Acsl4 (acyl-CoA synthetase long-chain family member 4) - Rat Genome Database

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Gene: Acsl4 (acyl-CoA synthetase long-chain family member 4) Rattus norvegicus
Analyze
Symbol: Acsl4
Name: acyl-CoA synthetase long-chain family member 4
RGD ID: 69401
Description: Enables arachidonate-CoA ligase activity. Involved in several processes, including dendritic spine development; lipid biosynthetic process; and positive regulation of insulin secretion. Located in mitochondrial membrane; neuronal cell body; and peroxisome. Human ortholog(s) of this gene implicated in intellectual disability and non-syndromic X-linked intellectual disability 63. Orthologous to human ACSL4 (acyl-CoA synthetase long chain family member 4); PARTICIPATES IN fatty acid beta degradation pathway; eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; fatty acid metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Acs4; arachidonate--CoA ligase; Facl4; fatty acid Coenzyme A ligase, long chain 4; fatty acid-Coenzyme A ligase long chain 4; fatty acid-Coenzyme A ligase, long chain 4; LACS 4; long-chain acyl-CoA synthetase 4; long-chain-fatty-acid--CoA ligase 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X110,739,633 - 110,803,416 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX110,739,648 - 110,803,261 (-)EnsemblGRCr8
mRatBN7.2X105,942,794 - 106,006,573 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX105,942,799 - 106,006,427 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX108,080,606 - 108,144,232 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X111,579,781 - 111,643,413 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X109,146,084 - 109,209,885 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X113,596,247 - 113,660,024 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX113,596,239 - 113,659,944 (-)Ensemblrn6Rnor6.0
Rnor_5.0X112,046,187 - 112,109,974 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X36,168,547 - 36,232,162 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX105,356,949 - 105,420,560 (-)NCBICelera
RGSC_v3.1X36,222,015 - 36,285,631 (+)NCBI
Cytogenetic MapXq33NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dichloropropan-2-ol  (ISO)
1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-hydroxybutyric acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
Angoline  (ISO)
apigenin  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
aurantio-obtusin  (ISO)
beauvericin  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
beryllium sulfate  (ISO)
betulinic acid  (ISO)
Betulonic acid  (ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
boric acid  (EXP)
buspirone  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
calciol  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
chloroquine  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclophosphamide  (ISO)
D-glucose  (EXP)
dehydroepiandrosterone  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
diisononyl phthalate  (ISO)
dimethyl fumarate  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (EXP)
diquat  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
enniatin  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
erastin  (ISO)
ethambutol  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
farnesol  (ISO)
fenofibrate  (ISO)
ferrostatin-1  (ISO)
fluoranthene  (ISO)
fluoxetine  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
Gastrodin  (ISO)
glucose  (EXP)
glutathione  (EXP)
glycidol  (EXP)
glycine betaine  (EXP)
GW 4064  (ISO)
GW 7647  (ISO)
hexadecanoic acid  (ISO)
hydrogen sulfide  (ISO)
indoline  (ISO)
indometacin  (EXP)
iron dextran  (ISO)
isoniazide  (EXP,ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (EXP)
L-glutamic acid  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP)
lead(II) chloride  (ISO)
Leonurine  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (EXP)
methapyrilene  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
N-ethylmaleimide  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
orotic acid  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pioglitazone  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
protosappanin A  (EXP,ISO)
pyrazinecarboxamide  (EXP)
rac-lactic acid  (ISO)
regorafenib  (ISO)
resveratrol  (ISO)
rifampicin  (EXP)
Salvianolic acid A  (ISO)
SB 431542  (ISO)
selenium atom  (EXP)
senecionine  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
succimer  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetradecane  (EXP)
thiazoles  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
tolterodine tartrate  (ISO)
topiramate  (EXP)
triacsin C  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
verteporfin  (EXP)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Effects of IL-15 on rat brown adipose tissue: uncoupling proteins and PPARs. Almendro V, etal., Obesity (Silver Spring). 2008 Feb;16(2):285-9.
2. Up-regulation of fatty acid metabolizing-enzymes mRNA in rat spinal cord during persistent peripheral local inflammation. Benani A, etal., Eur J Neurosci. 2003 Oct;18(7):1904-14.
3. Abnormal uterus with polycysts, accumulation of uterine prostaglandins, and reduced fertility in mice heterozygous for acyl-CoA synthetase 4 deficiency. Cho YY, etal., Biochem Biophys Res Commun 2001 Jun 22;284(4):993-7.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. A novel arachidonate-preferring acyl-CoA synthetase is present in steroidogenic cells of the rat adrenal, ovary, and testis. Kang MJ, etal., Proc Natl Acad Sci U S A 1997 Apr 1;94(7):2880-4.
7. Expression and characterization of recombinant rat Acyl-CoA synthetases 1, 4, and 5. Selective inhibition by triacsin C and thiazolidinediones. Kim JH, etal., J Biol Chem 2001 Jul 6;276(27):24667-73.
8. Diminished acyl-CoA synthetase isoform 4 activity in INS 832/13 cells reduces cellular epoxyeicosatrienoic acid levels and results in impaired glucose-stimulated insulin secretion. Klett EL, etal., J Biol Chem. 2013 Jul 26;288(30):21618-29. doi: 10.1074/jbc.M113.481077. Epub 2013 Jun 13.
9. Long-chain acyl-CoA synthetase isoforms differ in preferences for eicosanoid species and long-chain fatty acids. Klett EL, etal., J Lipid Res. 2017 May;58(5):884-894. doi: 10.1194/jlr.M072512. Epub 2017 Feb 16.
10. Rat liver acyl-CoA synthetase 4 is a peripheral-membrane protein located in two distinct subcellular organelles, peroxisomes, and mitochondrial-associated membrane. Lewin TM, etal., Arch Biochem Biophys. 2002 Aug 15;404(2):263-70.
11. Acyl-CoA synthetase isoforms 1, 4, and 5 are present in different subcellular membranes in rat liver and can be inhibited independently. Lewin TM, etal., J Biol Chem 2001 Jul 6;276(27):24674-9.
12. Rat long-chain acyl-CoA synthetase mRNA, protein, and activity vary in tissue distribution and in response to diet. Mashek DG, etal., J Lipid Res. 2006 Sep;47(9):2004-10. Epub 2006 Jun 13.
13. FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation. Meloni I, etal., Nat Genet 2002 Apr;30(4):436-40.
14. The XLMR gene ACSL4 plays a role in dendritic spine architecture. Meloni I, etal., Neuroscience. 2009 Mar 17;159(2):657-69. Epub 2008 Dec 24.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
24. Fatty acid transport by vectorial acylation in mammals: roles played by different isoforms of rat long-chain acyl-CoA synthetases. Tong F, etal., Arch Biochem Biophys. 2006 Mar 1;447(1):46-52. Epub 2006 Jan 23.
25. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. Watkins PA, etal., J Lipid Res. 2007 Dec;48(12):2736-50. Epub 2007 Aug 30.
Additional References at PubMed
PMID:9598324   PMID:10669417   PMID:12525535   PMID:14741744   PMID:17934335   PMID:18614015   PMID:19056867   PMID:19946888   PMID:20458337   PMID:21184843   PMID:21242590   PMID:21903867  
PMID:22366036   PMID:22633490   PMID:23159612   PMID:23376485   PMID:23455425   PMID:24095834   PMID:24269233   PMID:25500141   PMID:33246155   PMID:33314758   PMID:37541340   PMID:38462207  
PMID:38734267  


Genomics

Comparative Map Data
Acsl4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X110,739,633 - 110,803,416 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX110,739,648 - 110,803,261 (-)EnsemblGRCr8
mRatBN7.2X105,942,794 - 106,006,573 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX105,942,799 - 106,006,427 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX108,080,606 - 108,144,232 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X111,579,781 - 111,643,413 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X109,146,084 - 109,209,885 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X113,596,247 - 113,660,024 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX113,596,239 - 113,659,944 (-)Ensemblrn6Rnor6.0
Rnor_5.0X112,046,187 - 112,109,974 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X36,168,547 - 36,232,162 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX105,356,949 - 105,420,560 (-)NCBICelera
RGSC_v3.1X36,222,015 - 36,285,631 (+)NCBI
Cytogenetic MapXq33NCBI
ACSL4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X109,641,335 - 109,733,257 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX109,624,244 - 109,733,403 (-)Ensemblhg38GRCh38
GRCh37X108,884,564 - 108,976,486 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X108,771,220 - 108,863,277 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34X108,690,710 - 108,782,764NCBI
CeleraX109,364,202 - 109,456,256 (-)NCBICelera
Cytogenetic MapXq23NCBI
HuRefX98,507,227 - 98,598,360 (-)NCBIHuRef
CHM1_1X108,795,830 - 108,887,888 (-)NCBICHM1_1
T2T-CHM13v2.0X108,089,125 - 108,181,021 (-)NCBIT2T-CHM13v2.0
Acsl4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X141,100,989 - 141,173,792 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX141,100,989 - 141,173,531 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38X142,317,993 - 142,390,802 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX142,317,993 - 142,390,535 (-)Ensemblmm10GRCm38
MGSCv37X138,752,536 - 138,825,078 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X137,564,361 - 137,636,903 (-)NCBIMGSCv36mm8
CeleraX126,313,470 - 126,386,150 (-)NCBICelera
Cytogenetic MapXF2NCBI
cM MapX63.12NCBI
Acsl4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554906,143,833 - 6,228,452 (+)Ensembl
ChiLan1.0NW_0049554906,143,833 - 6,228,395 (+)NCBIChiLan1.0ChiLan1.0
ACSL4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X109,114,032 - 109,224,458 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X109,117,636 - 109,227,486 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X98,731,109 - 98,841,067 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X109,219,030 - 109,311,055 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX109,206,964 - 109,310,914 (-)EnsemblpanPan2panpan1.1
ACSL4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X82,864,506 - 82,943,984 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX82,866,823 - 82,916,789 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX68,942,879 - 69,022,158 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X84,514,941 - 84,594,878 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX84,514,969 - 84,594,499 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X81,992,030 - 82,071,595 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X83,686,230 - 83,765,682 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X83,514,931 - 83,594,528 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Acsl4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X82,117,850 - 82,200,866 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364995,456,986 - 5,540,144 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364995,456,985 - 5,540,115 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACSL4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX89,760,866 - 89,806,274 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X89,760,863 - 89,838,103 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X105,375,895 - 105,452,684 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACSL4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X97,488,414 - 97,575,251 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606522,691,629 - 22,774,770 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acsl4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248036,336,964 - 6,372,815 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248036,272,954 - 6,372,815 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Acsl4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X94,428,295 - 94,491,757 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Acsl4
255 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:669
Count of miRNA genes:289
Interacting mature miRNAs:388
Transcripts:ENSRNOT00000026057
Prediction methods:Miranda, Pita, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X97528096142528096Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX105359969157758123Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X80434318125434318Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX92979612117740458Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X105468858125434318Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX45182909117740458Rat
2302047Pia34Pristane induced arthritis QTL 345.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1996916163141916163Rat

Markers in Region
DXRat148  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8X110,805,015 - 110,805,223 (+)Marker Load Pipeline
mRatBN7.2X106,008,181 - 106,008,389 (+)MAPPERmRatBN7.2
Rnor_6.0X113,661,633 - 113,661,840NCBIRnor6.0
Rnor_5.0X112,111,578 - 112,111,785UniSTSRnor5.0
RGSC_v3.4X36,166,585 - 36,166,792UniSTSRGSC3.4
RGSC_v3.4X36,166,584 - 36,166,792RGDRGSC3.4
CeleraX105,422,315 - 105,422,522UniSTS
RGSC_v3.1X36,220,053 - 36,220,261RGD
FHH x ACI MapX32.4RGD
FHH x ACI MapX32.4UniSTS
Cytogenetic MapXq14UniSTS
BE096007  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X105,942,849 - 105,942,990 (+)MAPPERmRatBN7.2
Rnor_6.0X113,596,298 - 113,596,438NCBIRnor6.0
Rnor_5.0X112,046,243 - 112,046,383UniSTSRnor5.0
RGSC_v3.4X36,231,986 - 36,232,126UniSTSRGSC3.4
CeleraX105,356,985 - 105,357,125UniSTS
Cytogenetic MapXq14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001431649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_053623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH474047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D85189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000026057   ⟹   ENSRNOP00000026057
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX110,739,648 - 110,803,261 (-)Ensembl
mRatBN7.2 EnsemblX105,942,814 - 106,006,427 (-)Ensembl
Rnor_6.0 EnsemblX113,596,239 - 113,659,944 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101131   ⟹   ENSRNOP00000092221
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX110,739,648 - 110,776,019 (-)Ensembl
mRatBN7.2 EnsemblX105,942,799 - 105,982,500 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000130558   ⟹   ENSRNOP00000103546
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX110,739,648 - 110,778,293 (-)Ensembl
RefSeq Acc Id: NM_053623   ⟹   NP_446075
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X110,739,648 - 110,803,261 (-)NCBI
mRatBN7.2X105,942,814 - 106,006,427 (-)NCBI
Rnor_6.0X113,596,262 - 113,659,878 (-)NCBI
Rnor_5.0X112,046,187 - 112,109,974 (-)NCBI
RGSC_v3.4X36,168,547 - 36,232,162 (+)RGD
CeleraX105,356,949 - 105,420,560 (-)RGD
Sequence:
RefSeq Acc Id: XM_006257314   ⟹   XP_006257376
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X110,739,633 - 110,803,413 (-)NCBI
mRatBN7.2X105,942,794 - 106,006,491 (-)NCBI
Rnor_6.0X113,596,247 - 113,659,877 (-)NCBI
Rnor_5.0X112,046,187 - 112,109,974 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006257315   ⟹   XP_006257377
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X110,739,633 - 110,803,322 (-)NCBI
mRatBN7.2X105,942,794 - 106,006,490 (-)NCBI
Rnor_6.0X113,596,247 - 113,659,876 (-)NCBI
Rnor_5.0X112,046,187 - 112,109,974 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006257316   ⟹   XP_006257378
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X110,739,633 - 110,803,407 (-)NCBI
mRatBN7.2X105,942,794 - 106,006,573 (-)NCBI
Rnor_6.0X113,596,247 - 113,660,024 (-)NCBI
Rnor_5.0X112,046,187 - 112,109,974 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039099394   ⟹   XP_038955322
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X110,739,633 - 110,803,416 (-)NCBI
mRatBN7.2X105,942,794 - 106,006,491 (-)NCBI
RefSeq Acc Id: XM_039099395   ⟹   XP_038955323
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X110,757,015 - 110,803,326 (-)NCBI
mRatBN7.2X105,958,488 - 106,006,495 (-)NCBI
RefSeq Acc Id: XM_063279732   ⟹   XP_063135802
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X110,739,633 - 110,803,322 (-)NCBI
RefSeq Acc Id: XM_063279733   ⟹   XP_063135803
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X110,739,633 - 110,803,322 (-)NCBI
RefSeq Acc Id: XM_063279734   ⟹   XP_063135804
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X110,739,633 - 110,803,322 (-)NCBI
RefSeq Acc Id: NP_446075   ⟸   NM_053623
- UniProtKB: A6KG71 (UniProtKB/TrEMBL),   A0A8I6AVE1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257378   ⟸   XM_006257316
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006257376   ⟸   XM_006257314
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006257377   ⟸   XM_006257315
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000026057   ⟸   ENSRNOT00000026057
RefSeq Acc Id: XP_038955322   ⟸   XM_039099394
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038955323   ⟸   XM_039099395
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000092221   ⟸   ENSRNOT00000101131
RefSeq Acc Id: XP_063135804   ⟸   XM_063279734
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063135803   ⟸   XM_063279733
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063135802   ⟸   XM_063279732
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000103546   ⟸   ENSRNOT00000130558
Protein Domains
AMP-dependent synthetase/ligase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35547-F1-model_v2 AlphaFold O35547 1-711 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701963
Promoter ID:EPDNEW_R12487
Type:initiation region
Name:Acsl4_1
Description:acyl-CoA synthetase long-chain family member 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X113,659,866 - 113,659,926EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69401 AgrOrtholog
BioCyc Gene G2FUF-1515 BioCyc
BioCyc Pathway FAO-PWY [fatty acid beta-oxidation I (generic)] BioCyc
  PWY-5143 [long-chain fatty acid activation] BioCyc
  PWY-5972 [stearate biosynthesis I (animals)] BioCyc
  PWY-6000 [gamma-linolenate biosynthesis II (animals)] BioCyc
  PWY-7049 [icosapentaenoate biosynthesis II (6-desaturase, mammals)] BioCyc
  PWY-8181 [2-methyl-branched fatty acid beta-oxidation] BioCyc
  PWY3DJ-11470 [sphingosine and sphingosine-1-phosphate metabolism] BioCyc
  PWY66-387 [3-methyl-branched fatty acid alpha-oxidation] BioCyc
  PWY66-388 [ceramide degradation by alpha-oxidation] BioCyc
  PWY66-389 [phytol degradation] BioCyc
  PWY66-391 [fatty acid beta-oxidation VI (mammalian peroxisome)] BioCyc
BioCyc Pathway Image FAO-PWY BioCyc
  PWY-5143 BioCyc
  PWY-5972 BioCyc
  PWY-6000 BioCyc
  PWY-7049 BioCyc
  PWY-8181 BioCyc
  PWY3DJ-11470 BioCyc
  PWY66-387 BioCyc
  PWY66-388 BioCyc
  PWY66-389 BioCyc
  PWY66-391 BioCyc
Ensembl Genes ENSRNOG00000019180 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000026057 ENTREZGENE
  ENSRNOT00000026057.7 UniProtKB/Swiss-Prot
  ENSRNOT00000130558 ENTREZGENE
Gene3D-CATH 3.30.300.30 UniProtKB/Swiss-Prot
  3.40.50.12780 UniProtKB/Swiss-Prot
InterPro AMP-bd_C_sf UniProtKB/Swiss-Prot
  AMP-binding_CS UniProtKB/Swiss-Prot
  AMP-dep_Synth/Lig UniProtKB/Swiss-Prot
  AMP-dep_Synthh-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:113976 UniProtKB/Swiss-Prot
NCBI Gene 113976 ENTREZGENE
PANTHER LONG-CHAIN-FATTY-ACID--COA LIGASE UniProtKB/Swiss-Prot
  LONG-CHAIN-FATTY-ACID--COA LIGASE 4 UniProtKB/Swiss-Prot
Pfam AMP-binding UniProtKB/Swiss-Prot
PhenoGen Acsl4 PhenoGen
PROSITE AMP_BINDING UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019180 RatGTEx
Superfamily-SCOP Acetyl-CoA synthetase-like UniProtKB/Swiss-Prot
TIGR TC205409
UniProt A0A8I6AVE1 ENTREZGENE, UniProtKB/TrEMBL
  A6KG71 ENTREZGENE, UniProtKB/TrEMBL
  ACSL4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Acsl4  acyl-CoA synthetase long-chain family member 4  Facl4  fatty acid Coenzyme A ligase, long chain 4  Symbol and Name updated 1299863 APPROVED
2002-06-10 Facl4  fatty acid Coenzyme A ligase, long chain 4      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference