FXYD1 (FXYD domain containing ion transport regulator 1)

Gene: FXYD1 (FXYD domain containing ion transport regulator 1) Chlorocebus sabaeus

Analyze

Symbol:

FXYD1

Name:

FXYD domain containing ion transport regulator 1

RGD ID:

18775654

Description:

ENCODES a protein that exhibits ATPase binding (ortholog); myosin binding (ortholog); INVOLVED IN negative regulation of protein glutathionylation (ortholog); positive regulation of inorganic anion transmembrane transport (ortholog); positive regulation of organic acid transport (ortholog); ASSOCIATED WITH Brugada syndrome 5 (ortholog); Cardiomegaly (ortholog); congestive heart failure (ortholog); FOUND IN caveola (ortholog); intercalated disc (ortholog); sarcolemma (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

phospholemman

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	30,071,852 - 30,076,012 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	30,073,136 - 30,075,699 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666073	7,845,205 - 7,849,364 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Brugada syndrome 5 (ISO)

Cardiomegaly (ISO)

congestive heart failure (ISO)

dystonia (ISO)

genetic disease (ISO)

hereditary spastic paraplegia 75 (ISO)

Myocardial Ischemia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

monoatomic ion transport (IEA)

negative regulation of protein glutathionylation (ISO)

positive regulation of inorganic anion transmembrane transport (ISO)

positive regulation of organic acid transport (ISO)

positive regulation of sodium ion export across plasma membrane (IEA)

potassium ion transport (IEA)

regulation of cardiac muscle cell contraction (ISO)

regulation of cardiac muscle cell membrane potential (IEA)

regulation of cytosolic calcium ion concentration (ISO)

regulation of monoatomic ion transport (IEA)

sodium ion transport (IEA)

Cellular Component

apical plasma membrane (IEA)

caveola (IEA,ISO)

intercalated disc (ISO)

membrane (IEA)

plasma membrane (IEA)

sarcolemma (IEA,ISO)

T-tubule (IEA)

Molecular Function

ATPase binding (ISO)

ion channel regulator activity (IEA)

myosin binding (ISO)

protein binding (ISO)

sodium channel regulator activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

FXYD1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	30,071,852 - 30,076,012 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	30,073,136 - 30,075,699 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666073	7,845,205 - 7,849,364 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

FXYD1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	35,137,188 - 35,143,109 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	35,138,824 - 35,143,109 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	35,629,728 - 35,634,013 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	40,321,572 - 40,325,794 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	40,321,571 - 40,325,793	NCBI
Celera	19	32,343,168 - 32,347,389 (+)	NCBI		Celera
Cytogenetic Map	19	q13.12	NCBI
HuRef	19	32,137,604 - 32,141,943 (+)	NCBI		HuRef
CHM1_1	19	35,631,706 - 35,635,892 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	37,681,906 - 37,687,737 (+)	NCBI		T2T-CHM13v2.0

Fxyd1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	30,751,103 - 30,758,332 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	30,751,103 - 30,756,624 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	31,051,678 - 31,055,873 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	31,051,678 - 31,057,199 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	31,836,697 - 31,840,675 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	30,760,440 - 30,764,415 (-)	NCBI		MGSCv36	mm8
Celera	7	25,619,198 - 25,623,176 (-)	NCBI		Celera
Cytogenetic Map	7	B1	NCBI
cM Map	7	19.29	NCBI

Fxyd1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	95,414,556 - 95,418,645 (-)	NCBI		GRCr8
mRatBN7.2	1	86,287,163 - 86,291,478 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	86,287,165 - 86,291,278 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	91,707,554 - 91,711,603 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	100,173,699 - 100,177,749 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	93,465,832 - 93,469,879 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	89,484,197 - 89,488,279 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	89,484,199 - 89,488,223 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	90,639,290 - 90,643,385 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	86,095,551 - 86,098,079 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	86,173,662 - 86,176,167 (-)	NCBI
Celera	1	80,656,116 - 80,660,202 (-)	NCBI		Celera
Cytogenetic Map	1	q21	NCBI

Fxyd1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955468	4,457,985 - 4,460,528 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955468	4,456,909 - 4,460,895 (+)	NCBI	ChiLan1.0	ChiLan1.0

FXYD1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	41,151,080 - 41,155,360 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	43,134,412 - 43,138,681 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	32,080,180 - 32,089,141 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	40,821,536 - 40,827,352 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	40,824,448 - 40,827,039 (+)	Ensembl	panpan1.1		panPan2

FXYD1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	117,436,239 - 117,440,619 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	117,430,865 - 117,439,718 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	116,836,898 - 116,841,243 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	118,033,833 - 118,038,215 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	118,033,833 - 118,037,313 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	117,596,446 - 117,600,789 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	117,221,771 - 117,226,106 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	118,278,254 - 118,282,589 (-)	NCBI		UU_Cfam_GSD_1.0

Fxyd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	10,526,623 - 10,528,799 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936570	1,117,816 - 1,118,860 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936570	1,117,083 - 1,121,059 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FXYD7
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	6	44,668,591 - 44,681,846 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	40,067,196 - 40,071,693 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Fxyd1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624794	8,368,519 - 8,371,764 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624794	8,368,519 - 8,372,480 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium	36		60
Low		17
Below cutoff		1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007996312	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007996314	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007996315	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000041	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000002566 ⟹ ENSCSAP00000000869

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	6	30,073,136 - 30,075,699 (+)	Ensembl

RefSeq Acc Id:

XM_007996312 ⟹ XP_007994503

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	6	30,071,852 - 30,076,012 (+)	NCBI
Vero_WHO_p1.0	NW_023666073	7,845,205 - 7,849,364 (+)	NCBI

Sequence:

show sequence

CGGCGCGTCCAGCTCTGGGCCAGGGGGTCCAAAGTGCTCAGCCCCCGGGGCACAGCAGGACGTT
TGGGGGCCTTCTTTCAGCAGGGGACAGCCCGATTGGGGACAATGGCGTCTCTTGGCCACATCTT
GGTTTTCTGTGTGAGTCTCATCACCATGGCCAAGGCAGAAAGTCCAAAGGAGCAAGACCCGTTC
ACTTACGACTACCAGTCCCTGCGGATCGGAGGCCTCATCATCGCCGGGATACTCTTCATCCTGG
GTATCCTCATTGTGCTCAGCAGAAGATGCCGGTGCAAGTTCAACCAGCAGCAGAGGACTGGGGA
ACCCGATGAAGAGGAGGGAACTTTCCGCAGCTCCATCCGCCGTCTGTCCACCCGCAGGCGGTAG
AAACAACTGGCGCGATGGAATCTGGCCAGGACTCCCCTGGCACCTGACGTCTCCCACGCTCCAC
CTGCGCGCCCACCGTCCCCTCCGTCGCCCCTTCCCCAGCCCTACTCCCGCAGACTCCCCCTGCC
GCCCAGACTTCCAATAAAACGTGCGTTCCTCTCGACA

hide sequence

RefSeq Acc Id:

XM_007996314 ⟹ XP_007994505

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	6	30,072,705 - 30,076,012 (+)	NCBI
Vero_WHO_p1.0	NW_023666073	7,846,044 - 7,849,364 (+)	NCBI

Sequence:

show sequence

AGAGGGCAGGGAGCTGGGATTTCGCGGGGCACAGTGAGGCCGGGTGTGTAGGCAGGTGGGACTT
GGGCGTGCCCCGCTGTCTCCTGCTCCGTGTTTGTGTGAGGTAGCGCCTCCTCTGCCCTGCCAGG
GACAATGGCGTCTCTTGGCCACATCTTGGTTTTCTGTGTGAGTCTCATCACCATGGCCAAGGCA
GAAAGTCCAAAGGAGCAAGACCCGTTCACTTACGACTACCAGTCCCTGCGGATCGGAGGCCTCA
TCATCGCCGGGATACTCTTCATCCTGGGTATCCTCATTGTGCTCAGCAGAAGATGCCGGTGCAA
GTTCAACCAGCAGCAGAGGACTGGGGAACCCGATGAAGAGGAGGGAACTTTCCGCAGCTCCATC
CGCCGTCTGTCCACCCGCAGGCGGTAGAAACAACTGGCGCGATGGAATCTGGCCAGGACTCCCC
TGGCACCTGACGTCTCCCACGCTCCACCTGCGCGCCCACCGTCCCCTCCGTCGCCCCTTCCCCA
GCCCTACTCCCGCAGACTCCCCCTGCCGCCCAGACTTCCAATAAAACGTGCGTTCCTCTCGACA

hide sequence

RefSeq Acc Id:

XM_007996315 ⟹ XP_007994506

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	6	30,072,051 - 30,076,012 (+)	NCBI
Vero_WHO_p1.0	NW_023666073	7,845,403 - 7,849,364 (+)	NCBI

Sequence:

show sequence

GGCCAACCTAAGAGGGAGGGAGTGTGGCTGGGGCAGTGGGTTCTGCAGGGTGGGATGTGGGCGA
CTCCTCCCTGCCCTGCTGGTGCGTGTGCACCCTGGCAGGGTGTGGAATTCGGACACACACATGT
GTAGGGCTGGTTGCGTCACTGTGTGGGGGCACCGGAGGCCCAGAGGAGGAGTACTGGATGCCTG
ACGGTGTTTACACCCCACGTCCTGCTCCAACCAGAAGTTTGGGAAGAGGACAATGGCGTCTCTT
GGCCACATCTTGGTTTTCTGTGTGAGTCTCATCACCATGGCCAAGGCAGAAAGTCCAAAGGAGC
AAGACCCGTTCACTTACGACTACCAGTCCCTGCGGATCGGAGGCCTCATCATCGCCGGGATACT
CTTCATCCTGGGTATCCTCATTGTGCTCAGCAGAAGATGCCGGTGCAAGTTCAACCAGCAGCAG
AGGACTGGGGAACCCGATGAAGAGGAGGGAACTTTCCGCAGCTCCATCCGCCGTCTGTCCACCC
GCAGGCGGTAGAAACAACTGGCGCGATGGAATCTGGCCAGGACTCCCCTGGCACCTGACGTCTC
CCACGCTCCACCTGCGCGCCCACCGTCCCCTCCGTCGCCCCTTCCCCAGCCCTACTCCCGCAGA
CTCCCCCTGCCGCCCAGACTTCCAATAAAACGTGCGTTCCTCTCGACA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007994503	(Get FASTA)	NCBI Sequence Viewer
	XP_007994505	(Get FASTA)	NCBI Sequence Viewer
	XP_007994506	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000000869
	ENSCSAP00000000869.1

RefSeq Acc Id:	XP_007994503 ⟸ XM_007996312
- UniProtKB:	A0A0D9QWY0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_007994506 ⟸ XM_007996315
- UniProtKB:	A0A0D9QWY0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_007994505 ⟸ XM_007996314
- UniProtKB:	A0A0D9QWY0 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000000869 ⟸ ENSCSAT00000002566

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000004535	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000002566.1	UniProtKB/TrEMBL
Gene3D-CATH	Single helix bin	UniProtKB/TrEMBL
InterPro	FXYD_motif	UniProtKB/TrEMBL
	Ion-transport_regulator_FXYD	UniProtKB/TrEMBL
	PLM	UniProtKB/TrEMBL
KEGG Report	csab:103234496	UniProtKB/TrEMBL
NCBI Gene	FXYD1	ENTREZGENE
PANTHER	PHOSPHOLEMMAN	UniProtKB/TrEMBL
	SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT GAMMA	UniProtKB/TrEMBL
Pfam	ATP1G1_PLM_MAT8	UniProtKB/TrEMBL
PROSITE	FXYD	UniProtKB/TrEMBL
UniProt	A0A0D9QWY0	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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