Pttg1 (PTTG1 regulator of sister chromatid separation, securin) - Rat Genome Database

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Gene: Pttg1 (PTTG1 regulator of sister chromatid separation, securin) Rattus norvegicus
Analyze
Symbol: Pttg1
Name: PTTG1 regulator of sister chromatid separation, securin
RGD ID: 68359
Description: Enables heat shock protein binding activity and ribosome binding activity. Involved in negative regulation of cell population proliferation and regulation of cell growth. Predicted to be located in cytosol. Predicted to be active in axoneme and nucleus. Orthologous to several human genes including PTTG1 (PTTG1 regulator of sister chromatid separation, securin); PARTICIPATES IN cell cycle pathway, mitotic; INTERACTS WITH 1,3-dinitrobenzene; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Pituitary tumor transforming; Pituitary tumor transforming gene; pituitary tumor-transforming 1; pituitary tumor-transforming gene 1 protein; Pttg; securin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81028,394,940 - 28,406,410 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1028,394,814 - 28,406,309 (-)EnsemblGRCr8
mRatBN7.21027,893,466 - 27,904,965 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1027,893,689 - 27,904,837 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1032,659,668 - 32,665,276 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0101,198,056 - 1,203,663 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01027,630,195 - 27,635,798 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01029,014,332 - 29,026,088 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1029,020,049 - 29,026,002 (-)Ensemblrn6Rnor6.0
Rnor_5.01028,856,281 - 28,868,004 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41028,527,409 - 28,532,831 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1027,392,215 - 27,397,637 (-)NCBICelera
RGSC_v3.11028,528,480 - 28,533,880 (-)NCBI
Cytogenetic Map10q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-naringenin  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,3-dinitrobenzene  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-methylcholine  (ISO)
2-nitrofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,7-dihydropurine-6-thione  (EXP)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
Abemaciclib  (ISO)
acetamide  (EXP)
acrolein  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antimony(0)  (ISO)
antimycin A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-D-glucosamine  (EXP)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol AF  (ISO)
buspirone  (EXP)
butein  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbendazim  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
DDE  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
dieldrin  (EXP)
diethylstilbestrol  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
Echimidine  (ISO)
Enterolactone  (ISO)
ethanol  (EXP)
fenamidone  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gefitinib  (ISO)
geraniol  (ISO)
GW 7647  (ISO)
heptachlor  (EXP)
idarubicin  (ISO)
indole-3-methanol  (EXP)
irinotecan  (EXP)
isobutanol  (ISO)
Lasiocarpine  (ISO)
leflunomide  (EXP,ISO)
leptomycin B  (ISO)
levofloxacin  (EXP)
lidocaine  (EXP)
mercaptopurine  (EXP)
mercury atom  (ISO)
mercury(0)  (ISO)
methapyrilene  (EXP)
methcathinone  (ISO)
methyl methanesulfonate  (ISO)
mirex  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (ISO)
monoethyl phthalate  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nimesulide  (EXP)
nitric oxide  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP)
propanal  (ISO)
purine-6-thiol  (EXP)
pyrimidifen  (ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
riddelliine  (ISO)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
titanium dioxide  (EXP,ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
Triptolide  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (EXP,ISO)
tunicamycin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vincaleukoblastine  (ISO)
vorinostat  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axoneme  (IEA,ISO)
cilium  (IEA,ISO)
cytoplasm  (IEA,ISO)
cytosol  (ISO)
nucleus  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Functional role of estrogen in pituitary tumor pathogenesis. Heaney AP, etal., J Clin Invest 2002 Jan;109(2):277-83.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. Isolation and characterization of a pituitary tumor-transforming gene (PTTG). Pei L and Melmed S, Mol Endocrinol 1997 Apr;11(4):433-41.
7. Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells. Pei L J Biol Chem. 1999 Jan 29;274(5):3151-8.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:9478977   PMID:9811450   PMID:12477932   PMID:12970167   PMID:14561405   PMID:15845362   PMID:16533945   PMID:17325031   PMID:19800905   PMID:25023895   PMID:27250217   PMID:35050550  
PMID:37018988  


Genomics

Comparative Map Data
Pttg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81028,394,940 - 28,406,410 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1028,394,814 - 28,406,309 (-)EnsemblGRCr8
mRatBN7.21027,893,466 - 27,904,965 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1027,893,689 - 27,904,837 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1032,659,668 - 32,665,276 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0101,198,056 - 1,203,663 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01027,630,195 - 27,635,798 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01029,014,332 - 29,026,088 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1029,020,049 - 29,026,002 (-)Ensemblrn6Rnor6.0
Rnor_5.01028,856,281 - 28,868,004 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41028,527,409 - 28,532,831 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1027,392,215 - 27,397,637 (-)NCBICelera
RGSC_v3.11028,528,480 - 28,533,880 (-)NCBI
Cytogenetic Map10q21NCBI
PTTG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385160,421,855 - 160,428,744 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5160,421,816 - 160,428,748 (+)Ensemblhg38GRCh38
GRCh375159,848,862 - 159,855,751 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365159,781,443 - 159,788,324 (+)NCBIBuild 36Build 36hg18NCBI36
Build 345159,781,442 - 159,788,323NCBI
Celera5155,881,349 - 155,888,231 (+)NCBICelera
Cytogenetic Map5q33.3NCBI
HuRef5154,942,291 - 154,949,173 (+)NCBIHuRef
CHM1_15159,281,784 - 159,288,665 (+)NCBICHM1_1
T2T-CHM13v2.05160,950,365 - 160,957,262 (+)NCBIT2T-CHM13v2.0
Pttg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391143,311,097 - 43,317,417 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1143,311,077 - 43,317,078 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381143,420,244 - 43,427,463 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1143,420,250 - 43,426,251 (-)Ensemblmm10GRCm38
MGSCv371143,233,750 - 43,239,750 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361143,263,687 - 43,269,404 (-)NCBIMGSCv36mm8
Celera1148,048,753 - 48,054,761 (-)NCBICelera
Cytogenetic Map11B1.1NCBI
cM Map1125.68NCBI
Pttg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540814,293,957 - 14,301,422 (+)Ensembl
ChiLan1.0NW_00495540814,293,704 - 14,301,357 (+)NCBIChiLan1.0ChiLan1.0
PTTG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24155,607,256 - 155,614,192 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15153,746,802 - 153,753,738 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05155,812,745 - 155,819,684 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15162,506,954 - 162,513,869 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5162,506,832 - 162,513,869 (+)EnsemblpanPan2panpan1.1
PTTG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1450,301,868 - 50,309,636 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha450,197,498 - 50,205,256 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0450,737,382 - 50,745,152 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl450,737,391 - 50,744,665 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1450,545,760 - 50,553,525 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0450,669,501 - 50,677,252 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0451,189,832 - 51,197,602 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101977070
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494754,812,154 - 54,812,816 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936841274,750 - 275,133 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936841274,458 - 275,148 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTTG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12362,781,184 - 62,787,832 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603414,816,659 - 14,823,249 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pttg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473329,134,720 - 29,147,261 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Pttg1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1926,245,259 - 26,256,623 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pttg1
42 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:20
Count of miRNA genes:19
Interacting mature miRNAs:20
Transcripts:ENSRNOT00000005070
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
631531Iresp2Immunoglobin response QTL26.3blood immunoglobulin E amount (VT:0002492)serum immunoglobulin E level (CMO:0002101)102342212132490778Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
D10Wox45  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81028,407,427 - 28,407,657 (+)Marker Load Pipeline
mRatBN7.21027,905,955 - 27,906,187 (+)MAPPERmRatBN7.2
Rnor_6.01029,027,121 - 29,027,348NCBIRnor6.0
Rnor_5.01028,869,037 - 28,869,264UniSTSRnor5.0
RGSC_v3.41028,534,193 - 28,534,422UniSTSRGSC3.4
Celera1027,398,999 - 27,399,226UniSTS
Cytogenetic Map10q21UniSTS
RH133996  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81028,400,644 - 28,401,517 (+)Marker Load Pipeline
mRatBN7.21027,899,170 - 27,900,043 (+)MAPPERmRatBN7.2
Rnor_6.01029,020,027 - 29,020,899NCBIRnor6.0
Rnor_5.01028,861,943 - 28,862,815UniSTSRnor5.0
RGSC_v3.41028,527,410 - 28,528,282UniSTSRGSC3.4
Celera1027,392,216 - 27,393,088UniSTS
RH 3.4 Map10292.9UniSTS
Cytogenetic Map10q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000005070   ⟹   ENSRNOP00000005070
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1028,400,667 - 28,406,309 (-)Ensembl
mRatBN7.2 Ensembl1027,899,193 - 27,904,837 (-)Ensembl
Rnor_6.0 Ensembl1029,020,049 - 29,026,002 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093944   ⟹   ENSRNOP00000086678
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1028,394,814 - 28,406,309 (-)Ensembl
mRatBN7.2 Ensembl1027,893,689 - 27,904,837 (-)Ensembl
RefSeq Acc Id: NM_022391   ⟹   NP_071786
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81028,400,644 - 28,406,326 (-)NCBI
mRatBN7.21027,899,170 - 27,904,854 (-)NCBI
Rnor_6.01029,020,026 - 29,025,759 (-)NCBI
Rnor_5.01028,856,281 - 28,868,004 (-)NCBI
RGSC_v3.41028,527,409 - 28,532,831 (-)RGD
Celera1027,392,215 - 27,397,637 (-)RGD
Sequence:
RefSeq Acc Id: XM_006246142   ⟹   XP_006246204
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81028,400,644 - 28,406,401 (-)NCBI
mRatBN7.21027,899,170 - 27,904,965 (-)NCBI
Rnor_6.01029,020,026 - 29,026,088 (-)NCBI
Rnor_5.01028,856,281 - 28,868,004 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006246143   ⟹   XP_006246205
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81028,400,644 - 28,406,316 (-)NCBI
mRatBN7.21027,899,170 - 27,904,835 (-)NCBI
Rnor_6.01029,020,026 - 29,025,989 (-)NCBI
Rnor_5.01028,856,281 - 28,868,004 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006246144   ⟹   XP_006246206
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81028,400,644 - 28,406,315 (-)NCBI
mRatBN7.21027,899,170 - 27,904,835 (-)NCBI
Rnor_6.01029,020,026 - 29,025,997 (-)NCBI
Rnor_5.01028,856,281 - 28,868,004 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039086789   ⟹   XP_038942717
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81028,394,940 - 28,406,410 (-)NCBI
mRatBN7.21027,893,466 - 27,904,965 (-)NCBI
RefSeq Acc Id: XM_063269812   ⟹   XP_063125882
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81028,400,644 - 28,406,237 (-)NCBI
RefSeq Acc Id: XM_063269813   ⟹   XP_063125883
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81028,394,940 - 28,405,876 (-)NCBI
RefSeq Acc Id: XM_063269814   ⟹   XP_063125884
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81028,394,940 - 28,406,359 (-)NCBI
RefSeq Acc Id: NP_071786   ⟸   NM_022391
- UniProtKB: P97613 (UniProtKB/Swiss-Prot),   A6HDM7 (UniProtKB/TrEMBL),   B0BMT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246204   ⟸   XM_006246142
- Peptide Label: isoform X1
- UniProtKB: P97613 (UniProtKB/Swiss-Prot),   A6HDM7 (UniProtKB/TrEMBL),   B0BMT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246206   ⟸   XM_006246144
- Peptide Label: isoform X1
- UniProtKB: P97613 (UniProtKB/Swiss-Prot),   A6HDM7 (UniProtKB/TrEMBL),   B0BMT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246205   ⟸   XM_006246143
- Peptide Label: isoform X1
- UniProtKB: P97613 (UniProtKB/Swiss-Prot),   A6HDM7 (UniProtKB/TrEMBL),   B0BMT1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005070   ⟸   ENSRNOT00000005070
RefSeq Acc Id: XP_038942717   ⟸   XM_039086789
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A1P6 (UniProtKB/TrEMBL),   A6HDM7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000086678   ⟸   ENSRNOT00000093944
RefSeq Acc Id: XP_063125884   ⟸   XM_063269814
- Peptide Label: isoform X2
- UniProtKB: A6HDM7 (UniProtKB/TrEMBL),   A0A8I6A1P6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125883   ⟸   XM_063269813
- Peptide Label: isoform X1
- UniProtKB: P97613 (UniProtKB/Swiss-Prot),   A6HDM7 (UniProtKB/TrEMBL),   B0BMT1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125882   ⟸   XM_063269812
- Peptide Label: isoform X1
- UniProtKB: P97613 (UniProtKB/Swiss-Prot),   A6HDM7 (UniProtKB/TrEMBL),   B0BMT1 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97613-F1-model_v2 AlphaFold P97613 1-199 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697111
Promoter ID:EPDNEW_R7636
Type:initiation region
Name:Pttg1_1
Description:pituitary tumor-transforming 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01029,026,045 - 29,026,105EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68359 AgrOrtholog
BioCyc Gene G2FUF-25455 BioCyc
Ensembl Genes ENSRNOG00000003802 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005070 ENTREZGENE
  ENSRNOT00000005070.6 UniProtKB/Swiss-Prot
  ENSRNOT00000093944 ENTREZGENE
IMAGE_CLONE IMAGE:9032805 IMAGE-MGC_LOAD
InterPro Securin_separation_inhibitor UniProtKB/Swiss-Prot
KEGG Report rno:64193 UniProtKB/Swiss-Prot
MGC_CLONE MGC:187213 IMAGE-MGC_LOAD
NCBI Gene Pttg1 ENTREZGENE
PANTHER PTHR10418 UniProtKB/Swiss-Prot
  SECURIN UniProtKB/Swiss-Prot
Pfam Securin UniProtKB/Swiss-Prot
PhenoGen Pttg1 PhenoGen
RatGTEx ENSRNOG00000003802 RatGTEx
TIGR TC217859
UniProt A0A8I6A1P6 ENTREZGENE, UniProtKB/TrEMBL
  A6HDM7 ENTREZGENE, UniProtKB/TrEMBL
  B0BMT1 ENTREZGENE, UniProtKB/TrEMBL
  P97613 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-03 Pttg1  PTTG1 regulator of sister chromatid separation, securin  Pttg1  pituitary tumor-transforming 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Pttg1  pituitary tumor-transforming 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the pituitary adenoma during the rat estrus cycle 70521
gene_expression displays highest mRNA expression in pituitary tumor cells 68295
gene_process induced by estrogen 70521
gene_regulation progesterone down inhibits mRNA induction 70521