Eif4e (eukaryotic translation initiation factor 4E) - Rat Genome Database

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Gene: Eif4e (eukaryotic translation initiation factor 4E) Rattus norvegicus
Analyze
Symbol: Eif4e
Name: eukaryotic translation initiation factor 4E
RGD ID: 69647
Description: Enables eukaryotic initiation factor 4G binding activity. Involved in lung development. Part of eukaryotic translation initiation factor 4F complex. Is active in glutamatergic synapse and postsynaptic cytosol. Biomarker of vascular dementia. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human EIF4E (eukaryotic translation initiation factor 4E); PARTICIPATES IN CRM1 export pathway; mTOR signaling pathway; translation initiation pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: eIF-4E; eIF-4F 25 kDa subunit; eukaryotic initiation factor 4E; MGC93265; mRNA cap-binding protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82229,736,309 - 229,772,628 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2229,739,897 - 229,774,105 (+)EnsemblGRCr8
mRatBN7.22227,066,519 - 227,099,261 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2227,066,673 - 227,098,683 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2234,815,680 - 234,847,577 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02232,715,418 - 232,747,307 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02227,580,081 - 227,611,970 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02243,819,616 - 243,853,987 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2243,820,661 - 243,852,631 (+)Ensemblrn6Rnor6.0
Rnor_5.02262,354,375 - 262,387,512 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42236,072,748 - 236,104,714 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2219,223,372 - 219,255,078 (+)NCBICelera
RGSC_v3.12236,059,487 - 236,091,453 (+)NCBI
Cytogenetic Map2q44NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-anisomycin  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nonylphenol  (ISO)
4-tert-Octylphenol  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7-methyl-7,8-dihydroguanosine-5'-diphosphate  (ISO)
7-methyl-GTP  (ISO)
acetylleucyl-leucyl-norleucinal  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
cycloheximide  (EXP,ISO)
cypermethrin  (ISO)
D-glucitol  (ISO)
D-glucose  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dibutylstannane  (ISO)
dicrotophos  (ISO)
Dictamnine  (ISO)
Dihydrotanshinone I  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
ethyl methanesulfonate  (ISO)
everolimus  (ISO)
flavonoids  (EXP)
fluoxetine  (EXP)
flurbiprofen  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
furfural  (ISO)
genistein  (ISO)
glucose  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
guanosine  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
ibuprofen  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
jaspamide  (ISO)
kojic acid  (ISO)
lactacystin  (ISO)
linuron  (EXP)
lipopolysaccharide  (ISO)
LY294002  (ISO)
metformin  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
naphthalene  (ISO)
nefazodone  (EXP)
niclosamide  (ISO)
nicotine  (ISO)
nitrates  (ISO)
Nutlin-3  (ISO)
okadaic acid  (ISO)
orlistat  (ISO)
oxybenzone  (ISO)
ozone  (ISO)
p-tert-Amylphenol  (ISO)
perfluorooctanoic acid  (EXP)
perhexiline  (ISO)
phenanthrene  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
piroxicam  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (ISO)
quercetin  (ISO)
quinolone  (ISO)
resveratrol  (ISO)
ribavirin  (ISO)
rottlerin  (ISO)
SB 203580  (ISO)
sirolimus  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sorafenib  (ISO)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (EXP)
thapsigargin  (EXP,ISO)
thiophenes  (ISO)
titanium dioxide  (ISO)
triadimefon  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Localization of translational components at the ultramicroscopic level at postsynaptic sites of the rat brain. Asaki C, etal., Brain Res. 2003 May 16;972(1-2):168-76.
2. Inhibition of Cap-initiation complexes linked to a novel mechanism of eIF4G depletion in acute myocardial ischemia. Connolly EP, etal., Cell Death Differ. 2006 Sep;13(9):1586-94. Epub 2006 Jan 27.
3. Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Fingar DC, etal., Genes Dev 2002 Jun 15;16(12):1472-87.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. The scanning mechanism of eukaryotic translation initiation. Hinnebusch AG Annu Rev Biochem. 2014;83:779-812. doi: 10.1146/annurev-biochem-060713-035802. Epub 2014 Jan 29.
7. Transcriptional regulation of the rat eIF4E gene in cardiac muscle cells: the role of specific elements in the promoter region. Makhlouf AA, etal., Gene 2001 Apr 4;267(1):1-12.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Abundant expression of translation initiation factor EIF-4E in post-meiotic germ cells of the rat testis. Miyagi Y, etal., Lab Invest 1995 Dec;73(6):890-8.
10. Postage for the messenger: designating routes for nuclear mRNA export. Natalizio BJ and Wente SR, Trends Cell Biol. 2013 Aug;23(8):365-73. doi: 10.1016/j.tcb.2013.03.006. Epub 2013 Apr 11.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. Global and gene-specific translational regulation in rat lung development. Otulakowski G, etal., Am J Respir Cell Mol Biol. 2009 May;40(5):555-67. Epub 2008 Oct 23.
14. Transforming growth factor-alpha attenuates N-methyl-D-aspartic acid toxicity in cortical cultures by preventing protein synthesis inhibition through an Erk1/2-dependent mechanism. Petegnief V, etal., J Biol Chem 2003 Aug 8;278(32):29552-9. Epub 2003 May 27.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus. Tang SJ, etal., Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):467-72. doi: 10.1073/pnas.012605299. Epub 2001 Dec 26.
21. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
22. Acute oral leucine administration stimulates protein synthesis during chronic sepsis through enhanced association of eukaryotic initiation factor 4G with eukaryotic initiation factor 4E in rats. Vary TC J Nutr. 2007 Sep;137(9):2074-9.
23. Acute alcohol intoxication enhances myocardial eIF4G phosphorylation despite reducing mTOR signaling. Vary TC, etal., Am J Physiol Heart Circ Physiol. 2005 Jan;288(1):H121-8. Epub 2004 Sep 23.
24. Effect of electroacupuncture on the expression of mTOR and eIF4E in hippocampus of rats with vascular dementia. Zhu Y, etal., Neurol Sci. 2013 Jul;34(7):1093-7. doi: 10.1007/s10072-012-1209-4. Epub 2012 Oct 9.
Additional References at PubMed
PMID:7939721   PMID:9204908   PMID:10100614   PMID:11319880   PMID:12388085   PMID:12441348   PMID:12477932   PMID:14673156   PMID:15489334   PMID:15545827   PMID:15919658   PMID:16010989  
PMID:16236269   PMID:16271312   PMID:16289705   PMID:16306159   PMID:17556672   PMID:17634255   PMID:18337562   PMID:18426977   PMID:18805096   PMID:19074679   PMID:19393246   PMID:19750007  
PMID:20458337   PMID:20616046   PMID:21289279   PMID:21883093   PMID:22578813   PMID:22681889   PMID:22792342   PMID:23263185   PMID:23359369   PMID:23814182   PMID:24990923   PMID:25304210  
PMID:25456498   PMID:25822952   PMID:30361391   PMID:31877332   PMID:33864263   PMID:34638676   PMID:37175950   PMID:37442236  


Genomics

Comparative Map Data
Eif4e
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82229,736,309 - 229,772,628 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2229,739,897 - 229,774,105 (+)EnsemblGRCr8
mRatBN7.22227,066,519 - 227,099,261 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2227,066,673 - 227,098,683 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2234,815,680 - 234,847,577 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02232,715,418 - 232,747,307 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02227,580,081 - 227,611,970 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02243,819,616 - 243,853,987 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2243,820,661 - 243,852,631 (+)Ensemblrn6Rnor6.0
Rnor_5.02262,354,375 - 262,387,512 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42236,072,748 - 236,104,714 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2219,223,372 - 219,255,078 (+)NCBICelera
RGSC_v3.12236,059,487 - 236,091,453 (+)NCBI
Cytogenetic Map2q44NCBI
EIF4E
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38498,879,276 - 98,929,133 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl498,878,761 - 98,929,150 (-)Ensemblhg38GRCh38
GRCh37499,800,427 - 99,850,284 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364100,020,235 - 100,070,139 (-)NCBIBuild 36Build 36hg18NCBI36
Build 344100,158,390 - 100,208,294NCBI
Celera497,096,811 - 97,149,290 (-)NCBICelera
Cytogenetic Map4q23NCBI
HuRef495,536,964 - 95,590,638 (-)NCBIHuRef
CHM1_1499,776,200 - 99,828,797 (-)NCBICHM1_1
T2T-CHM13v2.04102,194,230 - 102,244,088 (-)NCBIT2T-CHM13v2.0
Eif4e
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393138,231,952 - 138,265,457 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3138,231,940 - 138,265,457 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm383138,526,191 - 138,559,696 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3138,526,179 - 138,559,696 (+)Ensemblmm10GRCm38
MGSCv373138,189,155 - 138,220,563 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv363139,028,114 - 139,059,540 (+)NCBIMGSCv36mm8
MGSCv363138,463,578 - 138,494,986 (+)NCBIMGSCv36mm8
Celera3144,941,218 - 144,979,363 (+)NCBICelera
Cytogenetic Map3G3NCBI
cM Map364.3NCBI
Eif4e
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554059,122,228 - 9,159,711 (-)Ensembl
ChiLan1.0NW_0049554059,122,960 - 9,159,095 (-)NCBIChiLan1.0ChiLan1.0
EIF4E
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2396,934,680 - 96,996,884 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1497,210,548 - 97,272,855 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0491,268,463 - 91,329,800 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14101,941,142 - 101,994,809 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4101,941,142 - 101,994,809 (-)EnsemblpanPan2panpan1.1
EIF4E
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13221,064,202 - 21,108,998 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3221,065,270 - 21,124,483 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3220,756,689 - 20,865,742 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03221,250,297 - 21,359,208 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3221,248,141 - 21,359,179 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13221,216,653 - 21,325,304 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03221,042,830 - 21,151,969 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03218,743,751 - 18,852,925 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Eif4e
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530120,577,678 - 20,621,269 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365203,922,339 - 3,960,359 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365203,922,457 - 3,964,721 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF4E
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8121,409,731 - 121,464,471 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.18121,409,633 - 121,464,467 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28130,593,991 - 130,647,458 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EIF4E
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1747,002,522 - 47,053,060 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl747,001,008 - 47,051,571 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603725,432,821 - 25,482,200 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eif4e
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1320,593,495 - 20,624,470 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Eif4e
161 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:145
Count of miRNA genes:120
Interacting mature miRNAs:129
Transcripts:ENSRNOT00000068613
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631563Hcuc3Hepatic copper content QTL 33.87liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2212145502231732847Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2202029709236904960Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2210956252251712708Rat
8693697Alc36Alcohol consumption QTL 3620.592drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2219814164239320906Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2214404877251712708Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2204795005249795005Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2214404877251712708Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2218051934251712708Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2186850607231850607Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2192287802237287802Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2214404877251712708Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2196140964251540988Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2214404877251712708Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2205135267250135267Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2188565047233565047Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2221088977243501206Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2184856304229856304Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2184856304229856304Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2220274283249795005Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2184856304229856304Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2203664411248664411Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2214404877251712708Rat
8693622Alc26Alcohol consumption QTL 262.40.667drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2223810546243965570Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2184856304229856304Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2192287802237287802Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2220274283249795005Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat

Markers in Region
PMC56953P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.02160,278,303 - 160,278,975NCBIRnor5.0
Rnor_5.01110,873,480 - 10,874,161NCBIRnor5.0
RGSC_v3.4118,684,445 - 8,685,125UniSTSRGSC3.4
RGSC_v3.42141,098,844 - 141,099,515UniSTSRGSC3.4
Celera118,630,255 - 8,630,935UniSTS
Celera2130,778,183 - 130,778,854UniSTS
Cytogenetic Map2q44UniSTS
Eif4e  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.02262,385,948 - 262,386,705NCBIRnor5.0
Rnor_5.02160,279,340 - 160,279,850NCBIRnor5.0
RGSC_v3.42236,103,383 - 236,103,907UniSTSRGSC3.4
RGSC_v3.42141,099,881 - 141,100,390UniSTSRGSC3.4
Celera2219,253,747 - 219,254,271UniSTS
Celera2130,779,220 - 130,779,729UniSTS
Cytogenetic Map2q44UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000089744
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2229,739,897 - 229,771,358 (+)Ensembl
mRatBN7.2 Ensembl2227,066,673 - 227,097,991 (+)Ensembl
Rnor_6.0 Ensembl2243,829,781 - 243,850,864 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090526   ⟹   ENSRNOP00000073799
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2227,067,378 - 227,098,683 (+)Ensembl
Rnor_6.0 Ensembl2243,820,661 - 243,852,631 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093355   ⟹   ENSRNOP00000076114
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2229,739,897 - 229,771,074 (+)Ensembl
mRatBN7.2 Ensembl2227,066,673 - 227,098,194 (+)Ensembl
Rnor_6.0 Ensembl2243,840,134 - 243,850,928 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102814   ⟹   ENSRNOP00000091657
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2229,740,753 - 229,772,052 (+)Ensembl
mRatBN7.2 Ensembl2227,067,384 - 227,098,491 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104325   ⟹   ENSRNOP00000095190
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2227,085,014 - 227,098,501 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000134211   ⟹   ENSRNOP00000107519
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2229,740,871 - 229,774,105 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000160020   ⟹   ENSRNOP00000109140
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2229,741,720 - 229,774,105 (+)Ensembl
RefSeq Acc Id: NM_053974   ⟹   NP_446426
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82229,740,753 - 229,772,628 (+)NCBI
mRatBN7.22227,067,384 - 227,099,261 (+)NCBI
Rnor_6.02243,820,696 - 243,852,631 (+)NCBI
Rnor_5.02262,354,375 - 262,387,512 (+)NCBI
RGSC_v3.42236,072,748 - 236,104,714 (+)RGD
Celera2219,223,372 - 219,255,078 (+)RGD
Sequence:
RefSeq Acc Id: XM_017590592   ⟹   XP_017446081
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82229,736,309 - 229,772,327 (+)NCBI
mRatBN7.22227,066,519 - 227,099,261 (+)NCBI
Rnor_6.02243,820,532 - 243,853,987 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063281172   ⟹   XP_063137242
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82229,739,531 - 229,772,327 (+)NCBI
RefSeq Acc Id: XM_063281173   ⟹   XP_063137243
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82229,741,186 - 229,772,327 (+)NCBI
RefSeq Acc Id: XM_063281174   ⟹   XP_063137244
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82229,749,784 - 229,772,327 (+)NCBI
RefSeq Acc Id: XM_063281175   ⟹   XP_063137245
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82229,749,772 - 229,772,327 (+)NCBI
RefSeq Acc Id: NP_446426   ⟸   NM_053974
- UniProtKB: P63074 (UniProtKB/Swiss-Prot),   A6HW37 (UniProtKB/TrEMBL),   A0A8I6AT12 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446081   ⟸   XM_017590592
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AG37 (UniProtKB/TrEMBL),   A6HW38 (UniProtKB/TrEMBL),   A0A8I6AT12 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073799   ⟸   ENSRNOT00000090526
Ensembl Acc Id: ENSRNOP00000076114   ⟸   ENSRNOT00000093355
Ensembl Acc Id: ENSRNOP00000095190   ⟸   ENSRNOT00000104325
Ensembl Acc Id: ENSRNOP00000091657   ⟸   ENSRNOT00000102814
RefSeq Acc Id: XP_063137242   ⟸   XM_063281172
- Peptide Label: isoform X1
- UniProtKB: P63074 (UniProtKB/Swiss-Prot),   A0A8I6AT12 (UniProtKB/TrEMBL),   A6HW37 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137243   ⟸   XM_063281173
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063137245   ⟸   XM_063281175
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063137244   ⟸   XM_063281174
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000109140   ⟸   ENSRNOT00000160020
Ensembl Acc Id: ENSRNOP00000107519   ⟸   ENSRNOT00000134211

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63074-F1-model_v2 AlphaFold P63074 1-217 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691791
Promoter ID:EPDNEW_R2315
Type:multiple initiation site
Name:Eif4e_1
Description:eukaryotic translation initiation factor 4E
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02243,820,696 - 243,820,756EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69647 AgrOrtholog
BioCyc Gene G2FUF-51057 BioCyc
Ensembl Genes ENSRNOG00000052343 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000093355 ENTREZGENE
  ENSRNOT00000093355.2 UniProtKB/Swiss-Prot
  ENSRNOT00000102814 ENTREZGENE
Gene3D-CATH 3.30.760.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7122606 IMAGE-MGC_LOAD
InterPro TIF_eIF4e-like UniProtKB/Swiss-Prot
  TIF_eIF_4E UniProtKB/Swiss-Prot
  TIF_eIF_4E_CS UniProtKB/Swiss-Prot
KEGG Report rno:117045 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93265 IMAGE-MGC_LOAD
NCBI Gene 117045 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 4E UniProtKB/Swiss-Prot
  PTHR11960 UniProtKB/Swiss-Prot
Pfam IF4E UniProtKB/Swiss-Prot
PhenoGen Eif4e PhenoGen
PROSITE IF4E UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000052343 RatGTEx
Superfamily-SCOP SSF55418 UniProtKB/Swiss-Prot
TIGR TC229222
UniProt A0A1W2Q627_RAT UniProtKB/TrEMBL
  A0A8I6AG37 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AT12 ENTREZGENE
  A0A8I6GKW2_RAT UniProtKB/TrEMBL
  A0ABK0LED5_RAT UniProtKB/TrEMBL
  A0ABK0LUA9_RAT UniProtKB/TrEMBL
  A6HW37 ENTREZGENE, UniProtKB/TrEMBL
  A6HW38 ENTREZGENE, UniProtKB/TrEMBL
  IF4E_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P20415 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Eif4e  eukaryotic translation initiation factor 4E      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function binds to the 7-methylguanosine cap of mRNA and facilitates binding of mRNA to the 40 S ribosome during translation initiation 68706
gene_function binds to the 7-methylguanosine cap of mRNA and facilitates binding of mRNA to the 40 S ribosome during translation initiation 68886
gene_process regulates translational efficiency of mRNAs 68706
gene_process regulates translational efficiency of mRNAs 68886
gene_process may function in cell growth 68706
gene_process may function in cell growth 68886