Myod1 (myogenic differentiation 1) - Rat Genome Database

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Gene: Myod1 (myogenic differentiation 1) Rattus norvegicus
Analyze
Symbol: Myod1
Name: myogenic differentiation 1
RGD ID: 631429
Description: Enables E-box binding activity. Involved in response to muscle stretch; skeletal muscle atrophy; and skeletal muscle tissue regeneration. Predicted to be located in euchromatin; myofibril; and nucleus. Predicted to be part of transcription regulator complex. Used to study congestive heart failure. Biomarker of hypertension and obesity. Human ortholog(s) of this gene implicated in congenital myopathy 17. Orthologous to human MYOD1 (myogenic differentiation 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 28-Homobrassinolide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC156574; myoblast determination protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81106,021,161 - 106,023,871 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1106,021,161 - 106,023,871 (+)EnsemblGRCr8
mRatBN7.2196,884,864 - 96,887,574 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,884,948 - 96,887,554 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1102,270,899 - 102,273,609 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01110,742,884 - 110,745,594 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01104,033,260 - 104,035,970 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01102,396,538 - 102,399,248 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1102,396,538 - 102,399,248 (+)Ensemblrn6Rnor6.0
Rnor_5.01103,481,604 - 103,484,314 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4196,910,190 - 96,912,900 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera191,133,211 - 91,135,921 (+)NCBICelera
RGSC_v3.1196,988,300 - 96,991,011 (+)NCBI
Cytogenetic Map1q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(S)-naringenin  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
28-Homobrassinolide  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-azacytidine  (EXP,ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
acetic acid  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
antimycin A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
boric acid  (ISO)
Botulinum toxin type A  (EXP)
bromochloroacetic acid  (ISO)
bupivacaine  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
capsaicin  (ISO)
carmustine  (ISO)
chromium atom  (EXP)
dexamethasone  (ISO)
diacetylmonoxime  (ISO)
dicyclanil  (ISO)
dimethylarsinous acid  (ISO)
genistein  (EXP)
indinavir  (ISO)
indoxyl sulfate  (ISO)
isotretinoin  (ISO)
lamivudine  (ISO)
latrunculin B  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
ML-7  (ISO)
niclosamide  (ISO)
nitrofen  (EXP)
perfluorooctanoic acid  (EXP)
Ptaquiloside  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
salubrinal  (ISO)
saquinavir  (ISO)
SB 203580  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
spermine  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
theaflavin  (ISO)
Theaflavin 3,3'-digallate  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
valproic acid  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell differentiation  (IEA)
cellular response to estradiol stimulus  (IEA,ISO,ISS)
cellular response to glucocorticoid stimulus  (ISO)
cellular response to oxygen levels  (ISO)
cellular response to starvation  (ISO)
cellular response to tumor necrosis factor  (ISO)
DNA-templated transcription  (IEA)
muscle cell differentiation  (IEA,ISO)
muscle organ development  (IEA,ISO)
myoblast differentiation  (ISO,ISS)
myoblast fate determination  (ISO,ISS)
myoblast fusion  (ISO)
myotube cell development  (IEA,ISO)
myotube differentiation  (ISO)
myotube differentiation involved in skeletal muscle regeneration  (ISO)
negative regulation of myoblast proliferation  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of muscle cell differentiation  (IEA,ISO,ISS)
positive regulation of myoblast differentiation  (IBA)
positive regulation of myoblast fusion  (IEA,ISO)
positive regulation of skeletal muscle fiber development  (IBA)
positive regulation of skeletal muscle tissue regeneration  (ISO,ISS)
positive regulation of snRNA transcription by RNA polymerase II  (IEA,ISO,ISS)
positive regulation of transcription by RNA polymerase II  (IEA,ISO,ISS)
protein unfolding  (IEA,ISO)
regulation of alternative mRNA splicing, via spliceosome  (ISO,ISS)
regulation of DNA-templated transcription  (IEA)
regulation of gene expression  (IEA,ISO)
regulation of RNA splicing  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IBA,ISO)
response to muscle stretch  (IEP)
skeletal muscle atrophy  (IEP)
skeletal muscle cell differentiation  (IBA,IEA,ISO)
skeletal muscle fiber adaptation  (ISO)
skeletal muscle fiber development  (ISO)
skeletal muscle tissue development  (ISO,ISS)
skeletal muscle tissue regeneration  (IEA,IEP,IMP,ISO)
striated muscle cell differentiation  (ISO,ISS)

Cellular Component
chromatin  (IEA,ISO)
cytoplasm  (IEA,ISO)
euchromatin  (IEA,ISO)
myofibril  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO,ISS)
transcription regulator complex  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Fenofibrate administration to arthritic rats increases adiponectin and leptin and prevents oxidative muscle wasting. Castillero E, etal., Endocr Connect. 2012 Jun 8;1(1):1-12. doi: 10.1530/EC-12-0003. Print 2012 Jul 1.
2. The role of primary myogenic regulatory factors in the developing diaphragmatic muscle in the nitrofen-induced diaphragmatic hernia. Dingemann J, etal., Pediatr Surg Int. 2011 Jun;27(6):579-82. doi: 10.1007/s00383-010-2834-8.
3. Acetylation is important for MyoD function in adult mice. Duquet A, etal., EMBO Rep. 2006 Nov;7(11):1140-6. Epub 2006 Oct 6.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. Ge K, etal., Nature. 2002 May 30;417(6888):563-7.
6. VITO-1 is an essential cofactor of TEF1-dependent muscle-specific gene regulation. Gunther S, etal., Nucleic Acids Res. 2004 Feb 3;32(2):791-802. Print 2004.
7. Nerve activity-independent regulation of skeletal muscle atrophy: role of MyoD and myogenin in satellite cells and myonuclei. Hyatt JP, etal., Am J Physiol Cell Physiol 2003 Nov;285(5):C1161-73. Epub 2003 Jul 2.
8. MyoD is indispensable for muscle-specific alternative splicing in mouse mitochondrial ATP synthase gamma-subunit pre-mRNA. Ichida M, etal., J Biol Chem. 1998 Apr 3;273(14):8492-501.
9. Netrins and neogenin promote myotube formation. Kang JS, etal., J Cell Biol. 2004 Nov 8;167(3):493-504. Epub 2004 Nov 1.
10. TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3. Liu D, etal., Genes Dev. 2001 Nov 15;15(22):2950-66.
11. The homeodomain protein Barx2 promotes myogenic differentiation and is regulated by myogenic regulatory factors. Meech R, etal., J Biol Chem. 2003 Mar 7;278(10):8269-78. Epub 2002 Dec 16.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Age-associated disruption of molecular clock expression in skeletal muscle of the spontaneously hypertensive rat. Miyazaki M, etal., PLoS One. 2011;6(11):e27168. doi: 10.1371/journal.pone.0027168. Epub 2011 Nov 4.
14. Acceleration of muscle regeneration by local injection of muscle-specific microRNAs in rat skeletal muscle injury model. Nakasa T, etal., J Cell Mol Med. 2010 Oct;14(10):2495-505. doi: 10.1111/j.1582-4934.2009.00898.x.
15. Satellite cell proliferation is reduced in muscles of obese Zucker rats but restored with loading. Peterson JM, etal., Am J Physiol Cell Physiol. 2008 Aug;295(2):C521-8. Epub 2008 May 28.
16. Short bouts of stretching increase myo-D, myostatin and atrogin-1 in rat soleus muscle. Peviani SM, etal., Muscle Nerve. 2007 Mar;35(3):363-70.
17. GOA pipeline RGD automated data pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Recovery of skeletal muscle mass after extensive injury: positive effects of increased contractile activity. Richard-Bulteau H, etal., Am J Physiol Cell Physiol. 2008 Feb;294(2):C467-76. Epub 2007 Dec 12.
20. Growth hormone attenuates skeletal muscle changes in experimental chronic heart failure. Santos DP, etal., Growth Horm IGF Res. 2010 Apr;20(2):149-55. doi: 10.1016/j.ghir.2009.11.007. Epub 2010 Jan 8.
21. Regulation of E-box DNA binding during in vivo and in vitro activation of rat and human hepatic stellate cells. Vincent KJ, etal., Gut. 2001 Nov;49(5):713-9.
22. Jun, Fos, MyoD1, and myogenin proteins are increased in skeletal muscle fiber nuclei after denervation. Weis J Acta Neuropathol. 1994;87(1):63-70.
23. Antisense inhibition of myoD expression in regenerating rat soleus muscle is followed by an increase in the mRNA levels of myoD, myf-5 and myogenin and by a retarded regeneration. Zador E, etal., Biochim Biophys Acta 2002 Jun 12;1590(1-3):52-63.
24. The skeletal muscle Wnt pathway may modulate insulin resistance and muscle development in a diet-induced obese rat model. Zhou D, etal., Obesity (Silver Spring). 2012 Aug;20(8):1577-84. doi: 10.1038/oby.2012.42. Epub 2012 Feb 21.
Additional References at PubMed
PMID:1321778   PMID:1348494   PMID:2503252   PMID:7659522   PMID:8269513   PMID:9234731   PMID:9862959   PMID:10672515   PMID:11076940   PMID:11714687   PMID:12037670   PMID:12477932  
PMID:12782625   PMID:12878168   PMID:12895031   PMID:15192231   PMID:15572127   PMID:15634692   PMID:15706034   PMID:15743821   PMID:15890200   PMID:15921681   PMID:16245309   PMID:16901893  
PMID:17034040   PMID:17761773   PMID:17855775   PMID:17904117   PMID:17940050   PMID:18676376   PMID:18849500   PMID:19121967   PMID:19170063   PMID:19319192   PMID:19531352   PMID:19723510  
PMID:19796622   PMID:20069545   PMID:20139084   PMID:20833138   PMID:20956524   PMID:21131290   PMID:21668966   PMID:21832073   PMID:21858842   PMID:22147266   PMID:22358842   PMID:22638570  
PMID:22740650   PMID:24301466   PMID:24349514   PMID:24361185   PMID:25085416   PMID:25217815   PMID:25640239   PMID:25809587   PMID:26658965   PMID:26914683   PMID:31619581  


Genomics

Comparative Map Data
Myod1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81106,021,161 - 106,023,871 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1106,021,161 - 106,023,871 (+)EnsemblGRCr8
mRatBN7.2196,884,864 - 96,887,574 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,884,948 - 96,887,554 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1102,270,899 - 102,273,609 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01110,742,884 - 110,745,594 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01104,033,260 - 104,035,970 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01102,396,538 - 102,399,248 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1102,396,538 - 102,399,248 (+)Ensemblrn6Rnor6.0
Rnor_5.01103,481,604 - 103,484,314 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4196,910,190 - 96,912,900 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera191,133,211 - 91,135,921 (+)NCBICelera
RGSC_v3.1196,988,300 - 96,991,011 (+)NCBI
Cytogenetic Map1q22NCBI
MYOD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381117,719,571 - 17,722,136 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1117,719,571 - 17,722,136 (+)Ensemblhg38GRCh38
GRCh371117,741,118 - 17,743,683 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361117,697,686 - 17,700,254 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341117,697,734 - 17,700,254NCBI
Celera1117,873,623 - 17,876,191 (+)NCBICelera
Cytogenetic Map11p15.1NCBI
HuRef1117,425,110 - 17,427,678 (+)NCBIHuRef
CHM1_11117,740,837 - 17,743,405 (+)NCBICHM1_1
T2T-CHM13v2.01117,817,261 - 17,819,826 (+)NCBIT2T-CHM13v2.0
Myod1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39746,025,898 - 46,028,516 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl746,025,898 - 46,028,523 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38746,376,474 - 46,379,092 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl746,376,474 - 46,379,099 (+)Ensemblmm10GRCm38
MGSCv37753,631,844 - 53,634,462 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36746,244,524 - 46,247,137 (+)NCBIMGSCv36mm8
Celera741,849,969 - 41,852,587 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map730.03NCBI
Myod1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541432,523,924 - 32,526,674 (+)Ensembl
ChiLan1.0NW_00495541432,523,959 - 32,526,575 (+)NCBIChiLan1.0ChiLan1.0
MYOD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2920,051,315 - 20,053,878 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11120,011,813 - 20,014,376 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01117,772,317 - 17,774,884 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11117,456,124 - 17,458,690 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1117,456,124 - 17,458,690 (+)EnsemblpanPan2panpan1.1
MYOD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12140,257,792 - 40,260,461 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2140,258,027 - 40,259,712 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2139,757,431 - 39,759,334 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02141,362,253 - 41,364,156 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2141,362,471 - 41,364,912 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12140,375,120 - 40,377,023 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02140,582,881 - 40,584,784 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02140,921,445 - 40,923,349 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Myod1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494745,372,988 - 45,375,811 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365281,407,661 - 1,409,573 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365281,407,187 - 1,409,683 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYOD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl241,415,775 - 41,424,435 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1241,422,522 - 41,424,236 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2244,483,015 - 44,484,730 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MYOD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1147,250,927 - 47,254,572 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl147,251,551 - 47,253,284 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038144,644,005 - 144,646,580 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myod1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247669,345,613 - 9,347,326 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247669,345,390 - 9,347,985 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Myod1
37 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:95
Count of miRNA genes:74
Interacting mature miRNAs:86
Transcripts:ENSRNOT00000015109
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat

Markers in Region
D1Hmgc6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,886,977 - 96,887,167 (+)MAPPERmRatBN7.2
Rnor_6.01102,398,652 - 102,398,841NCBIRnor6.0
Rnor_5.01103,483,718 - 103,483,907UniSTSRnor5.0
RGSC_v3.4196,912,304 - 96,912,493UniSTSRGSC3.4
Celera191,135,325 - 91,135,514UniSTS
RH 3.4 Map1908.9RGD
RH 3.4 Map1908.9UniSTS
Cytogenetic Map1q22UniSTS
D1Bda21  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,886,002 - 96,886,338 (+)MAPPERmRatBN7.2
Rnor_6.01102,397,677 - 102,398,012NCBIRnor6.0
Rnor_5.01103,482,743 - 103,483,078UniSTSRnor5.0
RGSC_v3.4196,911,329 - 96,911,664UniSTSRGSC3.4
Celera191,134,350 - 91,134,685UniSTS
Cytogenetic Map1q22UniSTS
PMC133998P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,885,438 - 96,886,220 (+)MAPPERmRatBN7.2
Rnor_6.01102,397,113 - 102,397,894NCBIRnor6.0
Rnor_5.01103,482,179 - 103,482,960UniSTSRnor5.0
RGSC_v3.4196,910,765 - 96,911,546UniSTSRGSC3.4
Celera191,133,786 - 91,134,567UniSTS
Cytogenetic Map1q22UniSTS
PMC86965P5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,884,755 - 96,884,910 (+)MAPPERmRatBN7.2
Rnor_6.01102,396,430 - 102,396,584NCBIRnor6.0
Rnor_5.01103,481,496 - 103,481,650UniSTSRnor5.0
RGSC_v3.4196,910,082 - 96,910,236UniSTSRGSC3.4
Celera191,133,103 - 91,133,257UniSTS
Cytogenetic Map1q22UniSTS
Myod1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,886,195 - 96,887,462 (+)MAPPERmRatBN7.2
Rnor_6.01102,397,870 - 102,399,136NCBIRnor6.0
Rnor_5.01103,482,936 - 103,484,202UniSTSRnor5.0
Celera191,134,543 - 91,135,809UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
8 12 38 83 57 54 26 23 26 6 167 94 10 54 31 49 28 5 5

Sequence


Ensembl Acc Id: ENSRNOT00000015109   ⟹   ENSRNOP00000015109
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1106,021,161 - 106,023,871 (+)Ensembl
mRatBN7.2 Ensembl196,884,948 - 96,887,554 (+)Ensembl
Rnor_6.0 Ensembl1102,396,538 - 102,399,248 (+)Ensembl
RefSeq Acc Id: NM_176079   ⟹   NP_788268
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,021,161 - 106,023,871 (+)NCBI
mRatBN7.2196,884,864 - 96,887,574 (+)NCBI
Rnor_6.01102,396,538 - 102,399,248 (+)NCBI
Rnor_5.01103,481,604 - 103,484,314 (+)NCBI
RGSC_v3.4196,910,190 - 96,912,900 (+)RGD
Celera191,133,211 - 91,135,921 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_788268 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41661 (Get FASTA)   NCBI Sequence Viewer  
  AAI27481 (Get FASTA)   NCBI Sequence Viewer  
  EDM07266 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015109
GenBank Protein Q02346 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_788268   ⟸   NM_176079
- UniProtKB: Q02346 (UniProtKB/Swiss-Prot),   A0JPK9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015109   ⟸   ENSRNOT00000015109
Protein Domains
bHLH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q02346-F1-model_v2 AlphaFold Q02346 1-318 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631429 AgrOrtholog
BioCyc Gene G2FUF-59629 BioCyc
Ensembl Genes ENSRNOG00000011306 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000015109 ENTREZGENE
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:8366406 IMAGE-MGC_LOAD
InterPro Basic UniProtKB/Swiss-Prot
  bHLH_dom UniProtKB/Swiss-Prot
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot
  Myf5 UniProtKB/Swiss-Prot
  Myogenic_factor UniProtKB/Swiss-Prot
KEGG Report rno:337868 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156574 IMAGE-MGC_LOAD
NCBI Gene 337868 ENTREZGENE
PANTHER MYOBLAST DETERMINATION PROTEIN 1 UniProtKB/Swiss-Prot
  PTHR11534 UniProtKB/Swiss-Prot
Pfam Basic UniProtKB/Swiss-Prot
  HLH UniProtKB/Swiss-Prot
  Myf5 UniProtKB/Swiss-Prot
PhenoGen Myod1 PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011306 RatGTEx
SMART BASIC UniProtKB/Swiss-Prot
  HLH UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot
UniProt A0JPK9 ENTREZGENE, UniProtKB/TrEMBL
  F7F8D2_RAT UniProtKB/TrEMBL
  MYOD1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-11 Myod1  myogenic differentiation 1      Symbol and Name status set to approved 625702 APPROVED