Grip2 (glutamate receptor interacting protein 2) - Rat Genome Database

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Gene: Grip2 (glutamate receptor interacting protein 2) Rattus norvegicus
Analyze
Symbol: Grip2
Name: glutamate receptor interacting protein 2
RGD ID: 621668
Description: Enables glutamate receptor binding activity. Involved in positive regulation of AMPA glutamate receptor clustering; positive regulation of excitatory postsynaptic potential; and positive regulation of neuron maturation. Located in several cellular components, including dendritic shaft; neuronal cell body; and postsynaptic membrane. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Orthologous to human GRIP2 (glutamate receptor interacting protein 2); INTERACTS WITH 1-naphthyl isothiocyanate; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Abp; AMPA receptor binding protein; AMPA receptor-interacting protein GRIP2; glutamate receptor-interacting protein 2; GRIP-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Grip2_v1 ; Grip2_v3 ; Grip2_v2
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84125,828,609 - 125,913,693 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4125,828,609 - 125,913,750 (-)EnsemblGRCr8
mRatBN7.24124,271,456 - 124,356,538 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4124,271,456 - 124,321,268 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4129,738,401 - 129,788,280 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04125,512,831 - 125,562,709 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04124,137,377 - 124,187,253 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04123,585,184 - 123,636,040 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4123,586,231 - 123,636,040 (+)Ensemblrn6Rnor6.0
Rnor_5.04188,120,198 - 188,170,081 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44125,951,936 - 126,001,803 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4113,190,739 - 113,240,094 (-)NCBICelera
RGSC_v3.14126,196,782 - 126,267,614NCBI
Cytogenetic Map4q34NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains. Bruckner K, etal., Neuron 1999 Mar;22(3):511-24.
2. Differential palmitoylation directs the AMPA receptor-binding protein ABP to spines or to intracellular clusters. DeSouza S, etal., J Neurosci 2002 May 1;22(9):3493-503.
3. Characterization of the glutamate receptor-interacting proteins GRIP1 and GRIP2. Dong H, etal., J Neurosci 1999 Aug 15;19(16):6930-41.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking. Lu W and Ziff EB, Neuron. 2005 Aug 4;47(3):407-21.
6. NMDA receptor activation potentiates inhibitory transmission through GABA receptor-associated protein-dependent exocytosis of GABA(A) receptors. Marsden KC, etal., J Neurosci. 2007 Dec 26;27(52):14326-37.
7. Regulation of synaptic structure and function by palmitoylated AMPA receptor binding protein. Misra C, etal., Mol Cell Neurosci. 2010 Apr;43(4):341-52. Epub 2010 Jan 18.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. NSF binding to GluR2 regulates synaptic transmission. Nishimune A, etal., Neuron. 1998 Jul;21(1):87-97.
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABP. Srivastava S, etal., Neuron 1998 Sep;21(3):581-91.
13. The proteoglycan NG2 is complexed with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by the PDZ glutamate receptor interaction protein (GRIP) in glial progenitor cells. Implications for glial-neuronal signaling. Stegmuller J, etal., J Biol Chem. 2003 Feb 7;278(6):3590-8. Epub 2002 Nov 27.
14. Association of AMPA receptors with a subset of glutamate receptor-interacting protein in vivo. Wyszynski M, etal., J Neurosci 1999 Aug 1;19(15):6528-37.
15. GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex. Ye B, etal., Neuron 2000 Jun;26(3):603-17.
Additional References at PubMed
PMID:20956289   PMID:23117660  


Genomics

Comparative Map Data
Grip2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84125,828,609 - 125,913,693 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4125,828,609 - 125,913,750 (-)EnsemblGRCr8
mRatBN7.24124,271,456 - 124,356,538 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4124,271,456 - 124,321,268 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4129,738,401 - 129,788,280 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04125,512,831 - 125,562,709 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04124,137,377 - 124,187,253 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04123,585,184 - 123,636,040 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4123,586,231 - 123,636,040 (+)Ensemblrn6Rnor6.0
Rnor_5.04188,120,198 - 188,170,081 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44125,951,936 - 126,001,803 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4113,190,739 - 113,240,094 (-)NCBICelera
RGSC_v3.14126,196,782 - 126,267,614NCBI
Cytogenetic Map4q34NCBI
GRIP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38314,489,107 - 14,603,017 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl314,489,107 - 14,556,075 (-)Ensemblhg38GRCh38
GRCh37314,530,615 - 14,581,849 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36314,510,177 - 14,558,592 (-)NCBIBuild 36Build 36hg18NCBI36
Celera314,468,851 - 14,521,806 (-)NCBICelera
Cytogenetic Map3p25.1NCBI
HuRef314,466,560 - 14,519,524 (-)NCBIHuRef
CHM1_1314,481,705 - 14,534,637 (-)NCBICHM1_1
T2T-CHM13v2.0314,491,513 - 14,605,422 (-)NCBIT2T-CHM13v2.0
Grip2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39691,738,433 - 91,820,884 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl691,738,490 - 91,804,231 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38691,761,452 - 91,843,954 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl691,761,509 - 91,827,250 (-)Ensemblmm10GRCm38
MGSCv37691,711,503 - 91,757,387 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36691,727,013 - 91,754,107 (-)NCBIMGSCv36mm8
Celera693,655,323 - 93,701,161 (-)NCBICelera
Cytogenetic Map6D1NCBI
cM Map640.8NCBI
Grip2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542917,134,158 - 17,160,036 (-)Ensembl
ChiLan1.0NW_00495542917,132,520 - 17,177,547 (-)NCBIChiLan1.0ChiLan1.0
GRIP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2214,473,295 - 14,584,909 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1314,476,377 - 14,589,672 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0314,411,825 - 14,525,388 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1314,754,145 - 14,803,236 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl314,756,638 - 14,804,952 (-)EnsemblpanPan2panpan1.1
GRIP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1204,618,702 - 4,677,040 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl204,620,179 - 4,677,263 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha204,656,123 - 4,753,287 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0204,640,107 - 4,737,316 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl204,640,110 - 4,737,507 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1204,358,668 - 4,455,875 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0204,681,321 - 4,778,501 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0204,692,533 - 4,789,738 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Grip2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494218,600,766 - 18,632,699 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936602278,252 - 314,720 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936602276,964 - 334,942 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRIP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1369,988,459 - 70,088,718 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11369,949,608 - 70,088,719 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21377,365,567 - 77,515,248 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GRIP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12250,429,351 - 50,546,403 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2250,433,405 - 50,468,769 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041115,948,998 - 116,063,753 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grip2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248721,233,797 - 1,264,722 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248721,215,698 - 1,264,723 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Grip2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1655,133,394 - 55,182,231 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Grip2
481 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:642
Count of miRNA genes:188
Interacting mature miRNAs:245
Transcripts:ENSRNOT00000013232, ENSRNOT00000049657, ENSRNOT00000057098
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)486583980149763391Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)496731383141731383Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)492406430137406430Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4117737142152833657Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4123870974168870974Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4108206096153206096Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4111383604156383604Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)475939858140508796Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)488883695133883695Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4103834277148834277Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)488883695133883695Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4107346299152346299Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4117559384162559384Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4111383604156383604Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)474169813134199155Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)486058928131411333Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)475939858140508796Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4124700988169700988Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)484349032129349032Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)482336765127336765Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4113634167149763391Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4116184844161184844Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)486583980131583980Rat
12798527Anxrr58Anxiety related response QTL 584.110.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4121020385148834277Rat

Markers in Region
RH136997  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24124,271,492 - 124,271,679 (-)MAPPERmRatBN7.2
Rnor_6.04123,635,817 - 123,636,003NCBIRnor6.0
Rnor_5.04188,169,858 - 188,170,044UniSTSRnor5.0
RGSC_v3.44125,951,973 - 125,952,159UniSTSRGSC3.4
Celera4113,190,776 - 113,190,962UniSTS
RH 3.4 Map4736.04UniSTS
Cytogenetic Map4q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
11 12 67 158 66 65 34 78 34 6 310 178 10 134 79 92 31 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000013232   ⟹   ENSRNOP00000013232
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4125,828,609 - 125,878,419 (-)Ensembl
mRatBN7.2 Ensembl4124,271,456 - 124,321,268 (-)Ensembl
Rnor_6.0 Ensembl4123,586,327 - 123,634,089 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000049657   ⟹   ENSRNOP00000041016
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4125,828,609 - 125,878,419 (-)Ensembl
mRatBN7.2 Ensembl4124,271,456 - 124,321,268 (-)Ensembl
Rnor_6.0 Ensembl4123,586,231 - 123,636,040 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096201   ⟹   ENSRNOP00000083408
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4125,828,609 - 125,855,051 (-)Ensembl
mRatBN7.2 Ensembl4124,271,456 - 124,297,900 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000137049   ⟹   ENSRNOP00000110627
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4125,839,096 - 125,898,599 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000144463   ⟹   ENSRNOP00000101025
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4125,828,609 - 125,913,750 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000159958   ⟹   ENSRNOP00000105286
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4125,828,609 - 125,866,145 (-)Ensembl
RefSeq Acc Id: NM_138535   ⟹   NP_612544
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84125,828,609 - 125,878,419 (-)NCBI
mRatBN7.24124,271,456 - 124,321,268 (-)NCBI
Rnor_6.04123,586,231 - 123,636,040 (+)NCBI
Rnor_5.04188,120,198 - 188,170,081 (+)NCBI
RGSC_v3.44125,951,936 - 126,001,803 (-)RGD
Celera4113,190,739 - 113,240,094 (-)RGD
Sequence:
RefSeq Acc Id: XM_006236895   ⟹   XP_006236957
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84125,828,609 - 125,880,610 (-)NCBI
mRatBN7.24124,271,456 - 124,323,417 (-)NCBI
Rnor_6.04123,585,184 - 123,636,040 (+)NCBI
Rnor_5.04188,120,198 - 188,170,081 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008763122   ⟹   XP_008761344
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84125,838,806 - 125,880,596 (-)NCBI
mRatBN7.24124,281,646 - 124,323,415 (-)NCBI
Rnor_6.04123,585,185 - 123,625,807 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592425   ⟹   XP_017447914
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84125,828,609 - 125,878,213 (-)NCBI
mRatBN7.24124,271,456 - 124,310,618 (-)NCBI
Rnor_6.04123,598,607 - 123,636,040 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039106989   ⟹   XP_038962917
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84125,828,609 - 125,913,693 (-)NCBI
mRatBN7.24124,271,456 - 124,356,538 (-)NCBI
RefSeq Acc Id: XR_005503145
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84125,833,160 - 125,880,596 (-)NCBI
mRatBN7.24124,276,007 - 124,323,415 (-)NCBI
RefSeq Acc Id: NP_612544   ⟸   NM_138535
- UniProtKB: O88961 (UniProtKB/Swiss-Prot),   Q9WU36 (UniProtKB/Swiss-Prot),   Q9WTW1 (UniProtKB/Swiss-Prot),   A0A8I5ZW05 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236957   ⟸   XM_006236895
- Peptide Label: isoform X3
- UniProtKB: A0A0H2UHH8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008761344   ⟸   XM_008763122
- Peptide Label: isoform X4
- UniProtKB: A6IBA9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447914   ⟸   XM_017592425
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZW05 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000013232   ⟸   ENSRNOT00000013232
Ensembl Acc Id: ENSRNOP00000041016   ⟸   ENSRNOT00000049657
RefSeq Acc Id: XP_038962917   ⟸   XM_039106989
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZW05 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000083408   ⟸   ENSRNOT00000096201
Ensembl Acc Id: ENSRNOP00000105286   ⟸   ENSRNOT00000159958
Ensembl Acc Id: ENSRNOP00000110627   ⟸   ENSRNOT00000137049
Ensembl Acc Id: ENSRNOP00000101025   ⟸   ENSRNOT00000144463
Protein Domains
PDZ

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WTW1-F1-model_v2 AlphaFold Q9WTW1 1-1043 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693255
Promoter ID:EPDNEW_R3779
Type:single initiation site
Name:Grip2_1
Description:glutamate receptor interacting protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04123,586,363 - 123,586,423EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621668 AgrOrtholog
BioCyc Gene G2FUF-43709 BioCyc
Ensembl Genes ENSRNOG00000009726 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000013232 ENTREZGENE
  ENSRNOT00000013232.7 UniProtKB/Swiss-Prot
  ENSRNOT00000049657 ENTREZGENE
  ENSRNOT00000049657.6 UniProtKB/Swiss-Prot
  ENSRNOT00000137049 ENTREZGENE
  ENSRNOT00000144463 ENTREZGENE
  ENSRNOT00000159958 ENTREZGENE
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot
InterPro GRIP1/2 UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  PDZ_6 UniProtKB/Swiss-Prot
  PDZ_sf UniProtKB/Swiss-Prot
KEGG Report rno:171571 UniProtKB/Swiss-Prot
NCBI Gene 171571 ENTREZGENE
PANTHER PTHR46227 UniProtKB/Swiss-Prot
  PTHR46227:SF4 UniProtKB/Swiss-Prot
Pfam PDZ UniProtKB/Swiss-Prot
  PDZ_6 UniProtKB/Swiss-Prot
PhenoGen Grip2 PhenoGen
PROSITE PDZ UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009726 RatGTEx
SMART PDZ UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50156 UniProtKB/Swiss-Prot
UniProt A0A0H2UHH8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZW05 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LUL2_RAT UniProtKB/TrEMBL
  A6IBA7_RAT UniProtKB/TrEMBL
  A6IBA9 ENTREZGENE, UniProtKB/TrEMBL
  A6IBB0_RAT UniProtKB/TrEMBL
  A6IBB1_RAT UniProtKB/TrEMBL
  A6IBB2_RAT UniProtKB/TrEMBL
  GRIP2_RAT UniProtKB/Swiss-Prot
  O88961 ENTREZGENE
  Q9WTW1 ENTREZGENE
  Q9WU36 ENTREZGENE
UniProt Secondary O88961 UniProtKB/Swiss-Prot
  Q9WU36 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Grip2  glutamate receptor interacting protein 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Grip2  glutamate receptor interacting protein 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization enriched in synaptic plasma membrane and postsynaptic density fractions 632957
gene_expression expressed in brain 632957
gene_function binds to the C terminus of the GluR2 and GluR3 subunits of AMPA receptors 625696
gene_process plays a role in long-term potentiation and long-term depression in the delivery and anchorage of AMPA receptors at synapses 625696
gene_transcript contains three splice variants 625696