Tubb3 (tubulin, beta 3 class III) - Rat Genome Database

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Gene: Tubb3 (tubulin, beta 3 class III) Rattus norvegicus
Analyze
Symbol: Tubb3
Name: tubulin, beta 3 class III
RGD ID: 628595
Description: Enables peptide binding activity. Involved in neuron differentiation. Located in axon. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 1 and congenital fibrosis of the extraocular muscles 3A. Orthologous to human TUBB3 (tubulin beta 3 class III); PARTICIPATES IN phagocytosis pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3',4,4',5-Pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: neuron-specific class III beta-tubulin; tubulin beta-3 chain; tubulin, beta 3
RGD Orthologs
Human
Mouse
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81968,365,687 - 68,374,741 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1968,365,587 - 68,374,740 (+)EnsemblGRCr8
mRatBN7.21951,457,187 - 51,466,243 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1951,457,184 - 51,466,243 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1958,251,389 - 58,260,397 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01958,928,868 - 58,937,934 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01961,149,989 - 61,158,997 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01956,220,759 - 56,229,813 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1956,220,755 - 56,229,813 (+)Ensemblrn6Rnor6.0
Rnor_5.01966,931,880 - 66,940,930 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41953,742,652 - 53,751,706 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1950,689,724 - 50,698,713 (+)NCBICelera
RGSC_v3.14155,058,769 - 155,059,105 (+)NCBI
Cytogenetic Map19q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-citrinin  (ISO)
(-)-demecolcine  (ISO)
(S)-amphetamine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2-bromohexadecanoic acid  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-[3-(4-tert-butylphenyl)-2-methylpropyl]-2,6-dimethylmorpholine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (ISO)
abamectin  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
all-trans-retinoic acid  (EXP,ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
Anatoxin a  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
atorvastatin calcium  (EXP)
atrazine  (EXP,ISO)
Azaspiracid  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbofuran  (EXP)
carbon nanotube  (ISO)
cefaloridine  (EXP)
CGP 52608  (ISO)
CHIR 99021  (ISO)
chlordecone  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP)
cobalt dichloride  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
curcumin  (EXP)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (ISO)
cytarabine  (ISO)
DAPT  (ISO)
decabromodiphenyl ether  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
diethyl phthalate  (EXP,ISO)
diisobutyl phthalate  (EXP,ISO)
diisononyl phthalate  (EXP,ISO)
dimethyl sulfoxide  (ISO)
dinophysistoxin 1  (ISO)
disulfiram  (ISO)
Doramectin  (ISO)
elemental selenium  (ISO)
emodin  (ISO)
endosulfan  (EXP)
enniatin  (ISO)
ethanol  (EXP,ISO)
ethylparaben  (ISO)
fenpropidin  (ISO)
fluoxetine  (ISO)
flusilazole  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
gentamycin  (EXP)
glutathione  (ISO)
glyphosate  (ISO)
GSK-J4  (ISO)
heptachlor  (EXP)
Icaritin  (ISO)
imidacloprid  (EXP)
indometacin  (ISO)
iohexol  (ISO)
iopamidol  (ISO)
ivermectin  (ISO)
kaempferol  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (EXP,ISO)
lead tetraacetate  (ISO)
Licochalcone B  (ISO)
manganese(II) chloride  (ISO)
methylmercury chloride  (ISO)
monocrotaline  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
niclosamide  (ISO)
Nutlin-3  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PD123319  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenol red  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
progesterone  (EXP)
rotenone  (ISO)
Salidroside  (ISO)
Salinomycin  (ISO)
sarin  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
SKF-96365 hydrochloride  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
spiroxamine  (ISO)
sterigmatocystin  (EXP)
sunitinib  (ISO)
tamibarotene  (EXP)
tamoxifen  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP)
vincristine  (ISO)
vitamin E  (ISO)
WIN 55212-2  (ISO)
XL147  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
axon  (IDA,IEA,ISO)
cell periphery  (IEA,ISO)
ciliary tip  (IEA,ISO)
cilium  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO)
cytoskeleton  (IEA)
dendrite  (IEA,ISO,ISS)
filopodium  (IEA,ISO,ISS)
growth cone  (IEA,ISO,ISS)
intercellular bridge  (IEA,ISO)
lamellipodium  (IEA,ISO,ISS)
microtubule  (IBA,IEA,ISO)
microtubule cytoskeleton  (IEA,ISO,ISS)
mitotic spindle  (IEA,ISO)
neuronal cell body  (IEA,ISO)
sperm end piece  (IEA,ISO)
sperm principal piece  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cloning and characterization of the 5'-flanking region of the rat neuron-specific Class III beta-tubulin gene. Dennis K, etal., Gene 2002 Jul 10;294(1-2):269-77.
2. Peptide neuroprotection through specific interaction with brain tubulin. Divinski I, etal., J Neurochem. 2006 Aug;98(3):973-84.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Synaptotagmin 11 interacts with components of the RNA-induced silencing complex RISC in clonal pancreatic beta-cells. Milochau A, etal., FEBS Lett. 2014 Jun 27;588(14):2217-22. doi: 10.1016/j.febslet.2014.05.031. Epub 2014 May 29.
7. Identification of a polymorphic, neuron-specific chromatin remodeling complex. Olave I, etal., Genes Dev. 2002 Oct 1;16(19):2509-17.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8855335   PMID:12134159   PMID:12477932   PMID:15003631   PMID:15255972   PMID:15277470   PMID:15489334   PMID:16820281   PMID:16892058   PMID:17761882   PMID:18076286   PMID:18220421  
PMID:18556119   PMID:18614158   PMID:19036983   PMID:19389377   PMID:20074521   PMID:21499258   PMID:21525035   PMID:21630459   PMID:21734264   PMID:21958528   PMID:22949634   PMID:23090999  
PMID:23284756   PMID:23434913   PMID:23533145   PMID:24378336   PMID:24464040   PMID:25433207   PMID:26561800   PMID:28223217   PMID:28426968   PMID:28483977   PMID:29476059   PMID:31686426  


Genomics

Comparative Map Data
Tubb3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81968,365,687 - 68,374,741 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1968,365,587 - 68,374,740 (+)EnsemblGRCr8
mRatBN7.21951,457,187 - 51,466,243 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1951,457,184 - 51,466,243 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1958,251,389 - 58,260,397 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01958,928,868 - 58,937,934 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01961,149,989 - 61,158,997 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01956,220,759 - 56,229,813 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1956,220,755 - 56,229,813 (+)Ensemblrn6Rnor6.0
Rnor_5.01966,931,880 - 66,940,930 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41953,742,652 - 53,751,706 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1950,689,724 - 50,698,713 (+)NCBICelera
RGSC_v3.14155,058,769 - 155,059,105 (+)NCBI
Cytogenetic Map19q12NCBI
TUBB3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381689,921,925 - 89,936,097 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1689,921,392 - 89,938,761 (+)Ensemblhg38GRCh38
GRCh371689,988,333 - 90,002,505 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361688,517,246 - 88,530,006 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341688,517,245 - 88,530,006NCBI
Celera1675,054,835 - 75,067,595 (+)NCBICelera
Cytogenetic Map16q24.3NCBI
HuRef1675,681,526 - 75,695,522 (+)NCBIHuRef
CHM1_11691,400,537 - 91,414,621 (+)NCBICHM1_1
T2T-CHM13v2.01696,008,170 - 96,022,338 (+)NCBIT2T-CHM13v2.0
Tubb3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398124,138,292 - 124,148,754 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8124,138,163 - 124,148,754 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm388123,411,553 - 123,422,015 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8123,411,424 - 123,422,015 (+)Ensemblmm10GRCm38
MGSCv378125,935,464 - 125,945,910 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368126,297,654 - 126,308,100 (+)NCBIMGSCv36mm8
Celera8127,654,088 - 127,664,534 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map872.1NCBI
TUBB3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1563,681,765 - 63,690,898 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl563,681,752 - 63,729,684 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha563,694,960 - 63,704,093 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0563,909,742 - 63,918,874 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl563,909,745 - 63,919,020 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1563,930,270 - 63,939,401 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0563,767,793 - 63,776,934 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0564,174,159 - 64,183,292 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tubb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934924,431,189 - 24,440,321 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936641184,765 - 193,819 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936641184,736 - 193,835 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TUBB3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1575,242,423 - 75,257,992 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl575,246,614 - 75,258,084 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666047162,137 - 179,147 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tubb3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624746124,014 - 130,476 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tubb3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11743,020,536 - 43,029,614 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:46
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000023452
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)196124916174246245Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat

Markers in Region
BE108480  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21951,467,365 - 51,467,573 (+)MAPPERmRatBN7.2
Rnor_6.01956,230,936 - 56,231,143NCBIRnor6.0
Rnor_5.01966,942,053 - 66,942,260UniSTSRnor5.0
RGSC_v3.41953,752,829 - 53,753,036UniSTSRGSC3.4
Celera1950,699,836 - 50,700,043UniSTS
RH 3.4 Map19716.7UniSTS
Cytogenetic Map19q12UniSTS
MARC_24021-24022:1029778648:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21951,465,188 - 51,465,794 (+)MAPPERmRatBN7.2
mRatBN7.291,918,543 - 1,919,149 (-)MAPPERmRatBN7.2
Rnor_6.099,967,112 - 9,967,717NCBIRnor6.0
Rnor_6.01956,228,759 - 56,229,364NCBIRnor6.0
Rnor_5.098,966,864 - 8,967,469UniSTSRnor5.0
Rnor_5.01966,939,876 - 66,940,481UniSTSRnor5.0
RGSC_v3.41953,750,652 - 53,751,257UniSTSRGSC3.4
Celera1950,697,659 - 50,698,264UniSTS
Celera96,598,574 - 6,599,179UniSTS
Cytogenetic Map19q12UniSTS
UniSTS:498328  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21951,465,873 - 51,466,083 (+)MAPPERmRatBN7.2
Rnor_6.01956,229,444 - 56,229,653NCBIRnor6.0
Rnor_5.01966,940,561 - 66,940,770UniSTSRnor5.0
RGSC_v3.41953,751,337 - 53,751,546UniSTSRGSC3.4
Celera1950,698,344 - 50,698,553UniSTS
Cytogenetic Map19q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 66 162 91 90 59 81 59 6 330 180 11 141 67 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000023452   ⟹   ENSRNOP00000023452
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1968,365,587 - 68,374,740 (+)Ensembl
mRatBN7.2 Ensembl1951,457,184 - 51,466,243 (+)Ensembl
Rnor_6.0 Ensembl1956,220,755 - 56,229,813 (+)Ensembl
RefSeq Acc Id: NM_139254   ⟹   NP_640347
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81968,365,687 - 68,374,741 (+)NCBI
mRatBN7.21951,457,187 - 51,466,243 (+)NCBI
Rnor_6.01956,220,759 - 56,229,813 (+)NCBI
Rnor_5.01966,931,880 - 66,940,930 (+)NCBI
RGSC_v3.41953,742,652 - 53,751,706 (+)RGD
Celera1950,689,724 - 50,698,713 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_640347 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH97281 (Get FASTA)   NCBI Sequence Viewer  
  AAM28680 (Get FASTA)   NCBI Sequence Viewer  
  EDL92810 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023452
  ENSRNOP00000023452.3
GenBank Protein Q4QRB4 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_640347   ⟸   NM_139254
- UniProtKB: Q6P9T8 (UniProtKB/Swiss-Prot),   Q8K5B6 (UniProtKB/Swiss-Prot),   Q4QRB4 (UniProtKB/Swiss-Prot),   A6IZY2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023452   ⟸   ENSRNOT00000023452
Protein Domains
Tubulin/FtsZ 2-layer sandwich   Tubulin/FtsZ GTPase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4QRB4-F1-model_v2 AlphaFold Q4QRB4 1-450 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701226
Promoter ID:EPDNEW_R11750
Type:single initiation site
Name:Tubb3_1
Description:tubulin, beta 3 class III
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01956,220,755 - 56,220,815EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628595 AgrOrtholog
BioCyc Gene G2FUF-5325 BioCyc
Ensembl Genes ENSRNOG00000017209 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023452 ENTREZGENE
  ENSRNOT00000023452.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.600 UniProtKB/Swiss-Prot
  3.30.1330.20 UniProtKB/Swiss-Prot
  3.40.50.1440 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7461390 IMAGE-MGC_LOAD
InterPro Beta-tubulin_BS UniProtKB/Swiss-Prot
  Beta_tubulin UniProtKB/Swiss-Prot
  Tub_FtsZ_C UniProtKB/Swiss-Prot
  Tubulin UniProtKB/Swiss-Prot
  Tubulin/FtsZ_2-layer-sand-dom UniProtKB/Swiss-Prot
  Tubulin/FtsZ_C_sf UniProtKB/Swiss-Prot
  Tubulin/FtsZ_GTPase_sf UniProtKB/Swiss-Prot
  Tubulin_C UniProtKB/Swiss-Prot
  Tubulin_CS UniProtKB/Swiss-Prot
  Tubulin_FtsZ_GTPase UniProtKB/Swiss-Prot
KEGG Report rno:246118 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114260 IMAGE-MGC_LOAD
NCBI Gene 246118 ENTREZGENE
PANTHER PTHR11588 UniProtKB/Swiss-Prot
Pfam Tubulin UniProtKB/Swiss-Prot
  Tubulin_C UniProtKB/Swiss-Prot
PhenoGen Tubb3 PhenoGen
PRINTS BETATUBULIN UniProtKB/Swiss-Prot
  TUBULIN UniProtKB/Swiss-Prot
PROSITE TUBULIN UniProtKB/Swiss-Prot
  TUBULIN_B_AUTOREG UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017209 RatGTEx
SMART Tubulin UniProtKB/Swiss-Prot
  Tubulin_C UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52490 UniProtKB/Swiss-Prot
  SSF55307 UniProtKB/Swiss-Prot
UniProt A6IZY2 ENTREZGENE, UniProtKB/TrEMBL
  Q4QRB4 ENTREZGENE
  Q6P9T8 ENTREZGENE
  Q8K5B6 ENTREZGENE
  TBB3_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q8K5B6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-10-19 Tubb3  tubulin, beta 3 class III  Tubb3  tubulin, beta 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-10-12 Tubb3  tubulin, beta 3  Tubb3  tubulin, beta 3 class III  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-10-10 Tubb3  tubulin, beta 3 class III  Tubb3  tubulin, beta 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Tubb3  tubulin, beta 3      Symbol and Name status set to approved 1299863 APPROVED
2003-02-27 Tubb3  tubulin, beta 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference