Slc38a1 (solute carrier family 38, member 1) - Rat Genome Database

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Gene: Slc38a1 (solute carrier family 38, member 1) Rattus norvegicus
Analyze
Symbol: Slc38a1
Name: solute carrier family 38, member 1
RGD ID: 69645
Description: Enables L-glutamine transmembrane transporter activity and amino acid:sodium symporter activity. Involved in L-glutamine import across plasma membrane; amino acid import; and female pregnancy. Located in external side of apical plasma membrane and neuronal cell body. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human SLC38A1 (solute carrier family 38 member 1); PARTICIPATES IN glutamate signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; acetamide; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: amino acid transporter A1; amino acid transporter system A1; Ata1; GlnT; glutamine transporter; N-system amino acid transporter 2; rATA1; Sat1; Snat1; sodium-coupled neutral amino acid symporter 1; sodium-coupled neutral amino acid transporter 1; solute carrier family 38 member 1; system A amino acid transporter 1; system A transporter 2; system N amino acid transporter 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87129,612,414 - 129,681,727 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7129,617,387 - 129,681,778 (-)EnsemblGRCr8
mRatBN7.27127,733,230 - 127,802,541 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7127,738,226 - 127,802,218 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7129,539,154 - 129,603,112 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07131,764,672 - 131,828,633 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07131,682,822 - 131,746,754 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07137,970,555 - 138,040,098 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7137,975,549 - 138,039,984 (-)Ensemblrn6Rnor6.0
Rnor_5.07137,598,311 - 137,667,871 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47135,252,257 - 135,316,256 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7124,242,806 - 124,306,590 (-)NCBICelera
RGSC_v3.17135,328,704 - 135,392,693 (-)NCBI
Cytogenetic Map7q35NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP)
cadmium sulfate  (ISO)
calyculin A  (ISO)
cannabidiol  (ISO)
cannabigerol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dieldrin  (EXP)
endosulfan  (EXP)
ethanol  (ISO)
fenpyroximate  (ISO)
fenvalerate  (EXP,ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gamma-aminobutyric acid  (EXP)
geldanamycin  (ISO)
graphite  (EXP)
heptachlor  (EXP)
hydrogen chloride  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mirex  (EXP)
N(4)-hydroxycytidine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
nickel dichloride  (ISO)
oxaliplatin  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phytoestrogen  (ISO)
pirinixic acid  (ISO)
progesterone  (EXP)
Pyridostigmine bromide  (EXP)
quercetin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
temozolomide  (ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zearalenone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Na+ transport by the neural glutamine transporter ATA1. Albers A, etal., Pflugers Arch. 2001 Oct;443(1):92-101. doi: 10.1007/s004240100663.
2. Functional expression of two system A glutamine transporter isoforms in rat auditory brainstem neurons. Blot A, etal., Neuroscience. 2009 Dec 15;164(3):998-1008. doi: 10.1016/j.neuroscience.2009.09.015. Epub 2009 Sep 12.
3. Glutamine uptake by neurons: interaction of protons with system a transporters. Chaudhry FA, etal., J Neurosci 2002 Jan 1;22(1):62-72.
4. Differential molecular regulation of glutamate in kindling resistant rats. Doi T, etal., Brain Res. 2011 Feb 23;1375:1-6. doi: 10.1016/j.brainres.2010.11.085. Epub 2010 Dec 4.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Functional properties and cellular distribution of the system A glutamine transporter SNAT1 support specialized roles in central neurons. Mackenzie B, etal., J Biol Chem 2003 Jun 27;278(26):23720-30. Epub 2003 Apr 8.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Yes-associated protein 1 and transcriptional coactivator with PDZ-binding motif activate the mammalian target of rapamycin complex 1 pathway by regulating amino acid transporters in hepatocellular carcinoma. Park YY, etal., Hepatology. 2016 Jan;63(1):159-72. doi: 10.1002/hep.28223. Epub 2015 Nov 26.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
13. Cloning and functional identification of a neuronal glutamine transporter. Varoqui H, etal., J Biol Chem 2000 Feb 11;275(6):4049-54.
14. Expression and role of SNAT3 in the placenta. Yoshioka C, etal., Placenta. 2009 Dec;30(12):1071-7. doi: 10.1016/j.placenta.2009.09.009. Epub 2009 Nov 5.
Additional References at PubMed
PMID:11325958   PMID:12477932   PMID:15521011   PMID:16023720   PMID:16200463   PMID:17323379   PMID:20458337   PMID:20492358   PMID:20602128   PMID:25957749   PMID:26590355  


Genomics

Comparative Map Data
Slc38a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87129,612,414 - 129,681,727 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7129,617,387 - 129,681,778 (-)EnsemblGRCr8
mRatBN7.27127,733,230 - 127,802,541 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7127,738,226 - 127,802,218 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7129,539,154 - 129,603,112 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07131,764,672 - 131,828,633 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07131,682,822 - 131,746,754 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07137,970,555 - 138,040,098 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7137,975,549 - 138,039,984 (-)Ensemblrn6Rnor6.0
Rnor_5.07137,598,311 - 137,667,871 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47135,252,257 - 135,316,256 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7124,242,806 - 124,306,590 (-)NCBICelera
RGSC_v3.17135,328,704 - 135,392,693 (-)NCBI
Cytogenetic Map7q35NCBI
SLC38A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381246,183,063 - 46,269,043 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1246,183,054 - 46,270,070 (-)Ensemblhg38GRCh38
GRCh371246,576,846 - 46,662,826 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361244,863,105 - 44,949,475 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341244,867,850 - 44,948,816NCBI
Celera1245,374,176 - 45,460,544 (-)NCBICelera
Cytogenetic Map12q13.11NCBI
HuRef1243,608,096 - 43,694,464 (-)NCBIHuRef
CHM1_11246,541,943 - 46,628,310 (-)NCBICHM1_1
T2T-CHM13v2.01246,142,659 - 46,228,603 (-)NCBIT2T-CHM13v2.0
Slc38a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391596,469,299 - 96,541,396 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1596,469,299 - 96,540,794 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381596,571,418 - 96,643,438 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1596,571,418 - 96,642,913 (-)Ensemblmm10GRCm38
MGSCv371596,401,849 - 96,473,344 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361596,402,709 - 96,452,131 (-)NCBIMGSCv36mm8
Celera1598,716,978 - 98,788,897 (-)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1552.53NCBI
Slc38a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555005,398,358 - 5,462,042 (-)Ensembl
ChiLan1.0NW_0049555005,393,211 - 5,468,827 (-)NCBIChiLan1.0ChiLan1.0
SLC38A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21047,895,936 - 47,984,817 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11247,895,548 - 47,981,585 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01242,464,360 - 42,550,324 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11243,333,087 - 43,419,502 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1243,362,597 - 43,413,616 (+)EnsemblpanPan2panpan1.1
SLC38A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1278,110,327 - 8,179,394 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl278,130,823 - 8,174,936 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2738,127,750 - 38,197,361 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0278,309,904 - 8,379,147 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl278,309,945 - 8,379,526 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1278,117,874 - 8,187,129 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0278,156,867 - 8,221,929 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02738,367,553 - 38,436,859 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc38a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494568,660,514 - 68,726,003 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365124,444,684 - 4,487,165 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365124,438,827 - 4,504,416 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC38A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl577,009,862 - 77,058,427 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1577,009,840 - 77,076,723 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2579,935,364 - 80,001,646 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC38A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11142,415,986 - 42,502,794 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1142,421,910 - 42,472,838 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037203,924,850 - 204,006,548 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc38a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248165,989,601 - 6,025,987 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248165,988,625 - 6,025,987 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Slc38a1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11269,413,580 - 269,481,657 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Slc38a1
482 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:63
Count of miRNA genes:53
Interacting mature miRNAs:59
Transcripts:ENSRNOT00000008138
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7121393075137014596Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7119280025135560836Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7115313999136544683Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)7116269196132020414Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
RH130789  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr87129,682,541 - 129,682,713 (+)Marker Load Pipeline
mRatBN7.27127,803,358 - 127,803,530 (+)MAPPERmRatBN7.2
Rnor_6.07138,040,771 - 138,040,942NCBIRnor6.0
Rnor_5.07137,668,527 - 137,668,698UniSTSRnor5.0
RGSC_v3.47135,317,397 - 135,317,568UniSTSRGSC3.4
Celera7124,307,731 - 124,307,902UniSTS
RH 3.4 Map71092.0UniSTS
Cytogenetic Map7q35UniSTS
RH131580  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27127,737,986 - 127,738,171 (+)MAPPERmRatBN7.2
Rnor_6.07137,975,310 - 137,975,494NCBIRnor6.0
Rnor_5.07137,603,066 - 137,603,250UniSTSRnor5.0
RGSC_v3.47135,252,026 - 135,252,210UniSTSRGSC3.4
Celera7124,242,575 - 124,242,759UniSTS
RH 3.4 Map71092.0UniSTS
Cytogenetic Map7q35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000008138   ⟹   ENSRNOP00000008138
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7129,617,387 - 129,681,778 (-)Ensembl
mRatBN7.2 Ensembl7127,738,226 - 127,802,218 (-)Ensembl
Rnor_6.0 Ensembl7137,975,549 - 138,039,630 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000089806   ⟹   ENSRNOP00000070624
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7137,975,772 - 138,039,984 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000148196   ⟹   ENSRNOP00000107722
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7129,618,558 - 129,681,401 (-)Ensembl
RefSeq Acc Id: NM_138832   ⟹   NP_620187
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87129,617,400 - 129,681,401 (-)NCBI
mRatBN7.27127,738,218 - 127,802,218 (-)NCBI
Rnor_6.07137,975,541 - 138,039,630 (-)NCBI
Rnor_5.07137,598,311 - 137,667,871 (-)NCBI
RGSC_v3.47135,252,257 - 135,316,256 (-)RGD
Celera7124,242,806 - 124,306,590 (-)RGD
Sequence:
RefSeq Acc Id: XM_006242277   ⟹   XP_006242339
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87129,612,414 - 129,680,003 (-)NCBI
mRatBN7.27127,733,230 - 127,800,819 (-)NCBI
Rnor_6.07137,970,555 - 138,039,326 (-)NCBI
Rnor_5.07137,598,311 - 137,667,871 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242280   ⟹   XP_006242342
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87129,612,414 - 129,681,726 (-)NCBI
mRatBN7.27127,733,230 - 127,802,169 (-)NCBI
Rnor_6.07137,970,555 - 138,039,731 (-)NCBI
Rnor_5.07137,598,311 - 137,667,871 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242281   ⟹   XP_006242343
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87129,612,414 - 129,681,727 (-)NCBI
mRatBN7.27127,733,230 - 127,802,541 (-)NCBI
Rnor_6.07137,970,555 - 138,040,098 (-)NCBI
Rnor_5.07137,598,311 - 137,667,871 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039078321   ⟹   XP_038934249
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87129,612,414 - 129,637,802 (-)NCBI
mRatBN7.27127,733,230 - 127,758,622 (-)NCBI
RefSeq Acc Id: XM_063262935   ⟹   XP_063119005
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87129,612,414 - 129,681,726 (-)NCBI
RefSeq Acc Id: XM_063262936   ⟹   XP_063119006
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87129,612,414 - 129,678,378 (-)NCBI
RefSeq Acc Id: NP_620187   ⟸   NM_138832
- UniProtKB: Q9JM15 (UniProtKB/Swiss-Prot),   A6KC24 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242343   ⟸   XM_006242281
- Peptide Label: isoform X1
- UniProtKB: Q9JM15 (UniProtKB/Swiss-Prot),   A6KC24 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242342   ⟸   XM_006242280
- Peptide Label: isoform X1
- UniProtKB: Q9JM15 (UniProtKB/Swiss-Prot),   A6KC24 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242339   ⟸   XM_006242277
- Peptide Label: isoform X1
- UniProtKB: Q9JM15 (UniProtKB/Swiss-Prot),   A6KC24 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008138   ⟸   ENSRNOT00000008138
Ensembl Acc Id: ENSRNOP00000070624   ⟸   ENSRNOT00000089806
RefSeq Acc Id: XP_038934249   ⟸   XM_039078321
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063119005   ⟸   XM_063262935
- Peptide Label: isoform X1
- UniProtKB: Q9JM15 (UniProtKB/Swiss-Prot),   A6KC24 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119006   ⟸   XM_063262936
- Peptide Label: isoform X1
- UniProtKB: Q9JM15 (UniProtKB/Swiss-Prot),   A6KC24 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000107722   ⟸   ENSRNOT00000148196
Protein Domains
Amino acid transporter transmembrane

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JM15-F1-model_v2 AlphaFold Q9JM15 1-485 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695608
Promoter ID:EPDNEW_R6133
Type:initiation region
Name:Slc38a1_1
Description:solute carrier family 38, member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07138,039,687 - 138,039,747EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69645 AgrOrtholog
BioCyc Gene G2FUF-32246 BioCyc
Ensembl Genes ENSRNOG00000005291 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008138 ENTREZGENE
  ENSRNOT00000008138.5 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7444889 IMAGE-MGC_LOAD
InterPro AA_transpt_TM UniProtKB/Swiss-Prot
KEGG Report rno:170567 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114262 IMAGE-MGC_LOAD
NCBI Gene Slc38a1 ENTREZGENE
PANTHER AMINO ACID TRANSPORTER UniProtKB/Swiss-Prot
  SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 1 UniProtKB/Swiss-Prot
Pfam Aa_trans UniProtKB/Swiss-Prot
PhenoGen Slc38a1 PhenoGen
RatGTEx ENSRNOG00000005291 RatGTEx
TIGR TC232025
UniProt A0ABK0LAS5_RAT UniProtKB/TrEMBL
  A6KC24 ENTREZGENE, UniProtKB/TrEMBL
  Q9JM15 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Slc38a1  solute carrier family 38, member 1      Symbol and Name status set to approved 70586 APPROVED
2002-02-27 Slc38a1  solute carrier family 38, member 1      Symbol and Name updated to reflect Human and Mouse nomenclature 70292 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localizes to somata and proximal dendrites 1299220
gene_function transports glutamine from glutamatergic neurons 68922
gene_process supplies glutamatergic neurons with serine and cysteine 68922
gene_process may have a role in providing metabolic fuel (via alpha-ketoglutarate) or precursors for glutathione synthesis 1299220