Pbp2 (phosphatidylethanolamine binding protein 2) - Rat Genome Database

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Gene: Pbp2 (phosphatidylethanolamine binding protein 2) Rattus norvegicus
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Symbol: Pbp2
Name: phosphatidylethanolamine binding protein 2
RGD ID: 621707
Description: Predicted to enable kinase inhibitor activity. Predicted to be involved in negative regulation of MAPK cascade. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human PEBP1 (phosphatidylethanolamine binding protein 1); INTERACTS WITH bisphenol A; bisphenol AF; C60 fullerene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Pebp-2; Pebp2; phosphatidylethanlomine binding protein 2; phosphatidylethanolamine-binding protein 2
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84169,887,160 - 169,888,454 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4169,856,292 - 169,889,596 (-)EnsemblGRCr8
mRatBN7.24168,155,827 - 168,157,121 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4168,155,709 - 168,157,117 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4174,451,059 - 174,452,353 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04170,232,299 - 170,233,593 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04168,858,346 - 168,859,641 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04169,091,841 - 169,093,135 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4169,091,841 - 169,093,135 (-)Ensemblrn6Rnor6.0
Rnor_5.04233,360,413 - 233,361,707 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44172,257,744 - 172,259,038 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4156,754,150 - 156,755,444 (-)NCBICelera
RGSC_v3.14172,502,715 - 172,503,919 (-)NCBI
Cytogenetic Map4q43NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Identification of a novel testis-specific member of the phosphatidylethanolamine binding protein family, pebp-2. Hickox DM, etal., Biol Reprod 2002 Sep;67(3):917-27.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Protein expression analysis of rat testes induced testicular toxicity with several reproductive toxicants. Yamamoto T, etal., J Toxicol Sci. 2005 May;30(2):111-26.

Genomics

Comparative Map Data
Pbp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84169,887,160 - 169,888,454 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4169,856,292 - 169,889,596 (-)EnsemblGRCr8
mRatBN7.24168,155,827 - 168,157,121 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4168,155,709 - 168,157,117 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4174,451,059 - 174,452,353 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04170,232,299 - 170,233,593 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04168,858,346 - 168,859,641 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04169,091,841 - 169,093,135 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4169,091,841 - 169,093,135 (-)Ensemblrn6Rnor6.0
Rnor_5.04233,360,413 - 233,361,707 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44172,257,744 - 172,259,038 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4156,754,150 - 156,755,444 (-)NCBICelera
RGSC_v3.14172,502,715 - 172,503,919 (-)NCBI
Cytogenetic Map4q43NCBI
Pbp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396135,286,127 - 135,287,382 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6135,286,125 - 135,287,403 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm386135,309,129 - 135,310,384 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6135,309,127 - 135,310,405 (-)Ensemblmm10GRCm38
MGSCv376135,259,147 - 135,260,402 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv366135,274,836 - 135,276,056 (-)NCBIMGSCv36mm8
Celera6138,256,667 - 138,257,922 (-)NCBICelera
Cytogenetic Map6G1NCBI
cM Map666.17NCBI

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:106
Count of miRNA genes:94
Interacting mature miRNAs:100
Transcripts:ENSRNOT00000011461
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4146370897184426481Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4134095016179095016Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4146370897184426481Rat
6478757Anxrr44Anxiety related response QTL 440.01087locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
1358364Sradr4Stress Responsive Adrenal Weight QTL 44.92adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)4131384565176384565Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4140059299181024663Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4157292416184426481Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4127263297172263297Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4126334185171334185Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4147299608184426481Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
6478782Anxrr52Anxiety related response QTL 520.02091locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
6478720Alc23Alcohol consumption QTL 230.00509drinking behavior trait (VT:0001422)ethanol drink intake rate to body weight ratio (CMO:0001616)4155834926184426481Rat
6478785Anxrr53Anxiety related response QTL 530.01397locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4137447185182447185Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4137430611182430611Rat
6478728Anxrr36Anxiety related response QTL 360.01061locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4148121375176967367Rat
6478733Anxrr37Anxiety related response QTL 370.00095locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
6478737Anxrr38Anxiety related response QTL 380.00159locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4160623982184426481Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 6 8 22 19 24 11 10 11 4 51 25 2 14 2 34 13 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000011461   ⟹   ENSRNOP00000066809
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4169,856,292 - 169,889,596 (-)Ensembl
mRatBN7.2 Ensembl4168,155,709 - 168,157,117 (-)Ensembl
Rnor_6.0 Ensembl4169,091,841 - 169,093,135 (-)Ensembl
RefSeq Acc Id: NM_001105756   ⟹   NP_001099226
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84169,887,160 - 169,888,454 (-)NCBI
mRatBN7.24168,155,827 - 168,157,121 (-)NCBI
Rnor_6.04169,091,841 - 169,093,135 (-)NCBI
Rnor_5.04233,360,413 - 233,361,707 (-)NCBI
RGSC_v3.44172,257,744 - 172,259,038 (-)RGD
Celera4156,754,150 - 156,755,444 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001099226 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM01625 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000066809
  ENSRNOP00000066809.1
RefSeq Acc Id: NP_001099226   ⟸   NM_001105756
- UniProtKB: M0RB80 (UniProtKB/TrEMBL),   A6IMG4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000066809   ⟸   ENSRNOT00000011461

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RB80-F1-model_v2 AlphaFold M0RB80 1-187 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693460
Promoter ID:EPDNEW_R3985
Type:initiation region
Name:Pbp2_1
Description:phosphatidylethanolamine binding protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04169,093,102 - 169,093,162EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621707 AgrOrtholog
BioCyc Gene G2FUF-42629 BioCyc
Ensembl Genes ENSRNOG00000008667 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011461 ENTREZGENE
  ENSRNOT00000011461.7 UniProtKB/TrEMBL
Gene3D-CATH 3.90.280.10 UniProtKB/TrEMBL
InterPro PEBP-like_sf UniProtKB/TrEMBL
  PEBP_euk UniProtKB/TrEMBL
  Phosphotidylethanolamine-bd_CS UniProtKB/TrEMBL
  PtdEtn-bd_prot_PEBP UniProtKB/TrEMBL
KEGG Report rno:246145 UniProtKB/TrEMBL
NCBI Gene 246145 ENTREZGENE
PANTHER PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 2 UniProtKB/TrEMBL
  PTHR11362 UniProtKB/TrEMBL
Pfam PBP UniProtKB/TrEMBL
PhenoGen Pbp2 PhenoGen
PROSITE PBP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008667 RatGTEx
Superfamily-SCOP PEBP UniProtKB/TrEMBL
UniProt A6IMG4 ENTREZGENE, UniProtKB/TrEMBL
  M0RB80 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-23 Pbp2  phosphatidylethanolamine binding protein 2  Pebp2  phosphatidylethanolamine binding protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-12-02 Pebp2  phosphatidylethanolamine binding protein 2  Pbp2  phosphatidylethanolamine binding protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-25 Pbp2  phosphatidylethanolamine binding protein 2  Pbp2  phosphatidylethanlomine binding protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-11 Pbp2  peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor  Pebp-2  phosphatidylethanlomine binding protein 2  Symbol updated to reflect Human and Mouse nomenclature 625702 APPROVED
2002-08-07 Pebp-2  phosphatidylethanlomine binding protein 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed only in testis in late meiotic and haploid germ cells 1299326