Epha3 (Eph receptor A3) - Rat Genome Database

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Gene: Epha3 (Eph receptor A3) Rattus norvegicus
Analyze
Symbol: Epha3
Name: Eph receptor A3
RGD ID: 68389
Description: Predicted to enable GPI-linked ephrin receptor activity; growth factor binding activity; and transmembrane-ephrin receptor activity. Involved in cellular response to interleukin-1; fever generation; and response to lipopolysaccharide. Predicted to be located in early endosome. Predicted to be active in several cellular components, including GABA-ergic synapse; dendrite; and presynapse. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human EPHA3 (EPH receptor A3); PARTICIPATES IN altered ephrin - ephrin receptor bidirectional signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: EK4; EPH-like kinase 4; ephrin type-A receptor 3; rEK4; tyrosine-protein kinase receptor REK4; tyrosine-protein kinase TYRO4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81114,585,041 - 14,920,721 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1114,586,727 - 14,920,425 (-)EnsemblGRCr8
mRatBN7.2111,138,485 - 1,474,102 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl111,140,985 - 1,473,900 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx119,737,055 - 10,069,925 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0112,530,362 - 2,863,260 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0111,635,123 - 1,968,001 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.011421,253 - 783,037 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl11421,135 - 782,954 (-)Ensemblrn6Rnor6.0
Rnor_5.011420,518 - 782,868 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.411696,185 - 1,033,287 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera111,134,161 - 1,466,533 (-)NCBICelera
RGSC_v3.111696,200 - 1,033,287 (-)NCBI
Cytogenetic Map11p12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-naphthylamine  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
alpha-amanitin  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP)
bucladesine  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cocaine  (EXP)
cyhalothrin  (EXP)
cypermethrin  (EXP)
DDD  (ISO)
DDE  (ISO)
DDT  (ISO)
dibutyl phthalate  (EXP)
dieldrin  (ISO)
dioxygen  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
endrin  (ISO)
entinostat  (ISO)
ethyl methanesulfonate  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (ISO)
genistein  (EXP,ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
medroxyprogesterone acetate  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nicotine  (ISO)
okadaic acid  (ISO)
ozone  (EXP)
panobinostat  (ISO)
permethrin  (EXP)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pioglitazone  (ISO)
ponatinib  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
pyrethrins  (EXP)
rofecoxib  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
valproic acid  (ISO)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
dendrite  (IBA)
early endosome  (ISO,ISS)
GABA-ergic synapse  (ISO)
membrane  (IEA)
plasma membrane  (IBA,IEA,ISO,ISS)
presynapse  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Inhibition of VEGF-dependent multistage carcinogenesis by soluble EphA receptors. Cheng N, etal., Neoplasia. 2003 Sep-Oct;5(5):445-56.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Upregulation of EphA3 receptor after spinal cord injury. Irizarry-Ramirez M, etal., J Neurotrauma. 2005 Aug;22(8):929-35.
4. Expression of Eph receptors and their ligands, ephrins, during lipopolysaccharide fever in rats. Ivanov AI, etal., Physiol Genomics. 2005 Apr 14;21(2):152-60. Epub 2005 Jan 25.
5. IL-1 beta alters the expression of the receptor tyrosine kinase gene r-EphA3 in neonatal rat cardiomyocytes. Li YY, etal., Am J Physiol 1998 Jan;274(1 Pt 2):H331-41.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Expression and function of the Eph A receptors and their ligands ephrins A in the rat thymus. Munoz JJ, etal., J Immunol 2002 Jul 1;169(1):177-84.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. The role of ephrins and Eph receptors in cancer. Surawska H, etal., Cytokine Growth Factor Rev 2004 Dec;15(6):419-33.
Additional References at PubMed
PMID:11870224   PMID:11877430   PMID:15145949   PMID:17046737   PMID:17910947   PMID:18403711   PMID:19505147   PMID:21135139   PMID:21791286   PMID:22275477   PMID:23242526   PMID:27721017  


Genomics

Comparative Map Data
Epha3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81114,585,041 - 14,920,721 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1114,586,727 - 14,920,425 (-)EnsemblGRCr8
mRatBN7.2111,138,485 - 1,474,102 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl111,140,985 - 1,473,900 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx119,737,055 - 10,069,925 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0112,530,362 - 2,863,260 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0111,635,123 - 1,968,001 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.011421,253 - 783,037 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl11421,135 - 782,954 (-)Ensemblrn6Rnor6.0
Rnor_5.011420,518 - 782,868 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.411696,185 - 1,033,287 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera111,134,161 - 1,466,533 (-)NCBICelera
RGSC_v3.111696,200 - 1,033,287 (-)NCBI
Cytogenetic Map11p12NCBI
EPHA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38389,107,621 - 89,482,134 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl389,107,522 - 89,482,437 (+)Ensemblhg38GRCh38
GRCh37389,156,771 - 89,531,284 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36389,239,364 - 89,613,974 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34389,239,501 - 89,532,185NCBI
Celera389,910,744 - 90,285,017 (+)NCBICelera
Cytogenetic Map3p11.1NCBI
HuRef389,169,906 - 89,544,877 (+)NCBIHuRef
CHM1_1389,109,505 - 89,484,203 (+)NCBICHM1_1
T2T-CHM13v2.0389,183,660 - 89,558,507 (+)NCBIT2T-CHM13v2.0
Epha3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391663,363,895 - 63,684,538 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1663,363,897 - 63,684,538 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381663,543,532 - 63,864,175 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1663,543,534 - 63,864,175 (-)Ensemblmm10GRCm38
MGSCv371663,545,044 - 63,863,983 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361663,487,420 - 63,806,359 (-)NCBIMGSCv36mm8
Celera1663,844,890 - 64,154,791 (-)NCBICelera
Cytogenetic Map16C1.3NCBI
cM Map1636.49NCBI
Epha3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554074,138,362 - 4,500,688 (-)Ensembl
ChiLan1.0NW_0049554074,135,671 - 4,500,900 (-)NCBIChiLan1.0ChiLan1.0
EPHA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2289,283,121 - 89,651,438 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1389,287,895 - 89,656,226 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0389,261,166 - 89,629,010 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1391,369,233 - 91,737,300 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl391,369,239 - 91,739,056 (+)EnsemblpanPan2panpan1.1
EPHA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.133770,234 - 1,092,063 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl33769,423 - 1,115,986 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha33949,355 - 1,298,894 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.033810,080 - 1,159,494 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl33810,033 - 1,149,524 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.133779,847 - 1,129,604 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.033811,416 - 1,161,165 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0331,284,819 - 1,381,967 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Epha3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404971462,842 - 799,414 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936610462,853 - 799,364 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936610462,842 - 799,466 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPHA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13166,592,493 - 166,942,767 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113166,592,492 - 166,942,791 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213177,406,602 - 177,539,843 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.213177,670,369 - 177,810,115 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EPHA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12287,480,220 - 87,840,628 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2287,480,126 - 87,838,512 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604178,860,955 - 79,218,698 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Epha3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247895,534,121 - 5,922,861 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247895,534,011 - 5,925,592 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Epha3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1478,541,273 - 78,867,160 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Epha3
2435 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:35
Count of miRNA genes:31
Interacting mature miRNAs:34
Transcripts:ENSRNOT00000040065
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11381815448818154Rat
1600394Edcs1Endometrial carcinoma susceptibility QTL12.90.04uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)111282315257823152Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)111080612555806125Rat

Markers in Region
Epha3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2111,140,949 - 1,141,092 (+)MAPPERmRatBN7.2
Rnor_6.011423,718 - 423,860NCBIRnor6.0
Rnor_5.011422,983 - 423,125UniSTSRnor5.0
RGSC_v3.411696,150 - 696,292UniSTSRGSC3.4
Celera111,134,126 - 1,134,268UniSTS
Cytogenetic Map11p12UniSTS
UniSTS:498373  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81114,608,253 - 14,608,321 (+)Marker Load Pipeline
mRatBN7.2111,161,712 - 1,161,779 (+)MAPPERmRatBN7.2
Rnor_6.011444,421 - 444,487NCBIRnor6.0
Rnor_5.011443,716 - 443,782UniSTSRnor5.0
RGSC_v3.411716,927 - 716,993UniSTSRGSC3.4
Celera111,154,834 - 1,154,900UniSTS
Cytogenetic Map11p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
11 9 67 146 91 90 59 26 59 6 252 123 11 125 51 89 31 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000040065   ⟹   ENSRNOP00000043263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1114,587,541 - 14,920,425 (-)Ensembl
mRatBN7.2 Ensembl111,140,985 - 1,473,900 (-)Ensembl
Rnor_6.0 Ensembl11423,753 - 782,954 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000090197   ⟹   ENSRNOP00000068593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1114,587,541 - 14,905,928 (-)Ensembl
mRatBN7.2 Ensembl111,140,985 - 1,459,294 (-)Ensembl
Rnor_6.0 Ensembl11421,135 - 768,644 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000122837   ⟹   ENSRNOP00000107600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1114,586,727 - 14,920,425 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000129933   ⟹   ENSRNOP00000108779
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1114,605,936 - 14,920,425 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000148608   ⟹   ENSRNOP00000108500
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1114,587,541 - 14,841,614 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000170454   ⟹   ENSRNOP00000110884
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1114,587,541 - 14,901,874 (-)Ensembl
RefSeq Acc Id: NM_031564   ⟹   NP_113752
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81114,587,541 - 14,920,425 (-)NCBI
mRatBN7.2111,140,985 - 1,473,900 (-)NCBI
Rnor_6.011423,753 - 782,954 (-)NCBI
Rnor_5.011420,518 - 782,868 (-)NCBI
RGSC_v3.411696,185 - 1,033,287 (-)RGD
Celera111,134,161 - 1,466,533 (-)RGD
Sequence:
RefSeq Acc Id: XM_006247976   ⟹   XP_006248038
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81114,585,041 - 14,920,721 (-)NCBI
mRatBN7.2111,138,485 - 1,474,100 (-)NCBI
Rnor_6.011421,253 - 783,037 (-)NCBI
Rnor_5.011420,518 - 782,868 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006247977   ⟹   XP_006248039
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81114,585,041 - 14,905,844 (-)NCBI
mRatBN7.2111,138,485 - 1,459,324 (-)NCBI
Rnor_6.011421,253 - 769,783 (-)NCBI
Rnor_5.011420,518 - 782,868 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039088234   ⟹   XP_038944162
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81114,585,041 - 14,920,618 (-)NCBI
mRatBN7.2111,138,485 - 1,474,102 (-)NCBI
RefSeq Acc Id: XM_039088235   ⟹   XP_038944163
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81114,585,041 - 14,905,723 (-)NCBI
mRatBN7.2111,138,485 - 1,459,191 (-)NCBI
RefSeq Acc Id: XM_039088236   ⟹   XP_038944164
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81114,585,041 - 14,844,711 (-)NCBI
mRatBN7.2111,138,485 - 1,398,187 (-)NCBI
RefSeq Acc Id: NP_113752   ⟸   NM_031564
- Peptide Label: precursor
- UniProtKB: O08680 (UniProtKB/Swiss-Prot),   G3V9D5 (UniProtKB/TrEMBL),   A6K4V7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248038   ⟸   XM_006247976
- Peptide Label: isoform X1
- UniProtKB: O08680 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006248039   ⟸   XM_006247977
- Peptide Label: isoform X2
- UniProtKB: O08680 (UniProtKB/Swiss-Prot),   A0A0G2JT71 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068593   ⟸   ENSRNOT00000090197
Ensembl Acc Id: ENSRNOP00000043263   ⟸   ENSRNOT00000040065
RefSeq Acc Id: XP_038944162   ⟸   XM_039088234
- Peptide Label: isoform X3
- UniProtKB: O08680 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038944163   ⟸   XM_039088235
- Peptide Label: isoform X4
- UniProtKB: O08680 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038944164   ⟸   XM_039088236
- Peptide Label: isoform X4
- UniProtKB: O08680 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000110884   ⟸   ENSRNOT00000170454
Ensembl Acc Id: ENSRNOP00000107600   ⟸   ENSRNOT00000122837
Ensembl Acc Id: ENSRNOP00000108500   ⟸   ENSRNOT00000148608
Ensembl Acc Id: ENSRNOP00000108779   ⟸   ENSRNOT00000129933
Protein Domains
Eph LBD   Fibronectin type-III   Protein kinase   SAM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08680-F1-model_v2 AlphaFold O08680 1-984 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68389 AgrOrtholog
BioCyc Gene G2FUF-22331 BioCyc
Ensembl Genes ENSRNOG00000030285 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000040065 ENTREZGENE
  ENSRNOT00000090197 ENTREZGENE
  ENSRNOT00000122837 ENTREZGENE
Gene3D-CATH 1.10.150.50 UniProtKB/Swiss-Prot
  2.60.40.10 UniProtKB/Swiss-Prot
  ephrin a2 ectodomain UniProtKB/Swiss-Prot
  Galactose-binding domain-like UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
  Tumor Necrosis Factor Receptor, subunit A, domain 2 UniProtKB/Swiss-Prot
InterPro Eph_TM UniProtKB/Swiss-Prot
  EphA3_rcpt_lig-bd UniProtKB/Swiss-Prot
  Ephrin_rcpt_lig-bd_dom UniProtKB/Swiss-Prot
  Ephrin_rcpt_TKs UniProtKB/Swiss-Prot
  FN3_dom UniProtKB/Swiss-Prot
  FN3_sf UniProtKB/Swiss-Prot
  Galactose-bd-like_sf UniProtKB/Swiss-Prot
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  SAM UniProtKB/Swiss-Prot
  SAM/pointed_sf UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Tyr-kin_ephrin_A/B_rcpt-like UniProtKB/Swiss-Prot
  Tyr_kinase_AS UniProtKB/Swiss-Prot
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Tyr_kinase_ephrin_rcpt UniProtKB/Swiss-Prot
  Tyr_kinase_rcpt_V_CS UniProtKB/Swiss-Prot
KEGG Report rno:29210 UniProtKB/Swiss-Prot
NCBI Gene 29210 ENTREZGENE
PANTHER EPH RECEPTOR A5 UniProtKB/Swiss-Prot
  EPHRIN TYPE-A RECEPTOR 3 UniProtKB/Swiss-Prot
Pfam EphA2_TM UniProtKB/Swiss-Prot
  Ephrin_lbd UniProtKB/Swiss-Prot
  Ephrin_rec_like UniProtKB/Swiss-Prot
  fn3 UniProtKB/Swiss-Prot
  Pkinase_Tyr UniProtKB/Swiss-Prot
  SAM_2 UniProtKB/Swiss-Prot
PhenoGen Epha3 PhenoGen
PIRSF TyrPK_ephrin_receptor UniProtKB/Swiss-Prot
PRINTS FNTYPEIII UniProtKB/Swiss-Prot
  TYRKINASE UniProtKB/Swiss-Prot
PROSITE EGF_2 UniProtKB/Swiss-Prot
  EPH_LBD UniProtKB/Swiss-Prot
  FN3 UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot
  RECEPTOR_TYR_KIN_V_1 UniProtKB/Swiss-Prot
  RECEPTOR_TYR_KIN_V_2 UniProtKB/Swiss-Prot
  SAM_DOMAIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000030285 RatGTEx
SMART EPH_lbd UniProtKB/Swiss-Prot
  Ephrin_rec_like UniProtKB/Swiss-Prot
  FN3 UniProtKB/Swiss-Prot
  SAM UniProtKB/Swiss-Prot
  TyrKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47769 UniProtKB/Swiss-Prot
  SSF49265 UniProtKB/Swiss-Prot
  SSF49785 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
  SSF57184 UniProtKB/Swiss-Prot
UniProt A0A0G2JT71 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LIZ6_RAT UniProtKB/TrEMBL
  A0ABK0LZK4_RAT UniProtKB/TrEMBL
  A0ABK0M121_RAT UniProtKB/TrEMBL
  A0ABK0M1C5_RAT UniProtKB/TrEMBL
  A6K4V7 ENTREZGENE, UniProtKB/TrEMBL
  EPHA3_RAT UniProtKB/Swiss-Prot
  G3V9D5 ENTREZGENE, UniProtKB/TrEMBL
  O08680 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Epha3  Eph receptor A3       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in leukemia cells, thymocytes from the subcapsulary region, cortex, and medulla and in epithelial cells of the thymic medulla 625721
gene_homology aa sequence for predicted gene shares 90-98% homology with human EPHA3, chick EphA3, and mouse EphA3 68243