Naglt1 (Na+ dependent glucose transporter 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Naglt1 (Na+ dependent glucose transporter 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Naglt1
Name: Na+ dependent glucose transporter 1
RGD ID: 631438
Description: Predicted to enable symporter activity. Involved in D-glucose import across plasma membrane. Located in brush border membrane. Orthologous to human MFSD4B (major facilitator superfamily domain containing 4B); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-nitrofluorene; 3,3',5-triiodo-L-thyronine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: major facilitator superfamily domain-containing protein 4B; Mfsd4b; MGC112591; rNaGLT1; sodium-dependent glucose transporter 1
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82044,965,951 - 44,978,400 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2044,949,395 - 44,978,687 (-)EnsemblGRCr8
mRatBN7.22043,411,550 - 43,423,873 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2043,394,843 - 43,423,873 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2045,160,541 - 45,172,841 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02044,819,750 - 44,832,046 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02045,569,736 - 45,582,176 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02045,095,232 - 45,107,532 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2045,094,791 - 45,107,555 (-)Ensemblrn6Rnor6.0
Rnor_5.02046,815,193 - 46,827,493 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42044,164,008 - 44,176,308 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2044,125,073 - 44,137,373 (-)NCBICelera
RGSC_v3.12044,187,018 - 44,199,319 (-)NCBI
Cytogenetic Map20q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Cloning and characterization of a novel Na+-dependent glucose transporter (NaGLT1) in rat kidney. Horiba N, etal., J Biol Chem 2003 Apr 25;278(17):14669-76.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:12832054   PMID:16627065  


Genomics

Variants

.
Variants in Naglt1
51 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:69
Count of miRNA genes:57
Interacting mature miRNAs:66
Transcripts:ENSRNOT00000057218
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202668936256021148Rat
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202679235356021148Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)201224324249189476Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202668936256021148Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)202074558556021148Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202668936256021148Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
70158Bp60Blood pressure QTL 603arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)203215696745978663Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202668936256021148Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
11 11 54 117 91 90 59 33 59 6 270 112 2 97 80 70 31 3 3

Sequence


Ensembl Acc Id: ENSRNOT00000057218   ⟹   ENSRNOP00000054044
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2044,966,102 - 44,978,687 (-)Ensembl
mRatBN7.2 Ensembl2043,411,550 - 43,423,873 (-)Ensembl
Rnor_6.0 Ensembl2045,094,791 - 45,107,555 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097726   ⟹   ENSRNOP00000087398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2044,949,395 - 44,978,400 (-)Ensembl
mRatBN7.2 Ensembl2043,394,843 - 43,423,873 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000127585   ⟹   ENSRNOP00000099402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2044,966,102 - 44,975,531 (-)Ensembl
RefSeq Acc Id: NM_176080   ⟹   NP_788269
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82044,966,102 - 44,978,400 (-)NCBI
mRatBN7.22043,411,550 - 43,423,873 (-)NCBI
Rnor_6.02045,095,232 - 45,107,532 (-)NCBI
Rnor_5.02046,815,193 - 46,827,493 (-)NCBI
RGSC_v3.42044,164,008 - 44,176,308 (-)RGD
Celera2044,125,073 - 44,137,373 (-)RGD
Sequence:
RefSeq Acc Id: XM_063279191   ⟹   XP_063135261
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82044,965,951 - 44,975,745 (-)NCBI
Protein Sequences
Protein RefSeqs NP_788269 (Get FASTA)   NCBI Sequence Viewer  
  XP_063135261 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH98651 (Get FASTA)   NCBI Sequence Viewer  
  BAC57446 (Get FASTA)   NCBI Sequence Viewer  
  EDL87832 (Get FASTA)   NCBI Sequence Viewer  
  EDL87833 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000054044
  ENSRNOP00000099402
GenBank Protein Q80T22 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_788269   ⟸   NM_176080
- UniProtKB: Q4KMB5 (UniProtKB/Swiss-Prot),   Q80T22 (UniProtKB/Swiss-Prot),   A0A0G2JSX3 (UniProtKB/TrEMBL),   A6KIH8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000054044   ⟸   ENSRNOT00000057218
Ensembl Acc Id: ENSRNOP00000087398   ⟸   ENSRNOT00000097726
RefSeq Acc Id: XP_063135261   ⟸   XM_063279191
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JSX3 (UniProtKB/TrEMBL),   A6KIH8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000099402   ⟸   ENSRNOT00000127585
Protein Domains
Major facilitator superfamily (MFS) profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80T22-F1-model_v2 AlphaFold Q80T22 1-484 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701654
Promoter ID:EPDNEW_R12178
Type:initiation region
Name:Naglt1_1
Description:Na+ dependent glucose transporter 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02045,107,537 - 45,107,597EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631438 AgrOrtholog
BioCyc Gene G2FUF-3454 BioCyc
Ensembl Genes ENSRNOG00000000590 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000057218 ENTREZGENE
  ENSRNOT00000127585 ENTREZGENE
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7130354 IMAGE-MGC_LOAD
InterPro MFS_trans_sf UniProtKB/Swiss-Prot
KEGG Report rno:337920 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112591 IMAGE-MGC_LOAD
NCBI Gene 337920 ENTREZGENE
PANTHER MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING 4B5 UniProtKB/Swiss-Prot
  SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1 UniProtKB/Swiss-Prot
PhenoGen Naglt1 PhenoGen
RatGTEx ENSRNOG00000000590 RatGTEx
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot
UniProt A0A0G2JSX3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A760_RAT UniProtKB/TrEMBL
  A0ABK0L714_RAT UniProtKB/TrEMBL
  A6KIH7_RAT UniProtKB/TrEMBL
  A6KIH8 ENTREZGENE, UniProtKB/TrEMBL
  MFS4B_RAT UniProtKB/Swiss-Prot
  Q4KMB5 ENTREZGENE
  Q80T22 ENTREZGENE
UniProt Secondary Q4KMB5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-09-30 Naglt1        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein 484-amino acid protein 633369