MSLN (mesothelin) - Rat Genome Database

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Gene: MSLN (mesothelin) Pan paniscus
Analyze
Symbol: MSLN
Name: mesothelin
RGD ID: 11772647
Description: INVOLVED IN pancreas development (ortholog); ASSOCIATED WITH adenocarcinoma (ortholog); bile duct carcinoma (ortholog); cholangiocarcinoma (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC100974383
RGD Orthologs
Human
Mouse
Rat
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2181,003,978 - 1,010,342 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1164,787,991 - 4,794,343 (+)NCBINHGRI_mPanPan1
PanPan1.116775,433 - 783,449 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl16777,146 - 783,449 (+)Ensemblpanpan1.1panPan2


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
MSLN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2181,003,978 - 1,010,342 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1164,787,991 - 4,794,343 (+)NCBINHGRI_mPanPan1
PanPan1.116775,433 - 783,449 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl16777,146 - 783,449 (+)Ensemblpanpan1.1panPan2
MSLN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3816760,734 - 768,865 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl16760,734 - 768,865 (+)EnsemblGRCh38hg38GRCh38
GRCh3716810,734 - 818,865 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3616751,134 - 758,866 (+)NCBINCBI36Build 36hg18NCBI36
Build 3416750,797 - 758,866NCBI
Celera161,010,640 - 1,018,740 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef16732,923 - 740,842 (+)NCBIHuRef
CHM1_116810,267 - 818,805 (+)NCBICHM1_1
T2T-CHM13v2.016764,710 - 773,383 (+)NCBIT2T-CHM13v2.0
Msln
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391725,967,587 - 25,973,352 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1725,967,587 - 25,973,352 (-)EnsemblGRCm39 Ensembl
GRCm381725,748,613 - 25,754,378 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1725,748,613 - 25,754,378 (-)EnsemblGRCm38mm10GRCm38
MGSCv371725,885,558 - 25,891,272 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361725,476,213 - 25,481,927 (-)NCBIMGSCv36mm8
Celera1726,280,944 - 26,286,658 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.85NCBI
Msln
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81015,276,489 - 15,285,921 (-)NCBIGRCr8
mRatBN7.21014,771,946 - 14,781,382 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1014,771,961 - 14,777,643 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1019,511,024 - 19,516,683 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01018,999,901 - 19,005,560 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01014,500,155 - 14,505,826 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01015,119,700 - 15,129,129 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1015,119,663 - 15,125,408 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01014,932,441 - 14,941,855 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41015,017,162 - 15,022,823 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11015,017,161 - 15,022,823 (-)NCBI
Celera1014,441,324 - 14,446,985 (-)NCBICelera
Cytogenetic Map10q12NCBI
LOC611363
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1639,827,985 - 39,834,945 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha641,092,644 - 41,096,610 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0640,171,101 - 40,175,067 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1639,859,730 - 39,863,696 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0639,819,938 - 39,823,904 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0640,298,820 - 40,302,786 (-)NCBIUU_Cfam_GSD_1.0
LOC100524016
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1341,025,892 - 41,029,302 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2341,448,610 - 41,452,017 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MSLN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.15681,923 - 690,530 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl5683,480 - 690,757 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606830,446,301 - 30,455,280 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Msln
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249131,570,832 - 1,580,058 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249131,566,516 - 1,576,605 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000034030   ⟹   ENSPPAP00000011374
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl16777,146 - 783,449 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000034036   ⟹   ENSPPAP00000011380
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl16777,316 - 783,318 (+)Ensembl
RefSeq Acc Id: XM_057300006   ⟹   XP_057155989
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2181,003,978 - 1,010,342 (+)NCBI
NHGRI_mPanPan1164,787,991 - 4,794,343 (+)NCBI
Protein Sequences
Protein RefSeqs XP_057155989 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000011374.1
  ENSPPAP00000011380.1
Reference Protein Sequences
RefSeq Acc Id: ENSPPAP00000011380   ⟸   ENSPPAT00000034036
RefSeq Acc Id: ENSPPAP00000011374   ⟸   ENSPPAT00000034030
RefSeq Acc Id: XP_057155989   ⟸   XM_057300006
- UniProtKB: A0A2R9A3C1 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000028895 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000034030.1 UniProtKB/TrEMBL
  ENSPPAT00000034036.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.970.40 UniProtKB/TrEMBL
InterPro Mesothelin UniProtKB/TrEMBL
  Stereocilin-rel UniProtKB/TrEMBL
KEGG Report pps:100974383 UniProtKB/TrEMBL
NCBI Gene MSLN ENTREZGENE
PANTHER MESOTHELIN UniProtKB/TrEMBL
  PTHR23412 UniProtKB/TrEMBL
Pfam Mesothelin UniProtKB/TrEMBL
UniProt A0A2R9A3C1 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9A6S2_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-05-02 MSLN  mesothelin  LOC100974383  mesothelin  Symbol and/or name change 5135510 APPROVED
2020-07-01 LOC100974383  mesothelin  MSLN  mesothelin  Symbol and/or name change 5135510 APPROVED