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Gene: Sec61a1 (SEC61 translocon subunit alpha 1) Rattus norvegicus

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Symbol:

Sec61a1

Name:

SEC61 translocon subunit alpha 1

RGD ID:

68321

Description:

Predicted to enable several functions, including calcium channel activity; protein transmembrane transporter activity; and ribosome binding activity. Involved in response to type II interferon. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of Sec61 translocon complex. Human ortholog(s) of this gene implicated in autosomal dominant tubulointerstitial kidney disease 5; common variable immunodeficiency; and severe congenital neutropenia. Orthologous to human SEC61A1 (SEC61 translocon subunit alpha 1); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; phagocytosis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; aconitine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

protein transport protein Sec61 subunit alpha; protein transport protein Sec61 subunit alpha isoform 1; Sec61 alpha 1 subunit; Sec61 alpha 1 subunit (S. cerevisiae); Sec61 alpha subunit homolog; sec61 alpha-1; Sec61 translocon alpha 1 subunit; SEC61, alpha subunit; SEC61, alpha subunit (S. cerevisiae); Sec61a

RGD Orthologs

Alliance Orthologs

More Info

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More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SEC61A1 (SEC61 translocon subunit alpha 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Sec61a1 (SEC61 translocon subunit alpha 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Sec61a1 (SEC61 translocon subunit alpha 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SEC61A1 (SEC61 translocon subunit alpha 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SEC61A1 (SEC61 translocon subunit alpha 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Sec61a1 (SEC61 translocon subunit alpha 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SEC61A1 (SEC61 translocon subunit alpha 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SEC61A1 (SEC61 translocon subunit alpha 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sec61a1 (SEC61 translocon subunit alpha 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Sec61a1 (SEC61 translocon subunit alpha 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	SEC61A2 (SEC61 translocon subunit alpha 2)	HGNC	OrthoDB
Homo sapiens (human):	NRP1 (neuropilin 1)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Sec61a1 (SEC61 translocon subunit alpha 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	SEC61A1 (SEC61 translocon subunit alpha 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	sec61a1l (Sec61 translocon alpha 1 subunit, like)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	sec61a1l (Sec61 translocon alpha 1 subunit, like)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	sec61a1 (Sec61 translocon alpha 1 subunit)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	sec-61	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SEC61	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Sec61alpha	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	sec61a1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	sec61a1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	122,530,785 - 122,545,141 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	122,530,789 - 122,545,141 (-)	Ensembl				GRCr8
mRatBN7.2	4	120,973,519 - 120,987,871 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	120,960,626 - 120,987,925 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	126,444,117 - 126,458,473 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	122,218,872 - 122,233,228 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	120,843,116 - 120,857,472 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	120,453,577 - 120,467,932 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	120,453,581 - 120,467,932 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	185,693,504 - 185,707,859 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	122,597,889 - 122,612,245 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	109,929,352 - 109,943,708 (-)	NCBI		Celera
RGSC_v3.1	4	122,842,369 - 122,856,726 (-)	NCBI
Cytogenetic Map	4	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant tubulointerstitial kidney disease 5 (ISO)

autosomal recessive Alport syndrome (ISO)

Common Variable Immunodeficiency 15 (ISO)

Craniofacial Abnormalities (ISO)

genetic disease (ISO)

Severe Congenital Neutropenia 11, Autosomal Dominant (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dimethoxyphenol (ISO)

2-hydroxypropanoic acid (ISO)

2-methylcholine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (EXP,ISO)

aconitine (EXP)

acrylamide (EXP)

ammonium chloride (EXP)

antirheumatic drug (ISO)

Aroclor 1254 (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

bisphenol F (EXP,ISO)

buspirone (EXP)

Butylbenzyl phthalate (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

calcium atom (ISO)

calcium(0) (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

clobetasol (ISO)

clofibrate (ISO)

clofibric acid (EXP)

copper(II) sulfate (ISO)

coumarin (ISO)

coumestrol (ISO)

Cuprizon (ISO)

cyclosporin A (ISO)

cyproconazole (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (EXP,ISO)

diethylstilbestrol (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

fipronil (EXP)

folic acid (ISO)

formaldehyde (ISO)

furfural (ISO)

genistein (ISO)

gentamycin (EXP)

glafenine (EXP)

glyphosate (ISO)

haloperidol (ISO)

ivermectin (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

N-nitrosodiethylamine (EXP)

nickel atom (ISO)

nimesulide (EXP)

paracetamol (ISO)

perfluorohexanesulfonic acid (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (EXP)

propiconazole (ISO)

rac-lactic acid (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sodium chloride (ISO)

sunitinib (ISO)

tamoxifen (ISO)

testosterone (ISO)

testosterone enanthate (ISO)

tetrachloromethane (ISO)

thapsigargin (EXP,ISO)

titanium dioxide (ISO)

triadimefon (ISO)

troglitazone (ISO)

tunicamycin (ISO)

valproic acid (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

calcium ion transmembrane transport (IEA)

cotranslational protein targeting to membrane (IEA,ISO,ISS)

endoplasmic reticulum organization (ISO)

post-translational protein targeting to endoplasmic reticulum membrane (ISO)

post-translational protein targeting to membrane, translocation (IBA,IEA,ISO,ISS)

pronephric nephron development (IEA,ISO,ISS)

protein insertion into ER membrane (IEA,ISO,ISS)

protein targeting to ER (ISO)

protein transport (IEA)

response to type II interferon (IEP)

SRP-dependent cotranslational protein targeting to membrane (ISO)

SRP-dependent cotranslational protein targeting to membrane, translocation (IBA,IEA,ISO)

Cellular Component

endoplasmic reticulum (IEA,ISO)

endoplasmic reticulum membrane (IEA,ISO,ISS)

membrane (IEA,ISO)

Sec61 translocon complex (IBA,IEA,ISO)

Molecular Function

calcium channel activity (IEA,ISO,ISS)

protein binding (ISO)

protein transmembrane transporter activity (IBA)

ribosome binding (IBA,IEA,ISO,ISS)

signal sequence binding (IBA)

transmembrane transporter activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Endoplasmic Reticulum-associated degradation pathway (IEA)

phagocytosis pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation.	Gorlich D, etal., Cell 1992 Oct 30;71(3):489-503.
3.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	Interferon-gamma potentiates endoplasmic reticulum stress-induced death by reducing pancreatic beta cell defence mechanisms.	Pirot P, etal., Diabetologia. 2006 Jun;49(6):1229-36. Epub 2006 Apr 8.
6.	GOA pipeline	RGD automated data pipeline
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:12477932	PMID:14508489	PMID:14508490	PMID:14596596	PMID:16705175	PMID:16778019	PMID:18480044	PMID:22375059	PMID:27392076	PMID:28782633	PMID:29719251

Genomics

Comparative Map Data

Sec61a1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	122,530,785 - 122,545,141 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	122,530,789 - 122,545,141 (-)	Ensembl				GRCr8
mRatBN7.2	4	120,973,519 - 120,987,871 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	120,960,626 - 120,987,925 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	126,444,117 - 126,458,473 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	122,218,872 - 122,233,228 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	120,843,116 - 120,857,472 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	120,453,577 - 120,467,932 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	120,453,581 - 120,467,932 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	185,693,504 - 185,707,859 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	122,597,889 - 122,612,245 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	109,929,352 - 109,943,708 (-)	NCBI		Celera
RGSC_v3.1	4	122,842,369 - 122,856,726 (-)	NCBI
Cytogenetic Map	4	q34	NCBI

SEC61A1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	128,051,641 - 128,071,683 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	128,051,641 - 128,071,705 (+)	Ensembl			hg38	GRCh38
GRCh37	3	127,770,484 - 127,790,526 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	129,253,902 - 129,273,216 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	3	129,253,909 - 129,273,223	NCBI
Celera	3	126,201,130 - 126,220,443 (+)	NCBI		Celera
Cytogenetic Map	3	q21.3	NCBI
HuRef	3	125,151,693 - 125,170,962 (+)	NCBI		HuRef
CHM1_1	3	127,734,421 - 127,753,735 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	130,786,219 - 130,806,258 (+)	NCBI		T2T-CHM13v2.0

Sec61a1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	88,480,589 - 88,495,782 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	88,480,561 - 88,495,887 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	6	88,503,607 - 88,518,800 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	88,503,579 - 88,518,905 (-)	Ensembl			mm10	GRCm38
MGSCv37	6	88,453,601 - 88,468,794 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	6	88,469,248 - 88,484,441 (-)	NCBI		MGSCv36	mm8
Celera	6	90,445,389 - 90,460,590 (-)	NCBI		Celera
Cytogenetic Map	6	D1	NCBI
cM Map	6	39.51	NCBI

Sec61a1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955429	15,637,325 - 15,652,556 (-)	Ensembl
ChiLan1.0	NW_004955429	15,637,461 - 15,652,556 (-)	NCBI	ChiLan1.0	ChiLan1.0

SEC61A1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	125,970,165 - 125,989,780 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	125,974,887 - 125,994,502 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	125,091,916 - 125,111,238 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	132,457,658 - 132,476,935 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	132,457,005 - 132,476,935 (+)	Ensembl			panPan2	panpan1.1

SEC61A1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	2,070,739 - 2,087,790 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	2,070,248 - 2,087,789 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	2,106,985 - 2,124,750 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	2,091,105 - 2,109,038 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	2,091,058 - 2,109,038 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	1,812,164 - 1,829,894 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	2,138,938 - 2,156,767 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	2,099,082 - 2,117,009 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Sec61a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404942	20,536,221 - 20,546,520 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936798	578,038 - 587,192 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936798	578,090 - 587,010 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SEC61A1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	72,254,464 - 72,269,914 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	13	72,254,462 - 72,276,484 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	79,737,470 - 79,751,229 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SEC61A1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	52,977,101 - 52,994,766 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	52,976,872 - 52,992,039 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666041	113,361,009 - 113,378,787 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sec61a1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624961	467,656 - 477,884 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624961	466,234 - 477,880 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Sec61a1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	6	57,802,034 - 57,816,577 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Sec61a1
149 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	231
Count of miRNA genes:	143
Interacting mature miRNAs:	180
Transcripts:	ENSRNOT00000018454
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1582232	Gluco25	Glucose level QTL 25	3.6	0.0023	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	86583980	149763391	Rat
631689	Scl4	Serum cholesterol level QTL 4	1.9	0.008	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	4	96731383	141731383	Rat
2302049	Pia32	Pristane induced arthritis QTL 32	5.1	0.001	blood autoantibody amount (VT:0003725)	serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)	4	107346299	152346299	Rat
1358352	Srcrt3	Stress Responsive Cort QTL 3	2.29		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	39431983	123203361	Rat
1578655	Bmd11	Bone mineral density QTL 11	11		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	4	92406430	137406430	Rat
1300116	Hrtrt5	Heart rate QTL 5	3.76		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	4	117737142	152833657	Rat
10755501	Bp390	Blood pressure QTL 390	2.5		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	4	27730518	170099664	Rat
6478763	Anxrr46	Anxiety related response QTL 46		0.07428	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	112427331	157427331	Rat
6478760	Anxrr45	Anxiety related response QTL 45		0.06717	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	112427331	157427331	Rat
1331802	Srn5	Serum renin concentration QTL 5	3.045		renin activity (VT:0005581)	plasma renin activity level (CMO:0000116)	4	117559384	162559384	Rat
61330	Eau1	Experimental allergic uveoretinitis QTL 1		0.0003	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	4	26234499	134199155	Rat
738009	Sach4	Saccharine consumption QTL 4	4.9	0.000016	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	60916264	184426481	Rat
2306545	Iddm39	Insulin dependent diabetes mellitus QTL 39			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	78687630	123687630	Rat
7207480	Bss105	Bone structure and strength QTL 105	8.1		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	4	111383604	156383604	Rat
634335	Anxrr16	Anxiety related response QTL 16	7.22		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	4	94638356	168870820	Rat
737821	Hcar9	Hepatocarcinoma resistance QTL 9	3.7		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	4	106848959	168870974	Rat
731165	Uae21	Urinary albumin excretion QTL 21	2.4	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	4	108206096	153206096	Rat
631646	Stl4	Serum triglyceride level QTL 4	6.5	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	4	74169813	134199155	Rat
634334	Xhs3	X-ray hypersensitivity QTL 3	10		intestine integrity trait (VT:0010554)	post-insult time to onset of moribundity (CMO:0001896)	4	86058928	131411333	Rat
61406	Scwia1	Streptococcal cell wall induced arthritis QTL 1	2.3		joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	4	75939858	140508796	Rat
1549832	Bss3	Bone structure and strength QTL 3	11		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	4	111383604	156383604	Rat
1354612	Foco1	Food consumption QTL 1	8.87		eating behavior trait (VT:0001431)	food intake rate (CMO:0000427)	4	45429897	149763204	Rat
70177	Xhs1	X-ray hypersensitivity QTL 1	25.1		intestine integrity trait (VT:0010554)	post-insult time to onset of moribundity (CMO:0001896)	4	82944895	154403548	Rat
6909128	Pancm4	Pancreatic morphology QTL 4	11.35		pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	4	27862204	126119996	Rat
2303168	Bp330	Blood pressure QTL 330	4.25	0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	5889999	148002343	Rat
738031	Alc14	Alcohol consumption QTL 14	7.6	0.00003	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	60916264	174095838	Rat
61476	Aia3	Adjuvant induced arthritis QTL 3	3.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	75939858	140508796	Rat
1576316	Ept5	Estrogen-induced pituitary tumorigenesis QTL 5	3.8		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	4	100752691	179366077	Rat
1641919	Alc22	Alcohol consumption QTL 22		0.0005	drinking behavior trait (VT:0001422)	ethanol drink intake rate (CMO:0001407)	4	65060960	127749483	Rat
631662	Hcar2	Hepatocarcinoma resistance QTL 2	3.1	0.0003	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	4	84349032	129349032	Rat
1576305	Emca6	Estrogen-induced mammary cancer QTL 6	5.8		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	4	45429709	157555683	Rat
61418	Pia5	Pristane induced arthritis QTL 5	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	63245026	129846354	Rat
738016	Alc16	Alcohol consumption QTL 16	3.6	0.00015	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	60916264	184426481	Rat
1358202	Gluco11	Glucose level QTL 11	2.4	0.02	adipocyte glucose uptake trait (VT:0004185)	absolute change in adipocyte glucose uptake (CMO:0000873)	4	86709649	168870974	Rat
1354660	Salc1	Saline consumption QTL 1	11.26		drinking behavior trait (VT:0001422)	saline drink intake rate (CMO:0001627)	4	45429897	149763204	Rat
1641833	Alc21	Alcohol consumption QTL 21	8.6	0.0001	drinking behavior trait (VT:0001422)	ethanol drink intake rate (CMO:0001407)	4	57664252	127749483	Rat
2306899	Bp338	Blood pressure QTL 338		0.071	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	82336765	127336765	Rat
631674	Iddm14	Insulin dependent diabetes mellitus QTL 14			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	4	65495851	159259805	Rat
2293840	Kiddil9	Kidney dilation QTL 9	2.9		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	4	113634167	149763391	Rat
12798519	Anxrr54	Anxiety related response QTL 54	2.54	0.05	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	116184844	161184844	Rat
1578670	Bss14	Bone structure and strength QTL 14	16.4		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	4	88883695	133883695	Rat
12798523	Anxrr56	Anxiety related response QTL 56	2.83	0.05	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	86583980	131583980	Rat
70201	Gcr1	Gastric cancer resistance QTL 1	2.7		stomach morphology trait (VT:0000470)	stomach tumor susceptibility score (CMO:0002043)	4	103834277	148834277	Rat
70200	Alc18	Alcohol consumption QTL 18	9.2		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	4	57613339	151163960	Rat
12798527	Anxrr58	Anxiety related response QTL 58	4.11	0.05	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	121020385	148834277	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	12212457	182430611	Rat
1578662	Bss15	Bone structure and strength QTL 15	19.6		femur width (VT:1000666)	femoral neck width (CMO:0001695)	4	88883695	133883695	Rat

Markers in Region

RH125916

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	120,973,527 - 120,973,780 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	120,453,586 - 120,453,838	NCBI	Rnor6.0
Rnor_5.0	4	185,693,513 - 185,693,765	UniSTS	Rnor5.0
RGSC_v3.4	4	122,597,898 - 122,598,150	UniSTS	RGSC3.4
Celera	4	109,929,361 - 109,929,613	UniSTS
Cytogenetic Map	4	q34	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	163	91	90	59	92	59	6	356	192	11	142	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_199256	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC119580	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC094530	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473957	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ764372	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M96630	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000018454 ⟹ ENSRNOP00000018455

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	122,530,789 - 122,545,141 (-)	Ensembl
mRatBN7.2 Ensembl	4	120,960,626 - 120,987,925 (-)	Ensembl
Rnor_6.0 Ensembl	4	120,453,581 - 120,467,932 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000100731 ⟹ ENSRNOP00000082887

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	120,960,626 - 120,987,622 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000100854 ⟹ ENSRNOP00000087817

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	120,960,626 - 120,987,901 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000111696 ⟹ ENSRNOP00000088931

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	120,960,626 - 120,987,622 (-)	Ensembl

RefSeq Acc Id:

NM_199256 ⟹ NP_954865

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	122,530,785 - 122,545,141 (-)	NCBI
mRatBN7.2	4	120,973,519 - 120,987,871 (-)	NCBI
Rnor_6.0	4	120,453,577 - 120,467,932 (-)	NCBI
Rnor_5.0	4	185,693,504 - 185,707,859 (-)	NCBI
RGSC_v3.4	4	122,597,889 - 122,612,245 (-)	RGD
Celera	4	109,929,352 - 109,943,708 (-)	RGD

Sequence:

show sequence

GACGTGTCTCTCGGCTGAGGAAGCGCGCTCCAGATCTAGCAGCACCGTCGCCTCACTCGAAGTG
GAGCGCAGTCGAGGCAGGGAGTGTAGTCGGACCAGCCACCGCCATGGCGATCAAATTTCTGGAA
GTCATCAAGCCATTCTGTGTCATCTTGCCGGAAATTCAGAAGCCAGAGAGAAAGATTCAGTTTA
AGGAGAAGGTGTTGTGGACGGCCATCACCCTCTTCATCTTCTTAGTATGCTGCCAGATTCCCCT
GTTTGGCATCATGTCTTCAGACTCAGCTGACCCCTTCTACTGGATGCGAGTGATTCTGGCCTCT
AACAGAGGTACCTTGATGGAGCTGGGTATCTCTCCTATTGTCACGTCCGGCCTTATCATGCAGC
TCTTAGCTGGTGCCAAGATAATTGAAGTTGGGGACACCCCGAAAGACCGAGCTCTCTTCAATGG
AGCCCAAAAGTTGTTTGGAATGATCATCACTATCGGTCAGTCCATTGTGTACGTGATGACGGGC
ATGTACGGGGACCCTTCAGAGATGGGTGCTGGAATCTGCCTGCTGATCACCATTCAGCTCTTTG
TTGCTGGCTTAATTGTCCTACTTTTGGATGAACTCCTGCAGAAAGGATATGGCTTGGGCTCTGG
CATCTCTCTCTTCATTGCGACTAATATCTGTGAGACCATTGTATGGAAGGCATTCAGCCCCACC
ACTGTCAACACTGGCCGAGGGATGGAATTTGAAGGCGCCATCATTGCGCTGTTCCACCTGCTGG
CCACCCGCACAGACAAGGTCCGAGCCCTTCGAGAGGCATTCTACCGCCAGAACCTCCCTAACCT
CATGAACCTGATTGCCACCATCTTCGTCTTTGCTGTTGTCATCTATTTCCAGGGCTTCCGAGTG
GACCTTCCAATCAAGTCGGCGCGTTACCGAGGCCAGTACAATACCTACCCCATCAAGCTCTTCT
ACACCTCCAACATTCCCATCATCTTGCAGTCTGCTCTGGTGTCCAACCTGTATGTCATCTCCCA
GATGCTGTCAGCACGTTTCAGTGGCAACCTGCTGGTTAGCCTGCTGGGCACCTGGTCGGATACG
TCATCTGGGGGCCCAGCCCGTGCTTACCCAGTTGGTGGCCTGTGTTACTACCTGTCTCCTCCGG
AATCATTCGGCTCAGTGCTGGAGGACCCTGTCCATGCGGTCGTGTACATTGTATTCATGCTGGG
TTCCTGTGCATTCTTTTCCAAAACATGGATCGAAGTTTCGGGTTCTTCTGCCAAAGATGTTGCC
AAGCAGCTGAAGGAGCAGCAGATGGTGATGAGAGGCCACAGGGAGACCTCCATGGTGCATGAGC
TCAACCGGTACATCCCCACAGCTGCAGCCTTCGGTGGGCTGTGCATTGGGGCCCTCTCTGTCCT
GGCTGATTTCCTGGGTGCTATCGGGTCTGGCACCGGGATCCTGCTGGCGGTCACCATCATCTAC
CAGTACTTTGAGATCTTCGTCAAAGAGCAGAGCGAGGTGGGCAGCATGGGAGCCCTTCTCTTCT
GAGCCTCGTGTGCCTGTGGACCAGGGTGAGGGCACAGGCTCCAGAACTGCCCCGGAAGGGTGCT
CTTACTGCTGGAGCATGCTACTGTGGCATAGGGACTTTAATTTTTTTTTTTTTAATTTCATATC
TTTTCATTCCACTGTGTAAAGTGCTAGGAAATTTCCAATTTGAAGTTTTGCTTTTTCTGACATT
GGCAAGAGACTGATAGAAGTGAATTGTTAGCTGATGTCTGGGGTGTGATAACAAATTGTCCCCA
AGTTTCCAATGTAACTTTTATTTAAACCCTTGCACTTCTCAGTGCCTGGCAGCTGCAAGGGTCC
CAACTGCCCCGAGGCAGTCTGTGGCCCTGGTTGAAGGAAGCACAAACTACAAGATGTCTGCATC
TCCTCTGGGCATGCAGACGGGTGAGGATCAGCATCCGCGTGTCTGCTGTTGCCAGCAGGGAGGG
GATTACTGGCTTTACCTTGAGCCTGGCCTCACTAGGTAGCTAGGCACATGTAAAGGGTCCTTGT
GCTCTTTTCCAGGTCCCACTAGAAAGGGAGGTCCTGTGGTGGCCACCTCTGTCTTCCTACCGAG
AACTTCCTGTTCCAGGTTTTAGAGTTTTCTTGTTGTTAGGACCAAATGTAGACTGGCTGAGGAC
CTATAGGAAAATCAAACTGGGTTCAGAGATCTCTTAAGGAAGTTGCTCAAAATCCTTTTTATAG
TTAAGGTGTCTGGGGTAGCAGATAACATGGGTCTGAGGGTTAGAAGCCTCAGGTCTATAGGAAA
GGCCCCTTCTTAAGATAGAAACTGTCTAACAGCAAGGGTACAAAGGCTACAGTTTGAGGTCAGA
GCAATCAGAGCTTGTCAGCTTACCTTAAGACACAGGAGGGTCCAGTTGTTCACACAAGGGGGCA
GGAGCTCTGGTGGGTGTGCAGCCATGTGGTCACAGCCTGCCAGCAGCAAGACACGTGGGTCCGC
CACACCTCAGTGGAAGTAGCAAATGCCTCCCTGACCCAGGGCTTCTAGGGACTCTTGCTGCTAT
GCTTGCCAGCAAATGGCAATCAAGGGACAATTAGCCACTTGCCCCGACACAGGTCAGCATCAGG
GCCCTTGCACATAGCCCAGGACTCACACCATATCACACGTGGCCTTGTCTAGACCCAGTCCTGA
GCAGAGGAGCCTGGTGCCCTCCCAGTCCACAGGGTCTTCCCACTGCCCCTCCTCTGCCACTGCC
ACAGAGCAGCAGGGCTTCCCACCTACCGTAGGGACTCCACAGCTTCTGGCAAGCGGGTGCAGAG
TCCCCAGCTCTGGGCTGTGCTGAGGAGCATCAGGCCTAGAGGAGTCCACAGTCTCACTTGCTGC
TGTAGCTGTCAGCCGGGCCTGGTGGCTTGTGGTTGATGGTCACTGTTAGTGGGTGAGTAGGGAT
GACCTGGCTTCCAAGAGGACTGTCACTGTGGACACCAAAATGGCTTAACTGAGATACAGTGAAA
ACATGACAAATAAACCAACTTTTTACAAAAAAAAAAAAAAAAAAAAAAAAAGG

hide sequence

Protein Sequences


Protein RefSeqs	NP_954865	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA42125	(Get FASTA)	NCBI Sequence Viewer
	AAH94530	(Get FASTA)	NCBI Sequence Viewer
	EDL91313	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000018455
GenBank Protein	P61621	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_954865 ⟸ NM_199256
- Peptide Label:	isoform 1
- UniProtKB:	Q505I3 (UniProtKB/Swiss-Prot), P61621 (UniProtKB/Swiss-Prot), A6IB45 (UniProtKB/TrEMBL), A0A8I6GFI1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAIKFLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYW MRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMIITIGQS IVYVMTGMYGDPSEMGAGICLLITIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIV WKAFSPTTVNTGRGMEFEGAIIALFHLLATRTDKVRALREAFYRQNLPNLMNLIATIFVFAVVI YFQGFRVDLPIKSARYRGQYNTYPIKLFYTSNIPIILQSALVSNLYVISQMLSARFSGNLLVSL LGTWSDTSSGGPARAYPVGGLCYYLSPPESFGSVLEDPVHAVVYIVFMLGSCAFFSKTWIEVSG SSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPTAAAFGGLCIGALSVLADFLGAIGSGTGIL LAVTIIYQYFEIFVKEQSEVGSMGALLF hide sequence

Ensembl Acc Id:

ENSRNOP00000018455 ⟸ ENSRNOT00000018454

Ensembl Acc Id:

ENSRNOP00000082887 ⟸ ENSRNOT00000100731

Ensembl Acc Id:

ENSRNOP00000087817 ⟸ ENSRNOT00000100854

Ensembl Acc Id:

ENSRNOP00000088931 ⟸ ENSRNOT00000111696

Protein Domains

Translocon Sec61/SecY plug

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P61621-F1-model_v2	AlphaFold	P61621	1-476	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693236

Promoter ID:

EPDNEW_R3758

Type:

initiation region

Name:

Sec61a1_1

Description:

Sec61 translocon alpha 1 subunit

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	4	120,467,935 - 120,467,995	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:68321	AgrOrtholog
BioCyc Gene	G2FUF-43810	BioCyc
Ensembl Genes	ENSRNOG00000013743	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000018454	ENTREZGENE
Gene3D-CATH	1.10.3370.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7320508	IMAGE-MGC_LOAD
InterPro	SecY/SEC61-alpha	UniProtKB/Swiss-Prot
	SecY_CS	UniProtKB/Swiss-Prot
	SecY_dom_sf	UniProtKB/Swiss-Prot
	Translocon_Sec61/SecY_plug_dom	UniProtKB/Swiss-Prot
KEGG Report	rno:80843	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:105264	IMAGE-MGC_LOAD
NCBI Gene	80843	ENTREZGENE
PANTHER	PTHR10906	UniProtKB/Swiss-Prot
Pfam	Plug_translocon	UniProtKB/Swiss-Prot
	SecY	UniProtKB/Swiss-Prot
PhenoGen	Sec61a1	PhenoGen
PIRSF	SecY	UniProtKB/Swiss-Prot
PROSITE	SECY_1	UniProtKB/Swiss-Prot
	SECY_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000013743	RatGTEx
Superfamily-SCOP	SSF103491	UniProtKB/Swiss-Prot
UniProt	A0A8I6GFI1	ENTREZGENE
	A6IB45	ENTREZGENE, UniProtKB/TrEMBL
	P61621	ENTREZGENE
	Q505I3	ENTREZGENE
	S61A1_RAT	UniProtKB/Swiss-Prot
UniProt Secondary	P38378	UniProtKB/Swiss-Prot
	P57726	UniProtKB/Swiss-Prot
	Q505I3	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-12-06	Sec61a1	SEC61 translocon subunit alpha 1	Sec61a1	Sec61 translocon alpha 1 subunit	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-08-11	Sec61a1	Sec61 translocon alpha 1 subunit	Sec61a1	Sec61 alpha 1 subunit (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Sec61a1	Sec61 alpha 1 subunit (S. cerevisiae)		SEC61, alpha subunit (S. cerevisiae)	Name updated	1299863	APPROVED
2004-09-10	Sec61a1	SEC61, alpha subunit (S. cerevisiae)	Sec61a		Symbol and Name updated	1299863	APPROVED
2002-06-10	Sec61a	SEC61, alpha subunit (S. cerevisiae)			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	localized to membrane-bound ribosomes	68306
gene_homology	shows 50% sequence identity with the yeast protein	68306

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)