Acsl4 (acyl-CoA synthetase long-chain family member 4) - Rat Genome Database

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Gene: Acsl4 (acyl-CoA synthetase long-chain family member 4) Rattus norvegicus
Analyze
Symbol: Acsl4
Name: acyl-CoA synthetase long-chain family member 4
RGD ID: 69401
Description: Enables arachidonate-CoA ligase activity. Involved in several processes, including dendritic spine development; long-chain fatty-acyl-CoA biosynthetic process; and positive regulation of insulin secretion. Located in mitochondrial membrane; neuronal cell body; and peroxisome. Human ortholog(s) of this gene implicated in intellectual disability and non-syndromic X-linked intellectual disability 63. Orthologous to human ACSL4 (acyl-CoA synthetase long chain family member 4); PARTICIPATES IN fatty acid beta degradation pathway; eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; fatty acid metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Acs4; arachidonate--CoA ligase; Facl4; fatty acid Coenzyme A ligase, long chain 4; fatty acid-Coenzyme A ligase long chain 4; fatty acid-Coenzyme A ligase, long chain 4; LACS 4; long-chain acyl-CoA synthetase 4; long-chain-fatty-acid--CoA ligase 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X110,739,633 - 110,803,416 (-)NCBIGRCr8
mRatBN7.2X105,942,794 - 106,006,573 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX105,942,799 - 106,006,427 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX108,080,606 - 108,144,232 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X111,579,781 - 111,643,413 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X109,146,084 - 109,209,885 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X113,596,247 - 113,660,024 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX113,596,239 - 113,659,944 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X112,046,187 - 112,109,974 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X36,168,547 - 36,232,162 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X36,222,015 - 36,285,631 (+)NCBI
CeleraX105,356,949 - 105,420,560 (-)NCBICelera
Cytogenetic MapXq33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dichloropropan-2-ol  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-hydroxybutyric acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
Angoline  (ISO)
apigenin  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
aurantio-obtusin  (ISO)
beauvericin  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beryllium sulfate  (ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
buspirone  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
calciol  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
chloroquine  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
cyclophosphamide  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
dimethyl fumarate  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
enniatin  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethambutol  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
farnesol  (ISO)
fenofibrate  (ISO)
ferrostatin-1  (ISO)
fluoranthene  (ISO)
fluoxetine  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
Gastrodin  (ISO)
glutathione  (EXP)
glycidol  (EXP)
GW 4064  (ISO)
GW 7647  (ISO)
hexadecanoic acid  (ISO)
hydrogen sulfide  (ISO)
indoline  (ISO)
indometacin  (EXP)
isoniazide  (EXP)
ivermectin  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (EXP)
L-glutamic acid  (ISO)
L-methionine  (ISO)
lead(II) chloride  (ISO)
maneb  (ISO)
melatonin  (EXP)
methapyrilene  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
oleic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
pyrazinecarboxamide  (EXP)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rifampicin  (EXP)
SB 431542  (ISO)
selenium atom  (EXP)
senecionine  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
succimer  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetradecane  (EXP)
thiazoles  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
topiramate  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
verteporfin  (EXP)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Effects of IL-15 on rat brown adipose tissue: uncoupling proteins and PPARs. Almendro V, etal., Obesity (Silver Spring). 2008 Feb;16(2):285-9.
2. Up-regulation of fatty acid metabolizing-enzymes mRNA in rat spinal cord during persistent peripheral local inflammation. Benani A, etal., Eur J Neurosci. 2003 Oct;18(7):1904-14.
3. Abnormal uterus with polycysts, accumulation of uterine prostaglandins, and reduced fertility in mice heterozygous for acyl-CoA synthetase 4 deficiency. Cho YY, etal., Biochem Biophys Res Commun 2001 Jun 22;284(4):993-7.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. A novel arachidonate-preferring acyl-CoA synthetase is present in steroidogenic cells of the rat adrenal, ovary, and testis. Kang MJ, etal., Proc Natl Acad Sci U S A 1997 Apr 1;94(7):2880-4.
7. Expression and characterization of recombinant rat Acyl-CoA synthetases 1, 4, and 5. Selective inhibition by triacsin C and thiazolidinediones. Kim JH, etal., J Biol Chem 2001 Jul 6;276(27):24667-73.
8. Diminished acyl-CoA synthetase isoform 4 activity in INS 832/13 cells reduces cellular epoxyeicosatrienoic acid levels and results in impaired glucose-stimulated insulin secretion. Klett EL, etal., J Biol Chem. 2013 Jul 26;288(30):21618-29. doi: 10.1074/jbc.M113.481077. Epub 2013 Jun 13.
9. Long-chain acyl-CoA synthetase isoforms differ in preferences for eicosanoid species and long-chain fatty acids. Klett EL, etal., J Lipid Res. 2017 May;58(5):884-894. doi: 10.1194/jlr.M072512. Epub 2017 Feb 16.
10. Rat liver acyl-CoA synthetase 4 is a peripheral-membrane protein located in two distinct subcellular organelles, peroxisomes, and mitochondrial-associated membrane. Lewin TM, etal., Arch Biochem Biophys. 2002 Aug 15;404(2):263-70.
11. Acyl-CoA synthetase isoforms 1, 4, and 5 are present in different subcellular membranes in rat liver and can be inhibited independently. Lewin TM, etal., J Biol Chem 2001 Jul 6;276(27):24674-9.
12. Rat long-chain acyl-CoA synthetase mRNA, protein, and activity vary in tissue distribution and in response to diet. Mashek DG, etal., J Lipid Res. 2006 Sep;47(9):2004-10. Epub 2006 Jun 13.
13. FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation. Meloni I, etal., Nat Genet 2002 Apr;30(4):436-40.
14. The XLMR gene ACSL4 plays a role in dendritic spine architecture. Meloni I, etal., Neuroscience. 2009 Mar 17;159(2):657-69. Epub 2008 Dec 24.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
24. Fatty acid transport by vectorial acylation in mammals: roles played by different isoforms of rat long-chain acyl-CoA synthetases. Tong F, etal., Arch Biochem Biophys. 2006 Mar 1;447(1):46-52. Epub 2006 Jan 23.
25. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. Watkins PA, etal., J Lipid Res. 2007 Dec;48(12):2736-50. Epub 2007 Aug 30.
Additional References at PubMed
PMID:9598324   PMID:10669417   PMID:12525535   PMID:14741744   PMID:17934335   PMID:18614015   PMID:19056867   PMID:19946888   PMID:20458337   PMID:21184843   PMID:21242590   PMID:21903867  
PMID:22366036   PMID:22633490   PMID:23159612   PMID:23376485   PMID:23455425   PMID:24095834   PMID:24269233   PMID:25500141   PMID:33246155   PMID:33314758   PMID:37541340   PMID:38462207  


Genomics

Comparative Map Data
Acsl4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X110,739,633 - 110,803,416 (-)NCBIGRCr8
mRatBN7.2X105,942,794 - 106,006,573 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX105,942,799 - 106,006,427 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX108,080,606 - 108,144,232 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X111,579,781 - 111,643,413 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X109,146,084 - 109,209,885 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X113,596,247 - 113,660,024 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX113,596,239 - 113,659,944 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X112,046,187 - 112,109,974 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X36,168,547 - 36,232,162 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X36,222,015 - 36,285,631 (+)NCBI
CeleraX105,356,949 - 105,420,560 (-)NCBICelera
Cytogenetic MapXq33NCBI
ACSL4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X109,641,335 - 109,733,257 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX109,624,244 - 109,733,403 (-)EnsemblGRCh38hg38GRCh38
GRCh37X108,884,564 - 108,976,486 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X108,771,220 - 108,863,277 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X108,690,710 - 108,782,764NCBI
CeleraX109,364,202 - 109,456,256 (-)NCBICelera
Cytogenetic MapXq23NCBI
HuRefX98,507,227 - 98,598,360 (-)NCBIHuRef
CHM1_1X108,795,830 - 108,887,888 (-)NCBICHM1_1
T2T-CHM13v2.0X108,089,125 - 108,181,021 (-)NCBIT2T-CHM13v2.0
Acsl4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X141,100,989 - 141,173,792 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX141,100,989 - 141,173,531 (-)EnsemblGRCm39 Ensembl
GRCm38X142,317,993 - 142,390,802 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX142,317,993 - 142,390,535 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X138,752,536 - 138,825,078 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X137,564,361 - 137,636,903 (-)NCBIMGSCv36mm8
CeleraX126,313,470 - 126,386,150 (-)NCBICelera
Cytogenetic MapXF2NCBI
cM MapX63.12NCBI
Acsl4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554906,143,833 - 6,228,452 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554906,143,833 - 6,228,395 (+)NCBIChiLan1.0ChiLan1.0
ACSL4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X109,114,032 - 109,224,458 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X109,117,636 - 109,227,486 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X98,731,109 - 98,841,067 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X109,219,030 - 109,311,055 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX109,206,964 - 109,310,914 (-)Ensemblpanpan1.1panPan2
ACSL4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X82,864,506 - 82,943,984 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX82,866,823 - 82,916,789 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX68,942,879 - 69,022,158 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X84,514,941 - 84,594,878 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX84,514,969 - 84,594,499 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X81,992,030 - 82,071,595 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X83,686,230 - 83,765,682 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X83,514,931 - 83,594,528 (-)NCBIUU_Cfam_GSD_1.0
Acsl4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X82,117,850 - 82,200,866 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364995,456,986 - 5,540,144 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364995,456,985 - 5,540,115 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACSL4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX89,760,866 - 89,806,274 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X89,760,863 - 89,838,103 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X105,375,895 - 105,452,684 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACSL4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X97,488,414 - 97,575,251 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606522,691,629 - 22,774,770 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acsl4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248036,336,964 - 6,372,815 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248036,272,954 - 6,372,815 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Acsl4
221 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:669
Count of miRNA genes:289
Interacting mature miRNAs:388
Transcripts:ENSRNOT00000026057
Prediction methods:Miranda, Pita, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X75294106120294106Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat

Markers in Region
DXRat148  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X106,008,181 - 106,008,389 (+)MAPPERmRatBN7.2
Rnor_6.0X113,661,633 - 113,661,840NCBIRnor6.0
Rnor_5.0X112,111,578 - 112,111,785UniSTSRnor5.0
RGSC_v3.4X36,166,584 - 36,166,792RGDRGSC3.4
RGSC_v3.4X36,166,585 - 36,166,792UniSTSRGSC3.4
RGSC_v3.1X36,220,053 - 36,220,261RGD
CeleraX105,422,315 - 105,422,522UniSTS
FHH x ACI MapX32.4RGD
FHH x ACI MapX32.4UniSTS
Cytogenetic MapXq14UniSTS
BE096007  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X105,942,849 - 105,942,990 (+)MAPPERmRatBN7.2
Rnor_6.0X113,596,298 - 113,596,438NCBIRnor6.0
Rnor_5.0X112,046,243 - 112,046,383UniSTSRnor5.0
RGSC_v3.4X36,231,986 - 36,232,126UniSTSRGSC3.4
CeleraX105,356,985 - 105,357,125UniSTS
Cytogenetic MapXq14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 22 57 41 19 41 8 8 74 35 36 11 8
Low 1 21 3 5
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000026057   ⟹   ENSRNOP00000026057
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX105,942,814 - 106,006,427 (-)Ensembl
Rnor_6.0 EnsemblX113,596,239 - 113,659,944 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101131   ⟹   ENSRNOP00000092221
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX105,942,799 - 105,982,500 (-)Ensembl
RefSeq Acc Id: NM_053623   ⟹   NP_446075
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X110,739,648 - 110,803,261 (-)NCBI
mRatBN7.2X105,942,814 - 106,006,427 (-)NCBI
Rnor_6.0X113,596,262 - 113,659,878 (-)NCBI
Rnor_5.0X112,046,187 - 112,109,974 (-)NCBI
RGSC_v3.4X36,168,547 - 36,232,162 (+)RGD
CeleraX105,356,949 - 105,420,560 (-)RGD
Sequence:
RefSeq Acc Id: XM_006257314   ⟹   XP_006257376
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X110,739,633 - 110,803,413 (-)NCBI
mRatBN7.2X105,942,794 - 106,006,491 (-)NCBI
Rnor_6.0X113,596,247 - 113,659,877 (-)NCBI
Rnor_5.0X112,046,187 - 112,109,974 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006257315   ⟹   XP_006257377
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X110,739,633 - 110,803,322 (-)NCBI
mRatBN7.2X105,942,794 - 106,006,490 (-)NCBI
Rnor_6.0X113,596,247 - 113,659,876 (-)NCBI
Rnor_5.0X112,046,187 - 112,109,974 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006257316   ⟹   XP_006257378
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X110,739,633 - 110,803,407 (-)NCBI
mRatBN7.2X105,942,794 - 106,006,573 (-)NCBI
Rnor_6.0X113,596,247 - 113,660,024 (-)NCBI
Rnor_5.0X112,046,187 - 112,109,974 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039099394   ⟹   XP_038955322
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X110,739,633 - 110,803,416 (-)NCBI
mRatBN7.2X105,942,794 - 106,006,491 (-)NCBI
RefSeq Acc Id: XM_039099395   ⟹   XP_038955323
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X110,757,015 - 110,803,326 (-)NCBI
mRatBN7.2X105,958,488 - 106,006,495 (-)NCBI
RefSeq Acc Id: XM_063279732   ⟹   XP_063135802
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X110,739,633 - 110,803,322 (-)NCBI
RefSeq Acc Id: XM_063279733   ⟹   XP_063135803
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X110,739,633 - 110,803,322 (-)NCBI
RefSeq Acc Id: XM_063279734   ⟹   XP_063135804
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X110,739,633 - 110,803,322 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_446075   ⟸   NM_053623
- UniProtKB: A6KG71 (UniProtKB/TrEMBL),   A0A8I6AVE1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257378   ⟸   XM_006257316
- Peptide Label: isoform X2
- UniProtKB: A6KG71 (UniProtKB/TrEMBL),   A0A8I6AVE1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257376   ⟸   XM_006257314
- Peptide Label: isoform X1
- UniProtKB: O35547 (UniProtKB/Swiss-Prot),   A0A8I6AVE1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257377   ⟸   XM_006257315
- Peptide Label: isoform X2
- UniProtKB: A6KG71 (UniProtKB/TrEMBL),   A0A8I6AVE1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000026057   ⟸   ENSRNOT00000026057
RefSeq Acc Id: XP_038955322   ⟸   XM_039099394
- Peptide Label: isoform X1
- UniProtKB: O35547 (UniProtKB/Swiss-Prot),   A0A8I6AVE1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955323   ⟸   XM_039099395
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000092221   ⟸   ENSRNOT00000101131
RefSeq Acc Id: XP_063135804   ⟸   XM_063279734
- Peptide Label: isoform X2
- UniProtKB: A6KG71 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135803   ⟸   XM_063279733
- Peptide Label: isoform X2
- UniProtKB: A6KG71 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135802   ⟸   XM_063279732
- Peptide Label: isoform X1
- UniProtKB: O35547 (UniProtKB/Swiss-Prot)
Protein Domains
AMP-dependent synthetase/ligase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35547-F1-model_v2 AlphaFold O35547 1-711 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701963
Promoter ID:EPDNEW_R12487
Type:initiation region
Name:Acsl4_1
Description:acyl-CoA synthetase long-chain family member 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X113,659,866 - 113,659,926EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69401 AgrOrtholog
BioCyc Gene G2FUF-1515 BioCyc
BioCyc Pathway FAO-PWY [fatty acid beta-oxidation I (generic)] BioCyc
  PWY-5143 [long-chain fatty acid activation] BioCyc
  PWY-5972 [stearate biosynthesis I (animals)] BioCyc
  PWY-6000 [gamma-linolenate biosynthesis II (animals)] BioCyc
  PWY-7049 [icosapentaenoate biosynthesis II (6-desaturase, mammals)] BioCyc
  PWY-8181 [2-methyl-branched fatty acid beta-oxidation] BioCyc
  PWY3DJ-11470 [sphingosine and sphingosine-1-phosphate metabolism] BioCyc
  PWY66-387 [3-methyl-branched fatty acid alpha-oxidation] BioCyc
  PWY66-388 [ceramide degradation by alpha-oxidation] BioCyc
  PWY66-389 [phytol degradation] BioCyc
  PWY66-391 [fatty acid beta-oxidation VI (mammalian peroxisome)] BioCyc
BioCyc Pathway Image FAO-PWY BioCyc
  PWY-5143 BioCyc
  PWY-5972 BioCyc
  PWY-6000 BioCyc
  PWY-7049 BioCyc
  PWY-8181 BioCyc
  PWY3DJ-11470 BioCyc
  PWY66-387 BioCyc
  PWY66-388 BioCyc
  PWY66-389 BioCyc
  PWY66-391 BioCyc
Ensembl Genes ENSRNOG00000019180 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055024794 UniProtKB/Swiss-Prot
  ENSRNOG00060018877 UniProtKB/Swiss-Prot
  ENSRNOG00065026083 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000026057 ENTREZGENE
  ENSRNOT00000026057.7 UniProtKB/Swiss-Prot
  ENSRNOT00000101131.1 UniProtKB/TrEMBL
  ENSRNOT00055042740 UniProtKB/Swiss-Prot
  ENSRNOT00060032631 UniProtKB/Swiss-Prot
  ENSRNOT00065045017 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.300.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.12780 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AMP-bd_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AMP-binding_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AMP-dep_Synth/Lig UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AMP-dep_Synthh-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:113976 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 113976 ENTREZGENE
PANTHER LONG-CHAIN-FATTY-ACID--COA LIGASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LONG-CHAIN-FATTY-ACID--COA LIGASE 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AMP-binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Acsl4 PhenoGen
PROSITE AMP_BINDING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019180 RatGTEx
  ENSRNOG00055024794 RatGTEx
  ENSRNOG00060018877 RatGTEx
  ENSRNOG00065026083 RatGTEx
Superfamily-SCOP Acetyl-CoA synthetase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC205409
UniProt A0A8I6AVE1 ENTREZGENE, UniProtKB/TrEMBL
  A6KG71 ENTREZGENE, UniProtKB/TrEMBL
  ACSL4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Acsl4  acyl-CoA synthetase long-chain family member 4  Facl4  fatty acid Coenzyme A ligase, long chain 4  Symbol and Name updated 1299863 APPROVED
2002-06-10 Facl4  fatty acid Coenzyme A ligase, long chain 4      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference