Hspg2 (heparan sulfate proteoglycan 2) - Rat Genome Database

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Gene: Hspg2 (heparan sulfate proteoglycan 2) Rattus norvegicus
Analyze
Symbol: Hspg2
Name: heparan sulfate proteoglycan 2
RGD ID: 621770
Description: Enables collagen V binding activity. Involved in several processes, including animal organ regeneration; embryo implantation; and positive regulation of endothelial cell proliferation. Located in extracellular matrix. Biomarker of hypertension. Human ortholog(s) of this gene implicated in Schwartz-Jampel syndrome 1; Silverman-Handmaker type dyssegmental dysplasia; and osteochondrodysplasia. Orthologous to human HSPG2 (heparan sulfate proteoglycan 2); PARTICIPATES IN Hedgehog signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,2,2-tetramine; atrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AABR07073181.1; basement membrane-specific heparan sulfate proteoglycan core protein; LOC313641; Per; perlecan; perlecan (heparan sulfate proteoglycan 2)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85154,960,818 - 155,061,971 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5154,960,846 - 155,061,971 (+)EnsemblGRCr8
mRatBN7.25149,677,437 - 149,778,594 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5149,677,476 - 149,778,594 (+)EnsemblmRatBN7.2
Rnor_6.05155,812,096 - 155,913,751 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5155,812,105 - 155,885,829 (+)NCBIrn6Rnor6.0
Rnor_5.05159,568,612 - 159,669,759 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera5148,073,391 - 148,174,691 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
2,2'-Methylenebis(4-methyl-6-tert-butylphenol)  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
7,12-dimethyltetraphene  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
aspartame  (ISO)
atrazine  (EXP)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chromium(6+)  (ISO)
clobetasol  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
Cuprizon  (EXP)
cypermethrin  (ISO)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
glycidyl methacrylate  (ISO)
glyphosate  (EXP)
haloperidol  (ISO)
indometacin  (EXP)
inulin  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methamphetamine  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
miconazole  (ISO)
monosodium L-glutamate  (ISO)
nickel sulfate  (ISO)
obeticholic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
reserpine  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
streptozocin  (EXP)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Heparan sulfate proteoglycan synthesis and its expression are decreased in the retina of diabetic rats. Bollineni JS, etal., Curr Eye Res. 1997 Feb;16(2):127-30.
2. Perlecan and basement membrane-chondroitin sulfate proteoglycan (bamacan) are two basement membrane chondroitin/dermatan sulfate proteoglycans in the Engelbreth-Holm-Swarm tumor matrix. Couchman JR, etal., J Biol Chem. 1996 Apr 19;271(16):9595-602.
3. Proteoglycan gene expression in rat liver after partial hepatectomy. Gallai M, etal., Biochem Biophys Res Commun. 1996 Nov 21;228(3):690-4.
4. Perlecan-induced suppression of smooth muscle cell proliferation is mediated through increased activity of the tumor suppressor PTEN. Garl PJ, etal., Circ Res 2004 Feb 6;94(2):175-83. Epub 2003 Dec 1.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Laminin-6 assembles into multimolecular fibrillar complexes with perlecan and participates in mechanical-signal transduction via a dystroglycan-dependent, integrin-independent mechanism. Jones JC, etal., J Cell Sci. 2005 Jun 15;118(Pt 12):2557-66. Epub 2005 May 31.
7. Cyclic AMP regulates basement membrane heparan sulfate proteoglycan, perlecan, metabolism in rat glomerular epithelial cells. Ko CW, etal., Mol Cell Biochem 1996 Sep 6;162(1):65-73.
8. Hepatic gene expression response to acute indomethacin exposure. LaFramboise WA, etal., Mol Diagn Ther. 2006;10(3):187-96.
9. Down-regulation of perlecan expression contributes to the inhibition of rat cardiac microvascular endothelial cell proliferation induced by hypoxia. Li YZ, etal., Sheng Li Xue Bao. 2007 Apr 25;59(2):221-6.
10. Coarctation induces alterations in basement membranes in the cardiovascular system. Lipke DW, etal., Hypertension. 1993 Nov;22(5):743-53.
11. Perlecan inhibits smooth muscle cell adhesion to fibronectin: role of heparan sulfate. Lundmark K, etal., J Cell Physiol. 2001 Jul;188(1):67-74.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Perlecan, the major proteoglycan of basement membranes, is altered in patients with Schwartz-Jampel syndrome (chondrodystrophic myotonia). Nicole S, etal., Nat Genet. 2000 Dec;26(4):480-3.
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. SHh activity and localization is regulated by perlecan. Palma V, etal., Biol Res. 2011;44(1):63-7. doi: 10.4067/S0716-97602011000100008. Epub 2011 May 11.
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Comprehensive gene review and curation RGD comprehensive gene curation
19. Constitutive release of alpha4 type V collagen N-terminal domain by Schwann cells and binding to cell surface and extracellular matrix heparan sulfate proteoglycans. Rothblum K, etal., J Biol Chem. 2004 Dec 3;279(49):51282-8. Epub 2004 Sep 20.
20. Chondroitin sulphate and heparan sulfate proteoglycan are sequentially expressed in the uterine extracellular matrix during early pregnancy in the rat. Slater M and Murphy CR, Matrix Biol. 1999 Apr;18(2):125-31.
21. Reduced perlecan expression and accumulation in human carotid atherosclerotic lesions. Tran PK, etal., Atherosclerosis. 2007 Feb;190(2):264-70. Epub 2006 Apr 18.
22. High-glucose-induced structural changes in the heparan sulfate proteoglycan, perlecan, of cultured human aortic endothelial cells. Vogl-Willis CA and Edwards IJ, Biochim Biophys Acta. 2004 Apr 7;1672(1):36-45.
23. Syndecan-3 and perlecan are differentially expressed by progenitors and mature oligodendrocytes and accumulate in the extracellular matrix. Winkler S, etal., J Neurosci Res 2002 Aug 15;69(4):477-87.
Additional References at PubMed
PMID:7670489   PMID:10352025   PMID:10545953   PMID:10579729   PMID:11787818   PMID:11802174   PMID:12588956   PMID:12604605   PMID:12615671   PMID:15381701   PMID:15895400   PMID:15928325  
PMID:16407285   PMID:16502470   PMID:17525255   PMID:18757743   PMID:19056867   PMID:19199708   PMID:20551380   PMID:21126803   PMID:21289173   PMID:21362503   PMID:21423176   PMID:21747167  
PMID:21850672   PMID:22206666   PMID:22952693   PMID:23217742   PMID:23235151   PMID:23376485   PMID:23533145   PMID:23658023   PMID:23979707   PMID:24006456   PMID:25781054   PMID:26246161  
PMID:27068509   PMID:27559042   PMID:31505169  


Genomics

Comparative Map Data
Hspg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85154,960,818 - 155,061,971 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5154,960,846 - 155,061,971 (+)EnsemblGRCr8
mRatBN7.25149,677,437 - 149,778,594 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5149,677,476 - 149,778,594 (+)EnsemblmRatBN7.2
Rnor_6.05155,812,096 - 155,913,751 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5155,812,105 - 155,885,829 (+)NCBIrn6Rnor6.0
Rnor_5.05159,568,612 - 159,669,759 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera5148,073,391 - 148,174,691 (+)NCBICelera
Cytogenetic Map5q36NCBI
HSPG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38121,822,244 - 21,937,310 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl121,822,244 - 21,937,310 (-)Ensemblhg38GRCh38
GRCh37122,148,737 - 22,263,803 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36122,021,324 - 22,136,337 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34121,894,545 - 22,009,053NCBI
Celera120,471,674 - 20,545,742 (-)NCBICelera
Cytogenetic Map1p36.12NCBI
HuRef120,392,206 - 20,466,222 (-)NCBIHuRef
CHM1_1122,261,185 - 22,335,234 (-)NCBICHM1_1
T2T-CHM13v2.0121,646,052 - 21,761,123 (-)NCBIT2T-CHM13v2.0
Hspg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394137,196,062 - 137,297,941 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4137,196,080 - 137,297,941 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384137,468,751 - 137,570,630 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4137,468,769 - 137,570,630 (+)Ensemblmm10GRCm38
MGSCv374137,024,718 - 137,126,545 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364137,024,724 - 137,126,545 (+)NCBIMGSCv36mm8
Celera4135,720,332 - 135,778,896 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map469.93NCBI
Hspg2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554522,057,326 - 2,120,280 (-)Ensembl
ChiLan1.0NW_0049554522,056,428 - 2,141,937 (-)NCBIChiLan1.0ChiLan1.0
HSPG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21205,002,944 - 205,117,920 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11204,114,809 - 204,229,767 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0121,014,951 - 21,129,937 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1121,979,504 - 22,053,395 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl121,979,504 - 22,053,400 (-)EnsemblpanPan2panpan1.1
HSPG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1277,263,534 - 77,366,558 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl277,301,858 - 77,367,724 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha273,772,098 - 73,871,430 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0277,826,669 - 77,926,300 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl277,860,347 - 77,926,289 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1274,646,666 - 74,745,989 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0275,656,010 - 75,755,977 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0276,659,904 - 76,759,494 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hspg2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505841,582,855 - 41,654,168 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364747,408,518 - 7,467,851 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364747,407,622 - 7,478,950 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSPG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl679,849,698 - 79,958,334 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1679,849,691 - 79,958,283 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2673,882,694 - 73,947,389 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HSPG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120110,693,858 - 110,809,467 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20110,693,854 - 110,809,466 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660335,486,539 - 5,602,022 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hspg2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247646,640,087 - 6,708,130 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247646,639,152 - 6,736,161 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Hspg2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1120,657,390 - 20,759,001 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hspg2
774 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:133
Count of miRNA genes:92
Interacting mature miRNAs:110
Transcripts:ENSRNOT00000039341, ENSRNOT00000055950
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5149642129171146538Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5134369218156289444Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5149805999162987697Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5149661912166600247Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat

Markers in Region
D5Rat66  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85154,984,653 - 154,984,822 (+)Marker Load Pipeline
mRatBN7.25149,701,273 - 149,701,442 (+)MAPPERmRatBN7.2
Rnor_6.05155,835,939 - 155,836,107NCBIRnor6.0
Rnor_5.05159,592,438 - 159,592,606UniSTSRnor5.0
RGSC_v3.45156,250,789 - 156,250,957UniSTSRGSC3.4
RGSC_v3.45156,250,788 - 156,250,957RGDRGSC3.4
Celera5148,097,234 - 148,097,402UniSTS
RGSC_v3.15156,260,828 - 156,260,996RGD
RH 3.4 Map51009.5RGD
RH 3.4 Map51009.5UniSTS
RH 2.0 Map5942.8RGD
SHRSP x BN Map586.3899RGD
Cytogenetic Map5q36UniSTS
BE099553  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25149,696,343 - 149,696,511 (+)MAPPERmRatBN7.2
Rnor_6.05155,831,009 - 155,831,176NCBIRnor6.0
Rnor_5.05159,587,508 - 159,587,675UniSTSRnor5.0
RGSC_v3.45156,245,859 - 156,246,026UniSTSRGSC3.4
Celera5148,092,304 - 148,092,471UniSTS
RH 3.4 Map51008.4UniSTS
Cytogenetic Map5q36UniSTS
RH129941  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25149,778,277 - 149,778,464 (+)MAPPERmRatBN7.2
Rnor_6.05155,913,181 - 155,913,367NCBIRnor6.0
Rnor_5.05159,669,441 - 159,669,627UniSTSRnor5.0
RGSC_v3.45156,328,593 - 156,328,779UniSTSRGSC3.4
Celera5148,174,121 - 148,174,307UniSTS
RH 3.4 Map51009.6UniSTS
Cytogenetic Map5q36UniSTS
AU047918  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25149,701,129 - 149,701,368 (+)MAPPERmRatBN7.2
Rnor_6.05155,835,795 - 155,836,033NCBIRnor6.0
Rnor_5.05159,592,294 - 159,592,532UniSTSRnor5.0
RGSC_v3.45156,250,645 - 156,250,883UniSTSRGSC3.4
Celera5148,097,090 - 148,097,328UniSTS
Cytogenetic Map5q36UniSTS
BM385095  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25149,707,869 - 149,708,044 (+)MAPPERmRatBN7.2
Rnor_6.05155,842,533 - 155,842,707NCBIRnor6.0
Rnor_5.05159,599,032 - 159,599,206UniSTSRnor5.0
RGSC_v3.45156,257,392 - 156,257,566UniSTSRGSC3.4
Celera5148,103,829 - 148,104,003UniSTS
RH 3.4 Map51009.1UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 18 44 28 99 56 11 43 36 32 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000039341   ⟹   ENSRNOP00000034954
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5154,960,846 - 155,061,971 (+)Ensembl
mRatBN7.2 Ensembl5149,709,722 - 149,750,988 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098496   ⟹   ENSRNOP00000086030
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5154,960,846 - 155,061,971 (+)Ensembl
mRatBN7.2 Ensembl5149,677,476 - 149,778,594 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105209   ⟹   ENSRNOP00000097780
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5154,960,846 - 155,061,971 (+)Ensembl
mRatBN7.2 Ensembl5149,677,476 - 149,778,594 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000160537   ⟹   ENSRNOP00000101785
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5154,960,846 - 155,061,971 (+)Ensembl
RefSeq Acc Id: NM_001427438   ⟹   NP_001414367
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85154,960,846 - 155,061,971 (+)NCBI
RefSeq Acc Id: XM_039111301   ⟹   XP_038967229
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85154,960,818 - 155,061,971 (+)NCBI
mRatBN7.25149,677,437 - 149,778,594 (+)NCBI
RefSeq Acc Id: XM_063287774   ⟹   XP_063143844
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85154,960,818 - 155,061,971 (+)NCBI
RefSeq Acc Id: XM_063287775   ⟹   XP_063143845
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85154,960,818 - 155,061,971 (+)NCBI
RefSeq Acc Id: XM_063287776   ⟹   XP_063143846
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85154,960,818 - 155,051,890 (+)NCBI
RefSeq Acc Id: XP_038967229   ⟸   XM_039111301
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ASH2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000086030   ⟸   ENSRNOT00000098496
Ensembl Acc Id: ENSRNOP00000034954   ⟸   ENSRNOT00000039341
Ensembl Acc Id: ENSRNOP00000097780   ⟸   ENSRNOT00000105209
RefSeq Acc Id: XP_063143845   ⟸   XM_063287775
- Peptide Label: isoform X3
- UniProtKB: A0A8I6ASH2 (UniProtKB/TrEMBL),   A0A8I6A2S5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143844   ⟸   XM_063287774
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ASH2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143846   ⟸   XM_063287776
- Peptide Label: isoform X4
- UniProtKB: A0A8I6ASH2 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001414367   ⟸   NM_001427438
- Peptide Label: precursor
- UniProtKB: A0A8I6ASH2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000101785   ⟸   ENSRNOT00000160537
Protein Domains
EGF-like   Ig-like   Laminin EGF-like   Laminin G   Laminin IV type A   SEA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LTJ5-F1-model_v2 AlphaFold F1LTJ5 1-2449 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621770 AgrOrtholog
BioCyc Gene G2FUF-39476 BioCyc
Ensembl Genes ENSRNOG00000021437 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000039341.9 UniProtKB/TrEMBL
  ENSRNOT00000098496 ENTREZGENE
  ENSRNOT00000098496.2 UniProtKB/TrEMBL
  ENSRNOT00000105209 ENTREZGENE
  ENSRNOT00000105209.2 UniProtKB/TrEMBL
  ENSRNOT00000160537.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.200 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
  Tie2 ligand-binding domain superfamily UniProtKB/TrEMBL
InterPro Cell_Adh-Cytoskel_Orgn UniProtKB/TrEMBL
  ConA-like_subgrp UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
  Laminin/Netrin_ECM UniProtKB/TrEMBL
  Laminin_EGF UniProtKB/TrEMBL
  Laminin_G UniProtKB/TrEMBL
  Laminin_IV UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/TrEMBL
  LMN_ATRN_NET-like_EGF UniProtKB/TrEMBL
  SEA_dom UniProtKB/TrEMBL
NCBI Gene Hspg2 ENTREZGENE
PANTHER BASEMENT MEMBRANE-SPECIFIC HEPARAN SULFATE PROTEOGLYCAN CORE PROTEIN UniProtKB/TrEMBL
  CONTACTIN 5 UniProtKB/TrEMBL
  NETRIN/LAMININ-RELATED UniProtKB/TrEMBL
  WRAPPER_REGA-1_KLINGON HOMOLOG UniProtKB/TrEMBL
Pfam EGF UniProtKB/TrEMBL
  EGF_LMN_ATRN UniProtKB/TrEMBL
  I-set UniProtKB/TrEMBL
  Ig_3 UniProtKB/TrEMBL
  Laminin_B UniProtKB/TrEMBL
  Laminin_EGF UniProtKB/TrEMBL
  Laminin_G_1 UniProtKB/TrEMBL
  Ldl_recept_a UniProtKB/TrEMBL
PhenoGen Hspg2 PhenoGen
PRINTS LDLRECEPTOR UniProtKB/TrEMBL
PROSITE EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_LAM_1 UniProtKB/TrEMBL
  EGF_LAM_2 UniProtKB/TrEMBL
  IG_LIKE UniProtKB/TrEMBL
  LAM_G_DOMAIN UniProtKB/TrEMBL
  LAMININ_IVA UniProtKB/TrEMBL
  LDLRA_1 UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/TrEMBL
  SEA UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021437 RatGTEx
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  EGF_Lam UniProtKB/TrEMBL
  IGc2 UniProtKB/TrEMBL
  IGv UniProtKB/TrEMBL
  LamB UniProtKB/TrEMBL
  LamG UniProtKB/TrEMBL
  LDLa UniProtKB/TrEMBL
  SEA UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP ConA_like_lec_gl UniProtKB/TrEMBL
  EGF/Laminin UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
  SSF57424 UniProtKB/TrEMBL
UniProt A0A8I6A2S5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ASH2 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L0S5_RAT UniProtKB/TrEMBL
  F1LTJ5_RAT UniProtKB/TrEMBL
  O08591_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Hspg2  heparan sulfate proteoglycan 2  AABR07073181.1    Data merged from RGD:15003506 737654 PROVISIONAL
2019-11-08 AABR07073181.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2015-11-03 Hspg2  heparan sulfate proteoglycan 2  LOC313641  perlecan  Data merged from RGD:1564199 737654 APPROVED
2006-02-09 LOC313641  perlecan      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 Hspg2  heparan sulfate proteoglycan 2    perlecan (heparan sulfate proteoglycan 2)  Name updated 1299863 APPROVED
2002-08-07 Hspg2  perlecan (heparan sulfate proteoglycan 2)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation expression is reduced by glomerular adenylate cyclase 633166