PTTG1 (PTTG1 regulator of sister chromatid separation, securin) - Rat Genome Database

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Gene: PTTG1 (PTTG1 regulator of sister chromatid separation, securin) Pan paniscus
Analyze
Symbol: PTTG1
Name: PTTG1 regulator of sister chromatid separation, securin
RGD ID: 11677167
Description: ENCODES a protein that exhibits cysteine-type endopeptidase inhibitor activity (ortholog); heat shock protein binding (ortholog); molecular function activator activity (ortholog); INVOLVED IN chromosome segregation (ortholog); homologous chromosome segregation (ortholog); mitotic sister chromatid cohesion (ortholog); ASSOCIATED WITH hepatocellular carcinoma (ortholog); Pituitary Neoplasms (ortholog); psoriasis (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: pituitary tumor-transforming 1; securin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24155,607,256 - 155,614,192 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15153,746,802 - 153,753,738 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05155,812,745 - 155,819,684 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15162,506,954 - 162,513,869 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5162,506,832 - 162,513,869 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
nucleus  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PTTG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24155,607,256 - 155,614,192 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15153,746,802 - 153,753,738 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05155,812,745 - 155,819,684 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15162,506,954 - 162,513,869 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5162,506,832 - 162,513,869 (+)Ensemblpanpan1.1panPan2
PTTG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385160,421,855 - 160,428,744 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5160,421,855 - 160,428,739 (+)EnsemblGRCh38hg38GRCh38
GRCh375159,848,862 - 159,855,751 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365159,781,443 - 159,788,324 (+)NCBINCBI36Build 36hg18NCBI36
Build 345159,781,442 - 159,788,323NCBI
Celera5155,881,349 - 155,888,231 (+)NCBICelera
Cytogenetic Map5q33.3NCBI
HuRef5154,942,291 - 154,949,173 (+)NCBIHuRef
CHM1_15159,281,784 - 159,288,665 (+)NCBICHM1_1
T2T-CHM13v2.05160,950,365 - 160,957,262 (+)NCBIT2T-CHM13v2.0
Pttg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391143,311,097 - 43,317,417 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1143,311,077 - 43,317,078 (-)EnsemblGRCm39 Ensembl
GRCm381143,420,244 - 43,427,463 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1143,420,250 - 43,426,251 (-)EnsemblGRCm38mm10GRCm38
MGSCv371143,233,750 - 43,239,750 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361143,263,687 - 43,269,404 (-)NCBIMGSCv36mm8
Celera1148,048,753 - 48,054,761 (-)NCBICelera
Cytogenetic Map11B1.1NCBI
cM Map1125.68NCBI
Pttg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81028,394,940 - 28,406,410 (-)NCBIGRCr8
mRatBN7.21027,893,466 - 27,904,965 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1027,893,689 - 27,904,837 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1032,659,668 - 32,665,276 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0101,198,056 - 1,203,663 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01027,630,195 - 27,635,798 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01029,014,332 - 29,026,088 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1029,020,049 - 29,026,002 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01028,856,281 - 28,868,004 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41028,527,409 - 28,532,831 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11028,528,480 - 28,533,880 (-)NCBI
Celera1027,392,215 - 27,397,637 (-)NCBICelera
Cytogenetic Map10q21NCBI
Pttg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540814,293,704 - 14,301,357 (+)NCBIChiLan1.0ChiLan1.0
PTTG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1450,301,868 - 50,309,636 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha450,197,498 - 50,205,256 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0450,737,382 - 50,745,152 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl450,737,391 - 50,744,665 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1450,545,760 - 50,553,525 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0450,669,501 - 50,677,252 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0451,189,832 - 51,197,602 (-)NCBIUU_Cfam_GSD_1.0
LOC101977070
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494754,812,154 - 54,812,816 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936841274,458 - 275,148 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTTG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12362,781,184 - 62,787,832 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603414,816,659 - 14,823,249 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pttg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473329,134,720 - 29,147,261 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000037035   ⟹   ENSPPAP00000014353
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl5162,506,832 - 162,513,810 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000037043   ⟹   ENSPPAP00000014361
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl5162,507,051 - 162,513,869 (+)Ensembl
RefSeq Acc Id: XM_003808021   ⟹   XP_003808069
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v24155,607,256 - 155,614,192 (+)NCBI
NHGRI_mPanPan15153,746,802 - 153,753,738 (+)NCBI
Mhudiblu_PPA_v05155,812,745 - 155,819,684 (+)NCBI
PanPan1.15162,506,954 - 162,513,869 (+)NCBI
Sequence:
RefSeq Acc Id: XM_003808022   ⟹   XP_003808070
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v24155,607,473 - 155,614,192 (+)NCBI
NHGRI_mPanPan15153,747,017 - 153,753,738 (+)NCBI
Mhudiblu_PPA_v05155,812,955 - 155,819,684 (+)NCBI
PanPan1.15162,507,051 - 162,513,869 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034960912   ⟹   XP_034816803
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v24155,607,256 - 155,614,192 (+)NCBI
NHGRI_mPanPan15153,746,802 - 153,753,738 (+)NCBI
Mhudiblu_PPA_v05155,812,745 - 155,819,684 (+)NCBI
RefSeq Acc Id: XM_034960913   ⟹   XP_034816804
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v24155,607,357 - 155,614,192 (+)NCBI
NHGRI_mPanPan15153,746,903 - 153,753,738 (+)NCBI
Mhudiblu_PPA_v05155,812,869 - 155,819,684 (+)NCBI
Protein Sequences
Protein RefSeqs XP_003808069 (Get FASTA)   NCBI Sequence Viewer  
  XP_003808070 (Get FASTA)   NCBI Sequence Viewer  
  XP_034816803 (Get FASTA)   NCBI Sequence Viewer  
  XP_034816804 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABM54321 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000014353.1
  ENSPPAP00000014361.1
Reference Protein Sequences
RefSeq Acc Id: XP_003808069   ⟸   XM_003808021
- Peptide Label: isoform X2
- UniProtKB: A0A2R9ABT9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003808070   ⟸   XM_003808022
- Peptide Label: isoform X2
- UniProtKB: A0A2R9ABT9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034816803   ⟸   XM_034960912
- Peptide Label: isoform X1
- UniProtKB: A0A2R9ABT9 (UniProtKB/TrEMBL),   A0A2R9AFP4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034816804   ⟸   XM_034960913
- Peptide Label: isoform X1
- UniProtKB: A0A2R9ABT9 (UniProtKB/TrEMBL),   A0A2R9AFP4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000014361   ⟸   ENSPPAT00000037043
RefSeq Acc Id: ENSPPAP00000014353   ⟸   ENSPPAT00000037035


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000030326 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000037035.1 UniProtKB/TrEMBL
  ENSPPAT00000037043.1 UniProtKB/TrEMBL
InterPro Securin_separation_inhibitor UniProtKB/TrEMBL
KEGG Report pps:100978415 UniProtKB/TrEMBL
NCBI Gene PTTG1 ENTREZGENE
PANTHER PTHR10418 UniProtKB/TrEMBL
  SECURIN UniProtKB/TrEMBL
Pfam Securin UniProtKB/TrEMBL
UniProt A0A2R9ABT9 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AFP4 ENTREZGENE, UniProtKB/TrEMBL
  A1YG96_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-03-12 PTTG1  PTTG1 regulator of sister chromatid separation, securin    pituitary tumor-transforming 1  Symbol and/or name change 5135510 APPROVED