Uts2r (urotensin 2 receptor) - Rat Genome Database

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Gene: Uts2r (urotensin 2 receptor) Rattus norvegicus
Analyze
Symbol: Uts2r
Name: urotensin 2 receptor
RGD ID: 621884
Description: Enables urotensin II receptor activity. Involved in several processes, including positive regulation of vasoconstriction; regulation of blood pressure; and regulation of circadian sleep/wake cycle. Located in early endosome and recycling endosome. Used to study acute kidney failure; endomyocardial fibrosis; and hypertension. Biomarker of cardiomyopathy and myocardial infarction. Orthologous to human UTS2R (urotensin 2 receptor); INTERACTS WITH ammonium chloride; C60 fullerene; copper atom.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: G-protein coupled receptor 14; G-protein coupled sensory epithelial neuropeptide-like receptor; Gpr14; putative G protein-coupled receptor (SENR); putative G protein-coupled receptor (SENR) gene; Senr; UR-2-R; UR-II-R; urotensin II receptor; urotensin-2 receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810106,936,398 - 106,937,558 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10106,932,325 - 106,938,056 (+)EnsemblGRCr8
mRatBN7.210106,438,092 - 106,439,252 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10106,438,092 - 106,439,252 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10111,540,796 - 111,541,956 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010111,003,849 - 111,005,009 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010106,358,527 - 106,359,687 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010110,364,291 - 110,365,451 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10110,364,291 - 110,365,451 (+)Ensemblrn6Rnor6.0
Rnor_5.010109,951,008 - 109,952,168 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410110,394,782 - 110,395,942 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera10104,976,678 - 104,977,838 (+)NCBICelera
RGSC_v3.110110,409,285 - 110,410,446 (+)NCBI
Cytogenetic Map10q32.3NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Increased expression of urotensin II and its cognate receptor GPR14 in atherosclerotic lesions of the human aorta. Bousette N, etal., Atherosclerosis. 2004 Sep;176(1):117-23.
2. Urotensin-II receptor blockade with SB-611812 attenuates cardiac remodeling in experimental ischemic heart disease. Bousette N, etal., Peptides. 2006 Nov;27(11):2919-26. Epub 2006 Aug 17.
3. Pharmacology of the urotensin-II receptor antagonist palosuran (ACT-058362; 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl) -urea sulfate salt): first demonstration of a pathophysiological role of the urotensin System. Clozel M, etal., J Pharmacol Exp Ther. 2004 Oct;311(1):204-12. Epub 2004 May 14.
4. The urotensin-II receptor antagonist palosuran improves pancreatic and renal function in diabetic rats. Clozel M, etal., J Pharmacol Exp Ther. 2006 Mar;316(3):1115-21. Epub 2005 Nov 2.
5. Elevated expression of urotensin II and its receptor in diabetic cardiomyopathy. Dai HY, etal., J Diabetes Complications. 2008 Mar-Apr;22(2):137-43.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Contractile responses of aortae from WKY and SHR to vasoconstrictors. Gendron G, etal., Clin Exp Hypertens. 2004 Aug;26(6):511-23.
8. Arrestin-independent internalization and recycling of the urotensin receptor contribute to long-lasting urotensin II-mediated vasoconstriction. Giebing G, etal., Circ Res. 2005 Sep 30;97(7):707-15. Epub 2005 Sep 1.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Urotensin II modulates rapid eye movement sleep through activation of brainstem cholinergic neurons. Huitron-Resendiz S, etal., J Neurosci. 2005 Jun 8;25(23):5465-74.
11. Urotensin-II-mediated cardiomyocyte hypertrophy: effect of receptor antagonism and role of inflammatory mediators. Johns DG, etal., Naunyn Schmiedebergs Arch Pharmacol. 2004 Oct;370(4):238-50. Epub 2004 Sep 30.
12. Increased expression of urotensin II and urotensin II receptor in human diabetic nephropathy. Langham RG, etal., Am J Kidney Dis. 2004 Nov;44(5):826-31.
13. Central cardiovascular action of urotensin II in spontaneously hypertensive rats. Lin Y, etal., Hypertens Res. 2003 Oct;26(10):839-45.
14. Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors. Marchese A, etal., Genomics 1995 Sep 20;29(2):335-44.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Urotensin II and urotensin II-related peptide (URP) in cardiac ischemia-reperfusion injury. Prosser HC, etal., Peptides. 2008 May;29(5):770-7. Epub 2007 Aug 21.
18. GOA pipeline RGD automated data pipeline
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Urotensin II and renal function in the rat. Song W, etal., Kidney Int. 2006 Apr;69(8):1360-8.
21. Urotensin-II and its receptor (UT-R) are expressed in rat brain endothelial cells, and urotensin-II via UT-R stimulates angiogenesis in vivo and in vitro. Spinazzi R, etal., Int J Mol Med. 2006 Dec;18(6):1107-12.
22. A novel putative neuropeptide receptor expressed in neural tissue, including sensory epithelia. Tal M, etal., Biochem Biophys Res Commun 1995 Apr 17;209(2):752-9.
23. Diabetes-induced upregulation of urotensin II and its receptor plays an important role in TGF-beta1-mediated renal fibrosis and dysfunction. Tian L, etal., Am J Physiol Endocrinol Metab. 2008 Nov;295(5):E1234-42. Epub 2008 Sep 16.
24. Elevated expression of urotensin II and its receptor in skeletal muscle of diabetic mouse. Wang HX, etal., Regul Pept. 2009 Apr 10;154(1-3):85-90. doi: 10.1016/j.regpep.2009.01.004. Epub 2009 Jan 27.
25. Urotensin II accelerates cardiac fibrosis and hypertrophy of rats induced by isoproterenol. Zhang YG, etal., Acta Pharmacol Sin. 2007 Jan;28(1):36-43.
Additional References at PubMed
PMID:10581185   PMID:12495432   PMID:14550283   PMID:15273242   PMID:15458389   PMID:15476951   PMID:16290260   PMID:16685423   PMID:16942596   PMID:17628210   PMID:17905478   PMID:18082287  
PMID:18318439   PMID:18509066   PMID:18701623   PMID:18955095   PMID:19463745   PMID:19906507   PMID:20422157   PMID:20870804   PMID:21056072   PMID:21180151   PMID:21186587   PMID:22044114  
PMID:22245063   PMID:22563490   PMID:24878476   PMID:25175740   PMID:25803040   PMID:27208703   PMID:34866110  


Genomics

Comparative Map Data
Uts2r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810106,936,398 - 106,937,558 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10106,932,325 - 106,938,056 (+)EnsemblGRCr8
mRatBN7.210106,438,092 - 106,439,252 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10106,438,092 - 106,439,252 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10111,540,796 - 111,541,956 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010111,003,849 - 111,005,009 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010106,358,527 - 106,359,687 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010110,364,291 - 110,365,451 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10110,364,291 - 110,365,451 (+)Ensemblrn6Rnor6.0
Rnor_5.010109,951,008 - 109,952,168 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410110,394,782 - 110,395,942 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera10104,976,678 - 104,977,838 (+)NCBICelera
RGSC_v3.110110,409,285 - 110,410,446 (+)NCBI
Cytogenetic Map10q32.3NCBI
UTS2R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381782,371,765 - 82,377,458 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1782,368,266 - 82,377,709 (+)Ensemblhg38GRCh38
GRCh371780,329,641 - 80,335,334 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361777,925,490 - 77,926,659 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341777,925,489 - 77,926,659NCBI
Celera1776,924,342 - 76,925,511 (+)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1775,730,768 - 75,731,937 (+)NCBIHuRef
CHM1_11780,417,675 - 80,418,844 (+)NCBICHM1_1
T2T-CHM13v2.01783,240,931 - 83,246,624 (+)NCBIT2T-CHM13v2.0
Uts2r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911121,051,097 - 121,052,799 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11121,051,097 - 121,052,799 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3811121,160,271 - 121,161,973 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11121,160,271 - 121,161,973 (+)Ensemblmm10GRCm38
MGSCv3711121,021,585 - 121,023,287 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611120,976,361 - 120,978,063 (+)NCBIMGSCv36mm8
Celera11132,898,462 - 132,900,164 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1185.02NCBI
Uts2r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955506756,614 - 762,000 (-)Ensembl
ChiLan1.0NW_004955506756,859 - 761,891 (-)NCBIChiLan1.0ChiLan1.0
UTS2R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21998,913,633 - 98,918,934 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117103,817,766 - 103,823,271 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01776,783,432 - 76,788,639 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11782,592,312 - 82,593,702 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1782,592,312 - 82,593,702 (+)EnsemblpanPan2panpan1.1
UTS2R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha9587,915 - 589,510 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.09579,205 - 580,800 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl9579,646 - 580,884 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.19573,778 - 575,373 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.09734,681 - 736,277 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.09809,533 - 811,128 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Uts2r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602541,802 - 546,097 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493692324,952 - 31,083 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UTS2R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.112695,765 - 700,678 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2129,985 - 13,120 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UTS2R
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11674,284,472 - 74,291,074 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1674,288,333 - 74,289,502 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607745,928,730 - 45,935,411 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Uts2r
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1962,861,935 - 62,863,095 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:102
Count of miRNA genes:86
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000054926
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093723381107556066Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1089039175107713808Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1097202388107556066Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087807758107713808Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1091127270107556066Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091727883107713808Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1097202388107556066Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
7 11 22 59 30 28 19 43 19 6 122 80 9 44 8 36 9 4 4

Sequence


Ensembl Acc Id: ENSRNOT00000054926   ⟹   ENSRNOP00000051809
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10106,932,325 - 106,938,056 (+)Ensembl
mRatBN7.2 Ensembl10106,438,092 - 106,439,252 (+)Ensembl
Rnor_6.0 Ensembl10110,364,291 - 110,365,451 (+)Ensembl
RefSeq Acc Id: NM_020537   ⟹   NP_065412
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,936,398 - 106,937,558 (+)NCBI
mRatBN7.210106,438,092 - 106,439,252 (+)NCBI
Rnor_6.010110,364,291 - 110,365,451 (+)NCBI
Rnor_5.010109,951,008 - 109,952,168 (+)NCBI
RGSC_v3.410110,394,782 - 110,395,942 (+)RGD
Celera10104,976,678 - 104,977,838 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_065412 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA80111 (Get FASTA)   NCBI Sequence Viewer  
  AAC52593 (Get FASTA)   NCBI Sequence Viewer  
  BAA25251 (Get FASTA)   NCBI Sequence Viewer  
  BAA82357 (Get FASTA)   NCBI Sequence Viewer  
  EDM06933 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000051809
  ENSRNOP00000051809.1
GenBank Protein P49684 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_065412   ⟸   NM_020537
- UniProtKB: P48041 (UniProtKB/Swiss-Prot),   P49684 (UniProtKB/Swiss-Prot),   A6HLM8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000051809   ⟸   ENSRNOT00000054926
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49684-F1-model_v2 AlphaFold P49684 1-386 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621884 AgrOrtholog
BioCyc Gene G2FUF-22366 BioCyc
Ensembl Genes ENSRNOG00000036669 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000054926 ENTREZGENE
  ENSRNOT00000054926.2 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Urot_II_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:57305 UniProtKB/Swiss-Prot
NCBI Gene 57305 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot
  UROTENSIN-2 RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Uts2r PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  UROTENSIN2R UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000036669 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A6HLM8 ENTREZGENE, UniProtKB/TrEMBL
  P48041 ENTREZGENE
  P49684 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P48041 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Uts2r  urotensin 2 receptor  Senr  putative G protein-coupled receptor (SENR) gene  Symbol and Name updated 1299863 APPROVED
2002-08-07 Senr  putative G protein-coupled receptor (SENR) gene      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_homology shows 27% overall identity and 41% in the transmembrane domains to the somatostatin receptor SSTR 4 633970