Myod1 (myogenic differentiation 1) - Rat Genome Database

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Gene: Myod1 (myogenic differentiation 1) Rattus norvegicus
Analyze
Symbol: Myod1
Name: myogenic differentiation 1
RGD ID: 631429
Description: Enables E-box binding activity. Involved in response to muscle stretch; skeletal muscle atrophy; and skeletal muscle tissue regeneration. Predicted to be located in myofibril and nucleoplasm. Predicted to be part of euchromatin and transcription regulator complex. Used to study congestive heart failure. Biomarker of hypertension and obesity. Human ortholog(s) of this gene implicated in congenital myopathy 17. Orthologous to human MYOD1 (myogenic differentiation 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 28-Homobrassinolide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC156574; myoblast determination protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81106,021,161 - 106,023,871 (+)NCBIGRCr8
mRatBN7.2196,884,864 - 96,887,574 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,884,948 - 96,887,554 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1102,270,899 - 102,273,609 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01110,742,884 - 110,745,594 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01104,033,260 - 104,035,970 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01102,396,538 - 102,399,248 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1102,396,538 - 102,399,248 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01103,481,604 - 103,484,314 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,910,190 - 96,912,900 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1196,988,300 - 96,991,011 (+)NCBI
Celera191,133,211 - 91,135,921 (+)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to estradiol stimulus  (ISO,ISS)
cellular response to glucocorticoid stimulus  (ISO)
cellular response to oxygen levels  (ISO)
cellular response to starvation  (ISO)
cellular response to tumor necrosis factor  (ISO)
muscle cell differentiation  (ISO)
muscle organ development  (IEA,ISO)
myoblast differentiation  (ISO,ISS)
myoblast fate determination  (ISO,ISS)
myoblast fusion  (ISO)
myotube cell development  (IEA,ISO)
myotube differentiation  (ISO)
myotube differentiation involved in skeletal muscle regeneration  (ISO)
negative regulation of myoblast proliferation  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of muscle cell differentiation  (IEA,ISO,ISS)
positive regulation of myoblast differentiation  (IBA)
positive regulation of myoblast fusion  (IEA,ISO)
positive regulation of skeletal muscle fiber development  (IBA)
positive regulation of skeletal muscle tissue regeneration  (ISO,ISS)
positive regulation of snRNA transcription by RNA polymerase II  (ISO,ISS)
positive regulation of transcription by RNA polymerase II  (IEA,ISO,ISS)
regulation of alternative mRNA splicing, via spliceosome  (ISO,ISS)
regulation of gene expression  (ISO)
regulation of RNA splicing  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IBA,ISO)
response to muscle stretch  (IEP)
skeletal muscle atrophy  (IEP)
skeletal muscle cell differentiation  (IBA,ISO)
skeletal muscle fiber adaptation  (ISO)
skeletal muscle fiber development  (ISO)
skeletal muscle tissue development  (ISO,ISS)
skeletal muscle tissue regeneration  (IEP,IMP,ISO)
striated muscle cell differentiation  (ISO,ISS)
transcription by RNA polymerase II  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Fenofibrate administration to arthritic rats increases adiponectin and leptin and prevents oxidative muscle wasting. Castillero E, etal., Endocr Connect. 2012 Jun 8;1(1):1-12. doi: 10.1530/EC-12-0003. Print 2012 Jul 1.
2. The role of primary myogenic regulatory factors in the developing diaphragmatic muscle in the nitrofen-induced diaphragmatic hernia. Dingemann J, etal., Pediatr Surg Int. 2011 Jun;27(6):579-82. doi: 10.1007/s00383-010-2834-8.
3. Acetylation is important for MyoD function in adult mice. Duquet A, etal., EMBO Rep. 2006 Nov;7(11):1140-6. Epub 2006 Oct 6.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. Ge K, etal., Nature. 2002 May 30;417(6888):563-7.
6. VITO-1 is an essential cofactor of TEF1-dependent muscle-specific gene regulation. Gunther S, etal., Nucleic Acids Res. 2004 Feb 3;32(2):791-802. Print 2004.
7. Nerve activity-independent regulation of skeletal muscle atrophy: role of MyoD and myogenin in satellite cells and myonuclei. Hyatt JP, etal., Am J Physiol Cell Physiol 2003 Nov;285(5):C1161-73. Epub 2003 Jul 2.
8. MyoD is indispensable for muscle-specific alternative splicing in mouse mitochondrial ATP synthase gamma-subunit pre-mRNA. Ichida M, etal., J Biol Chem. 1998 Apr 3;273(14):8492-501.
9. Netrins and neogenin promote myotube formation. Kang JS, etal., J Cell Biol. 2004 Nov 8;167(3):493-504. Epub 2004 Nov 1.
10. TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3. Liu D, etal., Genes Dev. 2001 Nov 15;15(22):2950-66.
11. The homeodomain protein Barx2 promotes myogenic differentiation and is regulated by myogenic regulatory factors. Meech R, etal., J Biol Chem. 2003 Mar 7;278(10):8269-78. Epub 2002 Dec 16.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Age-associated disruption of molecular clock expression in skeletal muscle of the spontaneously hypertensive rat. Miyazaki M, etal., PLoS One. 2011;6(11):e27168. doi: 10.1371/journal.pone.0027168. Epub 2011 Nov 4.
14. Acceleration of muscle regeneration by local injection of muscle-specific microRNAs in rat skeletal muscle injury model. Nakasa T, etal., J Cell Mol Med. 2010 Oct;14(10):2495-505. doi: 10.1111/j.1582-4934.2009.00898.x.
15. Satellite cell proliferation is reduced in muscles of obese Zucker rats but restored with loading. Peterson JM, etal., Am J Physiol Cell Physiol. 2008 Aug;295(2):C521-8. Epub 2008 May 28.
16. Short bouts of stretching increase myo-D, myostatin and atrogin-1 in rat soleus muscle. Peviani SM, etal., Muscle Nerve. 2007 Mar;35(3):363-70.
17. GOA pipeline RGD automated data pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Recovery of skeletal muscle mass after extensive injury: positive effects of increased contractile activity. Richard-Bulteau H, etal., Am J Physiol Cell Physiol. 2008 Feb;294(2):C467-76. Epub 2007 Dec 12.
20. Growth hormone attenuates skeletal muscle changes in experimental chronic heart failure. Santos DP, etal., Growth Horm IGF Res. 2010 Apr;20(2):149-55. doi: 10.1016/j.ghir.2009.11.007. Epub 2010 Jan 8.
21. Regulation of E-box DNA binding during in vivo and in vitro activation of rat and human hepatic stellate cells. Vincent KJ, etal., Gut. 2001 Nov;49(5):713-9.
22. Jun, Fos, MyoD1, and myogenin proteins are increased in skeletal muscle fiber nuclei after denervation. Weis J Acta Neuropathol. 1994;87(1):63-70.
23. Antisense inhibition of myoD expression in regenerating rat soleus muscle is followed by an increase in the mRNA levels of myoD, myf-5 and myogenin and by a retarded regeneration. Zador E, etal., Biochim Biophys Acta 2002 Jun 12;1590(1-3):52-63.
24. The skeletal muscle Wnt pathway may modulate insulin resistance and muscle development in a diet-induced obese rat model. Zhou D, etal., Obesity (Silver Spring). 2012 Aug;20(8):1577-84. doi: 10.1038/oby.2012.42. Epub 2012 Feb 21.
Additional References at PubMed
PMID:1321778   PMID:1348494   PMID:2503252   PMID:7659522   PMID:8269513   PMID:9234731   PMID:9862959   PMID:10672515   PMID:11076940   PMID:11714687   PMID:12037670   PMID:12477932  
PMID:12782625   PMID:12878168   PMID:12895031   PMID:15192231   PMID:15572127   PMID:15634692   PMID:15706034   PMID:15743821   PMID:15890200   PMID:15921681   PMID:16245309   PMID:16901893  
PMID:17034040   PMID:17761773   PMID:17855775   PMID:17904117   PMID:17940050   PMID:18676376   PMID:18849500   PMID:19121967   PMID:19170063   PMID:19319192   PMID:19531352   PMID:19723510  
PMID:19796622   PMID:20069545   PMID:20139084   PMID:20833138   PMID:20956524   PMID:21131290   PMID:21668966   PMID:21832073   PMID:21858842   PMID:22147266   PMID:22358842   PMID:22638570  
PMID:22740650   PMID:24301466   PMID:24349514   PMID:24361185   PMID:25085416   PMID:25217815   PMID:25640239   PMID:25809587   PMID:26658965   PMID:26914683   PMID:31619581  


Genomics

Comparative Map Data
Myod1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81106,021,161 - 106,023,871 (+)NCBIGRCr8
mRatBN7.2196,884,864 - 96,887,574 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,884,948 - 96,887,554 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1102,270,899 - 102,273,609 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01110,742,884 - 110,745,594 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01104,033,260 - 104,035,970 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01102,396,538 - 102,399,248 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1102,396,538 - 102,399,248 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01103,481,604 - 103,484,314 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,910,190 - 96,912,900 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1196,988,300 - 96,991,011 (+)NCBI
Celera191,133,211 - 91,135,921 (+)NCBICelera
Cytogenetic Map1q22NCBI
MYOD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381117,719,571 - 17,722,136 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1117,719,571 - 17,722,136 (+)EnsemblGRCh38hg38GRCh38
GRCh371117,741,118 - 17,743,683 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361117,697,686 - 17,700,254 (+)NCBINCBI36Build 36hg18NCBI36
Build 341117,697,734 - 17,700,254NCBI
Celera1117,873,623 - 17,876,191 (+)NCBICelera
Cytogenetic Map11p15.1NCBI
HuRef1117,425,110 - 17,427,678 (+)NCBIHuRef
CHM1_11117,740,837 - 17,743,405 (+)NCBICHM1_1
T2T-CHM13v2.01117,817,261 - 17,819,826 (+)NCBIT2T-CHM13v2.0
Myod1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39746,025,898 - 46,028,516 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl746,025,898 - 46,028,523 (+)EnsemblGRCm39 Ensembl
GRCm38746,376,474 - 46,379,092 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl746,376,474 - 46,379,099 (+)EnsemblGRCm38mm10GRCm38
MGSCv37753,631,844 - 53,634,462 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36746,244,524 - 46,247,137 (+)NCBIMGSCv36mm8
Celera741,849,969 - 41,852,587 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map730.03NCBI
Myod1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541432,523,924 - 32,526,674 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541432,523,959 - 32,526,575 (+)NCBIChiLan1.0ChiLan1.0
MYOD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2920,051,315 - 20,053,878 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11120,011,813 - 20,014,376 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01117,772,317 - 17,774,884 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11117,456,124 - 17,458,690 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1117,456,124 - 17,458,690 (+)Ensemblpanpan1.1panPan2
MYOD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12140,257,792 - 40,260,461 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2140,258,027 - 40,259,712 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2139,757,431 - 39,759,334 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02141,362,253 - 41,364,156 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2141,362,471 - 41,364,912 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12140,375,120 - 40,377,023 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02140,582,881 - 40,584,784 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02140,921,445 - 40,923,349 (+)NCBIUU_Cfam_GSD_1.0
Myod1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494745,372,988 - 45,375,811 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365281,407,661 - 1,409,573 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365281,407,187 - 1,409,683 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYOD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl241,415,775 - 41,424,435 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1241,422,522 - 41,424,236 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2244,483,015 - 44,484,730 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103239432
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1147,250,927 - 47,254,572 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl147,251,551 - 47,253,284 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038144,644,005 - 144,646,580 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myod1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247669,345,613 - 9,347,326 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247669,345,390 - 9,347,985 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Myod1
21 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:95
Count of miRNA genes:74
Interacting mature miRNAs:86
Transcripts:ENSRNOT00000015109
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)194494440117601394Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat

Markers in Region
D1Hmgc6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,886,977 - 96,887,167 (+)MAPPERmRatBN7.2
Rnor_6.01102,398,652 - 102,398,841NCBIRnor6.0
Rnor_5.01103,483,718 - 103,483,907UniSTSRnor5.0
RGSC_v3.4196,912,304 - 96,912,493UniSTSRGSC3.4
Celera191,135,325 - 91,135,514UniSTS
RH 3.4 Map1908.9UniSTS
RH 3.4 Map1908.9RGD
Cytogenetic Map1q22UniSTS
D1Bda21  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,886,002 - 96,886,338 (+)MAPPERmRatBN7.2
Rnor_6.01102,397,677 - 102,398,012NCBIRnor6.0
Rnor_5.01103,482,743 - 103,483,078UniSTSRnor5.0
RGSC_v3.4196,911,329 - 96,911,664UniSTSRGSC3.4
Celera191,134,350 - 91,134,685UniSTS
Cytogenetic Map1q22UniSTS
PMC133998P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,885,438 - 96,886,220 (+)MAPPERmRatBN7.2
Rnor_6.01102,397,113 - 102,397,894NCBIRnor6.0
Rnor_5.01103,482,179 - 103,482,960UniSTSRnor5.0
RGSC_v3.4196,910,765 - 96,911,546UniSTSRGSC3.4
Celera191,133,786 - 91,134,567UniSTS
Cytogenetic Map1q22UniSTS
PMC86965P5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,884,755 - 96,884,910 (+)MAPPERmRatBN7.2
Rnor_6.01102,396,430 - 102,396,584NCBIRnor6.0
Rnor_5.01103,481,496 - 103,481,650UniSTSRnor5.0
RGSC_v3.4196,910,082 - 96,910,236UniSTSRGSC3.4
Celera191,133,103 - 91,133,257UniSTS
Cytogenetic Map1q22UniSTS
Myod1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,886,195 - 96,887,462 (+)MAPPERmRatBN7.2
Rnor_6.01102,397,870 - 102,399,136NCBIRnor6.0
Rnor_5.01103,482,936 - 103,484,202UniSTSRnor5.0
Celera191,134,543 - 91,135,809UniSTS
Cytogenetic Map1q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 4 1
Low 2 2 2 2 7 7 5 2 16 7 7
Below cutoff 2 23 31 16 16 16 27 19 14 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000015109   ⟹   ENSRNOP00000015109
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl196,884,948 - 96,887,554 (+)Ensembl
Rnor_6.0 Ensembl1102,396,538 - 102,399,248 (+)Ensembl
RefSeq Acc Id: NM_176079   ⟹   NP_788268
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,021,161 - 106,023,871 (+)NCBI
mRatBN7.2196,884,864 - 96,887,574 (+)NCBI
Rnor_6.01102,396,538 - 102,399,248 (+)NCBI
Rnor_5.01103,481,604 - 103,484,314 (+)NCBI
RGSC_v3.4196,910,190 - 96,912,900 (+)RGD
Celera191,133,211 - 91,135,921 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_788268 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41661 (Get FASTA)   NCBI Sequence Viewer  
  AAI27481 (Get FASTA)   NCBI Sequence Viewer  
  EDM07266 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015109.2
GenBank Protein Q02346 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_788268   ⟸   NM_176079
- UniProtKB: Q02346 (UniProtKB/Swiss-Prot),   A0JPK9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000015109   ⟸   ENSRNOT00000015109
Protein Domains
bHLH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q02346-F1-model_v2 AlphaFold Q02346 1-318 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631429 AgrOrtholog
BioCyc Gene G2FUF-59629 BioCyc
Ensembl Genes ENSRNOG00000011306 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015109.3 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8366406 IMAGE-MGC_LOAD
InterPro Basic UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bHLH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myf5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myogenic_factor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:337868 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:156574 IMAGE-MGC_LOAD
NCBI Gene 337868 ENTREZGENE
PANTHER MYOBLAST DETERMINATION PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11534 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Basic UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myf5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Myod1 PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011306 RatGTEx
SMART BASIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0JPK9 ENTREZGENE, UniProtKB/TrEMBL
  F7F8D2_RAT UniProtKB/TrEMBL
  MYOD1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-11 Myod1  myogenic differentiation 1      Symbol and Name status set to approved 625702 APPROVED