Fxyd1 (FXYD domain-containing ion transport regulator 1) - Rat Genome Database

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Gene: Fxyd1 (FXYD domain-containing ion transport regulator 1) Rattus norvegicus
Analyze
Symbol: Fxyd1
Name: FXYD domain-containing ion transport regulator 1
RGD ID: 69306
Description: Enables ATPase binding activity and myosin binding activity. Involved in positive regulation of transport; regulation of cardiac muscle cell contraction; and regulation of cytosolic calcium ion concentration. Located in several cellular components, including T-tubule; caveola; and intercalated disc. Biomarker of congestive heart failure. Orthologous to human FXYD1 (FXYD domain containing ion transport regulator 1); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: phospholemman; Plm; sodium/potassium-transporting ATPase subunit FXYD1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8195,414,556 - 95,418,645 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl195,414,557 - 95,418,591 (-)EnsemblGRCr8
mRatBN7.2186,287,163 - 86,291,478 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl186,287,165 - 86,291,278 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx191,707,554 - 91,711,603 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01100,173,699 - 100,177,749 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0193,465,832 - 93,469,879 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0189,484,197 - 89,488,279 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl189,484,199 - 89,488,223 (-)Ensemblrn6Rnor6.0
Rnor_5.0190,639,290 - 90,643,385 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4186,095,551 - 86,098,079 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera180,656,116 - 80,660,202 (-)NCBICelera
RGSC_v3.1186,173,662 - 86,176,167 (-)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(S)-nicotine  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amosite asbestos  (ISO)
amphetamine  (EXP)
ampicillin  (ISO)
Ampullosporin  (EXP)
Aroclor 1254  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
dibenzo[a,l]pyrene  (ISO)
dioxygen  (ISO)
diuron  (EXP)
doxorubicin  (EXP,ISO)
ethanol  (ISO)
ethylparaben  (ISO)
fenthion  (ISO)
flutamide  (EXP)
fulvestrant  (ISO)
furan  (EXP)
gentamycin  (EXP)
kainic acid  (ISO)
ketamine  (EXP)
lead(0)  (ISO)
Mesaconitine  (EXP)
methimazole  (EXP)
Moniliformin  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nicotine  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (ISO)
pioglitazone  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
rotenone  (EXP)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
trimellitic anhydride  (ISO)
undecane  (EXP)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification of an endogenous inhibitor of the cardiac Na+/Ca2+ exchanger, phospholemman. Ahlers BA, etal., J Biol Chem. 2005 May 20;280(20):19875-82. Epub 2005 Mar 17.
2. Characterization of the human and rat phospholemman (PLM) cDNAs and localization of the human PLM gene to chromosome 19q13.1. Chen LS, etal., Genomics 1997 May 1;41(3):435-43.
3. Overexpression of the Na+/K+ ATPase alpha2 but not alpha1 isoform attenuates pathological cardiac hypertrophy and remodeling. Correll RN, etal., Circ Res. 2014 Jan 17;114(2):249-56. doi: 10.1161/CIRCRESAHA.114.302293. Epub 2013 Nov 11.
4. Phospholemman, a single-span membrane protein, is an accessory protein of Na,K-ATPase in cerebellum and choroid plexus. Feschenko MS, etal., J Neurosci. 2003 Mar 15;23(6):2161-9.
5. Ischemia-induced phosphorylation of phospholemman directly activates rat cardiac Na/K-ATPase. Fuller W, etal., FASEB J. 2004 Jan;18(1):197-9. Epub 2003 Nov 3.
6. FXYD1, a modulator of Na,K-ATPase activity, facilitates female sexual development by maintaining gonadotrophin-releasing hormone neuronal excitability. Garcia-Rudaz C, etal., J Neuroendocrinol. 2009 Feb;21(2):108-22. doi: 10.1111/j.1365-2826.2008.01812.x.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Protein Phosphatase 1c Associated with the Cardiac Sodium Calcium Exchanger 1 Regulates Its Activity by Dephosphorylating Serine 68-phosphorylated Phospholemman. Hafver TL, etal., J Biol Chem. 2016 Feb 26;291(9):4561-79. doi: 10.1074/jbc.M115.677898. Epub 2015 Dec 14.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Effects of phospholemman downregulation on contractility and [Ca(2+)]i transients in adult rat cardiac myocytes. Mirza MA, etal., Am J Physiol Heart Circ Physiol. 2004 Apr;286(4):H1322-30. Epub 2003 Dec 18.
12. Reduction of phospholemman expression decreases osmosensitive taurine efflux in astrocytes. Moran J, etal., Biochim Biophys Acta. 2001 Apr 23;1538(2-3):313-20.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Expression of phospholemman and its association with Na+-K+-ATPase in skeletal muscle: effects of aging and exercise training. Reis J, etal., J Appl Physiol (1985). 2005 Oct;99(4):1508-15. Epub 2005 Jun 16.
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Overexpression of phospholemman alters contractility and [Ca(2+)](i) transients in adult rat myocytes. Song J, etal., Am J Physiol Heart Circ Physiol 2002 Aug;283(2):H576-83.
18. The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. Sweadner KJ and Rael E, Genomics 2000 Aug 15;68(1):41-56.
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
20. Phospholemman expression in extraglomerular mesangium and afferent arteriole of the juxtaglomerular apparatus. Wetzel RK and Sweadner KJ, Am J Physiol Renal Physiol. 2003 Jul;285(1):F121-9. Epub 2003 Mar 25.
21. A separate pool of cardiac phospholemman that does not regulate or associate with the sodium pump: multimers of phospholemman in ventricular muscle. Wypijewski KJ, etal., J Biol Chem. 2013 May 10;288(19):13808-20. doi: 10.1074/jbc.M113.460956. Epub 2013 Mar 26.
Additional References at PubMed
PMID:1710217   PMID:9486665   PMID:12169672   PMID:12606048   PMID:15563542   PMID:15653756   PMID:16373350   PMID:16921169   PMID:17095720   PMID:19339511   PMID:21325644   PMID:21454534  
PMID:21849407   PMID:21868384   PMID:22442718  


Genomics

Comparative Map Data
Fxyd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8195,414,556 - 95,418,645 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl195,414,557 - 95,418,591 (-)EnsemblGRCr8
mRatBN7.2186,287,163 - 86,291,478 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl186,287,165 - 86,291,278 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx191,707,554 - 91,711,603 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01100,173,699 - 100,177,749 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0193,465,832 - 93,469,879 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0189,484,197 - 89,488,279 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl189,484,199 - 89,488,223 (-)Ensemblrn6Rnor6.0
Rnor_5.0190,639,290 - 90,643,385 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4186,095,551 - 86,098,079 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera180,656,116 - 80,660,202 (-)NCBICelera
RGSC_v3.1186,173,662 - 86,176,167 (-)NCBI
Cytogenetic Map1q21NCBI
FXYD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381935,137,188 - 35,143,109 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1935,137,159 - 35,143,109 (+)Ensemblhg38GRCh38
GRCh371935,629,728 - 35,634,013 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361940,321,572 - 40,325,794 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341940,321,571 - 40,325,793NCBI
Celera1932,343,168 - 32,347,389 (+)NCBICelera
Cytogenetic Map19q13.12NCBI
HuRef1932,137,604 - 32,141,943 (+)NCBIHuRef
CHM1_11935,631,706 - 35,635,892 (+)NCBICHM1_1
T2T-CHM13v2.01937,681,906 - 37,687,737 (+)NCBIT2T-CHM13v2.0
Fxyd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39730,751,103 - 30,758,332 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl730,751,103 - 30,756,624 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38731,051,678 - 31,055,873 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl731,051,678 - 31,057,199 (-)Ensemblmm10GRCm38
MGSCv37731,836,697 - 31,840,675 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36730,760,440 - 30,764,415 (-)NCBIMGSCv36mm8
Celera725,619,198 - 25,623,176 (-)NCBICelera
Cytogenetic Map7B1NCBI
cM Map719.29NCBI
Fxyd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554684,457,985 - 4,460,528 (+)Ensembl
ChiLan1.0NW_0049554684,456,909 - 4,460,895 (+)NCBIChiLan1.0ChiLan1.0
FXYD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22041,151,080 - 41,155,360 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11943,134,412 - 43,138,681 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01932,080,180 - 32,089,141 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11940,821,536 - 40,827,352 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1940,824,448 - 40,827,039 (+)EnsemblpanPan2panpan1.1
FXYD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11117,436,239 - 117,440,619 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1117,430,865 - 117,439,718 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1116,836,898 - 116,841,243 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01118,033,833 - 118,038,215 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1118,033,833 - 118,037,313 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11117,596,446 - 117,600,789 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01117,221,771 - 117,226,106 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01118,278,254 - 118,282,589 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fxyd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934910,526,623 - 10,528,799 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365701,117,816 - 1,118,860 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365701,117,083 - 1,121,059 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FXYD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1630,071,852 - 30,076,012 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl630,073,136 - 30,075,699 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660737,845,205 - 7,849,364 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fxyd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247948,368,519 - 8,371,764 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247948,368,519 - 8,372,480 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Fxyd1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12164,975,492 - 164,979,571 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fxyd1
18 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:118
Count of miRNA genes:92
Interacting mature miRNAs:97
Transcripts:ENSRNOT00000028624
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 12 67 160 91 90 59 34 59 6 297 134 11 139 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006228839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC111870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB712570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM109156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U72246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000028624   ⟹   ENSRNOP00000028624
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl195,414,557 - 95,418,591 (-)Ensembl
mRatBN7.2 Ensembl186,287,166 - 86,291,202 (-)Ensembl
Rnor_6.0 Ensembl189,484,199 - 89,488,223 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102674   ⟹   ENSRNOP00000083421
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl195,414,558 - 95,417,718 (-)Ensembl
mRatBN7.2 Ensembl186,287,167 - 86,291,278 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107868   ⟹   ENSRNOP00000080325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl195,414,558 - 95,417,718 (-)Ensembl
mRatBN7.2 Ensembl186,287,167 - 86,290,329 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109818   ⟹   ENSRNOP00000079164
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl195,415,356 - 95,417,976 (-)Ensembl
mRatBN7.2 Ensembl186,287,165 - 86,291,249 (-)Ensembl
RefSeq Acc Id: NM_031648   ⟹   NP_113836
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8195,414,556 - 95,418,580 (-)NCBI
mRatBN7.2186,287,165 - 86,291,191 (-)NCBI
Rnor_6.0189,484,199 - 89,488,223 (-)NCBI
Rnor_5.0190,639,290 - 90,643,385 (-)NCBI
RGSC_v3.4186,095,551 - 86,098,079 (-)RGD
Celera180,656,116 - 80,660,202 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006228839   ⟹   XP_006228901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8195,414,556 - 95,417,767 (-)NCBI
mRatBN7.2186,287,163 - 86,290,374 (-)NCBI
Rnor_6.0189,484,197 - 89,487,404 (-)NCBI
Rnor_5.0190,639,290 - 90,643,385 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589629   ⟹   XP_017445118
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8195,414,556 - 95,418,619 (-)NCBI
mRatBN7.2186,287,163 - 86,291,129 (-)NCBI
Rnor_6.0189,484,197 - 89,488,226 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589630   ⟹   XP_017445119
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8195,414,556 - 95,417,753 (-)NCBI
mRatBN7.2186,287,163 - 86,290,345 (-)NCBI
Rnor_6.0189,484,197 - 89,487,361 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589631   ⟹   XP_017445120
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8195,414,556 - 95,418,638 (-)NCBI
mRatBN7.2186,287,163 - 86,291,243 (-)NCBI
Rnor_6.0189,484,197 - 89,488,230 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039088778   ⟹   XP_038944706
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8195,414,556 - 95,418,638 (-)NCBI
mRatBN7.2186,287,163 - 86,291,478 (-)NCBI
RefSeq Acc Id: XM_039088782   ⟹   XP_038944710
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8195,414,556 - 95,418,645 (-)NCBI
mRatBN7.2186,287,163 - 86,291,129 (-)NCBI
RefSeq Acc Id: XM_063272174   ⟹   XP_063128244
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8195,414,556 - 95,418,628 (-)NCBI
RefSeq Acc Id: XM_063272182   ⟹   XP_063128252
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8195,414,556 - 95,417,735 (-)NCBI
RefSeq Acc Id: XM_063272185   ⟹   XP_063128255
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8195,414,556 - 95,418,617 (-)NCBI
RefSeq Acc Id: XM_063272192   ⟹   XP_063128262
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8195,414,556 - 95,418,641 (-)NCBI
Protein Sequences
Protein RefSeqs NP_113836 (Get FASTA)   NCBI Sequence Viewer  
  XP_006228901 (Get FASTA)   NCBI Sequence Viewer  
  XP_017445118 (Get FASTA)   NCBI Sequence Viewer  
  XP_017445119 (Get FASTA)   NCBI Sequence Viewer  
  XP_017445120 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944706 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944710 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128244 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128252 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128255 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128262 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC53169 (Get FASTA)   NCBI Sequence Viewer  
  EDM07670 (Get FASTA)   NCBI Sequence Viewer  
  EDM07671 (Get FASTA)   NCBI Sequence Viewer  
  EDM07672 (Get FASTA)   NCBI Sequence Viewer  
  EDM07673 (Get FASTA)   NCBI Sequence Viewer  
  EDM07674 (Get FASTA)   NCBI Sequence Viewer  
  EDM07675 (Get FASTA)   NCBI Sequence Viewer  
  EDM07676 (Get FASTA)   NCBI Sequence Viewer  
  EDM07677 (Get FASTA)   NCBI Sequence Viewer  
  EDM07678 (Get FASTA)   NCBI Sequence Viewer  
  EDM07679 (Get FASTA)   NCBI Sequence Viewer  
  EDM07680 (Get FASTA)   NCBI Sequence Viewer  
  EDM07681 (Get FASTA)   NCBI Sequence Viewer  
  EDM07682 (Get FASTA)   NCBI Sequence Viewer  
  EDM07683 (Get FASTA)   NCBI Sequence Viewer  
  EDM07684 (Get FASTA)   NCBI Sequence Viewer  
  EDM07685 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000028624
  ENSRNOP00000083421
GenBank Protein O08589 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113836   ⟸   NM_031648
- Peptide Label: precursor
- UniProtKB: A0A0H2UHS8 (UniProtKB/TrEMBL),   A6JA55 (UniProtKB/TrEMBL),   A0A8I5ZW12 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006228901   ⟸   XM_006228839
- Peptide Label: isoform X5
- UniProtKB: O08589 (UniProtKB/Swiss-Prot),   A6JA62 (UniProtKB/TrEMBL),   A0A8I5ZW12 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017445120   ⟸   XM_017589631
- Peptide Label: isoform X5
- UniProtKB: O08589 (UniProtKB/Swiss-Prot),   A6JA62 (UniProtKB/TrEMBL),   A0A8I5ZW12 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017445118   ⟸   XM_017589629
- Peptide Label: isoform X1
- UniProtKB: A0A8I6G4X1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017445119   ⟸   XM_017589630
- Peptide Label: isoform X3
- UniProtKB: A6JA56 (UniProtKB/TrEMBL),   A0A8I5ZW12 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028624   ⟸   ENSRNOT00000028624
RefSeq Acc Id: XP_038944706   ⟸   XM_039088778
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038944710   ⟸   XM_039088782
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000083421   ⟸   ENSRNOT00000102674
Ensembl Acc Id: ENSRNOP00000079164   ⟸   ENSRNOT00000109818
Ensembl Acc Id: ENSRNOP00000080325   ⟸   ENSRNOT00000107868
RefSeq Acc Id: XP_063128262   ⟸   XM_063272192
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063128244   ⟸   XM_063272174
- Peptide Label: isoform X1
- UniProtKB: A0A8I6G4X1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128255   ⟸   XM_063272185
- Peptide Label: isoform X5
- UniProtKB: O08589 (UniProtKB/Swiss-Prot),   A0A8I5ZW12 (UniProtKB/TrEMBL),   A6JA62 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128252   ⟸   XM_063272182
- Peptide Label: isoform X5
- UniProtKB: O08589 (UniProtKB/Swiss-Prot),   A0A8I5ZW12 (UniProtKB/TrEMBL),   A6JA62 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08589-F1-model_v2 AlphaFold O08589 1-92 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689942
Promoter ID:EPDNEW_R467
Type:initiation region
Name:Fxyd1_1
Description:FXYD domain-containing ion transport regulator 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0189,488,234 - 89,488,294EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69306 AgrOrtholog
BioCyc Gene G2FUF-60049 BioCyc
Ensembl Genes ENSRNOG00000021079 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000028624 ENTREZGENE
  ENSRNOT00000102674 ENTREZGENE
Gene3D-CATH Single helix bin UniProtKB/Swiss-Prot
InterPro FXYD_motif UniProtKB/Swiss-Prot
  Ion-transport_regulator_FXYD UniProtKB/Swiss-Prot
  PLM UniProtKB/Swiss-Prot
NCBI Gene 58971 ENTREZGENE
PANTHER PHOSPHOLEMMAN UniProtKB/Swiss-Prot
  SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT GAMMA UniProtKB/Swiss-Prot
Pfam ATP1G1_PLM_MAT8 UniProtKB/Swiss-Prot
PhenoGen Fxyd1 PhenoGen
PROSITE FXYD UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000021079 RatGTEx
TIGR TC229427
UniProt A0A0H2UHS8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZPC3_RAT UniProtKB/TrEMBL
  A0A8I5ZW12 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G4X1 ENTREZGENE, UniProtKB/TrEMBL
  A6JA49_RAT UniProtKB/TrEMBL
  A6JA50_RAT UniProtKB/TrEMBL
  A6JA51_RAT UniProtKB/TrEMBL
  A6JA52_RAT UniProtKB/TrEMBL
  A6JA53_RAT UniProtKB/TrEMBL
  A6JA55 ENTREZGENE, UniProtKB/TrEMBL
  A6JA56 ENTREZGENE, UniProtKB/TrEMBL
  A6JA59_RAT UniProtKB/TrEMBL
  A6JA62 ENTREZGENE, UniProtKB/TrEMBL
  A6JA64_RAT UniProtKB/TrEMBL
  O08589 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Fxyd1  FXYD domain-containing ion transport regulator 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains FXYD (prolinephenylalanineXtyrosineaspartate) motif 632671
gene_function a major substrate for protein kinases A and C in heart and skeletal muscle 625647
gene_mutations_overexpression a major substrate for protein kinases A and C in heart and skeletal muscle  
gene_product member of the FXYD gene family of small ion transport regulators 625647
gene_protein 72 amino -acid 625647