Mertk (MER proto-oncogene, tyrosine kinase)

Gene: Mertk (MER proto-oncogene, tyrosine kinase) Rattus norvegicus

Analyze

Symbol:

Mertk

Name:

MER proto-oncogene, tyrosine kinase

RGD ID:

69283

Description:

Predicted to enable transmembrane receptor protein tyrosine kinase activity. Involved in phagocytosis and positive regulation of phagocytosis. Located in photoreceptor outer segment. Used to study retinal degeneration. Human ortholog(s) of this gene implicated in retinitis pigmentosa 38. Orthologous to human MERTK (MER proto-oncogene, tyrosine kinase); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

c-mer proto-oncogene tyrosine kinase; proto-oncogene c-Mer; proto-oncogene tyrosine-protein kinase Mer; Rdy; receptor tyrosine kinase MerTK; Receptor tyrosine tinase gene probably the gene for Rdy; retinal dystrophy; tyrosine-protein kinase Mer

RGD Orthologs

Alliance Genes

More Info

more info ...

Allele / Splice:

Mertk^rdy

Genetic Models:

RCS/Kyo

Is Marker For:

Strains: (LE x RCS-p⁺/LavRrrc)F1

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	136,391,936 - 136,498,366 (+)	NCBI		GRCr8
mRatBN7.2	3	115,939,351 - 116,045,141 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	115,939,351 - 116,046,554 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	119,836,222 - 119,942,080 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	128,431,776 - 128,537,642 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	126,092,272 - 126,198,124 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	121,235,230 - 121,340,932 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	121,235,119 - 121,342,444 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	128,669,534 - 128,777,078 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	116,308,387 - 116,416,414 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	116,213,959 - 116,321,987 (+)	NCBI
Celera	3	114,768,654 - 114,872,632 (+)	NCBI		Celera
Cytogenetic Map	3	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

carcinoma (ISO)

COVID-19 (ISO)

fundus dystrophy (ISO)

genetic disease (ISO)

IgA glomerulonephritis (ISO)

pulmonary embolism (ISO)

retinal degeneration (IAGP,IDA)

retinitis pigmentosa (ISO)

retinitis pigmentosa 38 (ISO)

Thromboembolism (ISO)

thrombosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-palmitoylglycerol (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

8-Br-cAMP (ISO)

acrylamide (ISO)

ADP (ISO)

aflatoxin B1 (ISO)

aldrin (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

bisphenol F (ISO)

bleomycin A2 (ISO)

caffeine (ISO)

calcitriol (ISO)

calix[6]arene (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlordecone (ISO)

chloroprene (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

clobetasol (ISO)

clofibrate (ISO)

copper atom (ISO)

copper(0) (ISO)

crocidolite asbestos (ISO)

Cuprizon (EXP)

cypermethrin (ISO)

cytarabine (ISO)

dabigatran (ISO)

DDD (ISO)

DDE (ISO)

DDT (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

dieldrin (ISO)

disodium selenite (ISO)

doxorubicin (ISO)

endosulfan (EXP)

endrin (ISO)

epoxiconazole (ISO)

ethanol (ISO)

fenofibrate (ISO)

folic acid (ISO)

gamma-hexachlorocyclohexane (ISO)

lead diacetate (EXP)

lidocaine (EXP)

lipopolysaccharide (ISO)

methylisothiazolinone (ISO)

nickel atom (ISO)

nickel dichloride (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

paraquat (ISO)

perfluorooctanoic acid (ISO)

phorbol 13-acetate 12-myristate (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

propiconazole (ISO)

rotenone (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

serpentine asbestos (ISO)

silicon dioxide (ISO)

simvastatin (ISO)

sodium arsenite (ISO)

sodium dichromate (ISO)

sulforaphane (ISO)

sunitinib (ISO)

tamoxifen (ISO)

testosterone (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

topotecan (EXP)

tremolite asbestos (ISO)

trichostatin A (ISO)

triclosan (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic cell clearance (ISO)

cell migration (IBA,IEA)

cell surface receptor protein tyrosine kinase signaling pathway (IEA)

establishment of localization in cell (ISO)

lymphocyte activation (ISO)

natural killer cell differentiation (ISO)

negative regulation of cytokine production (ISO)

negative regulation of leukocyte apoptotic process (ISO)

negative regulation of lymphocyte activation (ISO)

nervous system development (IBA,IEA)

neutrophil clearance (ISO)

phagocytosis (IBA,IDA,IMP,ISO)

platelet activation (ISO)

positive regulation of phagocytosis (IDA,ISO)

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ISO)

protein phosphorylation (IDA)

retina development in camera-type eye (ISO)

secretion by cell (ISO)

spermatogenesis (ISO)

substrate adhesion-dependent cell spreading (ISO)

vagina development (ISO)

Cellular Component

cytoplasm (ISO)

extracellular space (ISO)

membrane (IEA)

photoreceptor outer segment (IDA)

plasma membrane (IBA,IEA)

receptor complex (IBA,IEA)

Molecular Function

ATP binding (IEA)

protein binding (ISO)

protein tyrosine kinase activity (IEA)

transmembrane receptor protein tyrosine kinase activity (IBA,IEA,NAS)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal retina pigment epithelium morphology (IAGP)

retina photoreceptor degeneration (IAGP)

thin retina outer nuclear layer (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Mer receptor tyrosine kinase signaling participates in platelet function.	Chen C, etal., Arterioscler Thromb Vasc Biol. 2004 Jun;24(6):1118-23. Epub 2004 May 6.
2.	Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat.	D'Cruz PM, etal., Hum Mol Genet 2000 Mar 1;9(4):645-51.
3.	Mertk triggers uptake of photoreceptor outer segments during phagocytosis by cultured retinal pigment epithelial cells.	Feng W, etal., J Biol Chem 2002 May 10;277(19):17016-22. Epub 2002 Feb 22.
4.	Focal adhesion kinase signaling promotes phagocytosis of integrin-bound photoreceptors.	Finnemann SC EMBO J 2003 Aug 15;22(16):4143-54.
5.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
7.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
8.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
9.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
10.	GOA pipeline	RGD automated data pipeline
11.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	Correction of the retinal dystrophy phenotype of the RCS rat by viral gene transfer of Mertk.	Vollrath D, etal., Proc Natl Acad Sci U S A 2001 Oct 23;98(22):12584-9.

Additional References at PubMed

PMID:1299193	PMID:10227296	PMID:11452127	PMID:15180281	PMID:15650770	PMID:16751775	PMID:17442946	PMID:18159085	PMID:18393392	PMID:18395422	PMID:19204785	PMID:20238011
PMID:21052544	PMID:22871113	PMID:23353780	PMID:23878224	PMID:26283020	PMID:26458944	PMID:28210098	PMID:28500071	PMID:29440417	PMID:29659094	PMID:30054542	PMID:34440696
PMID:34829984

Genomics

Comparative Map Data

Mertk
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	136,391,936 - 136,498,366 (+)	NCBI		GRCr8
mRatBN7.2	3	115,939,351 - 116,045,141 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	115,939,351 - 116,046,554 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	119,836,222 - 119,942,080 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	128,431,776 - 128,537,642 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	126,092,272 - 126,198,124 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	121,235,230 - 121,340,932 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	121,235,119 - 121,342,444 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	128,669,534 - 128,777,078 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	116,308,387 - 116,416,414 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	116,213,959 - 116,321,987 (+)	NCBI
Celera	3	114,768,654 - 114,872,632 (+)	NCBI		Celera
Cytogenetic Map	3	q36	NCBI

MERTK
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	111,898,607 - 112,029,561 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	111,898,607 - 112,029,561 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	112,656,184 - 112,787,138 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	112,372,662 - 112,503,416 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	112,372,415 - 112,503,168	NCBI
Celera	2	106,258,379 - 106,389,184 (-)	NCBI		Celera
Cytogenetic Map	2	q13	NCBI
HuRef	2	105,169,541 - 105,300,438 (+)	NCBI		HuRef
CHM1_1	2	112,661,190 - 112,791,926 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	112,325,012 - 112,456,507 (+)	NCBI		T2T-CHM13v2.0

Mertk
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	128,540,836 - 128,645,082 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	128,540,876 - 128,644,814 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	128,698,915 - 128,803,162 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	128,698,956 - 128,802,894 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	128,524,733 - 128,627,923 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	128,390,438 - 128,493,628 (+)	NCBI		MGSCv36	mm8
Celera	2	129,929,620 - 130,029,340 (+)	NCBI		Celera
Cytogenetic Map	2	F1	NCBI
cM Map	2	62.63	NCBI

Mertk
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955470	2,065,411 - 2,167,909 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955470	2,065,468 - 2,167,909 (-)	NCBI	ChiLan1.0	ChiLan1.0

MERTK
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	16,046,414 - 16,179,196 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	16,049,177 - 16,181,960 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	89,977,226 - 90,109,970 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	113,055,554 - 113,162,556 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	113,056,852 - 113,162,052 (+)	Ensembl	panpan1.1		panPan2

MERTK
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	36,336,787 - 36,445,796 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	36,336,861 - 36,445,380 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	36,106,597 - 36,218,038 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	37,111,333 - 37,223,997 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	37,111,394 - 37,223,995 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	36,231,212 - 36,343,496 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	36,303,304 - 36,415,155 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	36,515,620 - 36,628,095 (+)	NCBI		UU_Cfam_GSD_1.0

Mertk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	81,712,891 - 81,810,395 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936783	607,382 - 704,889 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936783	607,425 - 704,879 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MERTK
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	44,349,385 - 44,483,402 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	44,349,377 - 44,483,400 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	45,947,411 - 45,961,016 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MERTK
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	14,971,858 - 15,100,736 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	15,001,471 - 15,101,025 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666080	4,589,380 - 4,720,259 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mertk
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624749	341,289 - 443,640 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624749	337,441 - 444,730 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Mertk
714 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	233
Count of miRNA genes:	172
Interacting mature miRNAs:	198
Transcripts:	ENSRNOT00000023419
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	29463235	118376539	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	38192233	133483320	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	43827364	121056321	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	47233211	147415807	Rat
631665	Bw8	Body weight QTL 8	5.5		body mass (VT:0001259)	body weight (CMO:0000012)	3	50437042	119183768	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	59242096	157323038	Rat
1300111	Rf12	Renal function QTL 12	3.78		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	61017749	121056321	Rat
12879848	Bw181	Body weght QTL 181		0.015	body mass (VT:0001259)	body weight (CMO:0000012)	3	70348525	121056321	Rat
2301414	Kidm37	Kidney mass QTL 37		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	70653097	121056321	Rat
1600376	Arunc5	Aerobic running capacity QTL 5		0.21	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	3	73376539	118376539	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	78196190	146592722	Rat
631649	Bp123	Blood pressure QTL 123	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	89772419	134772419	Rat
8694437	Bw167	Body weight QTL 167	22.46	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	3	91797474	136797474	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	94856903	159898684	Rat
724532	Cm17	Cardiac mass QTL 17	2		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	3	95735366	140735366	Rat
1354611	Despr2	Despair related QTL 2	3.03	0.0028	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	3	97084464	142084464	Rat
2293087	Iddm27	Insulin dependent diabetes mellitus QTL 27	2.68		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	97551417	147415807	Rat
2312659	Slep7	Serum leptin concentration QTL 7		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	3	98535255	168026850	Rat
2312670	Bw94	Body weight QTL 94		0.01	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	3	98535255	168026850	Rat
2312673	Scl63	Serum cholesterol level QTL 63		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	98535255	168026850	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	98535386	161695835	Rat
619618	Rf3	Renal disease susceptibility QTL 3	6.5	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate to body weight ratio (CMO:0001270)	3	107693393	152693393	Rat
1331758	Bp207	Blood pressure QTL 207	2.848		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	112287552	135181505	Rat
1578754	Stresp16	Stress response QTL 16	4	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	3	112681431	157681431	Rat
1358204	Insglur1	Insulin/glucose ratio QTL 1	3.8		blood glucose amount (VT:0000188)	serum insulin level (CMO:0000358)	3	115638168	135181505	Rat
1358204	Insglur1	Insulin/glucose ratio QTL 1	3.8		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	3	115638168	135181505	Rat

Markers in Region

AU048840

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	115,948,841 - 115,949,055 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	121,244,720 - 121,244,933	NCBI	Rnor6.0
Rnor_5.0	3	128,767,375 - 128,767,588	UniSTS	Rnor5.0
RGSC_v3.4	3	116,317,877 - 116,318,090	UniSTS	RGSC3.4
Celera	3	114,778,144 - 114,778,357	UniSTS
Cytogenetic Map	3	q36	UniSTS

MERTK

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	116,036,473 - 116,038,063 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	121,332,265 - 121,333,854	NCBI	Rnor6.0
Rnor_5.0	3	128,678,440 - 128,680,029	UniSTS	Rnor5.0
RGSC_v3.4	3	116,407,747 - 116,409,336	UniSTS	RGSC3.4
Celera	3	114,863,955 - 114,865,544	UniSTS
Cytogenetic Map	3	q36	UniSTS

Related Rat Strains

The following Strains have been annotated to Mertk

(LE x RCS-p⁺/LavRrrc)F1

Genetic Models

This gene Mertk is modified in the following models/strains:

RCS/Kyo

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			13	12	12	12			20	27	7	11
Low	3	43	44	29	7	29	8	11	54	8	34		8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_022943	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284527	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF208235	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF208236	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ221127	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KY305009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000023419 ⟹ ENSRNOP00000023419

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	115,968,752 - 116,046,554 (+)	Ensembl
Rnor_6.0 Ensembl	3	121,235,119 - 121,342,444 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000097978 ⟹ ENSRNOP00000076826

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	115,939,351 - 116,046,554 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000107394 ⟹ ENSRNOP00000082953

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	115,944,529 - 116,046,554 (+)	Ensembl

RefSeq Acc Id:

NM_022943 ⟹ NP_075232

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	136,392,574 - 136,498,366 (+)	NCBI
mRatBN7.2	3	115,939,351 - 116,045,141 (+)	NCBI
Rnor_6.0	3	121,235,230 - 121,340,932 (+)	NCBI
Rnor_5.0	3	128,669,534 - 128,777,078 (-)	NCBI
RGSC_v3.4	3	116,308,387 - 116,416,414 (+)	RGD
Celera	3	114,768,654 - 114,872,632 (+)	RGD

Sequence:

show sequence

CATCTGTCCGGAGAGAACTGCCAGATCCGCGGCCCCGCGATGGTTCTGGCCCCACTACTGCTGG
GGCTGCTGCTGCTATCCGCACTCTGGAATGGAGGCACTGCTGAAAAGGAGGAAGAAATCAAGCC
AGATCAGCCATTTTCAGGGCCTTTACCAGGGAGCCTACCAGCTGACCACAGGCCATTCTTCGCC
CCTCACTCCAGTGGGGACCAGCTGTCACCATCCCAGACTGGAAGATCACATCCAGCACACACAG
CCACTCCCCAGATGACCTCTGCAGCATCAAACCTCCTGCCTCCTGTTGCATTTAAAAACACAAT
TGGACGCATAGTACTTTCGGAACATAAAAGTGTCAAATTTAATTGCTCGATCAACATTCCTAAC
GTGTATCAAGAAACAGCTGGCATTTCGTGGTGGAAAGATGGAAAGGAACTGCTTGGGGCACATC
ATTCAATCACACAGTTTTATCCTGATGAGGAAGGGGTATCAATAATTGCATTGTTCAGCATAAC
CAGTGTGCAGCGCTCAGACAATGGGTCGTACATCTGTAAGATGAAGGTGAACGATAGAGAGGTT
GTGTCTGATCCCATATACGTGGAAGTCCAAGGACTCCCTTACTTTACTAAGCAGCCTGAGAGCG
TGAATGTCACCAGAAACACAGCCTTCAACCTCACCTGCCAGGCTGTGGGACCCCCTGAGCCCGT
CAACATCTTCTGGGTTCAAAATAGCAGCCGTGTTAATGAAAATCCAGAAAGGTCCCCGTCTGTC
CTAACTGTCGCTGGTCTGACAGAGACCGCAGTCTTCAGCTGTGAGGCCCACAACGACAAAGGAC
TGACGGTGTCCAAGGGTGTACAGATCAACATCAAAGTCATCCCTTCCCCACCCACTGAAGTCCA
TATCCTCAACAGCACAGCGCACAGCATCCTGGTCTCCTGGGTCCCAGGGTTTGATGGCTACTCC
CCACTTCAGAACTGCAGCATTCAGGTCAAGGAAGCTGACCAGCTGAGTAATGGCTCAGTCATGG
TTTTTAATACCTCTGCTTCGCCACATCTGTATGAAGTCCAGCAGCTGCAAGCCCTGGCTAATTA
CAGCGTCACTGTGTCCTGTCGGAATGAGATTGGCTGGTCTGCAGTGAGCCCTTGGATCCTGGCC
AGCACTACAGAAGGAGCTCCAGCAGTGGCGCCTCTAAACATCACTGTGTTTCTGAACGAATCCA
GCAACAACCTGGAAATCAGATGGACGAAGCCTCCAATTAAGCGGCAGGATGGGGAACTGGTGGG
CTACCGGATATCTCACGTGTGGGAGAGTGCGGGGACTTCCAAAGAGCTTTCTGAAGAAGTCAGC
CAGAATGGCAGCTGGGCTCAGGTTCCTGTCCAAATGCACAATGCCACCTGCACAGTGAGAATCG
CCGTCATCACTAAAGGGGGCATTGGGCCCTTCAGTGAGCCAGTGGACGTAGCCATTCCGGAGCA
CAGTAGGGTAGATTACGCACCCTCATCAACCCCAGCCCCTGGCAACACCGAGTCTATGCTCATC
ATCCTGGGCTGCTTCTGCGGGTTTGTTCTCATGGGGTTGATTCTGTATCTTTCTCTGGCCATCA
AAAGGAGAGTCCAGGAAACAAAGTTTGGGGGTGCATTCTCCGAGGAGGACTCCCAATTAGTTGT
AAATTACAGAGCAAAGAAGTCCTTCTGTCGGCGAGCCATCGAGCTTACCTTGCAAAGCCTGGGG
GTGAGCGAGGAGCTGCAAAACAAGCTAGAAGATGTTGTGGTTGACAGAAATCTTCTAATTCTTG
GGAAAGTTCTGGGCGAAGGAGAGTTTGGGTCTGTAATGGAAGGAAATCTGAAGCAGGAAGATGG
GACTTCTCAGAAGGTGGCAGTGAAGACCATGAAGTTGGACAACTTTTCTCTACGGGAGATCGAG
GAGTTTCTCAGCGAAGCAGCGTGCATGAAAGACTTCAATCACCCAAACGTCATCCGGCTTCTAG
GCGTGTGTATAGAACTGAGCTCTCAAGGCATCCCGAAGCCCATGGTGATTTTACCCTTCATGAA
ATACGGAGACCTCCACACCTTCCTGCTATATTCCCGGATAGAATCAGTACCGAAGTCCATCCCC
CTGCAGACACTGCTGAAGTTCATGGTGGACATTGCCCAGGGAATGGAGTACCTGAGCAGCAGGA
ATTTTCTCCACAGGGATTTAGCTGCTCGGAATTGCATGTTGCGGGATGACATGACTGTCTGCGT
GGCAGACTTTGGCCTCTCTAAGAAGATTTACAGTGGTGATTATTACCGCCAAGGCCGCATTGCC
AAAATGCCTGTGAAGTGGATCGCCATAGAGAGCCTGGCGGACCGAGTCTACACAAGCAAGAGTG
ACGTGTGGGCTTTTGGCGTGACCATGTGGGAAATAGCAACACGGGGAATGACTCCCTATCCTGG
AGTCCAGAACCATGAGATGTACGATTACCTTCTCCACGGCCACAGGCTGAAGCAGCCCGAGGAC
TGCCTGGATGATCTGTATGAAATCATGTACTCTTGCTGGAGTGCTGATCCCCTGGACCGACCCA
CCTTCTCAGTGCTGAGGCTGCAGCTGGAAAAGCTCTCCGAGAGTTTGCCTGATGCCCAGGACAA
AGAATCCATCATCTACATCAATACACAGTTACTAGAGAGCTGCGAGGGCCTAGCCAACAGGTCC
TCCCTCGCAGGGCTAGACATGAACATTGATCCTGACTCCATCATTGCCTCTTGCACAGCAGGTG
CTGCTGTCAGCGTGGTCATGGCGGAAGTTCACGAGAACAACCTTCATGAGGAAAGATACATCTT
AAATGGGGGCAACGAGGAATGGGAAGATGTGGCCTCCACTCCATTTGCTACAGTCACAGCTGGA
AAAGATGGTGTGTTACCAGAGGACAGACTCACCAAAAATGGCATCTCCTGGTCTCACCATAGTA
CGCTACCCTTGGGGAGCCCATCACCAGATGAACTTCTGTTTGCAGACGACTCCTCGGGAGACTC
TGAAGTTCTGATGTGA

hide sequence

RefSeq Acc Id:

XM_063284527 ⟹ XP_063140597

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	136,391,936 - 136,480,115 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_075232	(Get FASTA)	NCBI Sequence Viewer
	XP_063140597	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAF44060	(Get FASTA)	NCBI Sequence Viewer
	AAF44061	(Get FASTA)	NCBI Sequence Viewer
	APO36716	(Get FASTA)	NCBI Sequence Viewer
	EDL80138	(Get FASTA)	NCBI Sequence Viewer
	EDL80139	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000023419.2
	ENSRNOP00000076826
	ENSRNOP00000076826.1
	ENSRNOP00000082953.1
	ENSRNOP00055007421
	ENSRNOP00060022174
	ENSRNOP00065018208
GenBank Protein	P57097	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_075232 ⟸ NM_022943
- Peptide Label:	precursor
- UniProtKB:	P57097 (UniProtKB/Swiss-Prot), A6HQ37 (UniProtKB/TrEMBL), A0A8I5ZYY3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MVLAPLLLGLLLLSALWNGGTAEKEEEIKPDQPFSGPLPGSLPADHRPFFAPHSSGDQLSPSQT GRSHPAHTATPQMTSAASNLLPPVAFKNTIGRIVLSEHKSVKFNCSINIPNVYQETAGISWWKD GKELLGAHHSITQFYPDEEGVSIIALFSITSVQRSDNGSYICKMKVNDREVVSDPIYVEVQGLP YFTKQPESVNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNENPERSPSVLTVAGLTETAVFS CEAHNDKGLTVSKGVQINIKVIPSPPTEVHILNSTAHSILVSWVPGFDGYSPLQNCSIQVKEAD QLSNGSVMVFNTSASPHLYEVQQLQALANYSVTVSCRNEIGWSAVSPWILASTTEGAPAVAPLN ITVFLNESSNNLEIRWTKPPIKRQDGELVGYRISHVWESAGTSKELSEEVSQNGSWAQVPVQMH NATCTVRIAVITKGGIGPFSEPVDVAIPEHSRVDYAPSSTPAPGNTESMLIILGCFCGFVLMGL ILYLSLAIKRRVQETKFGGAFSEEDSQLVVNYRAKKSFCRRAIELTLQSLGVSEELQNKLEDVV VDRNLLILGKVLGEGEFGSVMEGNLKQEDGTSQKVAVKTMKLDNFSLREIEEFLSEAACMKDFN HPNVIRLLGVCIELSSQGIPKPMVILPFMKYGDLHTFLLYSRIESVPKSIPLQTLLKFMVDIAQ GMEYLSSRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLA DRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDDLYEIMYSCW SADPLDRPTFSVLRLQLEKLSESLPDAQDKESIIYINTQLLESCEGLANRSSLAGLDMNIDPDS IIASCTAGAAVSVVMAEVHENNLHEERYILNGGNEEWEDVASTPFATVTAGKDGVLPEDRLTKN GISWSHHSTLPLGSPSPDELLFADDSSGDSEVLM hide sequence

RefSeq Acc Id:

ENSRNOP00000023419 ⟸ ENSRNOT00000023419

RefSeq Acc Id:

ENSRNOP00000076826 ⟸ ENSRNOT00000097978

RefSeq Acc Id:

ENSRNOP00000082953 ⟸ ENSRNOT00000107394

RefSeq Acc Id:	XP_063140597 ⟸ XM_063284527
- Peptide Label:	isoform X1

Protein Domains

Fibronectin type-III Ig-like Ig-like C2-type Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P57097-F1-model_v2	AlphaFold	P57097	1-994	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692414

Promoter ID:

EPDNEW_R2939

Type:

multiple initiation site

Name:

Mertk_1

Description:

MER proto-oncogene, tyrosine kinase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	121,235,112 - 121,235,172	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:69283	AgrOrtholog
BioCyc Gene	G2FUF-47937	BioCyc
Ensembl Genes	ENSRNOG00000017319	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00055005926	UniProtKB/Swiss-Prot
	ENSRNOG00060016090	UniProtKB/Swiss-Prot
	ENSRNOG00065014153	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000023419.5	UniProtKB/TrEMBL
	ENSRNOT00000097978	ENTREZGENE
	ENSRNOT00000097978.1	UniProtKB/Swiss-Prot
	ENSRNOT00000107394.1	UniProtKB/TrEMBL
	ENSRNOT00055009610	UniProtKB/Swiss-Prot
	ENSRNOT00060027596	UniProtKB/Swiss-Prot
	ENSRNOT00065023398	UniProtKB/Swiss-Prot
Gene3D-CATH	2.60.40.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	FN3_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FN3_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig-like_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig_sub	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Immunoglobulin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Kinase-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ser-Thr/Tyr_kinase_cat_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tyr_kinase_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tyr_kinase_cat_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:65037	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	65037	ENTREZGENE
PANTHER	TYROSINE-PROTEIN KINASE MER	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TYROSINE-PROTEIN KINASE RECEPTOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	fn3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PF00047	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PK_Tyr_Ser-Thr	UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
PhenoGen	Mertk	PhenoGen
PRINTS	TYRKINASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	FN3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IG_LIKE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_ATP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_TYR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000017319	RatGTEx
	ENSRNOG00055005926	RatGTEx
	ENSRNOG00060016090	RatGTEx
	ENSRNOG00065014153	RatGTEx
SMART	FN3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SM00409	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TyrKc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF48726	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF49265	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF56112	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A1L5L8Q5_RAT	UniProtKB/TrEMBL
	A0A8I5ZYY3	ENTREZGENE, UniProtKB/TrEMBL
	A0A8L2QC30_RAT	UniProtKB/TrEMBL
	A6HQ37	ENTREZGENE, UniProtKB/TrEMBL
	A6HQ38_RAT	UniProtKB/TrEMBL
	MERTK_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q9JL63_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-07-10	Mertk	MER proto-oncogene, tyrosine kinase	Mertk	c-mer proto-oncogene tyrosine kinase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-06-06	Mertk	c-mer proto-oncogene tyrosine kinase	Rdy	retinal dystrophy	Data merged from RGD:3550	737654	APPROVED
2003-04-09	Rdy	retinal dystrophy		Retinal dystrophy	Name updated	629478	APPROVED
2002-06-10	Rdy	Retinal dystrophy			Symbol and Name status set to approved	70586	APPROVED
2002-06-10	Mertk	c-mer proto-oncogene tyrosine kinase			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_disease	mutation causes the retinal dystrophy (rdy) phenotype in the Royal College of Surgeons (RCS) rat	69668
gene_disease	mutation causes the retinal dystrophy (rdy) phenotype in the Royal College of Surgeons (RCS) rat	1299193
gene_function	tyrosine kinase receptor	61793
gene_function	tyrosine kinase receptor	69668
gene_mutations_overexpression	gene transfer corrects a defect in retinal pigment epithelium (RPE) phagocytosis in the retinal dystrophy (rdy) locus of the Royal College of Surgeons (RCS) rat by restoring normal phagocytosis of shed photoreceptor outer segments	69668
gene_mutations_overexpression	gene transfer to the eyes of young Royal College of Surgeons (RCS) rats with (rdy) retinal dystrophy increases sensitivity to low intensity light	69668
gene_process	required for proper retina functioning	61793
gene_process	required for proper retina functioning	69668
gene_process	involved as a signaling molecule triggering outer segment uptake during phagocytosis	1299193
gene_product	member of the axl family	61793
gene_product	member of the axl family	69668
gene_protein	994 amino acids	61793
gene_protein	994 amino acids	69668

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Mammalian Phenotype

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Mammalian Phenotype