Lcn2 (lipocalin 2) - Rat Genome Database

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Gene: Lcn2 (lipocalin 2) Rattus norvegicus
Analyze
Symbol: Lcn2
Name: lipocalin 2
RGD ID: 69408
Description: Enables enterobactin binding activity; identical protein binding activity; and protease binding activity. Involved in several processes, including cellular response to cytokine stimulus; memory; and regulation of hippocampal neuron apoptotic process. Located in extracellular space. Used to study intrahepatic cholangiocarcinoma and retinal degeneration. Biomarker of several diseases, including acute kidney failure; congenital diaphragmatic hernia; obesity; transient cerebral ischemia; and traumatic brain injury. Human ortholog(s) of this gene implicated in urinary tract infection. Orthologous to human LCN2 (lipocalin 2); INTERACTS WITH (+)-schisandrin B; (-)-citrinin; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha-2-microglobulin-related protein; alpha-2U globulin-related protein; lipocalin 2 (oncogene 24p3); lipocalin 24p3; lipocalin-2; neutrophil gelatinase-associated lipocalin; NGAL; p25; siderocalin LCN2; Sip24
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8336,078,432 - 36,081,851 (-)NCBIGRCr8
mRatBN7.2315,680,688 - 15,684,033 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl315,680,687 - 15,684,095 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx318,749,510 - 18,752,856 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0327,334,505 - 27,337,851 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0325,585,359 - 25,588,705 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0311,414,189 - 11,417,534 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,414,186 - 11,417,546 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0316,763,059 - 16,766,404 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4311,511,402 - 11,514,747 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1311,407,773 - 11,411,119 (-)NCBI
Celera310,423,569 - 10,426,914 (-)NCBICelera
Cytogenetic Map3p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Lcn2RatAbscess  IEP 126781756mRNA more ...RGD 
Lcn2Ratacute cystitis disease_progressionISOLCN2 (Homo sapiens)126779559associated with urinary tract infectionRGD 
Lcn2Ratacute kidney failure  ISOLCN2 (Homo sapiens)126781714protein:increased expression:urineRGD 
Lcn2Ratacute kidney failure  ISOLCN2 (Homo sapiens)125973912associated with open cardiac surgeries and protein:increased expression:urine:RGD 
Lcn2Ratacute kidney failure  IEP 7244370protein:increased expression:urineRGD 
Lcn2Ratamyotrophic lateral sclerosis  IEP 126781758protein:increased expression:spinal cordRGD 
Lcn2Ratautosomal dominant polycystic kidney disease disease_progressionISOLCN2 (Homo sapiens)126781837 RGD 
Lcn2Ratautosomal dominant polycystic kidney disease  ISOLCN2 (Homo sapiens)126790531protein:increased expression:serum and urineRGD 
Lcn2RatCerebral Hemorrhage  IEP 126790480 RGD 
Lcn2RatChlamydophila Infections exacerbatesISOLcn2 (Mus musculus)126781720 RGD 
Lcn2Ratchronic kidney disease disease_progressionISOLcn2 (Mus musculus)126781837 RGD 
Lcn2Ratcolon cancer treatmentIEP 2316492 RGD 
Lcn2Ratcongenital diaphragmatic hernia  IEP 126790533mRNA:decreased expression:lungRGD 
Lcn2Ratcongenital diaphragmatic hernia  ISOLCN2 (Homo sapiens)126790533protein:decreased expression:amniotic fluidRGD 
Lcn2RatContrast-Induced Nephropathy  IEP 7245484associated with Diabetes Mellitus more ...RGD 
Lcn2RatContrast-Induced Nephropathy  IEP 7245471protein:increased expression:urine:RGD 
Lcn2RatCOVID-19  ISOLCN2 (Homo sapiens)38501088protein:increased expression:plasma (human)RGD 
Lcn2RatDiabetic Nephropathies  IEP 7245497protein:increased expression:urineRGD 
Lcn2RatDiabetic Nephropathies  ISOLCN2 (Homo sapiens)7245960associated with Diabetes Mellitus more ...RGD 
Lcn2Ratend stage renal disease onsetISOLCN2 (Homo sapiens)7245503protein:increased expression:urine:RGD 
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Lcn2Ratcongenital disorder of glycosylation Iu  ISOLCN2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:23109149 and PMID:28492532
Lcn2Ratdevelopmental and epileptic encephalopathy  ISOLCN2 (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathyClinVarPMID:18469812 more ...
Lcn2Ratdevelopmental and epileptic encephalopathy 31A  ISOLCN2 (Homo sapiens)8554872ClinVar Annotator: match by term: Epileptic encephalopathy more ...ClinVarPMID:18469812 more ...
Lcn2Ratdystonia  ISOLCN2 (Homo sapiens)8554872ClinVar Annotator: match by term: Dystonic disorderClinVarPMID:28492532
Lcn2Ratearly infantile epileptic encephalopathy  ISOLCN2 (Homo sapiens)8554872ClinVar Annotator: match by term: Early infantile epileptic encephalopathyClinVarPMID:18469812 more ...
Lcn2Ratprimary coenzyme Q10 deficiency 7  ISOLCN2 (Homo sapiens)8554872ClinVar Annotator: match by term: Neonatal encephalomyopathy-cardiomyopathy-respiratory distress syndromeClinVarPMID:22368301 more ...
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Lcn2Ratacute kidney failure  ISOLCN2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20623750 more ...
Lcn2Ratadult respiratory distress syndrome  ISOLCN2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25070658
Lcn2RatAnimal Hepatitis  ISOLCN2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18559427
Lcn2Ratbeta thalassemia  ISOLCN2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16755567
Lcn2Ratcalcinosis  ISOLCN2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21335463
Lcn2Ratceliac disease  ISOLCN2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:30097691
Lcn2RatChemical and Drug Induced Liver Injury  ISOLCN2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20362651 and PMID:20623750
Lcn2Ratchronic kidney disease  ISOLCN2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24714768
Lcn2Ratcontact dermatitis  ISOLCN2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25724174
Lcn2Ratdisease of cellular proliferation  ISOLCN2 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:17114340
Lcn2RatDrug-Related Side Effects and Adverse Reactions  ISOLCN2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28885000
Lcn2RatExperimental Liver Cirrhosis  ISOLCN2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17072980 and PMID:25380136
Lcn2Ratheart valve disease  ISOLCN2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21335463
Lcn2RatInflammation  ISOLCN2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20118187
Lcn2Ratkidney disease  ISOLCN2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19349640 more ...
Lcn2RatNeoplasm Metastasis  ISOLCN2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24570342
Lcn2Ratrheumatoid arthritis  ISOLCN2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:7554268
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Lcn2Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of LCN2 mRNA]CTDPMID:31150632
Lcn2Rat(-)-citrinin increases expressionEXP 6480464Citrinin results in increased expression of LCN2 mRNACTDPMID:23856526
Lcn2Rat1,1-dichloroethene increases expressionISOLcn2 (Mus musculus)6480464vinylidene chloride results in increased expression of LCN2 mRNACTDPMID:26682919
Lcn2Rat1-aminobenzotriazole multiple interactionsISOLcn2 (Mus musculus)6480464[1-aminobenzotriazole co-treated with ochratoxin A] results in increased expression of LCN2 proteinCTDPMID:36227364
Lcn2Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of LCN2 mRNACTDPMID:18289764 more ...
Lcn2Rat1-naphthyl isothiocyanate multiple interactionsISOLcn2 (Mus musculus)6480464pirinixic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of LCN2 mRNA] and PPARA protein affects the reaction [pirinixic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of LCN2 mRNA]]CTDPMID:27853831
Lcn2Rat1-naphthyl isothiocyanate increases expressionISOLcn2 (Mus musculus)64804641-Naphthylisothiocyanate results in increased expression of LCN2 mRNACTDPMID:27853831
Lcn2Rat11-deoxycorticosterone multiple interactionsEXP 6480464[Desoxycorticosterone co-treated with Sodium Chloride more ...CTDPMID:21135038
Lcn2Rat17alpha-ethynylestradiol multiple interactionsISOLcn2 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LCN2 mRNA and Ethinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of LCN2 mRNA]CTDPMID:12072388 and PMID:17942748
Lcn2Rat17alpha-ethynylestradiol increases expressionISOLcn2 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of LCN2 mRNACTDPMID:16467188 and PMID:17942748
Lcn2Rat17beta-estradiol multiple interactionsISOLCN2 (Homo sapiens)6480464[Estradiol co-treated with Medroxyprogesterone Acetate] results in decreased expression of LCN2 mRNA more ...CTDPMID:15866426 more ...
Lcn2Rat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of LCN2 mRNACTDPMID:15456929 and PMID:26945725
Lcn2Rat17beta-estradiol multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of LCN2 mRNA and [Estradiol co-treated with Plant Preparations] results in increased expression of LCN2 mRNACTDPMID:26945725 and PMID:32741896
Lcn2Rat17beta-estradiol increases expressionISOLcn2 (Mus musculus)6480464Estradiol results in increased expression of LCN2 mRNACTDPMID:15289156 more ...
Lcn2Rat17beta-estradiol increases expressionISOLCN2 (Homo sapiens)6480464Estradiol results in increased expression of LCN2 mRNACTDPMID:19619570
Lcn2Rat17beta-estradiol affects expressionISOLcn2 (Mus musculus)6480464Estradiol affects the expression of LCN2 mRNACTDPMID:15598610
Lcn2Rat17beta-estradiol multiple interactionsISOLcn2 (Mus musculus)6480464Estradiol inhibits the reaction [Lipopolysaccharides results in increased expression of LCN2 mRNA] and Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of LCN2 mRNA]CTDPMID:16977382 and PMID:24052564
Lcn2Rat17beta-estradiol 3-benzoate multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of LCN2 mRNACTDPMID:32741896
Lcn2Rat2,2',4,4'-Tetrabromodiphenyl ether increases expressionEXP 64804642 more ...CTDPMID:27291303
Lcn2Rat2,2',4,4'-Tetrabromodiphenyl ether affects expressionISOLcn2 (Mus musculus)64804642 more ...CTDPMID:30294300

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Biological Process
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Lcn2Ratacute-phase response  IEP 126781756 RGD 
Lcn2Ratapoptotic process involved_inIEAUniProtKB-KW:KW-00531600115GO_REF:0000043UniProtGO_REF:0000043
Lcn2Ratcellular response to amyloid-beta  IEP 126781834 RGD 
Lcn2Ratcellular response to hydrogen peroxide  IDA 2316500 RGD 
Lcn2Ratcellular response to hypoxia  IEP 126790489oxygen-glucose deprivationRGD 
Lcn2Ratcellular response to increased oxygen levels  IEP 126790489 RGD 
Lcn2Ratcellular response to interleukin-1  IEP 2316495IL-1betaRGD 
Lcn2Ratcellular response to interleukin-1  IEP 126781756 RGD 
Lcn2Ratcellular response to interleukin-6  IEP 126781756 RGD 
Lcn2Ratcellular response to lipopolysaccharide  IEP 2316495 RGD 
Lcn2Ratcellular response to nerve growth factor stimulus  IEP 126781755 RGD 
Lcn2Ratcellular response to nutrient levels  IEP 2303047serum deprivationRGD 
Lcn2Ratcellular response to tumor necrosis factor  IEP 2316495TNFalphaRGD 
Lcn2Ratcellular response to tumor necrosis factor  IEP 126781756 RGD 
Lcn2Ratcellular response to X-ray  IEP 126790570 RGD 
Lcn2Ratdefense response to bacterium involved_inISOLCN2 (Homo sapiens)1624291 PMID:27780864RGDPMID:27780864
Lcn2Ratdefense response to bacterium involved_inIEAUniProtKB:P80188 and ensembl:ENSP000002774801600115GO_REF:0000107EnsemblGO_REF:0000107
Lcn2Ratdefense response to bacterium involved_inISSUniProtKB:P801881600115GO_REF:0000024UniProtGO_REF:0000024
Lcn2Ratextrinsic apoptotic signaling pathway in absence of ligand acts_upstream_of_or_withinISOLcn2 (Mus musculus)1624291 PMID:16377569RGDPMID:16377569
Lcn2Ratextrinsic apoptotic signaling pathway in absence of ligand acts_upstream_of_or_withinIEAUniProtKB:P11672 and ensembl:ENSMUSP000000539621600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
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Lcn2Ratcytoplasmic vesicle located_inIEAUniProtKB-KW:KW-09681600115GO_REF:0000043UniProtGO_REF:0000043
Lcn2Ratcytoplasmic vesicle lumen located_inIEAUniProtKB-SubCell:SL-03251600115GO_REF:0000044UniProtGO_REF:0000044
Lcn2Ratextracellular region located_inIEAUniProtKB-SubCell:SL-02431600115GO_REF:0000044UniProtGO_REF:0000044
Lcn2Ratextracellular region located_inIEAUniProtKB:P11672 and ensembl:ENSMUSP000000539621600115GO_REF:0000107EnsemblGO_REF:0000107
Lcn2Ratextracellular region located_inISOLcn2 (Mus musculus)1624291 PMID:16377569RGDPMID:16377569
Lcn2Ratextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
Lcn2Ratextracellular region located_inISSUniProtKB:P116721600115GO_REF:0000024UniProtGO_REF:0000024
Lcn2Ratextracellular space  IDA 2316490 RGD 
Lcn2Ratextracellular space located_inIEAUniProtKB:P80188 and ensembl:ENSP000002774801600115GO_REF:0000107EnsemblGO_REF:0000107
Lcn2Ratextracellular space located_inISOLcn2 (Mus musculus)1624291 PMID:29402223RGDPMID:29402223
Lcn2Ratextracellular space located_inIEAUniProtKB:P11672 and ensembl:ENSMUSP000000539621600115GO_REF:0000107EnsemblGO_REF:0000107
Lcn2Ratextracellular space is_active_inIBAMGI:2387617 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Lcn2Ratextracellular space located_inISOLCN2 (Homo sapiens)1624291 PMID:25645918 and PMID:27780864RGDPMID:25645918 and PMID:27780864
Lcn2Ratextracellular space  IDA 126781758 RGD 
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Molecular Function
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Lcn2Ratenterobactin binding  IPIenterobactin126790532 RGD 
Lcn2Ratenterobactin binding enablesIEAUniProtKB:P80188 and ensembl:ENSP000002774801600115GO_REF:0000107EnsemblGO_REF:0000107
Lcn2Ratenterobactin binding enablesISOLCN2 (Homo sapiens)1624291 PMID:27780864 and PMID:35101443RGDPMID:27780864 and PMID:35101443
Lcn2Ratenterobactin binding enablesISSUniProtKB:P801881600115GO_REF:0000024UniProtGO_REF:0000024
Lcn2Ratidentical protein binding  IPILcn2 (Rattus norvegicus)2316510homodimerization and homotrimerizationRGD 
Lcn2Ratidentical protein binding enablesIEAUniProtKB:P80188 and ensembl:ENSP000002774801600115GO_REF:0000107EnsemblGO_REF:0000107
Lcn2Ratidentical protein binding enablesISOLCN2 (Homo sapiens)1624291UniProtKB:P80188 and PMID:32296183RGDPMID:32296183
Lcn2Ratiron ion binding enablesISSUniProtKB:P801881600115GO_REF:0000024UniProtGO_REF:0000024
Lcn2Ratiron ion binding enablesIEAUniProtKB:P11672 and ensembl:ENSMUSP000000539621600115GO_REF:0000107EnsemblGO_REF:0000107
Lcn2Ratiron ion binding enablesIEAUniProtKB:P80188 and ensembl:ENSP000002774801600115GO_REF:0000107EnsemblGO_REF:0000107
Lcn2Ratiron ion binding enablesISOLcn2 (Mus musculus)1624291 PMID:16377569 and PMID:20550936RGDPMID:16377569 and PMID:20550936
Lcn2Ratiron ion binding enablesISOLCN2 (Homo sapiens)1624291 PMID:27780864RGDPMID:27780864
Lcn2Ratiron ion binding enablesISSUniProtKB:P116721600115GO_REF:0000024UniProtGO_REF:0000024
Lcn2Ratiron ion sequestering activity enablesISSUniProtKB:P801881600115GO_REF:0000024UniProtGO_REF:0000024
Lcn2Ratiron ion sequestering activity enablesIEAUniProtKB:P80188 and ensembl:ENSP000002774801600115GO_REF:0000107EnsemblGO_REF:0000107
Lcn2Ratiron ion sequestering activity enablesISOLCN2 (Homo sapiens)1624291 PMID:27780864RGDPMID:27780864
Lcn2Ratprotease binding  IPIMmp9 (Rattus norvegicus)2316510 RGD 
Lcn2Ratprotein binding enablesISOLCN2 (Homo sapiens)1624291UniProtKB:A0A1U9X8X8 more ...RGDPMID:32296183 and PMID:33961781
Lcn2Ratprotein binding enablesISOLcn2 (Mus musculus)1624291UniProtKB:Q9D9E0 and PMID:16377569RGDPMID:16377569
Lcn2Ratsmall molecule binding enablesIEAInterPro:IPR0023451600115GO_REF:0000002InterProGO_REF:0000002
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Reference Title
Reference Citation
1. Urinary NGAL and KIM-1: biomarkers for assessment of acute ischemic kidney injury following nephron sparing surgery. Abassi Z, etal., J Urol. 2013 Apr;189(4):1559-66. doi: 10.1016/j.juro.2012.10.029. Epub 2012 Oct 22.
2. Neutrophil gelatinase-associated lipocalin (NGAL/Lcn2) is upregulated in gastric mucosa infected with Helicobacter pylori. Alpízar-Alpízar W, etal., Virchows Arch. 2009 Sep;455(3):225-33. doi: 10.1007/s00428-009-0825-8.
3. Early urinary and plasma biomarkers for experimental diabetic nephropathy. Alter ML, etal., Clin Lab. 2012;58(7-8):659-71.
4. Diet high in fructose leads to an overexpression of lipocalin-2 in rat fatty liver. Alwahsh SM, etal., World J Gastroenterol. 2014 Feb 21;20(7):1807-21. doi: 10.3748/wjg.v20.i7.1807.
5. Fructose induces tubulointerstitial injury in the kidney of mice. Aoyama M, etal., Biochem Biophys Res Commun. 2012 Mar 9;419(2):244-9. doi: 10.1016/j.bbrc.2012.02.001. Epub 2012 Feb 8.
6. Neutrophil gelatinase-associated lipocalin and interleukin-10 regulate intramacrophage Chlamydia pneumoniae replication by modulating intracellular iron homeostasis. Bellmann-Weiler R, etal., Immunobiology. 2013 Jul;218(7):969-78. doi: 10.1016/j.imbio.2012.11.004. Epub 2012 Nov 21.
7. Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury. Berger T, etal., Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1834-9. doi: 10.1073/pnas.0510847103. Epub 2006 Jan 30.
8. Neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule 1 (KIM-1) as predictors of incident CKD stage 3: the Atherosclerosis Risk in Communities (ARIC) Study. Bhavsar NA, etal., Am J Kidney Dis. 2012 Aug;60(2):233-40. doi: 10.1053/j.ajkd.2012.02.336. Epub 2012 Apr 28.
9. Reactive astrocytes secrete lcn2 to promote neuron death. Bi F, etal., Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4069-74. doi: 10.1073/pnas.1218497110. Epub 2013 Feb 19.
10. Long-term administration of aspirin inhibits tumour formation and triggers anti-neoplastic molecular changes in a pre-clinical model of colon carcinogenesis. Bousserouel S, etal., Oncol Rep. 2010 Feb;23(2):511-7.
11. Induction of neutrophil gelatinase-associated lipocalin in vascular injury via activation of nuclear factor-kappaB. Bu DX, etal., Am J Pathol. 2006 Dec;169(6):2245-53.
12. The primary structure of rat alpha 2 mu globulin-related protein. Chan YL, etal., Nucleic Acids Res 1988 Dec 9;16(23):11368.
13. Lipocalin 2 is required for pulmonary host defense against Klebsiella infection. Chan YR, etal., J Immunol. 2009 Apr 15;182(8):4947-56. doi: 10.4049/jimmunol.0803282.
14. Expression and localisation of brain-type organic cation transporter (BOCT/24p3R/LCN2R) in the normal rat hippocampus and after kainate-induced excitotoxicity. Chia WJ, etal., Neurochem Int. 2015 Aug;87:43-59. doi: 10.1016/j.neuint.2015.04.009. Epub 2015 May 21.
15. Chemopreventive and chemotherapeutic effect of dietary supplementation of vitamin D on cholangiocarcinoma in a Chemical-Induced animal model. Chiang KC, etal., Oncotarget. 2014 Jun 15;5(11):3849-61. doi: 10.18632/oncotarget.2000.
16. Lipocalin-2 Functions as Inhibitor of Innate Resistance to Mycobacterium tuberculosis. Dahl SL, etal., Front Immunol. 2018 Nov 26;9:2717. doi: 10.3389/fimmu.2018.02717. eCollection 2018.
17. The gonadal expression pattern of lipocalin‑2 and 24p3 receptor is modified in the gonads of the offspring of obese rats. De La Chesnaye E, etal., Mol Med Rep. 2020 Aug;22(2):1409-1419. doi: 10.3892/mmr.2020.11226. Epub 2020 Jun 12.
18. Lipocalin-2/Neutrophil Gelatinase-B Associated Lipocalin is Strongly Induced in Hearts of Rats With Autoimmune Myocarditis and in Human Myocarditis. Ding L, etal., Circ J. 2010 Jan 7.
19. Role of iron in brain lipocalin 2 upregulation after intracerebral hemorrhage in rats. Dong M, etal., Brain Res. 2013 Apr 10;1505:86-92. doi: 10.1016/j.brainres.2013.02.008. Epub 2013 Feb 15.
20. Lipocalin 2 and Blood-Brain Barrier Disruption in White Matter after Experimental Subarachnoid Hemorrhage. Egashira Y, etal., Acta Neurochir Suppl. 2016;121:131-4. doi: 10.1007/978-3-319-18497-5_23.
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PMID:2542864   PMID:12477932   PMID:16377569   PMID:16502470   PMID:16546827   PMID:17490638   PMID:19056867   PMID:20550936   PMID:21457438   PMID:21551085   PMID:22117066   PMID:22278021  
PMID:22349381   PMID:22664934   PMID:22833177   PMID:22889806   PMID:23012479   PMID:23158800   PMID:23360846   PMID:23376485   PMID:23481292   PMID:23533145   PMID:23940770   PMID:24006456  
PMID:24374540   PMID:24816434   PMID:25062286   PMID:25087119   PMID:25148248   PMID:25645918   PMID:25782996   PMID:26463963   PMID:27026710   PMID:27068509   PMID:27087673   PMID:27233602  
PMID:27756197   PMID:27780864   PMID:27865916   PMID:29367586   PMID:29378951   PMID:29402223   PMID:29704511   PMID:29845768   PMID:29980183   PMID:30087458   PMID:30367561   PMID:30404645  
PMID:30871254   PMID:31269059   PMID:31327865   PMID:31480394   PMID:32412814   PMID:32630021   PMID:32845875   PMID:33319934   PMID:33510115   PMID:37672148   PMID:39265498  



Lcn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8336,078,432 - 36,081,851 (-)NCBIGRCr8
mRatBN7.2315,680,688 - 15,684,033 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl315,680,687 - 15,684,095 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx318,749,510 - 18,752,856 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0327,334,505 - 27,337,851 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0325,585,359 - 25,588,705 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0311,414,189 - 11,417,534 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,414,186 - 11,417,546 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0316,763,059 - 16,766,404 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4311,511,402 - 11,514,747 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1311,407,773 - 11,411,119 (-)NCBI
Celera310,423,569 - 10,426,914 (-)NCBICelera
Cytogenetic Map3p12NCBI
LCN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389128,149,453 - 128,153,453 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9128,149,071 - 128,153,453 (+)EnsemblGRCh38hg38GRCh38
GRCh379130,911,732 - 130,915,732 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369129,951,553 - 129,955,555 (+)NCBINCBI36Build 36hg18NCBI36
Build 349127,991,271 - 127,995,288NCBI
Celera9101,562,624 - 101,566,626 (+)NCBICelera
Cytogenetic Map9q34.11NCBI
HuRef9100,525,402 - 100,529,404 (+)NCBIHuRef
CHM1_19131,062,742 - 131,066,744 (+)NCBICHM1_1
T2T-CHM13v2.09140,356,542 - 140,360,542 (+)NCBIT2T-CHM13v2.0
Lcn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39232,274,649 - 32,277,751 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl232,274,645 - 32,278,264 (-)EnsemblGRCm39 Ensembl
GRCm38232,384,637 - 32,387,739 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl232,384,633 - 32,388,252 (-)EnsemblGRCm38mm10GRCm38
MGSCv37232,240,157 - 32,243,259 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36232,206,646 - 32,209,748 (-)NCBIMGSCv36mm8
Celera232,090,046 - 32,093,150 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map222.09NCBI
LCN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21111,199,073 - 11,214,309 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1911,201,421 - 11,216,652 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0999,259,278 - 99,274,494 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19127,940,799 - 127,944,798 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9127,940,799 - 127,944,798 (+)Ensemblpanpan1.1panPan2
LCN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1955,328,118 - 55,342,535 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl955,328,133 - 55,332,038 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha954,522,898 - 54,537,231 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0956,250,316 - 56,264,670 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl956,250,331 - 56,254,237 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1955,010,191 - 55,024,522 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0955,324,906 - 55,339,237 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0955,416,588 - 55,430,934 (-)NCBIUU_Cfam_GSD_1.0
Lcn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947195,953,204 - 195,956,869 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648715,721,684 - 15,728,221 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648715,721,752 - 15,725,396 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LCN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1268,609,887 - 268,614,644 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11268,609,975 - 268,614,651 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21302,600,679 - 302,609,836 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LCN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1129,976,278 - 9,981,087 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl129,976,614 - 9,980,870 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660796,251,600 - 6,256,754 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

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Variants in Lcn2
27 total Variants

Predicted Target Of
Summary Value
Count of predictions:139
Count of miRNA genes:98
Interacting mature miRNAs:103
Transcripts:ENSRNOT00000018776
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 25 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)31043430624512004Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat

1 to 10 of 25 rows
AA946503  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8336,079,309 - 36,079,668 (+)Marker Load Pipeline
mRatBN7.2315,681,562 - 15,681,921 (+)MAPPERmRatBN7.2
Rnor_6.0311,415,064 - 11,415,422NCBIRnor6.0
Rnor_5.0316,763,934 - 16,764,292UniSTSRnor5.0
RGSC_v3.4311,512,277 - 11,512,635UniSTSRGSC3.4
Celera310,424,444 - 10,424,802UniSTS
RH 3.4 Map360.1UniSTS
Cytogenetic Map3p11UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 11 49 113 91 90 59 24 59 6 215 96 93 44 60 31



Ensembl Acc Id: ENSRNOT00000018776   ⟹   ENSRNOP00000018776
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl315,680,689 - 15,684,095 (-)Ensembl
Rnor_6.0 Ensembl311,414,186 - 11,417,546 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094191   ⟹   ENSRNOP00000078583
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl315,680,687 - 15,684,095 (-)Ensembl
RefSeq Acc Id: NM_130741   ⟹   NP_570097
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,078,435 - 36,081,780 (-)NCBI
mRatBN7.2315,680,688 - 15,684,033 (-)NCBI
Rnor_6.0311,414,189 - 11,417,534 (-)NCBI
Rnor_5.0316,763,059 - 16,766,404 (-)NCBI
RGSC_v3.4311,511,402 - 11,514,747 (-)RGD
Celera310,423,569 - 10,426,914 (-)RGD
Sequence:
RefSeq Acc Id: XM_063283025   ⟹   XP_063139095
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,078,432 - 36,081,851 (-)NCBI
RefSeq Acc Id: XM_063283026   ⟹   XP_063139096
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,078,432 - 36,081,851 (-)NCBI
1 to 11 of 11 rows
Protein RefSeqs NP_570097 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139095 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139096 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH89053 (Get FASTA)   NCBI Sequence Viewer  
  CAA31657 (Get FASTA)   NCBI Sequence Viewer  
  EDL93236 (Get FASTA)   NCBI Sequence Viewer  
  EDL93237 (Get FASTA)   NCBI Sequence Viewer  
  EDL93238 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018776
  ENSRNOP00000018776.3
GenBank Protein P30152 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
RefSeq Acc Id: NP_570097   ⟸   NM_130741
- Peptide Label: precursor
- UniProtKB: Q5HZF1 (UniProtKB/Swiss-Prot),   P30152 (UniProtKB/Swiss-Prot),   A6JU59 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018776   ⟸   ENSRNOT00000018776
Ensembl Acc Id: ENSRNOP00000078583   ⟸   ENSRNOT00000094191
RefSeq Acc Id: XP_063139096   ⟸   XM_063283026
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063139095   ⟸   XM_063283025
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZNE2 (UniProtKB/TrEMBL)
Lipocalin/cytosolic fatty-acid binding

Name Modeler Protein Id AA Range Protein Structure
AF-P30152-F1-model_v2 AlphaFold P30152 1-198 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13691985
Promoter ID:EPDNEW_R2510
Type:multiple initiation site
Name:Lcn2_1
Description:lipocalin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0311,417,542 - 11,417,602EPDNEW


1 to 30 of 30 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-50141 BioCyc
Ensembl Genes ENSRNOG00000013973 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018776 ENTREZGENE
  ENSRNOT00000018776.6 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.128.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7310185 IMAGE-MGC_LOAD
InterPro Calycin UniProtKB/Swiss-Prot
  LCN2/LCN12 UniProtKB/Swiss-Prot
  Lipocalin UniProtKB/Swiss-Prot
  Lipocln_cytosolic_FA-bd_dom UniProtKB/Swiss-Prot
KEGG Report rno:170496 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105339 IMAGE-MGC_LOAD
NCBI Gene 170496 ENTREZGENE
PANTHER NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN UniProtKB/Swiss-Prot
  PTHR11430 UniProtKB/Swiss-Prot
Pfam Lipocalin UniProtKB/Swiss-Prot
PharmGKB LCN2 RGD
PhenoGen Lcn2 PhenoGen
PRINTS LIPOCALIN UniProtKB/Swiss-Prot
  NGELATINASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013973 RatGTEx
Superfamily-SCOP SSF50814 UniProtKB/Swiss-Prot
TIGR TC207006
UniProt A0A8I5ZNE2 ENTREZGENE, UniProtKB/TrEMBL
  A6JU59 ENTREZGENE, UniProtKB/TrEMBL
  A6JU60_RAT UniProtKB/TrEMBL
  A6JU61_RAT UniProtKB/TrEMBL
  NGAL_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5HZF1 ENTREZGENE
UniProt Secondary Q5HZF1 UniProtKB/Swiss-Prot
1 to 30 of 30 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Lcn2  lipocalin 2      Name updated 70584 APPROVED

Note Type Note Reference