Oprl1 (opioid related nociceptin receptor 1) - Rat Genome Database

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Gene: Oprl1 (opioid related nociceptin receptor 1) Rattus norvegicus
Analyze
Symbol: Oprl1
Name: opioid related nociceptin receptor 1
RGD ID: 68438
Description: Predicted to enable neuropeptide binding activity and nociceptin receptor activity. Involved in several processes, including behavioral response to cocaine; negative regulation of signal transduction; and response to ethanol. Predicted to be located in cytoplasmic vesicle and membrane. Predicted to be active in neuron projection and synaptic membrane. Used to study alcohol use disorder. Biomarker of fetal alcohol spectrum disorder and sciatic neuropathy. Human ortholog(s) of this gene implicated in heroin dependence. Orthologous to human OPRL1 (opioid related nociceptin receptor 1); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: kappa-type 3 opioid receptor; KOR-3; KOR3; LC132; MOR-C; nociceptin receptor; nociceptin receptor ORL1; OFQR; opiate receptor-like 1; opioid receptor-like; opioid receptor-like 1; Oprl; ORL1; orphanin FQ receptor; orphanin FQ receptor-a; orphanin FQ receptor-b; orphanin FQ receptor-e; peptide receptor; ROR-C; seven transmembrane G protein-coupled receptor; XOR1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Oprl1m1Hubr
Genetic Models: WI-Oprl1m1Hubr-/- ; WI-Oprl1m1Hubr+/-
Candidate Gene For: Bp286
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83189,209,495 - 189,225,406 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3189,212,175 - 189,217,426 (+)EnsemblGRCr8
mRatBN7.23168,831,934 - 168,839,920 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3168,834,003 - 168,839,920 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3173,213,623 - 173,219,540 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03182,172,714 - 182,178,631 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03178,834,940 - 178,840,857 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03177,223,779 - 177,231,663 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3177,225,737 - 177,231,663 (+)Ensemblrn6Rnor6.0
Rnor_5.03180,932,344 - 180,943,574 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43170,869,862 - 170,873,417 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3163,747,719 - 163,753,636 (-)NCBICelera
RGSC_v3.13170,775,328 - 170,780,949 (+)NCBI
Cytogenetic Map3q43NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
AM-251  (ISO)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
atropine  (EXP)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
buprenorphine  (ISO)
Butylbenzyl phthalate  (ISO)
camptothecin  (ISO)
capsaicin  (EXP)
cefaloridine  (EXP)
cisplatin  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
ethanol  (EXP)
fenvalerate  (EXP)
folic acid  (ISO)
genistein  (EXP)
glyphosate  (ISO)
haloperidol  (ISO)
lamivudine  (ISO)
lipopolysaccharide  (ISO)
methamphetamine  (ISO)
methoxychlor  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
nicotine  (ISO)
nociceptin  (ISO)
Nonylphenol  (EXP)
Nutlin-3  (ISO)
oxidopamine  (EXP)
paracetamol  (ISO)
perfluorooctanoic acid  (EXP)
pirinixic acid  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-nitrosoglutathione  (ISO)
silicon dioxide  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
tebuconazole  (ISO)
thioglycolic acid  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Up-regulation of ORL-1 receptors in spinal tissue of allodynic rats after sciatic nerve injury. Briscini L, etal., Eur J Pharmacol. 2002 Jun 28;447(1):59-65.
2. Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a mu, delta or kappa opioid receptor type. Bunzow JR, etal., FEBS Lett 1994 Jun 27;347(2-3):284-8.
3. Dysregulation of Nociceptin/Orphanin FQ and Dynorphin Systems in the Extended Amygdala of Alcohol Preferring Marchigian Sardinian (msP) Rats. Caputi FF, etal., Int J Mol Sci. 2021 Feb 28;22(5):2448. doi: 10.3390/ijms22052448.
4. Precision therapeutic opioid dosing implications from genetic biomarkers and craving score. Chang HW, etal., Medicine (Baltimore). 2020 May 29;99(22):e20429. doi: 10.1097/MD.0000000000020429.
5. Molecular cloning, tissue distribution and chromosomal localization of a novel member of the opioid receptor gene family. Chen Y, etal., FEBS Lett 1994 Jun 27;347(2-3):279-83.
6. Pharmacological characterization of the nociceptin receptor which mediates reduction of alcohol drinking in rats. Ciccocioppo R, etal., Peptides. 2002 Jan;23(1):117-25.
7. Reversal of stress- and CRF-induced anorexia in rats by the synthetic nociceptin/orphanin FQ receptor agonist, Ro 64-6198. Ciccocioppo R, etal., Psychopharmacology (Berl). 2002 May;161(2):113-9. Epub 2002 Mar 22.
8. Activation of opioid receptor like-1 receptor in the spinal cord produces sex-specific antinociception in the rat: estrogen attenuates antinociception in the female, whereas testosterone is required for the expression of antinociception in the male. Claiborne J, etal., J Neurosci. 2006 Dec 13;26(50):13048-53.
9. Molecular cloning of the orphanin FQ receptor gene and differential tissue expression of splice variants in rat. Curro D, etal., Gene 2001 Mar 21;266(1-2):139-45.
10. Genetic deletion or pharmacological blockade of nociceptin/orphanin FQ receptors in the ventral tegmental area attenuates nicotine-motivated behaviour. Domi A, etal., Br J Pharmacol. 2022 Jun;179(11):2647-2658. doi: 10.1111/bph.15762. Epub 2022 Feb 10.
11. Dysregulation of nociceptin/orphanin FQ activity in the amygdala is linked to excessive alcohol drinking in the rat. Economidou D, etal., Biol Psychiatry. 2008 Aug 1;64(3):211-8. doi: 10.1016/j.biopsych.2008.02.004. Epub 2008 Mar 25.
12. Sex-related differences in the distribution of opioid receptor-like 1 receptor mRNA and colocalization with estrogen receptor mRNA in neurons of the spinal trigeminal nucleus caudalis in the rat. Flores CA, etal., Neuroscience. 2003;118(3):769-78.
13. cDNA cloning and regional distribution of a novel member of the opioid receptor family. Fukuda K, etal., FEBS Lett 1994 Apr 18;343(1):42-6.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
16. Opioid receptor-like 1 stimulation in the collecting duct induces aquaresis through vasopressin-independent aquaporin-2 downregulation. Hadrup N, etal., Am J Physiol Renal Physiol. 2004 Jul;287(1):F160-8. Epub 2004 Mar 9.
17. Gastric acid secretion stimulated by centrally injected nociceptin in urethane-anesthetized rats. Ishihara S, etal., Eur J Pharmacol. 2002 Apr 19;441(1-2):105-14.
18. Nociceptin/orphanin FQ decreases glutamate transmission and blocks ethanol-induced effects in the central amygdala of naive and ethanol-dependent rats. Kallupi M, etal., Neuropsychopharmacology. 2014 Apr;39(5):1081-92. doi: 10.1038/npp.2013.308. Epub 2013 Oct 30.
19. Genetic Deletion of the Nociceptin/Orphanin FQ Receptor in the Rat Confers Resilience to the Development of Drug Addiction. Kallupi M, etal., Neuropsychopharmacology. 2017 Feb;42(3):695-706. doi: 10.1038/npp.2016.171. Epub 2016 Aug 26.
20. Nociceptin inhibits uterine contractions in term-pregnant rats by signaling through multiple pathways. Klukovits A, etal., Biol Reprod. 2010 Jul;83(1):36-41. doi: 10.1095/biolreprod.109.082222. Epub 2010 Mar 17.
21. Molecular cloning of a novel G protein-coupled receptor related to the opiate receptor family. Lachowicz JE, etal., J Neurochem 1995 Jan;64(1):34-40.
22. Orphan opioid receptor antisense probes block orphanin FQ-induced hyperphagia. Leventhal L, etal., Eur J Pharmacol. 1998 May 15;349(1):R1-3.
23. Morphine-6beta-glucuronide-induced hyperphagia: characterization of opioid action by selective antagonists and antisense mapping in rats. Leventhal L, etal., J Pharmacol Exp Ther. 1998 Nov;287(2):538-44.
24. Expression of ORL1 mRNA in some brain nuclei in neuropathic pain rats. Ma F, etal., Brain Res. 2005 May 10;1043(1-2):214-7.
25. Nociceptin inhibits the neurogenic vasopressor response in the pithed rat via prejunctional ORL1 receptors. Malinowska B, etal., Naunyn Schmiedebergs Arch Pharmacol. 2000 Jan;361(1):80-4.
26. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
27. Acute and subchronic antinociceptive effects of nociceptin/orphanin FQ receptor agonists infused by intrathecal route in rats. Micheli L, etal., Eur J Pharmacol. 2015 May 5;754:73-81. doi: 10.1016/j.ejphar.2015.02.020. Epub 2015 Feb 19.
28. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
29. GOA pipeline RGD automated data pipeline
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Nociceptin/orphanin FQ receptor knockout rats: in vitro and in vivo studies. Rizzi A, etal., Neuropharmacology. 2011 Mar;60(4):572-9. doi: 10.1016/j.neuropharm.2010.12.010. Epub 2010 Dec 22.
33. Nociceptin/orphanin FQ presynaptically decreases GABAergic transmission and blocks the ethanol-induced increase of GABA release in central amygdala. Roberto M and Siggins GR, Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9715-20. doi: 10.1073/pnas.0601899103.
34. Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents. Ruggeri B, etal., J Child Psychol Psychiatry. 2018 Jun;59(6):650-658. doi: 10.1111/jcpp.12843. Epub 2017 Dec 2.
35. Modulation of Ca2+ channels by opioid receptor-like 1 receptors natively expressed in rat stellate ganglion neurons innervating cardiac muscle. Ruiz-Velasco V, etal., J Pharmacol Exp Ther. 2005 Sep;314(3):987-94. Epub 2005 Jun 3.
36. Pharmacological blockade or genetic knockout of the NOP receptor potentiates the rewarding effect of morphine in rats. Rutten K, etal., Drug Alcohol Depend. 2011 Apr 1;114(2-3):253-6. doi: 10.1016/j.drugalcdep.2010.10.004. Epub 2010 Nov 20.
37. Altered Global mRNA Expressions of Pain and Aggression Related Genes in the Blood of Children with Autism Spectrum Disorders. Sener EF, etal., J Mol Neurosci. 2019 Jan;67(1):89-96. doi: 10.1007/s12031-018-1213-0. Epub 2018 Dec 5.
38. Dynorphin A(1-17)-induced feeding: pharmacological characterization using selective opioid antagonists and antisense probes in rats. Silva RM, etal., J Pharmacol Exp Ther. 2002 May;301(2):513-8.
39. Role of nociceptin and opioid receptor like 1 on entrainment function in the rat suprachiasmatic nucleus. Sugino T, etal., Neuroscience. 2006;137(2):537-44. Epub 2005 Nov 28.
40. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
41. Retrodialysis of N/OFQ into the nucleus accumbens shell blocks cocaine-induced increases in extracellular dopamine and locomotor activity. Vazquez-DeRose J, etal., Eur J Pharmacol. 2013 Jan 15;699(1-3):200-6. doi: 10.1016/j.ejphar.2012.11.050. Epub 2012 Dec 5.
42. Two C-terminal amino acids, Ser(334) and Ser(335), are required for homologous desensitization and agonist-induced phosphorylation of opioid receptor-like 1 receptors. Wang HL, etal., Cell Signal. 2006 May;18(5):670-8. Epub 2005 Jul 14.
43. Heterodimerization of opioid receptor-like 1 and mu-opioid receptors impairs the potency of micro receptor agonist. Wang HL, etal., J Neurochem. 2005 Mar;92(6):1285-94.
44. cDNA cloning of an orphan opiate receptor gene family member and its splice variant. Wang JB, etal., FEBS Lett 1994 Jul 4;348(1):75-9.
45. Isolation of a novel cDNA encoding a putative membrane receptor with high homology to the cloned mu, delta, and kappa opioid receptors. Wick MJ, etal., Brain Res Mol Brain Res 1994 Nov;27(1):37-44.
46. Prenatal ethanol induces an anxiety phenotype and alters expression of dynorphin & nociceptin/orphanin FQ genes. Wille-Bille A, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jul 13;85:77-88. doi: 10.1016/j.pnpbp.2018.04.005. Epub 2018 Apr 18.
47. Buprenorphine activates mu and opioid receptor like-1 receptors simultaneously, but the analgesic effect is mainly mediated by mu receptor activation in the rat formalin test. Yamamoto T, etal., J Pharmacol Exp Ther. 2006 Jul;318(1):206-13. Epub 2006 Mar 24.
48. Chronic Oxycodone Self-administration Altered Reward-related Genes in the Ventral and Dorsal Striatum of C57BL/6J Mice: An RNA-seq Analysis. Zhang Y, etal., Neuroscience. 2018 Nov 21;393:333-349. doi: 10.1016/j.neuroscience.2018.07.032. Epub 2018 Jul 29.
49. Immunomodulatory activity of orphanin FQ/nociceptin on traumatic rats. Zhao H, etal., Acta Pharmacol Sin. 2002 Apr;23(4):343-8.
Additional References at PubMed
PMID:8137918   PMID:9915326   PMID:10571060   PMID:10814826   PMID:11726686   PMID:11973003   PMID:12217419   PMID:12568343   PMID:12842128   PMID:12842289   PMID:14660000   PMID:15282268  
PMID:15890775   PMID:15948180   PMID:16483692   PMID:17493706   PMID:17499882   PMID:17512052   PMID:17681177   PMID:17766480   PMID:18987291   PMID:19448152   PMID:19527777   PMID:19720395  
PMID:19765615   PMID:19887453   PMID:20159949   PMID:21925513   PMID:22074385   PMID:22075222   PMID:22120202   PMID:22371475   PMID:23337899   PMID:23669068   PMID:23869704   PMID:24452062  
PMID:24978951   PMID:25013167   PMID:25161013   PMID:25875798   PMID:26387568   PMID:26935148   PMID:27127846   PMID:27238748   PMID:28280884   PMID:28906039   PMID:34285372   PMID:38338936  


Genomics

Comparative Map Data
Oprl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83189,209,495 - 189,225,406 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3189,212,175 - 189,217,426 (+)EnsemblGRCr8
mRatBN7.23168,831,934 - 168,839,920 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3168,834,003 - 168,839,920 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3173,213,623 - 173,219,540 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03182,172,714 - 182,178,631 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03178,834,940 - 178,840,857 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03177,223,779 - 177,231,663 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3177,225,737 - 177,231,663 (+)Ensemblrn6Rnor6.0
Rnor_5.03180,932,344 - 180,943,574 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43170,869,862 - 170,873,417 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3163,747,719 - 163,753,636 (-)NCBICelera
RGSC_v3.13170,775,328 - 170,780,949 (+)NCBI
Cytogenetic Map3q43NCBI
OPRL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382064,080,082 - 64,100,643 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2064,079,967 - 64,100,649 (+)Ensemblhg38GRCh38
GRCh372062,711,435 - 62,731,996 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362062,181,932 - 62,202,440 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342062,181,931 - 62,202,440NCBI
Celera2059,397,677 - 59,420,493 (+)NCBICelera
Cytogenetic Map20q13.33NCBI
HuRef2059,457,992 - 59,460,858 (+)NCBIHuRef
CHM1_12062,612,487 - 62,633,363 (+)NCBICHM1_1
T2T-CHM13v2.02065,900,137 - 65,922,785 (+)NCBIT2T-CHM13v2.0
Oprl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392181,356,585 - 181,362,778 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2181,356,809 - 181,362,778 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382181,715,000 - 181,720,985 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2181,715,016 - 181,720,985 (+)Ensemblmm10GRCm38
MGSCv372181,449,749 - 181,455,677 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362181,644,450 - 181,650,378 (+)NCBIMGSCv36mm8
Celera2185,797,636 - 185,803,570 (+)NCBICelera
Cytogenetic Map2H4NCBI
cM Map2103.74NCBI
Oprl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955528161,673 - 167,937 (-)Ensembl
ChiLan1.0NW_004955528161,673 - 184,515 (-)NCBIChiLan1.0ChiLan1.0
OPRL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22169,902,762 - 69,922,334 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12069,894,773 - 69,914,345 (+)NCBINHGRI_mPanPan1
PanPan1.12062,004,176 - 62,017,866 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2062,004,176 - 62,017,866 (+)EnsemblpanPan2panpan1.1
OPRL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12447,530,039 - 47,537,477 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2447,508,136 - 47,537,250 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2446,652,476 - 46,671,129 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02448,657,531 - 48,675,053 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2448,643,216 - 48,676,696 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12447,502,159 - 47,521,409 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02447,626,586 - 47,644,098 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02448,365,597 - 48,383,399 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Oprl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640195,806,255 - 195,819,941 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651411,258,335 - 11,273,592 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493651411,264,392 - 11,273,584 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OPRL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1762,905,082 - 62,913,754 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11762,905,700 - 62,913,018 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
OPRL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12155,881 - 166,480 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2148,339 - 155,292 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
ChlSab1.1 Ensembl2148,339 - 155,292 (-)NCBIChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605047,581,078 - 47,599,812 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Oprl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474129,714,477 - 29,720,716 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474129,713,937 - 29,720,617 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Oprl1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15158,816,461 - 158,822,804 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1128
Count of miRNA genes:327
Interacting mature miRNAs:438
Transcripts:ENSRNOT00000022509, ENSRNOT00000031328, ENSRNOT00000045845
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1300161Rf10Renal function QTL 103.57renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)3181611379189428310Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3166376089189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3166376089189428310Rat

Markers in Region
D3Hmgc22  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23168,832,336 - 168,832,503 (+)MAPPERmRatBN7.2
Rnor_6.03177,224,083 - 177,224,247NCBIRnor6.0
Rnor_5.03180,932,614 - 180,932,778UniSTSRnor5.0
RGSC_v3.43170,867,500 - 170,867,664UniSTSRGSC3.4
Celera3163,755,135 - 163,755,299UniSTS
Cytogenetic Map3q43UniSTS
Oprl  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23168,838,089 - 168,838,321 (+)MAPPERmRatBN7.2
Rnor_6.03177,229,833 - 177,230,064NCBIRnor6.0
Rnor_5.03180,938,364 - 180,938,595UniSTSRnor5.0
RGSC_v3.43170,873,250 - 170,873,481UniSTSRGSC3.4
Celera3163,749,318 - 163,749,549UniSTS
Cytogenetic Map3q43UniSTS
RH139571  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23168,839,660 - 168,839,854 (+)MAPPERmRatBN7.2
Rnor_6.03177,231,404 - 177,231,597NCBIRnor6.0
Rnor_5.03180,939,935 - 180,940,128UniSTSRnor5.0
RGSC_v3.43170,874,821 - 170,875,014UniSTSRGSC3.4
Celera3163,747,785 - 163,747,978UniSTS
RH 3.4 Map31553.9UniSTS
Cytogenetic Map3q43UniSTS
RH140403  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23168,839,556 - 168,839,689 (+)MAPPERmRatBN7.2
Rnor_6.03177,231,300 - 177,231,432NCBIRnor6.0
Rnor_5.03180,939,831 - 180,939,963UniSTSRnor5.0
RGSC_v3.43170,874,717 - 170,874,849UniSTSRGSC3.4
Celera3163,747,950 - 163,748,082UniSTS
Cytogenetic Map3q43UniSTS
Oprl1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23168,837,767 - 168,838,013 (+)MAPPERmRatBN7.2
Rnor_6.03177,229,511 - 177,229,756NCBIRnor6.0
Rnor_5.03180,938,042 - 180,938,287UniSTSRnor5.0
RGSC_v3.43170,872,928 - 170,873,173UniSTSRGSC3.4
Celera3163,749,626 - 163,749,871UniSTS
Cytogenetic Map3q43UniSTS


Genetic Models
This gene Oprl1 is modified in the following models/strains:
WI-Oprl1m1Hubr-/-     WI-Oprl1m1Hubr+/-    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 1 30 125 46 33 22 13 22 2 108 61 2 110 15 59 11 12 12

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001318947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001318948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF115267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF178674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF216218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY152731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D16438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L28144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L29419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L33916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U01913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U05239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U07871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000031328   ⟹   ENSRNOP00000030087
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3189,212,175 - 189,217,426 (+)Ensembl
mRatBN7.2 Ensembl3168,834,003 - 168,839,920 (+)Ensembl
Rnor_6.0 Ensembl3177,226,417 - 177,230,117 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000045845   ⟹   ENSRNOP00000047053
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3168,834,003 - 168,839,920 (+)Ensembl
Rnor_6.0 Ensembl3177,225,737 - 177,231,663 (+)Ensembl
RefSeq Acc Id: NM_001318947   ⟹   NP_001305876
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83189,211,509 - 189,217,426 (+)NCBI
mRatBN7.23168,834,003 - 168,839,920 (+)NCBI
Rnor_6.03177,225,746 - 177,231,663 (+)NCBI
Celera3163,747,719 - 163,753,636 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001318948   ⟹   NP_001305877
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83189,211,509 - 189,217,426 (+)NCBI
mRatBN7.23168,834,003 - 168,839,920 (+)NCBI
Rnor_6.03177,225,746 - 177,231,663 (+)NCBI
Celera3163,747,719 - 163,753,636 (-)NCBI
Sequence:
RefSeq Acc Id: NM_031569   ⟹   NP_113757
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83189,211,509 - 189,217,426 (+)NCBI
mRatBN7.23168,834,003 - 168,839,920 (+)NCBI
Rnor_6.03177,225,746 - 177,231,663 (+)NCBI
Rnor_5.03180,932,344 - 180,943,574 (+)NCBI
RGSC_v3.43170,869,862 - 170,873,417 (+)RGD
Celera3163,747,719 - 163,753,636 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006235738   ⟹   XP_006235800
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83189,209,505 - 189,225,406 (+)NCBI
mRatBN7.23168,832,486 - 168,839,908 (+)NCBI
Rnor_6.03177,224,550 - 177,231,663 (+)NCBI
Rnor_5.03180,932,344 - 180,943,574 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006235739   ⟹   XP_006235801
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83189,209,498 - 189,225,406 (+)NCBI
mRatBN7.23168,832,483 - 168,839,908 (+)NCBI
Rnor_6.03177,224,550 - 177,231,663 (+)NCBI
Rnor_5.03180,932,344 - 180,943,574 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017591516   ⟹   XP_017447005
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83189,214,382 - 189,225,406 (+)NCBI
mRatBN7.23168,834,796 - 168,839,908 (+)NCBI
Rnor_6.03177,226,580 - 177,231,663 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039104431   ⟹   XP_038960359
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83189,209,513 - 189,225,406 (+)NCBI
mRatBN7.23168,831,934 - 168,839,908 (+)NCBI
RefSeq Acc Id: XM_039104432   ⟹   XP_038960360
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83189,209,495 - 189,225,406 (+)NCBI
mRatBN7.23168,832,482 - 168,839,908 (+)NCBI
RefSeq Acc Id: XM_039104433   ⟹   XP_038960361
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83189,209,510 - 189,225,406 (+)NCBI
mRatBN7.23168,832,489 - 168,839,908 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001305876 (Get FASTA)   NCBI Sequence Viewer  
  NP_001305877 (Get FASTA)   NCBI Sequence Viewer  
  NP_113757 (Get FASTA)   NCBI Sequence Viewer  
  XP_006235800 (Get FASTA)   NCBI Sequence Viewer  
  XP_006235801 (Get FASTA)   NCBI Sequence Viewer  
  XP_017447005 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960359 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960360 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960361 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA16201 (Get FASTA)   NCBI Sequence Viewer  
  AAA21025 (Get FASTA)   NCBI Sequence Viewer  
  AAA50827 (Get FASTA)   NCBI Sequence Viewer  
  AAA69927 (Get FASTA)   NCBI Sequence Viewer  
  AAC37661 (Get FASTA)   NCBI Sequence Viewer  
  AAC42041 (Get FASTA)   NCBI Sequence Viewer  
  AAF70553 (Get FASTA)   NCBI Sequence Viewer  
  AAF70554 (Get FASTA)   NCBI Sequence Viewer  
  AAF80988 (Get FASTA)   NCBI Sequence Viewer  
  AAF80989 (Get FASTA)   NCBI Sequence Viewer  
  AAF80990 (Get FASTA)   NCBI Sequence Viewer  
  AAF80991 (Get FASTA)   NCBI Sequence Viewer  
  AAF80992 (Get FASTA)   NCBI Sequence Viewer  
  AAN77720 (Get FASTA)   NCBI Sequence Viewer  
  AAO13225 (Get FASTA)   NCBI Sequence Viewer  
  BAA03908 (Get FASTA)   NCBI Sequence Viewer  
  EDL88670 (Get FASTA)   NCBI Sequence Viewer  
  EDL88671 (Get FASTA)   NCBI Sequence Viewer  
  EDL88672 (Get FASTA)   NCBI Sequence Viewer  
  EDL88673 (Get FASTA)   NCBI Sequence Viewer  
  EDL88674 (Get FASTA)   NCBI Sequence Viewer  
  EDL88675 (Get FASTA)   NCBI Sequence Viewer  
  EDL88676 (Get FASTA)   NCBI Sequence Viewer  
  EDL88677 (Get FASTA)   NCBI Sequence Viewer  
  EDL88678 (Get FASTA)   NCBI Sequence Viewer  
  EDL88679 (Get FASTA)   NCBI Sequence Viewer  
  EDL88680 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000030087
  ENSRNOP00000047053.1
GenBank Protein P35370 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113757   ⟸   NM_031569
- Peptide Label: isoform 1
- UniProtKB: Q791R4 (UniProtKB/Swiss-Prot),   P35370 (UniProtKB/Swiss-Prot),   A6KLW2 (UniProtKB/TrEMBL),   Q9JIN4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235801   ⟸   XM_006235739
- Peptide Label: isoform X2
- UniProtKB: F7FLX3 (UniProtKB/TrEMBL),   A6KLW8 (UniProtKB/TrEMBL),   Q8CH83 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235800   ⟸   XM_006235738
- Peptide Label: isoform X1
- UniProtKB: Q791R4 (UniProtKB/Swiss-Prot),   P35370 (UniProtKB/Swiss-Prot),   A6KLW2 (UniProtKB/TrEMBL),   Q9JIN4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001305876   ⟸   NM_001318947
- Peptide Label: isoform 1x
- UniProtKB: Q9JIN4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001305877   ⟸   NM_001318948
- Peptide Label: isoform 2
- UniProtKB: F7FLX3 (UniProtKB/TrEMBL),   A6KLW8 (UniProtKB/TrEMBL),   Q8CH83 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447005   ⟸   XM_017591516
- Peptide Label: isoform X3
- UniProtKB: A6KLW9 (UniProtKB/TrEMBL),   Q8CH83 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000030087   ⟸   ENSRNOT00000031328
Ensembl Acc Id: ENSRNOP00000047053   ⟸   ENSRNOT00000045845
RefSeq Acc Id: XP_038960359   ⟸   XM_039104431
- Peptide Label: isoform X1
- UniProtKB: P35370 (UniProtKB/Swiss-Prot),   Q791R4 (UniProtKB/Swiss-Prot),   A6KLW2 (UniProtKB/TrEMBL),   Q9JIN4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960360   ⟸   XM_039104432
- Peptide Label: isoform X2
- UniProtKB: F7FLX3 (UniProtKB/TrEMBL),   A6KLW8 (UniProtKB/TrEMBL),   Q8CH83 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960361   ⟸   XM_039104433
- Peptide Label: isoform X3
- UniProtKB: A6KLW9 (UniProtKB/TrEMBL),   Q8CH83 (UniProtKB/TrEMBL)
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35370-F1-model_v2 AlphaFold P35370 1-367 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68438 AgrOrtholog
BioCyc Gene G2FUF-46260 BioCyc
Ensembl Genes ENSRNOG00000016768 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000031328 ENTREZGENE
  ENSRNOT00000045845.4 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Opioid_rcpt UniProtKB/Swiss-Prot
  X_opioid_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:29256 UniProtKB/Swiss-Prot
NCBI Gene 29256 ENTREZGENE
PANTHER NEUROPEPTIDES RECEPTOR UniProtKB/Swiss-Prot
  NOCICEPTIN RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Oprl1 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  OPIOIDR UniProtKB/Swiss-Prot
  XOPIOIDR UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016768 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
TIGR TC229480
UniProt A6KLW2 ENTREZGENE, UniProtKB/TrEMBL
  A6KLW5_RAT UniProtKB/TrEMBL
  A6KLW8 ENTREZGENE, UniProtKB/TrEMBL
  A6KLW9 ENTREZGENE, UniProtKB/TrEMBL
  A6KLX2_RAT UniProtKB/TrEMBL
  F7FLX3 ENTREZGENE, UniProtKB/TrEMBL
  OPRX_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q791R4 ENTREZGENE
  Q8CH83 ENTREZGENE, UniProtKB/TrEMBL
  Q9JIN4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q791R4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-14 Oprl1  opioid related nociceptin receptor 1  Oprl1  opiate receptor-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Oprl1  opiate receptor-like 1  Oprl1  opioid receptor-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Oprl1  opioid receptor-like 1  Oprl  opioid receptor-like  Symbol and Name updated 1299863 APPROVED
2002-06-10 Oprl  opioid receptor-like      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in cortex, thalamus, subfornical organ, habenula, hypothalamus, central gray, dorsal raphe, locus coeruleus and the dorsal horn of the spinal cord 1299158
gene_function G protein-linked receptor with homology to opioid receptors 68282
gene_function G protein-linked receptor with homology to opioid receptors 68705
gene_process inhibits adenylate cyclase 68282
gene_process inhibits adenylate cyclase 68705
gene_process activates inwardly rectifying K+ channels 68282
gene_process activates inwardly rectifying K+ channels 68705
gene_process inhibits N-type voltage-operated Ca 2+ channels 68282
gene_process inhibits N-type voltage-operated Ca 2+ channels 68705
gene_process may represent a novel neuropeptide 68282
gene_process may represent a novel neuropeptide 68705