Msln (mesothelin) - Rat Genome Database

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Gene: Msln (mesothelin) Rattus norvegicus
Analyze
Symbol: Msln
Name: mesothelin
RGD ID: 69333
Description: Involved in pancreas development. Located in cell surface and extracellular space. Human ortholog(s) of this gene implicated in ovarian cancer; pancreas disease; pancreatic cancer; and pancreatic ductal carcinoma. Orthologous to human MSLN (mesothelin); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ERC/mesothelin; pre-pro-megakaryocyte-potentiating factor; protein expressed in renal carcinoma
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81015,276,489 - 15,285,921 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1015,275,659 - 15,282,153 (-)EnsemblGRCr8
mRatBN7.21014,771,946 - 14,781,382 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1014,771,961 - 14,777,643 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1019,511,024 - 19,516,683 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01018,999,901 - 19,005,560 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01014,500,155 - 14,505,826 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01015,119,700 - 15,129,129 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1015,119,663 - 15,125,408 (-)Ensemblrn6Rnor6.0
Rnor_5.01014,932,441 - 14,941,855 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41015,017,162 - 15,022,823 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1014,441,324 - 14,446,985 (-)NCBICelera
RGSC_v3.11015,017,161 - 15,022,823 (-)NCBI
Cytogenetic Map10q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,6-dimethoxyphenol  (ISO)
2-nitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
amphibole asbestos  (EXP)
arsenite(3-)  (ISO)
asbestos  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP)
bisphenol F  (ISO)
bromochloroacetic acid  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chloroprene  (EXP)
choline  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
copper(II) chloride  (ISO)
crocidolite asbestos  (ISO)
DDE  (ISO)
diethylstilbestrol  (EXP)
diuron  (EXP)
drometrizole  (ISO)
folic acid  (ISO)
furan  (EXP)
furfural  (ISO)
gemcitabine  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
indole-3-methanol  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
methotrexate  (ISO)
methylparaben  (ISO)
microcystin-LR  (EXP)
N-nitrosodiethylamine  (EXP)
nickel sulfate  (ISO)
nitrofen  (EXP)
ochratoxin A  (ISO)
okadaic acid  (ISO)
omega-6 fatty acid  (ISO)
ozone  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
serpentine asbestos  (EXP)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
Soman  (EXP)
streptozocin  (ISO)
tacrolimus hydrate  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetraphene  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triclosan  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Control of human mesothelin-expressing tumors by DNA vaccines. Chang CL, etal., Gene Ther. 2007 Aug;14(16):1189-98. Epub 2007 Jun 21.
2. An animal model of preclinical diagnosis of pancreatic ductal adenocarcinomas. Fukamachi K, etal., Biochem Biophys Res Commun. 2009 Dec 18;390(3):636-41. Epub 2009 Oct 8.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Establishment of a novel specific ELISA system for rat N- and C-ERC/mesothelin. Rat ERC/mesothelin in the body fluids of mice bearing mesothelioma. Hagiwara Y, etal., Cancer Sci. 2008 Apr;99(4):666-70. Epub 2008 Feb 24.
5. Mesothelin is overexpressed in pancreaticobiliary adenocarcinomas but not in normal pancreas and chronic pancreatitis. Hassan R, etal., Am J Clin Pathol. 2005 Dec;124(6):838-45.
6. Phase I study of SS1P, a recombinant anti-mesothelin immunotoxin given as a bolus I.V. infusion to patients with mesothelin-expressing mesothelioma, ovarian, and pancreatic cancers. Hassan R, etal., Clin Cancer Res. 2007 Sep 1;13(17):5144-9.
7. Expression and localization of mesothelin in developing rat pancreas. Hou LQ, etal., Dev Growth Differ. 2008 Sep;50(7):531-41.
8. Biomarkers in Diagnosis of pancreatic carcinoma in fine-needle aspirates. Jhala N, etal., Am J Clin Pathol. 2006 Oct;126(4):572-9.
9. Circulating mesothelin protein and cellular antimesothelin immunity in patients with pancreatic cancer. Johnston FM, etal., Clin Cancer Res. 2009 Nov 1;15(21):6511-8. Epub 2009 Oct 20.
10. Mesothelin is a malignant factor and therapeutic vaccine target for pancreatic cancer. Li M, etal., Mol Cancer Ther. 2008 Feb;7(2):286-96.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma. Sato N, etal., Cancer Res. 2003 Jul 15;63(14):4158-66.
17. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
19. Mapping and determination of the cDNA sequence of the Erc gene preferentially expressed in renal cell carcinoma in the Tsc2 gene mutant (Eker) rat model. Yamashita Y, etal., Biochem Biophys Res Commun 2000 Aug 18;275(1):134-40.
20. S100A4 protein and mesothelin expression in dysplasia and carcinoma of the extrahepatic bile duct. Zhao H, etal., Am J Clin Pathol. 2007 Mar;127(3):374-9.
Additional References at PubMed
PMID:15489334   PMID:20933535   PMID:24006456   PMID:24944479  


Genomics

Comparative Map Data
Msln
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81015,276,489 - 15,285,921 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1015,275,659 - 15,282,153 (-)EnsemblGRCr8
mRatBN7.21014,771,946 - 14,781,382 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1014,771,961 - 14,777,643 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1019,511,024 - 19,516,683 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01018,999,901 - 19,005,560 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01014,500,155 - 14,505,826 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01015,119,700 - 15,129,129 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1015,119,663 - 15,125,408 (-)Ensemblrn6Rnor6.0
Rnor_5.01014,932,441 - 14,941,855 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41015,017,162 - 15,022,823 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1014,441,324 - 14,446,985 (-)NCBICelera
RGSC_v3.11015,017,161 - 15,022,823 (-)NCBI
Cytogenetic Map10q12NCBI
MSLN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3816760,734 - 768,865 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl16760,734 - 768,866 (+)Ensemblhg38GRCh38
GRCh3716810,734 - 818,865 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3616751,134 - 758,866 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3416750,797 - 758,866NCBI
Celera161,010,640 - 1,018,740 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef16732,923 - 740,842 (+)NCBIHuRef
CHM1_116810,267 - 818,805 (+)NCBICHM1_1
T2T-CHM13v2.016764,710 - 773,383 (+)NCBIT2T-CHM13v2.0
Msln
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391725,967,587 - 25,973,352 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1725,967,587 - 25,973,352 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381725,748,613 - 25,754,378 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1725,748,613 - 25,754,378 (-)Ensemblmm10GRCm38
MGSCv371725,885,558 - 25,891,272 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361725,476,213 - 25,481,927 (-)NCBIMGSCv36mm8
Celera1726,280,944 - 26,286,658 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.85NCBI
MSLN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2181,003,978 - 1,010,342 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1164,787,991 - 4,794,343 (+)NCBINHGRI_mPanPan1
PanPan1.116775,433 - 783,449 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl16777,146 - 783,449 (+)EnsemblpanPan2panpan1.1
LOC611363
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1639,827,985 - 39,834,945 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha641,092,644 - 41,096,610 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0640,171,101 - 40,175,067 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.1639,859,730 - 39,863,696 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0639,819,938 - 39,823,904 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0640,298,820 - 40,302,786 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC100524016
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1341,025,892 - 41,029,302 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2341,448,610 - 41,452,017 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MSLN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.15681,923 - 690,530 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl5683,480 - 690,757 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606830,446,301 - 30,455,280 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Msln
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249131,570,832 - 1,580,058 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046249131,566,516 - 1,576,605 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Msln
94 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:104
Count of miRNA genes:79
Interacting mature miRNAs:87
Transcripts:ENSRNOT00000026395
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10117749933Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat

Markers in Region
BE099462  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21014,771,980 - 14,772,159 (+)MAPPERmRatBN7.2
Rnor_6.01015,119,735 - 15,119,913NCBIRnor6.0
Rnor_5.01014,932,456 - 14,932,634UniSTSRnor5.0
RGSC_v3.41015,017,170 - 15,017,348UniSTSRGSC3.4
Celera1014,441,332 - 14,441,510UniSTS
RH 3.4 Map10154.3UniSTS
Cytogenetic Map10q12-q21UniSTS
Cytogenetic Map10q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 10 67 113 91 90 59 31 59 6 283 129 9 87 71 92 31 5 5

Sequence


Ensembl Acc Id: ENSRNOT00000026395   ⟹   ENSRNOP00000026395
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1015,275,659 - 15,282,153 (-)Ensembl
mRatBN7.2 Ensembl1014,771,961 - 14,777,643 (-)Ensembl
Rnor_6.0 Ensembl1015,119,663 - 15,125,408 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102692   ⟹   ENSRNOP00000077428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1015,276,490 - 15,282,153 (-)Ensembl
mRatBN7.2 Ensembl1014,771,961 - 14,777,643 (-)Ensembl
RefSeq Acc Id: NM_031658   ⟹   NP_113846
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81015,276,490 - 15,282,153 (-)NCBI
mRatBN7.21014,771,973 - 14,777,636 (-)NCBI
Rnor_6.01015,119,727 - 15,125,388 (-)NCBI
Rnor_5.01014,932,441 - 14,941,855 (-)NCBI
RGSC_v3.41015,017,162 - 15,022,823 (-)RGD
Celera1014,441,324 - 14,446,985 (-)RGD
Sequence:
RefSeq Acc Id: XM_006246022   ⟹   XP_006246084
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81015,276,489 - 15,285,921 (-)NCBI
mRatBN7.21014,771,946 - 14,781,382 (-)NCBI
Rnor_6.01015,119,700 - 15,129,129 (-)NCBI
Rnor_5.01014,932,441 - 14,941,855 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_113846 (Get FASTA)   NCBI Sequence Viewer  
  XP_006246084 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH70934 (Get FASTA)   NCBI Sequence Viewer  
  BAB13512 (Get FASTA)   NCBI Sequence Viewer  
  EDM03949 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000077428
GenBank Protein Q9ERA7 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113846   ⟸   NM_031658
- Peptide Label: precursor
- UniProtKB: A0A8L2QE96 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246084   ⟸   XM_006246022
- Peptide Label: isoform X1
- UniProtKB: Q6IRG1 (UniProtKB/Swiss-Prot),   Q9ERA7 (UniProtKB/Swiss-Prot),   A6HD44 (UniProtKB/TrEMBL),   A0A8L2QE96 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026395   ⟸   ENSRNOT00000026395
Ensembl Acc Id: ENSRNOP00000077428   ⟸   ENSRNOT00000102692

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ERA7-F1-model_v2 AlphaFold Q9ERA7 1-625 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697055
Promoter ID:EPDNEW_R7580
Type:initiation region
Name:Msln_1
Description:mesothelin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01015,125,418 - 15,125,478EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69333 AgrOrtholog
BioCyc Gene G2FUF-25763 BioCyc
Ensembl Genes ENSRNOG00000019445 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000102692 ENTREZGENE
Gene3D-CATH 1.20.970.40 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7098161 IMAGE-MGC_LOAD
InterPro Mesothelin UniProtKB/Swiss-Prot
  Stereocilin-rel UniProtKB/Swiss-Prot
KEGG Report rno:60333 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91602 IMAGE-MGC_LOAD
NCBI Gene 60333 ENTREZGENE
PANTHER MESOTHELIN UniProtKB/Swiss-Prot
  PTHR23412 UniProtKB/Swiss-Prot
Pfam Mesothelin UniProtKB/Swiss-Prot
PhenoGen Msln PhenoGen
RatGTEx ENSRNOG00000019445 RatGTEx
TIGR TC231888
UniProt A0A8I5Y7R7_RAT UniProtKB/TrEMBL
  A0A8L2QE96 ENTREZGENE, UniProtKB/TrEMBL
  A6HD44 ENTREZGENE, UniProtKB/TrEMBL
  MSLN_RAT UniProtKB/Swiss-Prot
  Q6IRG1 ENTREZGENE
  Q9ERA7 ENTREZGENE
UniProt Secondary Q6IRG1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Msln  mesothelin      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression overexpressed in primary renal carcinomas (RCs) 68817
gene_homology 56.1% amino acid identity to human homolog 68817