Vgf (VGF nerve growth factor inducible) - Rat Genome Database

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Gene: Vgf (VGF nerve growth factor inducible) Rattus norvegicus
Analyze
Symbol: Vgf
Name: VGF nerve growth factor inducible
RGD ID: 69399
Description: Predicted to enable neuropeptide hormone activity. Involved in regulation of neuronal synaptic plasticity and synaptic signaling via neuropeptide. Located in neuronal cell body. Is active in glutamatergic synapse. Orthologous to human VGF (VGF nerve growth factor inducible); INTERACTS WITH (+)-pilocarpine; (R,R,R)-alpha-tocopherol; 1,3,5-trinitro-1,3,5-triazinane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100909521; neurosecretory protein VGF; neurosecretory protein VGF-like; VGF8a protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81225,274,004 - 25,281,803 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1225,273,333 - 25,282,703 (-)EnsemblGRCr8
mRatBN7.21219,637,313 - 19,645,123 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1219,637,320 - 19,640,341 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1220,774,908 - 20,777,923 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01221,387,621 - 21,390,636 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01220,452,159 - 20,455,174 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01222,677,302 - 22,680,630 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,677,607 - 22,680,630 (-)Ensemblrn6Rnor6.0
Rnor_5.01224,689,881 - 24,692,911 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41220,903,304 - 20,906,327 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1221,412,983 - 21,416,003 (-)NCBICelera
RGSC_v3.11220,892,915 - 20,895,939 (+)NCBI
Cytogenetic Map12q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
gastric ulcer  (ISO)
Hyperphagia  (ISO)
obesity  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(R,R,R)-alpha-tocopherol  (EXP)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,7-dihydropurine-6-thione  (EXP)
4,4'-sulfonyldiphenol  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acrylamide  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butanal  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
carmustine  (ISO)
choline  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
crocin-1  (EXP)
diquat  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fentanyl  (EXP)
fluoxetine  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gemcitabine  (ISO)
genistein  (EXP)
gentamycin  (EXP)
graphite  (EXP)
hydrogen chloride  (ISO)
indometacin  (EXP)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
Licochalcone B  (ISO)
lidocaine  (EXP)
linsidomine  (EXP)
lipopolysaccharide  (ISO)
manganese(II) chloride  (ISO)
mercaptopurine  (EXP)
methamphetamine  (EXP)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
niclosamide  (ISO)
ozone  (EXP)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paroxetine  (ISO)
pentanal  (ISO)
propanal  (ISO)
prostaglandin E2  (EXP)
purine-6-thiol  (EXP)
reserpine  (EXP)
rotenone  (ISO)
S-nitrosoglutathione  (ISO)
SB 431542  (ISO)
scopolamine  (EXP)
selenium atom  (ISO)
serpentine asbestos  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (EXP)
sotorasib  (ISO)
thapsigargin  (EXP,ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vitamin E  (ISO)
zalcitabine  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Brain-derived neurotrophic factor-induced gene expression reveals novel actions of VGF in hippocampal synaptic plasticity. Alder J, etal., J Neurosci. 2003 Nov 26;23(34):10800-8.
2. A prohormone convertase cleavage site within a predicted alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway. Garcia AL, etal., J Biol Chem. 2005 Dec 16;280(50):41595-608. Epub 2005 Oct 12.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. NGF induces the expression of the VGF gene through a cAMP response element. Hawley RJ, etal., J Neurosci 1992 Jul;12(7):2573-81.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Structure of the gene encoding VGF, a nervous system-specific mRNA that is rapidly and selectively induced by nerve growth factor in PC12 cells. Salton SR, etal., Mol Cell Biol 1991 May;11(5):2335-49.
11. Pro-VGF-derived peptides induce penile erection in male rats: possible involvement of oxytocin. Succu S, etal., Eur J Neurosci. 2004 Dec;20(11):3035-40.
12. Molecular constituents of the postsynaptic density fraction revealed by proteomic analysis using multidimensional liquid chromatography-tandem mass spectrometry. Yoshimura Y, etal., J Neurochem. 2004 Feb;88(3):759-68.
Additional References at PubMed
PMID:2676516   PMID:10381005   PMID:10433265   PMID:12177191   PMID:15051509   PMID:15706611   PMID:16141392   PMID:16631141   PMID:16983076   PMID:17440014   PMID:18059283   PMID:19077191  
PMID:19466987   PMID:20524965   PMID:20876237   PMID:23485923   PMID:23541636   PMID:24106277   PMID:25002582   PMID:25280008   PMID:25569790   PMID:30371765   PMID:33245952   PMID:35594706  


Genomics

Comparative Map Data
Vgf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81225,274,004 - 25,281,803 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1225,273,333 - 25,282,703 (-)EnsemblGRCr8
mRatBN7.21219,637,313 - 19,645,123 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1219,637,320 - 19,640,341 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1220,774,908 - 20,777,923 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01221,387,621 - 21,390,636 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01220,452,159 - 20,455,174 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01222,677,302 - 22,680,630 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,677,607 - 22,680,630 (-)Ensemblrn6Rnor6.0
Rnor_5.01224,689,881 - 24,692,911 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41220,903,304 - 20,906,327 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1221,412,983 - 21,416,003 (-)NCBICelera
RGSC_v3.11220,892,915 - 20,895,939 (+)NCBI
Cytogenetic Map12q12NCBI
VGF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387101,162,509 - 101,169,952 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7101,162,509 - 101,167,227 (-)Ensemblhg38GRCh38
GRCh377100,805,790 - 100,808,850 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367100,592,517 - 100,595,572 (-)NCBIBuild 36Build 36hg18NCBI36
Build 347100,399,231 - 100,402,287NCBI
Celera795,814,146 - 95,817,208 (-)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef795,398,955 - 95,401,959 (-)NCBIHuRef
CHM1_17100,736,252 - 100,739,314 (-)NCBICHM1_1
T2T-CHM13v2.07102,485,258 - 102,492,805 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27100,164,177 - 100,167,239 (-)NCBI
Vgf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395137,054,156 - 137,062,205 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5137,055,246 - 137,062,205 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm385137,025,301 - 137,033,351 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5137,026,392 - 137,033,351 (+)Ensemblmm10GRCm38
MGSCv375137,506,165 - 137,509,221 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365137,314,922 - 137,317,978 (+)NCBIMGSCv36mm8
Celera5134,047,034 - 134,050,090 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.13NCBI
Vgf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545616,119,073 - 16,126,968 (+)Ensembl
ChiLan1.0NW_00495545616,119,073 - 16,126,968 (+)NCBIChiLan1.0ChiLan1.0
VGF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26119,174,833 - 119,177,792 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17167,439,463 - 167,442,422 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0793,302,956 - 93,307,892 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17106,544,544 - 106,549,329 (-)NCBIPanPan1.1PanPan1.1panPan2
VGF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.168,701,289 - 8,704,386 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl68,700,667 - 8,704,397 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha610,398,631 - 10,401,711 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.068,520,838 - 8,523,920 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl68,520,536 - 8,523,897 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.168,480,897 - 8,483,981 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.068,451,358 - 8,454,443 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.068,616,024 - 8,619,109 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Vgf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344132,969,254 - 132,977,238 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365431,059,799 - 1,061,646 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365431,059,292 - 1,062,384 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VGF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl38,888,506 - 8,891,601 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.138,888,502 - 8,891,399 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
VGF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12812,016,216 - 12,021,151 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2812,018,800 - 12,020,647 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660704,329,143 - 4,332,216 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vgf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474016,105,227 - 16,109,905 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474016,105,187 - 16,109,922 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Vgf
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11616,984,299 - 16,987,556 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Vgf
110 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:223
Count of miRNA genes:150
Interacting mature miRNAs:163
Transcripts:ENSRNOT00000041808
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
61443Btemp2Thermal response to stress QTL 23.30.000094body temperature trait (VT:0005535)core body temperature (CMO:0001036)122013902826430640Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)12129775522Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12133700600Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12128133365Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)121223300030490641Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121746497946784661Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)12128606299Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)12133700556Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121874946936488809Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121874946934312613Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
2303568Bw88Body weight QTL 883body mass (VT:0001259)body weight (CMO:0000012)12128606299Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12790162533938215Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743833700556Rat

Markers in Region
D12Rat70  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21219,642,166 - 19,642,312 (+)MAPPERmRatBN7.2
Rnor_6.01222,682,228 - 22,682,373NCBIRnor6.0
Rnor_5.01224,694,509 - 24,694,654UniSTSRnor5.0
RGSC_v3.41220,901,332 - 20,901,478RGDRGSC3.4
RGSC_v3.41220,901,333 - 20,901,478UniSTSRGSC3.4
Celera1221,417,829 - 21,417,974UniSTS
RGSC_v3.11220,890,916 - 20,891,241RGD
SHRSP x BN Map1222.74RGD
SHRSP x BN Map1222.74UniSTS
Cytogenetic Map12q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 24 150 35 25 9 33 9 6 126 78 3 130 23 63 16 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000041808   ⟹   ENSRNOP00000050024
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1225,273,913 - 25,280,796 (-)Ensembl
mRatBN7.2 Ensembl1219,637,320 - 19,640,341 (-)Ensembl
Rnor_6.0 Ensembl1222,677,607 - 22,680,630 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000130466   ⟹   ENSRNOP00000110481
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1225,273,521 - 25,281,946 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000140575   ⟹   ENSRNOP00000109676
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1225,273,742 - 25,282,372 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000144947   ⟹   ENSRNOP00000102858
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1225,273,333 - 25,282,372 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000147010   ⟹   ENSRNOP00000099107
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1225,273,521 - 25,282,617 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000155118   ⟹   ENSRNOP00000104281
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1225,273,645 - 25,279,324 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000169093   ⟹   ENSRNOP00000105210
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1225,273,483 - 25,282,617 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000170533   ⟹   ENSRNOP00000104007
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1225,273,645 - 25,281,778 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000171607   ⟹   ENSRNOP00000109724
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1225,273,619 - 25,281,659 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000172822   ⟹   ENSRNOP00000107364
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1225,273,342 - 25,282,703 (-)Ensembl
RefSeq Acc Id: NM_001395575   ⟹   NP_001382504
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81225,274,004 - 25,277,020 (-)NCBI
mRatBN7.21219,637,313 - 19,640,329 (-)NCBI
RefSeq Acc Id: NM_030997   ⟹   NP_112259
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81225,274,004 - 25,277,020 (-)NCBI
mRatBN7.21219,637,313 - 19,640,329 (-)NCBI
Rnor_6.01222,677,607 - 22,680,630 (-)NCBI
Rnor_5.01224,689,881 - 24,692,911 (-)NCBI
RGSC_v3.41220,903,304 - 20,906,327 (+)RGD
Celera1221,412,983 - 21,416,003 (-)RGD
Sequence:
RefSeq Acc Id: XM_039089290   ⟹   XP_038945218
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81225,274,004 - 25,281,803 (-)NCBI
mRatBN7.21219,637,313 - 19,645,123 (-)NCBI
RefSeq Acc Id: XM_039089291   ⟹   XP_038945219
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81225,274,004 - 25,281,677 (-)NCBI
mRatBN7.21219,637,313 - 19,644,985 (-)NCBI
RefSeq Acc Id: XM_039089294   ⟹   XP_038945222
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81225,274,004 - 25,281,803 (-)NCBI
mRatBN7.21219,637,313 - 19,645,123 (-)NCBI
RefSeq Acc Id: NP_112259   ⟸   NM_030997
- Peptide Label: precursor
- UniProtKB: P20156 (UniProtKB/Swiss-Prot),   A6J052 (UniProtKB/TrEMBL),   F1LP80 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000050024   ⟸   ENSRNOT00000041808
RefSeq Acc Id: XP_038945222   ⟸   XM_039089294
- Peptide Label: isoform X1
- UniProtKB: F1LP80 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945218   ⟸   XM_039089290
- Peptide Label: isoform X1
- UniProtKB: F1LP80 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945219   ⟸   XM_039089291
- Peptide Label: isoform X1
- UniProtKB: F1LP80 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001382504   ⟸   NM_001395575
- Peptide Label: precursor
- UniProtKB: P20156 (UniProtKB/Swiss-Prot),   A6J052 (UniProtKB/TrEMBL),   F1LP80 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000105210   ⟸   ENSRNOT00000169093
Ensembl Acc Id: ENSRNOP00000102858   ⟸   ENSRNOT00000144947
Ensembl Acc Id: ENSRNOP00000104281   ⟸   ENSRNOT00000155118
Ensembl Acc Id: ENSRNOP00000109724   ⟸   ENSRNOT00000171607
Ensembl Acc Id: ENSRNOP00000107364   ⟸   ENSRNOT00000172822
Ensembl Acc Id: ENSRNOP00000099107   ⟸   ENSRNOT00000147010
Ensembl Acc Id: ENSRNOP00000110481   ⟸   ENSRNOT00000130466
Ensembl Acc Id: ENSRNOP00000109676   ⟸   ENSRNOT00000140575
Ensembl Acc Id: ENSRNOP00000104007   ⟸   ENSRNOT00000170533

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P20156-F1-model_v2 AlphaFold P20156 1-617 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698527
Promoter ID:EPDNEW_R9051
Type:single initiation site
Name:Vgf_1
Description:VGF nerve growth factor inducible
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01222,680,629 - 22,680,689EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69399 AgrOrtholog
BioCyc Gene G2FUF-19676 BioCyc
Ensembl Genes ENSRNOG00000001416 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000041808 ENTREZGENE
  ENSRNOT00000041808.3 UniProtKB/Swiss-Prot
  ENSRNOT00000155118 ENTREZGENE
InterPro VGF UniProtKB/Swiss-Prot
KEGG Report rno:29461 UniProtKB/Swiss-Prot
NCBI Gene 29461 ENTREZGENE
PANTHER NEUROSECRETORY PROTEIN VGF UniProtKB/Swiss-Prot
  PTHR15159 UniProtKB/Swiss-Prot
PhenoGen Vgf PhenoGen
RatGTEx ENSRNOG00000001416 RatGTEx
UniProt A0ABK0LAA4_RAT UniProtKB/TrEMBL
  A6J052 ENTREZGENE, UniProtKB/TrEMBL
  F1LP80 ENTREZGENE, UniProtKB/TrEMBL
  P20156 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Vgf  VGF nerve growth factor inducible  LOC100909521  neurosecretory protein VGF-like  Data merged from RGD:6503411 737654 PROVISIONAL
2012-07-05 LOC100909521  neurosecretory protein VGF-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Vgf  VGF nerve growth factor inducible       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains TATAA and CCAAT elements, several GC boxes, and a consensus cAMP response element binding protein (CREB) binding site 69396
gene_expression mRNA expressed in central and peripheral nervous system tissue 69396
gene_regulation gene induction regulated by neuronal growth factor (NGF) and cAMP-mediated agents 730082