Ppm1f (protein phosphatase, Mg2+/Mn2+ dependent, 1F) - Rat Genome Database

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Gene: Ppm1f (protein phosphatase, Mg2+/Mn2+ dependent, 1F) Rattus norvegicus
Analyze
Symbol: Ppm1f
Name: protein phosphatase, Mg2+/Mn2+ dependent, 1F
RGD ID: 631363
Description: Enables protein serine/threonine phosphatase activity. Involved in intracellular signal transduction and protein dephosphorylation. Located in cytosol and perinuclear region of cytoplasm. Orthologous to human PPM1F (protein phosphatase, Mg2+/Mn2+ dependent 1F); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; calcium/calmodulin dependent kinase 2 signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ca(2+)/calmodulin-dependent protein kinase phosphatase; calcium/calmodulin-dependent protein kinase phosphatase; CaM-kinase phosphatase; CaMKPase; partner of PIX 2; protein phosphatase 1F; protein phosphatase 1F (PP2C domain containing)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81197,568,627 - 97,598,613 (-)NCBIGRCr8
mRatBN7.21184,064,422 - 84,094,410 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1184,064,420 - 84,094,340 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1192,790,922 - 92,818,479 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01185,452,053 - 85,479,612 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01184,505,643 - 84,533,204 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01188,313,709 - 88,343,726 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1188,313,709 - 88,343,627 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01191,368,795 - 91,398,731 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,086,968 - 86,114,278 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,127,564 - 86,154,875 (-)NCBI
Celera1182,821,775 - 82,848,989 (-)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Ppm1fRatchromosome 22q11.2 deletion syndrome, distal  ISOPPM1F (Homo sapiens)8554872ClinVar Annotator: match by term: Chromosome 22q11.2 deletion syndrome and distalClinVarPMID:21681106 more ...
Ppm1fRatDiGeorge syndrome  ISOPPM1F (Homo sapiens)8554872ClinVar Annotator: match by term: DiGeorge syndromeClinVarPMID:32581362

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Object Symbol
Species
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Reference
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Original Reference(s)
Ppm1fRat1,2-dimethylhydrazine multiple interactionsISOPpm1f (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of PPM1F mRNACTDPMID:22206623
Ppm1fRat17beta-estradiol affects expressionISOPPM1F (Homo sapiens)6480464Estradiol affects the expression of PPM1F mRNACTDPMID:22574217
Ppm1fRat17beta-estradiol increases expressionISOPpm1f (Mus musculus)6480464Estradiol results in increased expression of PPM1F mRNACTDPMID:39298647
Ppm1fRat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of PPM1F mRNACTDPMID:22298810
Ppm1fRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of PPM1F mRNACTDPMID:34747641
Ppm1fRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOPpm1f (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of PPM1F mRNACTDPMID:21570461
Ppm1fRat4,4'-sulfonyldiphenol affects methylationISOPpm1f (Mus musculus)6480464bisphenol S affects the methylation of PPM1F geneCTDPMID:31683443
Ppm1fRat4-hydroxyphenyl retinamide increases expressionISOPpm1f (Mus musculus)6480464Fenretinide results in increased expression of PPM1F mRNACTDPMID:28973697
Ppm1fRat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of PPM1F mRNACTDPMID:24780913 and PMID:30047161
Ppm1fRatacetamide decreases expressionEXP 6480464acetamide results in decreased expression of PPM1F mRNACTDPMID:31881176
Ppm1fRatacrylamide decreases expressionISOPPM1F (Homo sapiens)6480464Acrylamide results in decreased expression of PPM1F mRNACTDPMID:32763439
Ppm1fRataflatoxin B1 increases expressionISOPpm1f (Mus musculus)6480464Aflatoxin B1 results in increased expression of PPM1F mRNACTDPMID:19770486
Ppm1fRataflatoxin B1 increases methylationISOPPM1F (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of PPM1F geneCTDPMID:27153756
Ppm1fRatamitrole decreases expressionEXP 6480464Amitrole results in decreased expression of PPM1F mRNACTDPMID:30047161
Ppm1fRatammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of PPM1F mRNACTDPMID:16483693
Ppm1fRatamphetamine decreases expressionEXP 6480464Amphetamine results in decreased expression of PPM1F mRNACTDPMID:30779732
Ppm1fRataristolochic acid A increases expressionISOPPM1F (Homo sapiens)6480464aristolochic acid I results in increased expression of PPM1F mRNACTDPMID:33212167
Ppm1fRatbenzatropine decreases expressionISOPPM1F (Homo sapiens)6480464Benztropine results in decreased expression of PPM1F proteinCTDPMID:34122009
Ppm1fRatbenzo[a]pyrene multiple interactionsISOPPM1F (Homo sapiens)6480464chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of PPM1F mRNA]CTDPMID:19152381
Ppm1fRatbenzo[a]pyrene decreases methylationISOPPM1F (Homo sapiens)6480464Benzo(a)pyrene results in decreased methylation of PPM1F 3' UTR and Benzo(a)pyrene results in decreased methylation of PPM1F 5' UTRCTDPMID:27901495

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Biological Process
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Object Symbol
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Original Reference(s)
Ppm1fRatapoptotic process involved_inIEAUniProtKB-KW:KW-00531600115GO_REF:0000043UniProtGO_REF:0000043
Ppm1fRatcellular response to xenobiotic stimulus involved_inISOPPM1F (Homo sapiens)1624291 PMID:20801214RGDPMID:20801214
Ppm1fRatcellular response to xenobiotic stimulus involved_inIEAUniProtKB:P49593 and ensembl:ENSP000002632121600115GO_REF:0000107EnsemblGO_REF:0000107
Ppm1fRatcellular response to xenobiotic stimulus involved_inISSUniProtKB:P495931600115GO_REF:0000024UniProtGO_REF:0000024
Ppm1fRatintracellular signal transduction involved_inIEAUniProtKB:P49593 and ensembl:ENSP000002632121600115GO_REF:0000107EnsemblGO_REF:0000107
Ppm1fRatintracellular signal transduction involved_inIDA 8553939PMID:11559703UniProt 
Ppm1fRatintracellular signal transduction involved_inISSUniProtKB:P495931600115GO_REF:0000024UniProtGO_REF:0000024
Ppm1fRatintracellular signal transduction involved_inISOPPM1F (Homo sapiens)1624291 PMID:11559703RGDPMID:11559703
Ppm1fRatnegative regulation of cell-cell adhesion mediated by cadherin involved_inISOPPM1F (Homo sapiens)1624291 PMID:24338362RGDPMID:24338362
Ppm1fRatnegative regulation of cell-cell adhesion mediated by cadherin involved_inIEAUniProtKB:P49593 and ensembl:ENSP000002632121600115GO_REF:0000107EnsemblGO_REF:0000107
Ppm1fRatnegative regulation of DNA-templated transcription involved_inISSUniProtKB:P495931600115GO_REF:0000024UniProtGO_REF:0000024
Ppm1fRatnegative regulation of DNA-templated transcription involved_inIEAUniProtKB:P49593 and ensembl:ENSP000002632121600115GO_REF:0000107EnsemblGO_REF:0000107
Ppm1fRatnegative regulation of DNA-templated transcription involved_inISOPPM1F (Homo sapiens)1624291 PMID:20016286RGDPMID:20016286
Ppm1fRatnegative regulation of protein transport involved_inISOPPM1F (Homo sapiens)1624291 PMID:24338362RGDPMID:24338362
Ppm1fRatnegative regulation of protein transport involved_inIEAUniProtKB:P49593 and ensembl:ENSP000002632121600115GO_REF:0000107EnsemblGO_REF:0000107
Ppm1fRatpositive regulation of cell migration involved_inISOPPM1F (Homo sapiens)1624291RNAcentral:URS00001C770D_9606 PMID:26498692RGDPMID:26498692
Ppm1fRatpositive regulation of cell migration involved_inIEAUniProtKB:P49593 and ensembl:ENSP000002632121600115GO_REF:0000107EnsemblGO_REF:0000107
Ppm1fRatpositive regulation of cell-substrate adhesion involved_inISSUniProtKB:P495931600115GO_REF:0000024UniProtGO_REF:0000024
Ppm1fRatpositive regulation of cell-substrate adhesion involved_inIEAUniProtKB:P49593 and ensembl:ENSP000002632121600115GO_REF:0000107EnsemblGO_REF:0000107
Ppm1fRatpositive regulation of cell-substrate adhesion involved_inISOPPM1F (Homo sapiens)1624291 PMID:20016286RGDPMID:20016286
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Cellular Component
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Object Symbol
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Original Reference(s)
Ppm1fRatcytosol located_inISOPPM1F (Homo sapiens)1624291 PMID:11559703RGDPMID:11559703
Ppm1fRatcytosol is_active_inIBAPANTHER:PTN002675945 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ppm1fRatcytosol located_inTAS 1600115Reactome:R-RNO-9619459ReactomeReactome:R-RNO-9619459
Ppm1fRatcytosol located_inIDA 632383PMID:10348902UniProt 
Ppm1fRatcytosol located_inTAS 1600115Reactome:R-RNO-9619472ReactomeReactome:R-RNO-9619472
Ppm1fRatcytosol located_inIEAUniProtKB:P49593 and ensembl:ENSP000002632121600115GO_REF:0000107EnsemblGO_REF:0000107
Ppm1fRatnucleus is_active_inIBAPANTHER:PTN002302067 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ppm1fRatperinuclear region of cytoplasm located_inIDA 632383PMID:10348902UniProt 
Ppm1fRatprotein-containing complex part_ofISOPPM1F (Homo sapiens)1624291 PMID:11864573RGDPMID:11864573
Ppm1fRatprotein-containing complex part_ofIEAUniProtKB:P49593 and ensembl:ENSP000002632121600115GO_REF:0000107EnsemblGO_REF:0000107
Ppm1fRatprotein-containing complex part_ofISSUniProtKB:P495931600115GO_REF:0000024UniProtGO_REF:0000024
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Molecular Function
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Object Symbol
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Original Reference(s)
Ppm1fRatcalmodulin-dependent protein phosphatase activity enablesISSUniProtKB:P495931600115GO_REF:0000024UniProtGO_REF:0000024
Ppm1fRatcalmodulin-dependent protein phosphatase activity enablesIEAUniProtKB:P49593 and ensembl:ENSP000002632121600115GO_REF:0000107EnsemblGO_REF:0000107
Ppm1fRatcalmodulin-dependent protein phosphatase activity enablesISOPPM1F (Homo sapiens)1624291 PMID:11559703 and PMID:15140879RGDPMID:11559703 and PMID:15140879
Ppm1fRatcation binding enablesIEAInterPro:IPR0002221600115GO_REF:0000002InterProGO_REF:0000002
Ppm1fRathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Ppm1fRatmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Ppm1fRatphosphoprotein phosphatase activity  IDA 7241141 RGD 
Ppm1fRatphosphoprotein phosphatase activity enablesIEAARBA:ARBA000276511600115GO_REF:0000117UniProtGO_REF:0000117
Ppm1fRatphosphoprotein phosphatase activity enablesIEAUniProtKB-KW:KW-09041600115GO_REF:0000043UniProtGO_REF:0000043
Ppm1fRatprotein binding enablesISOPPM1F (Homo sapiens)1624291UniProtKB:O60610 more ...RGDPMID:11559703 more ...
Ppm1fRatprotein serine/threonine phosphatase activity  IDA 7241145 RGD 
Ppm1fRatprotein serine/threonine phosphatase activity enablesIEARHEA:20629 and RHEA:470041600115GO_REF:0000116RHEAGO_REF:0000116
Ppm1fRatprotein serine/threonine phosphatase activity enablesIEAUniProtKB:P49593 and ensembl:ENSP000002632121600115GO_REF:0000107EnsemblGO_REF:0000107
Ppm1fRatprotein serine/threonine phosphatase activity enablesIEAEC:3.1.3.161600115GO_REF:0000003UniProtGO_REF:0000003
Ppm1fRatprotein serine/threonine phosphatase activity enablesIEAInterPro:IPR0156551600115GO_REF:0000002InterProGO_REF:0000002
Ppm1fRatprotein serine/threonine phosphatase activity enablesISOPPM1F (Homo sapiens)1624291 PMID:11559703 more ...RGDPMID:11559703 more ...
Ppm1fRatprotein serine/threonine phosphatase activity enablesISSUniProtKB:P495931600115GO_REF:0000024UniProtGO_REF:0000024
Ppm1fRatprotein serine/threonine phosphatase activity enablesTAS 1600115Reactome:R-RNO-9619472ReactomeReactome:R-RNO-9619472
Ppm1fRatprotein serine/threonine phosphatase activity enablesTAS 1600115Reactome:R-RNO-9619459ReactomeReactome:R-RNO-9619459
Ppm1fRatprotein tyrosine/serine/threonine phosphatase activity enablesISOPPM1F (Homo sapiens)1624291 PMID:24338362RGDPMID:24338362
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RGD Manual Annotations


  

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Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Negative regulation of multifunctional Ca2+/calmodulin-dependent protein kinases: physiological and pharmacological significance of protein phosphatases. Ishida A, etal., Br J Pharmacol. 2008 Jun;154(4):729-40. doi: 10.1038/bjp.2008.127. Epub 2008 May 5.
3. Phosphorylation and activation of Ca2+/calmodulin-dependent protein kinase phosphatase by Ca2+/calmodulin-dependent protein kinase II. Kameshita I, etal., FEBS Lett. 1999 Aug 6;456(2):249-52.
4. Molecular cloning of Ca2+/calmodulin-dependent protein kinase phosphatase. Kitani T, etal., J Biochem (Tokyo) 1999 Jun;125(6):1022-8.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Mutational analysis of Ca(2+)/calmodulin-dependent protein kinase phosphatase (CaMKP). Tada Y, etal., Arch Biochem Biophys. 2006 Aug 15;452(2):174-85. Epub 2006 Jun 21.
9. The Caenorhabditis elegans sex-determining protein FEM-2 and its human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein kinase phosphatases that promote apoptosis. Tan KM, etal., J Biol Chem. 2001 Nov 23;276(47):44193-202. Epub 2001 Sep 14.
10. Ppm1E is an in cellulo AMP-activated protein kinase phosphatase. Voss M, etal., Cell Signal. 2011 Jan;23(1):114-24. doi: 10.1016/j.cellsig.2010.08.010. Epub 2010 Aug 27.
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PMID:11864573   PMID:12477932   PMID:15140879   PMID:20016286   PMID:23991411   PMID:24338362   PMID:26498692  



Ppm1f
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81197,568,627 - 97,598,613 (-)NCBIGRCr8
mRatBN7.21184,064,422 - 84,094,410 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1184,064,420 - 84,094,340 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1192,790,922 - 92,818,479 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01185,452,053 - 85,479,612 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01184,505,643 - 84,533,204 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01188,313,709 - 88,343,726 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1188,313,709 - 88,343,627 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01191,368,795 - 91,398,731 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,086,968 - 86,114,278 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,127,564 - 86,154,875 (-)NCBI
Celera1182,821,775 - 82,848,989 (-)NCBICelera
Cytogenetic Map11q23NCBI
PPM1F
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382221,919,425 - 21,952,848 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2221,919,425 - 21,952,848 (-)EnsemblGRCh38hg38GRCh38
GRCh372222,273,798 - 22,307,220 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362220,603,793 - 20,637,217 (-)NCBINCBI36Build 36hg18NCBI36
Build 342220,598,346 - 20,631,771NCBI
Celera226,091,333 - 6,124,791 (-)NCBICelera
Cytogenetic Map22q11.22NCBI
HuRef225,230,870 - 5,264,327 (-)NCBIHuRef
CHM1_12222,273,889 - 22,307,348 (-)NCBICHM1_1
T2T-CHM13v2.02222,332,962 - 22,366,379 (-)NCBIT2T-CHM13v2.0
Ppm1f
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391616,714,314 - 16,745,239 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1616,714,333 - 16,745,228 (+)EnsemblGRCm39 Ensembl
GRCm381616,896,469 - 16,927,375 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1616,896,469 - 16,927,364 (+)EnsemblGRCm38mm10GRCm38
MGSCv371616,903,414 - 16,927,455 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361616,816,884 - 16,840,925 (+)NCBIMGSCv36mm8
Celera1617,475,388 - 17,499,499 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1610.48NCBI
Ppm1f
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544217,227,723 - 17,252,383 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544217,233,258 - 17,256,009 (+)NCBIChiLan1.0ChiLan1.0
PPM1F
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22331,461,495 - 31,494,626 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12234,010,360 - 34,043,505 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0224,039,032 - 4,072,165 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12220,520,022 - 20,553,128 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2220,520,022 - 20,553,128 (-)Ensemblpanpan1.1panPan2
PPM1F
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12631,162,810 - 31,193,586 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2631,166,593 - 31,193,587 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2631,118,870 - 31,149,720 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02632,568,771 - 32,599,639 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2632,568,771 - 32,599,645 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12630,617,044 - 30,647,882 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02630,241,110 - 30,271,944 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02631,331,626 - 31,362,486 (-)NCBIUU_Cfam_GSD_1.0
Ppm1f
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118140,937,979 - 140,967,888 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366191,786,178 - 1,816,109 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366191,786,223 - 1,816,083 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPM1F
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1450,040,663 - 50,063,325 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11450,040,612 - 50,083,047 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21453,483,164 - 53,505,869 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPM1F
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,167,925 - 4,200,550 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl194,167,908 - 4,200,953 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660852,802,752 - 2,835,380 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppm1f
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247471,420,835 - 1,446,143 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247471,417,004 - 1,446,211 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Ppm1f
198 total Variants

Predicted Target Of
Summary Value
Count of predictions:62
Count of miRNA genes:60
Interacting mature miRNAs:60
Transcripts:ENSRNOT00000002530
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat

RH129096  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21184,064,432 - 84,064,621 (+)MAPPERmRatBN7.2
Rnor_6.01188,313,722 - 88,313,910NCBIRnor6.0
Rnor_5.01191,368,806 - 91,368,994UniSTSRnor5.0
RGSC_v3.41186,084,339 - 86,084,527UniSTSRGSC3.4
Celera1182,819,146 - 82,819,334UniSTS
Cytogenetic Map11q23UniSTS
BF400290  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21184,068,434 - 84,068,629 (+)MAPPERmRatBN7.2
Rnor_6.01188,317,724 - 88,317,918NCBIRnor6.0
Rnor_5.01191,372,808 - 91,373,002UniSTSRnor5.0
RGSC_v3.41186,088,341 - 86,088,535UniSTSRGSC3.4
Celera1182,823,148 - 82,823,342UniSTS
RH 3.4 Map2858.8UniSTS
Cytogenetic Map11q23UniSTS
BF403121  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21184,068,433 - 84,068,629 (+)MAPPERmRatBN7.2
Rnor_6.01188,317,723 - 88,317,918NCBIRnor6.0
Rnor_5.01191,372,807 - 91,373,002UniSTSRnor5.0
RGSC_v3.41186,088,340 - 86,088,535UniSTSRGSC3.4
Celera1182,823,147 - 82,823,342UniSTS
RH 3.4 Map11652.9UniSTS
Cytogenetic Map11q23UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000002530   ⟹   ENSRNOP00000002530
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1184,064,420 - 84,094,340 (-)Ensembl
Rnor_6.0 Ensembl1188,313,709 - 88,343,627 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112083   ⟹   ENSRNOP00000084851
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1184,064,420 - 84,080,034 (-)Ensembl
RefSeq Acc Id: NM_175755   ⟹   NP_786931
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,571,267 - 97,598,565 (-)NCBI
mRatBN7.21184,067,062 - 84,094,360 (-)NCBI
Rnor_6.01188,316,351 - 88,343,647 (-)NCBI
Rnor_5.01191,368,795 - 91,398,731 (-)NCBI
RGSC_v3.41186,086,968 - 86,114,278 (-)RGD
Celera1182,821,775 - 82,848,989 (-)RGD
Sequence:
RefSeq Acc Id: XM_006248674   ⟹   XP_006248736
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,568,627 - 97,598,591 (-)NCBI
mRatBN7.21184,064,422 - 84,094,348 (-)NCBI
Rnor_6.01188,313,709 - 88,343,627 (-)NCBI
Rnor_5.01191,368,795 - 91,398,731 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039088064   ⟹   XP_038943992
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,568,627 - 97,598,613 (-)NCBI
mRatBN7.21184,064,422 - 84,094,410 (-)NCBI
1 to 10 of 10 rows
Protein RefSeqs NP_786931 (Get FASTA)   NCBI Sequence Viewer  
  XP_006248736 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943992 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66854 (Get FASTA)   NCBI Sequence Viewer  
  BAA82477 (Get FASTA)   NCBI Sequence Viewer  
  EDL77865 (Get FASTA)   NCBI Sequence Viewer  
  EDL77866 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000002530
  ENSRNOP00000002530.3
GenBank Protein Q9WVR7 (Get FASTA)   NCBI Sequence Viewer  
1 to 10 of 10 rows
RefSeq Acc Id: NP_786931   ⟸   NM_175755
- UniProtKB: Q9WVR7 (UniProtKB/Swiss-Prot),   B2RYP5 (UniProtKB/TrEMBL),   A0A8I6A062 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248736   ⟸   XM_006248674
- Peptide Label: isoform X1
- UniProtKB: Q9WVR7 (UniProtKB/Swiss-Prot),   B2RYP5 (UniProtKB/TrEMBL),   A0A8I6A062 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002530   ⟸   ENSRNOT00000002530
RefSeq Acc Id: XP_038943992   ⟸   XM_039088064
- Peptide Label: isoform X1
- UniProtKB: Q9WVR7 (UniProtKB/Swiss-Prot),   B2RYP5 (UniProtKB/TrEMBL),   A0A8I6A062 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000084851   ⟸   ENSRNOT00000112083
PPM-type phosphatase

Name Modeler Protein Id AA Range Protein Structure
AF-Q9WVR7-F1-model_v2 AlphaFold Q9WVR7 1-450 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698340
Promoter ID:EPDNEW_R8865
Type:multiple initiation site
Name:Ppm1f_1
Description:protein phosphatase, Mg2+/Mn2+ dependent, 1F
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01188,343,665 - 88,343,725EPDNEW


1 to 27 of 27 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-20564 BioCyc
Ensembl Genes ENSRNOG00000037909 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002530 ENTREZGENE
  ENSRNOT00000002530.6 UniProtKB/Swiss-Prot
Gene3D-CATH 3.60.40.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:9098491 IMAGE-MGC_LOAD
InterPro PP2C UniProtKB/Swiss-Prot
  PP2C_BS UniProtKB/Swiss-Prot
  PPM-type_dom_sf UniProtKB/Swiss-Prot
  PPM-type_phosphatase_dom UniProtKB/Swiss-Prot
KEGG Report rno:287931 UniProtKB/Swiss-Prot
MGC_CLONE MGC:188760 IMAGE-MGC_LOAD
NCBI Gene 287931 ENTREZGENE
PANTHER PROTEIN PHOSPHATASE 1F UniProtKB/Swiss-Prot
  PTHR13832 UniProtKB/Swiss-Prot
Pfam PP2C UniProtKB/Swiss-Prot
PhenoGen Ppm1f PhenoGen
PROSITE PPM_1 UniProtKB/Swiss-Prot
  PPM_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000037909 RatGTEx
SMART PP2C_SIG UniProtKB/Swiss-Prot
  PP2Cc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF81606 UniProtKB/Swiss-Prot
UniProt A0A8I6A062 ENTREZGENE, UniProtKB/TrEMBL
  A6JSP2_RAT UniProtKB/TrEMBL
  B2RYP5 ENTREZGENE, UniProtKB/TrEMBL
  PPM1F_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 27 of 27 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Ppm1f  protein phosphatase, Mg2+/Mn2+ dependent, 1F  Ppm1f  protein phosphatase 1F (PP2C domain containing)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-11 Ppm1f  protein phosphatase 1F (PP2C domain containing)  CaMKPase  calcium/calmodulin-dependent protein kinase phosphatase  Symbol and Name updated to reflect Human and Mouse nomenclature 625702 APPROVED

Note Type Note Reference
gene_cellular_localization localized to cytoplasm 632383
gene_protein 450 amino acids 632383