, etal., Proc Natl Acad Sci U S A 1990 Aug;87(16):6029-33.
9. Crystal structure of a mammalian CTP: phosphocholine cytidylyltransferase catalytic domain reveals novel active site residues within a highly conserved nucleotidyltransferase fold. Lee J, etal., J Biol Chem. 2009 Nov 27;284(48):33535-48. doi: 10.1074/jbc.M109.053363. Epub 2009 Sep 25.
10. Structural basis for autoinhibition of CTP:phosphocholine cytidylyltransferase (CCT), the regulatory enzyme in phosphatidylcholine synthesis, by its membrane-binding amphipathic helix. Lee J, etal., J Biol Chem. 2014 Jan 17;289(3):1742-55. doi: 10.1074/jbc.M113.526970. Epub 2013 Nov 25.
11. Baculovirus-mediated expression of rat liver CTP:phosphocholine cytidylyltransferase. MacDonald JI and Kent C, Protein Expr Purif 1993 Feb;4(1):1-7.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Functions of membrane binding domain of CTP:phosphocholine cytidylyltransferase in alveolar type II cells. Ridsdale R, etal., Am J Respir Cell Mol Biol. 2010 Jul;43(1):74-87. doi: 10.1165/rcmb.2009-0231OC. Epub 2009 Aug 14.
21. CTP:Phosphocholine Cytidylyltransferase alpha Is a Cytosolic Protein in Pulmonary Epithelial Cells and Tissues. Ridsdale R, etal., J Biol Chem 2001 Dec 28;276(52):49148-55.
22. Expression of wild-type and mutant rat liver CTP: phosphocholine cytidylyltransferase in a cytidylyltransferase-deficient Chinese hamster ovary cell line. Sweitzer TD and Kent C, Arch Biochem Biophys. 1994 May 15;311(1):107-16. doi: 10.1006/abbi.1994.1215.
23. Lipid-induced conformational switch in the membrane binding domain of CTP:phosphocholine cytidylyltransferase: a circular dichroism study. Taneva S, etal., Biochemistry. 2003 Oct 14;42(40):11768-76. doi: 10.1021/bi035234k.
24. Identification of an 11-residue portion of CTP-phosphocholine cytidylyltransferase that is required for enzyme-membrane interactions. Yang J, etal., Biochem J. 1997 Jul 1;325 ( Pt 1):29-38.
Additional References at PubMed
PMID:8144639   PMID:8810902   PMID:8889548   PMID:11829742   PMID:12477932   PMID:12584202   PMID:15069071   PMID:15169678   PMID:15489334   PMID:15798219   PMID:18980580   PMID:21207859  
PMID:21504799   PMID:22988242   PMID:23155050   PMID:27032756  


Genomics

Comparative Map Data
Pcyt1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81181,818,914 - 81,862,623 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1181,819,285 - 81,862,395 (-)EnsemblGRCr8
mRatBN7.21168,313,860 - 68,357,828 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1168,313,882 - 68,357,357 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1177,154,021 - 77,194,395 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01169,818,577 - 69,859,107 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01168,843,143 - 68,883,509 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01171,547,865 - 71,592,037 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1171,548,222 - 71,591,502 (-)Ensemblrn6Rnor6.0
Rnor_5.01174,632,576 - 74,676,227 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41170,133,325 - 70,173,686 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1167,749,599 - 67,789,957 (-)NCBICelera
RGSC_v3.11170,190,913 - 70,212,531 (-)NCBI
Cytogenetic Map11q22NCBI
PCYT1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383196,234,368 - 196,287,726 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3196,214,222 - 196,287,957 (-)Ensemblhg38GRCh38
GRCh373195,961,239 - 196,014,597 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363197,449,650 - 197,498,981 (-)NCBIBuild 36Build 36hg18NCBI36
Build 343197,453,567 - 197,502,894NCBI
Celera3194,546,889 - 194,595,863 (-)NCBICelera
Cytogenetic Map3q29NCBI
HuRef3193,264,968 - 193,311,721 (-)NCBIHuRef
CHM1_13195,936,083 - 195,985,409 (-)NCBICHM1_1
T2T-CHM13v2.03198,953,844 - 199,007,214 (-)NCBIT2T-CHM13v2.0
Pcyt1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391632,249,739 - 32,293,883 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1632,249,739 - 32,293,888 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381632,430,921 - 32,475,065 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1632,430,921 - 32,475,070 (+)Ensemblmm10GRCm38
MGSCv371632,431,007 - 32,475,151 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361632,350,743 - 32,391,762 (+)NCBIMGSCv36mm8
Celera1632,915,098 - 32,958,968 (+)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1622.69NCBI
Pcyt1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542012,464,857 - 12,500,574 (-)Ensembl
ChiLan1.0NW_00495542012,464,857 - 12,513,017 (-)NCBIChiLan1.0ChiLan1.0
PCYT1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22194,098,897 - 194,161,227 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13194,103,614 - 194,166,603 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03193,574,603 - 193,633,601 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13203,522,292 - 203,576,851 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3203,517,951 - 203,576,854 (-)EnsemblpanPan2panpan1.1
PCYT1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13329,363,282 - 29,414,635 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3329,358,452 - 29,430,424 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3329,387,581 - 29,438,871 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03329,596,717 - 29,648,017 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3329,591,886 - 29,667,214 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13329,386,580 - 29,435,254 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03329,437,747 - 29,489,070 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03330,060,502 - 30,111,773 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pcyt1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602124,946,958 - 125,000,520 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936784884,751 - 938,282 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936784884,751 - 938,901 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCYT1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13133,818,761 - 133,850,996 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113133,794,337 - 133,851,004 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213143,232,171 - 143,288,868 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PCYT1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11590,905,691 - 90,944,485 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604164,720,023 - 64,792,685 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pcyt1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473061,418,013 - 61,466,016 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473061,417,030 - 61,466,028 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Pcyt1a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1417,242,011 - 17,283,598 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pcyt1a
1168 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:581
Count of miRNA genes:269
Interacting mature miRNAs:345
Transcripts:ENSRNOT00000002403
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)112252474682951192Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)114644316891443168Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)117330848796070872Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)117961851999753367Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)117385089499753367Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)115893182292356038Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)115775483796071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116859932196497754Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)117330831599753367Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat

Markers in Region
D11Rat106  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21168,340,154 - 68,340,286 (+)MAPPERmRatBN7.2
Rnor_6.01171,574,148 - 71,574,279NCBIRnor6.0
Rnor_5.01174,658,871 - 74,659,002UniSTSRnor5.0
RGSC_v3.41170,156,499 - 70,156,631RGDRGSC3.4
RGSC_v3.41170,156,500 - 70,156,631UniSTSRGSC3.4
Celera1167,772,773 - 67,772,904UniSTS
RGSC_v3.11170,214,089 - 70,214,220RGD
RH 3.4 Map11377.3RGD
RH 3.4 Map11377.3UniSTS
SHRSP x BN Map1132.1299RGD
SHRSP x BN Map1132.1299UniSTS
Cytogenetic Map11q22UniSTS
RH130304  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21168,329,751 - 68,329,965 (+)MAPPERmRatBN7.2
Rnor_6.01171,563,743 - 71,563,956NCBIRnor6.0
Rnor_5.01174,648,466 - 74,648,679UniSTSRnor5.0
RGSC_v3.41170,146,095 - 70,146,308UniSTSRGSC3.4
Celera1167,762,368 - 67,762,581UniSTS
RH 3.4 Map11404.1UniSTS
Cytogenetic Map11q22UniSTS
STS-L28957  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21168,317,232 - 68,317,418 (+)MAPPERmRatBN7.2
mRatBN7.22177,510,964 - 177,511,135 (+)MAPPERmRatBN7.2
Rnor_6.01171,551,224 - 71,551,409NCBIRnor6.0
Rnor_6.02191,936,958 - 191,937,125NCBIRnor6.0
Rnor_5.01174,635,949 - 74,636,134UniSTSRnor5.0
RGSC_v3.41170,133,576 - 70,133,761UniSTSRGSC3.4
Celera2174,081,535 - 174,081,706UniSTS
Celera1167,749,850 - 67,750,035UniSTS
Cytogenetic Map2q34UniSTS
Cytogenetic Map11q22UniSTS
BE108960  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21168,355,414 - 68,355,611 (+)MAPPERmRatBN7.2
Rnor_6.01171,589,406 - 71,589,602NCBIRnor6.0
Rnor_5.01174,674,129 - 74,674,325UniSTSRnor5.0
RGSC_v3.41170,171,760 - 70,171,956UniSTSRGSC3.4
Celera1167,788,033 - 67,788,229UniSTS
RH 3.4 Map11373.83UniSTS
Cytogenetic Map11q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000002403   ⟹   ENSRNOP00000002403
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1181,819,285 - 81,862,395 (-)Ensembl
mRatBN7.2 Ensembl1168,313,882 - 68,357,357 (-)Ensembl
Rnor_6.0 Ensembl1171,548,222 - 71,591,502 (-)Ensembl
RefSeq Acc Id: NM_078622   ⟹   NP_511177
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,822,036 - 81,862,397 (-)NCBI
mRatBN7.21168,316,982 - 68,357,340 (-)NCBI
Rnor_6.01171,550,973 - 71,591,504 (-)NCBI
Rnor_5.01174,632,576 - 74,676,227 (-)NCBI
RGSC_v3.41170,133,325 - 70,173,686 (-)RGD
Celera1167,749,599 - 67,789,957 (-)RGD
Sequence:
RefSeq Acc Id: XM_006248444   ⟹   XP_006248506
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,818,914 - 81,862,332 (-)NCBI
mRatBN7.21168,313,860 - 68,357,363 (-)NCBI
Rnor_6.01171,547,865 - 71,591,401 (-)NCBI
Rnor_5.01174,632,576 - 74,676,227 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008768694   ⟹   XP_008766916
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,818,914 - 81,862,623 (-)NCBI
mRatBN7.21168,313,860 - 68,357,828 (-)NCBI
Rnor_6.01171,547,865 - 71,592,037 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039087919   ⟹   XP_038943847
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,818,914 - 81,862,302 (-)NCBI
mRatBN7.21168,313,860 - 68,356,967 (-)NCBI
RefSeq Acc Id: NP_511177   ⟸   NM_078622
- UniProtKB: P19836 (UniProtKB/Swiss-Prot),   A6IRR3 (UniProtKB/TrEMBL),   A6IRR5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248506   ⟸   XM_006248444
- Peptide Label: isoform X1
- UniProtKB: P19836 (UniProtKB/Swiss-Prot),   A6IRR3 (UniProtKB/TrEMBL),   A6IRR5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008766916   ⟸   XM_008768694
- Peptide Label: isoform X1
- UniProtKB: P19836 (UniProtKB/Swiss-Prot),   A6IRR3 (UniProtKB/TrEMBL),   A6IRR5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002403   ⟸   ENSRNOT00000002403
RefSeq Acc Id: XP_038943847   ⟸   XM_039087919
- Peptide Label: isoform X1
- UniProtKB: P19836 (UniProtKB/Swiss-Prot),   A6IRR3 (UniProtKB/TrEMBL),   A6IRR5 (UniProtKB/TrEMBL)
Protein Domains
Cytidyltransferase-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P19836-F1-model_v2 AlphaFold P19836 1-367 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698210
Promoter ID:EPDNEW_R8734
Type:initiation region
Name:Pcyt1a_1
Description:phosphate cytidylyltransferase 1, choline, alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01171,591,512 - 71,591,572EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70515 AgrOrtholog
BioCyc Gene G2FUF-21096 BioCyc
BioCyc Pathway PWY-3561 [choline biosynthesis III] BioCyc
  PWY-7782 [plasmalogen biosynthesis] BioCyc
  PWY3O-450 [phosphatidylcholine biosynthesis I] BioCyc
BioCyc Pathway Image PWY-3561 BioCyc
  PWY-7782 BioCyc
  PWY3O-450 BioCyc
Ensembl Genes ENSRNOG00000001762 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002403 ENTREZGENE
  ENSRNOT00000002403.4 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.620 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7127059 IMAGE-MGC_LOAD
InterPro CCT UniProtKB/Swiss-Prot
  Cyt_trans-like UniProtKB/Swiss-Prot
  Pcy1-like UniProtKB/Swiss-Prot
  Rossmann-like_a/b/a_fold UniProtKB/Swiss-Prot
KEGG Report rno:140544 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93248 IMAGE-MGC_LOAD
NCBI Gene 140544 ENTREZGENE
PANTHER CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE A UniProtKB/Swiss-Prot
  PTHR10739 UniProtKB/Swiss-Prot
Pfam CTP_transf_like UniProtKB/Swiss-Prot
PhenoGen Pcyt1a PhenoGen
RatGTEx ENSRNOG00000001762 RatGTEx
Superfamily-SCOP Nucleotidylyl transferase UniProtKB/Swiss-Prot
UniProt A6IRR3 ENTREZGENE, UniProtKB/TrEMBL
  A6IRR5 ENTREZGENE, UniProtKB/TrEMBL
  P19836 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-18 Pcyt1a  phosphate cytidylyltransferase 1A, choline  Pcyt1a  phosphate cytidylyltransferase 1, choline, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2021-03-09 Pcyt1a  phosphate cytidylyltransferase 1, choline, alpha  LOC100911343  choline-phosphate cytidylyltransferase A-like  Data merged from RGD:6493475 737654 PROVISIONAL
2012-07-05 LOC100911343  choline-phosphate cytidylyltransferase A-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-10-24 Pcyt1a  phosphate cytidylyltransferase 1, choline, alpha  Pcyt1a  phosphate cytidylyltransferase 1, choline, alpha isoform  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Pcyt1a  phosphate cytidylyltransferase 1, choline, alpha isoform      Symbol and Name status set to approved 625702 APPROVED
2002-06-10 Pcyt1a  phosphate cytidylyltransferase 1, choline, alpha isoform      Symbol and Name status set to provisional 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a 58-residue amphipathic alpha-helix mediating binding to cell membranes 70012
gene_expression located in pulmonary epithelial cell 70012
gene_expression located in pulmonary epithelial cell 70228
gene_function catalyzes the transfer of choline from phosphocholine to CDP-choline in the Kennedy (CDP-choline) pathway 70012
gene_function catalyzes the transfer of choline from phosphocholine to CDP-choline in the Kennedy (CDP-choline) pathway 70228
gene_process rate-limiting enzyme in the synthesis of phosphotidylcholine 70012
gene_process rate-limiting enzyme in the synthesis of phosphotidylcholine 70228