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Gene: Tie1 (tyrosine kinase with immunoglobulin-like and EGF-like domains 1) Rattus norvegicus

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Symbol:

Tie1

Name:

tyrosine kinase with immunoglobulin-like and EGF-like domains 1

RGD ID:

621642

Description:

Predicted to enable transmembrane receptor protein tyrosine kinase activity. Involved in vasculogenesis. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human TIE1 (tyrosine kinase with immunoglobulin like and EGF like domains 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; atrazine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

tyrosine kinase receptor 1; tyrosine-protein kinase receptor Tie-1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	137,285,408 - 137,305,047 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	137,285,408 - 137,304,981 (-)	Ensembl				GRCr8
mRatBN7.2	5	132,000,013 - 132,019,658 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	132,000,015 - 132,019,592 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	134,707,265 - 134,726,814 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	136,461,906 - 136,481,457 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	136,484,304 - 136,503,857 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	137,294,544 - 137,321,116 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	137,294,544 - 137,321,121 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	141,084,008 - 141,111,659 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	138,945,238 - 138,964,631 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	130,545,484 - 130,565,067 (-)	NCBI		Celera
RGSC_v3.1	5	138,956,127 - 138,959,186 (-)	NCBI
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Lymphatic Malformation 11 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,4'-trichlorobiphenyl (ISO)

2-hydroxypropanoic acid (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

atrazine (EXP,ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

C60 fullerene (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

cantharidin (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

clofibrate (ISO)

cobalt dichloride (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

DDT (ISO)

doxorubicin (ISO)

entinostat (ISO)

fonofos (ISO)

formaldehyde (ISO)

furosemide (EXP)

kojic acid (ISO)

manganese(II) chloride (ISO)

methamphetamine (EXP)

ozone (ISO)

paracetamol (ISO)

parathion (ISO)

PCB138 (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP)

phenobarbital (ISO)

phosgene (ISO)

pirinixic acid (ISO)

Ptaquiloside (ISO)

rac-lactic acid (ISO)

SCH 23390 (EXP)

sodium arsenite (ISO)

sodium fluoride (ISO)

sodium lactate (ISO)

tamoxifen (ISO)

terbufos (ISO)

tert-butyl hydroperoxide (ISO)

testosterone enanthate (ISO)

toluene (EXP)

trichloroethene (EXP,ISO)

triclosan (ISO)

triptonide (ISO)

tris(2-butoxyethyl) phosphate (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

angiogenesis (IEA)

aortic valve morphogenesis (IEA,ISO)

blood vessel development (ISO)

branching involved in lymph vessel morphogenesis (IEA,ISO)

branching morphogenesis of an epithelial tube (IEA)

cell differentiation (IEA)

cell surface receptor protein tyrosine kinase signaling pathway (IBA)

circulatory system development (IEA)

heart development (IEA)

in utero embryonic development (ISO)

lymphatic endothelial cell differentiation (ISO)

negative regulation of angiogenesis (ISO)

negative regulation of cell migration (ISO)

plasma membrane fusion (ISO)

positive regulation of angiogenesis (IBA)

regulation of endothelial cell proliferation (ISO)

regulation of extracellular matrix assembly (ISO)

response to retinoic acid (IEA,ISO)

tissue remodeling (IEA,ISO)

vasculogenesis (IDA)

Cellular Component

membrane (IEA)

plasma membrane (IBA,IEA,ISO)

receptor complex (IBA)

Molecular Function

ATP binding (IEA)

kinase activity (IEA)

nucleotide binding (IEA)

protein binding (ISO)

protein kinase activity (IEA)

protein tyrosine kinase activity (IEA)

transferase activity (IEA)

transmembrane receptor protein tyrosine kinase activity (IBA,IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Expression of tie1 and tie2 proteins during reendothelialization in balloon-injured rat carotid artery.	Fujikawa K, etal., J Vasc Res 1999 Jul-Aug;36(4):272-81.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9683559	PMID:11172728	PMID:12477932	PMID:14966366	PMID:15548727	PMID:17717145	PMID:18439490	PMID:23918385

Genomics

Comparative Map Data

Tie1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	137,285,408 - 137,305,047 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	137,285,408 - 137,304,981 (-)	Ensembl				GRCr8
mRatBN7.2	5	132,000,013 - 132,019,658 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	132,000,015 - 132,019,592 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	134,707,265 - 134,726,814 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	136,461,906 - 136,481,457 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	136,484,304 - 136,503,857 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	137,294,544 - 137,321,116 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	137,294,544 - 137,321,121 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	141,084,008 - 141,111,659 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	138,945,238 - 138,964,631 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	130,545,484 - 130,565,067 (-)	NCBI		Celera
RGSC_v3.1	5	138,956,127 - 138,959,186 (-)	NCBI
Cytogenetic Map	5	q36	NCBI

TIE1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	43,300,982 - 43,323,108 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	43,300,971 - 43,323,108 (+)	Ensembl			hg38	GRCh38
GRCh37	1	43,766,653 - 43,788,779 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	43,539,251 - 43,561,366 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	43,435,756 - 43,457,871	NCBI
Celera	1	42,048,758 - 42,070,929 (+)	NCBI		Celera
Cytogenetic Map	1	p34.2	NCBI
HuRef	1	41,886,193 - 41,908,461 (+)	NCBI		HuRef
CHM1_1	1	43,883,045 - 43,905,255 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	43,171,478 - 43,193,657 (+)	NCBI		T2T-CHM13v2.0

Tie1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	118,328,388 - 118,347,046 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	118,328,388 - 118,347,258 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	4	118,471,191 - 118,489,849 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	118,471,191 - 118,490,061 (-)	Ensembl			mm10	GRCm38
MGSCv37	4	118,143,796 - 118,162,454 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	4	117,969,123 - 117,987,993 (-)	NCBI		MGSCv36	mm8
Celera	4	117,196,542 - 117,215,172 (-)	NCBI		Celera
Cytogenetic Map	4	D2.1	NCBI
cM Map	4	54.67	NCBI

Tie1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955537	2,894,914 - 2,914,284 (+)	Ensembl
ChiLan1.0	NW_004955537	2,894,913 - 2,914,284 (+)	NCBI	ChiLan1.0	ChiLan1.0

TIE1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	183,486,976 - 183,509,122 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	182,628,363 - 182,650,510 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	42,602,333 - 42,624,471 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	43,979,838 - 44,002,167 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	43,979,838 - 44,002,167 (+)	Ensembl			panPan2	panpan1.1

TIE1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	16,838,267 - 16,857,004 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	15	16,838,582 - 16,856,946 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	16,966,265 - 16,985,016 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	15	17,005,994 - 17,024,782 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	15	17,005,994 - 17,024,743 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	15	16,798,449 - 16,817,196 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	15	16,867,446 - 16,886,176 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	15	16,941,001 - 16,959,771 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Tie1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	58,884,532 - 58,904,470 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	24,709,424 - 24,729,245 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	24,709,424 - 24,729,246 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TIE1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	167,919,668 - 167,940,870 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	167,919,662 - 167,947,253 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	155,288,305 - 155,322,123 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TIE1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	89,483,089 - 89,505,716 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	89,483,039 - 89,505,246 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666033	27,415,677 - 27,438,411 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tie1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624892	2,626,875 - 2,645,841 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624892	2,626,999 - 2,645,841 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Tie1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	38,541,631 - 38,560,976 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Tie1
124 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	171
Count of miRNA genes:	121
Interacting mature miRNAs:	126
Transcripts:	ENSRNOT00000027414
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331796	Thshl2	Thyroid stimulating hormone level QTL 2	2.3		blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	5	102105698	152749382	Rat
2303586	Gluco52	Glucose level QTL 52	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	100826632	145826632	Rat
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	130249266	172190305	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	44924861	153890773	Rat
8552960	Pigfal15	Plasma insulin-like growth factor 1 level QTL 15			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	116702075	161702075	Rat
1354583	Despr3	Despair related QTL3	4.98	0.0002	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	5	132930505	172190305	Rat
1300122	Wbc1	White blood cell count QTL 1	2.75		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	5	130678987	145274255	Rat
7365049	Bp359	Blood pressure QTL 359			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	133308734	140009902	Rat
61452	Ciaa5	CIA Autoantibody QTL 5	3.5		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	5	99905133	172190305	Rat
70156	Niddm30	Non-insulin dependent diabetes mellitus QTL 30	3.98		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	5	134369218	156289444	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	133789363	172190305	Rat
7411582	Foco3	Food consumption QTL 3	7.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	5	92583776	137583776	Rat
1331803	Rf32	Renal function QTL 32	2.798		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	134369199	172190305	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	65089051	166764498	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	136631198	172190305	Rat
7207486	Bss109	Bone structure and strength QTL 109			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	5	112142946	157142946	Rat
7207481	Bss106	Bone structure and strength QTL 106	7.9		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	112142946	157142946	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	110770739	155770739	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	133081618	172190305	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	51657967	166600247	Rat
1549838	Bss4	Bone structure and strength QTL 4	9.2		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	5	112142946	157142946	Rat
1581505	Rf54	Renal function QTL 54			kidney physiology trait (VT:0002136)	kidney 20-HETE level (CMO:0001854)	5	133270647	172190305	Rat
7411564	Bw135	Body weight QTL 135		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	92583776	137583776	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	133789363	172190305	Rat
8657050	Bw146	Body weight QTL 146	19.84	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	98972960	143972960	Rat
1581510	Cm54	Cardiac mass QTL 54	3.4	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	125969677	172190305	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55124766	172190305	Rat
7411601	Foco12	Food consumption QTL 12	19.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	5	92583776	137583776	Rat
2303618	Vencon1	Ventilatory control QTL 1	3.8		respiration trait (VT:0001943)	oxygen consumption (CMO:0002169)	5	100826632	145826632	Rat
2317056	Wbc3	White blood cell count QTL 3	2.51	0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	5	111236572	156236572	Rat
7394710	Emca12	Estrogen-induced mammary cancer QTL 12			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	94034903	139034903	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	131708216	172190305	Rat
1598847	Cm62	Cardiac mass QTL 62	3.4		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	114131300	159131300	Rat
2293642	Bss37	Bone structure and strength QTL 37	4.64	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	125969677	156302135	Rat
70189	Mcs5	Mammary carcinoma susceptibility QTL 5	10.51		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	60601597	137492949	Rat
7207488	Bss110	Bone structure and strength QTL 1	8.4		femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	5	112142946	157142946	Rat
8694441	Bw169	Body weight QTL 169	17.61	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	5	116702075	161702075	Rat
7207491	Bss112	Bone structure and strength QTL 112	7		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	5	112142946	157142946	Rat
8694389	Bw160	Body weight QTL 160	6.17	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	5	116702075	161702075	Rat
1354598	Srn6	Serum renin concentration QTL 6	3.8		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	5	74335621	156302135	Rat
8694198	Abfw3	Abdominal fat weight QTL 3	16.13	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	5	116702075	161702075	Rat
1298089	Scl14	Serum cholesterol level QTL 14	5.8	0.0004	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	114131300	159131300	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	133081618	172190305	Rat
6903316	Bw113	Body weight QTL 113	2	0.0103	body mass (VT:0001259)	body weight (CMO:0000012)	5	92881678	137881678	Rat
1358187	Emca1	Estrogen-induced mammary cancer QTL 1	4.4		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	5	104262817	153890625	Rat

Markers in Region

RH137377

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	132,000,011 - 132,000,196 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	137,294,543 - 137,294,727	NCBI	Rnor6.0
Rnor_5.0	5	141,084,007 - 141,084,191	UniSTS	Rnor5.0
RGSC_v3.4	5	138,945,235 - 138,945,419	UniSTS	RGSC3.4
Celera	5	130,545,481 - 130,545,665	UniSTS
RH 3.4 Map	5	864.1	UniSTS
Cytogenetic Map	5	q36	UniSTS

UniSTS:498727

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	132,005,377 - 132,005,444 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	137,307,117 - 137,307,183	NCBI	Rnor6.0
Rnor_5.0	5	141,097,736 - 141,097,802	UniSTS	Rnor5.0
RGSC_v3.4	5	138,950,870 - 138,950,936	UniSTS	RGSC3.4
Celera	5	130,550,867 - 130,550,933	UniSTS
Cytogenetic Map	5	q36	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	163	91	90	59	92	59	6	356	192	11	141	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053545	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006238720	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF030377	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC085911	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC169020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000027414 ⟹ ENSRNOP00000027414

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	137,285,408 - 137,304,981 (-)	Ensembl
mRatBN7.2 Ensembl	5	132,000,015 - 132,019,592 (-)	Ensembl
Rnor_6.0 Ensembl	5	137,294,544 - 137,321,121 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000093097

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	5	137,294,544 - 137,321,054 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000093122

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	5	137,295,896 - 137,296,821 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000137312 ⟹ ENSRNOP00000106828

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	137,285,408 - 137,304,981 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000156581 ⟹ ENSRNOP00000107274

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	137,285,408 - 137,304,981 (-)	Ensembl

RefSeq Acc Id:

NM_053545 ⟹ NP_445997

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	137,285,408 - 137,304,981 (-)	NCBI
mRatBN7.2	5	132,000,015 - 132,019,592 (-)	NCBI
Rnor_6.0	5	137,294,546 - 137,321,050 (-)	NCBI
Rnor_5.0	5	141,084,008 - 141,111,659 (-)	NCBI
RGSC_v3.4	5	138,945,238 - 138,964,631 (-)	RGD
Celera	5	130,545,484 - 130,565,067 (-)	RGD

Sequence:

show sequence

CTGACCCCGGGCCCAGCCGGCCTCGGCTGGCCCAGGTCAGCCTCCGGAGTATGGTCTGGTGGGG
ATCCCCTTTCCTGCTCCCCATTCTTTTTCTGGCCTCTCATGTTGGTGCATCCGTGGATTTAACA
CTGCTGGCCAATCTGCGTATCACCGAACCCCAGCGTTTCTTCCTGACCTGTGTGTCTGGTGAGG
CGGGAGCAGGGAGGAGCTCCGACGTCTGGGGCCCGCCCCTGCTGCTGGAAAAGGATGATCGCAT
AGTGCGCACCTTCCCACCCGGGCAGCCCCTGCACCTCACTCGCAACGGTTCACACCAGGTCACG
CTGCGGGGCTTCTCCAAGCCCTCGGATTTAGTAGGCGTCTTCTCCTGCGTGGGTGGAGCTGGCA
CGAGGCGCACTCGAGTCCTCTATGTGCACAACAGCCCGGGGGCACACCTGTTTCCAGACAAGGT
CACACACACGGTGAACAAAGGTGATACCGCTGTGCTTTCTGCACGAGTGCACAAGGAAAAGCAG
ACTGATGTGATTTGGAAGAACAATGGATCCTACTTCCATACCCTAGACTGGCATGAGGCCCATG
ATGGGCGGTTTCAACTGCAGCTCCAAAATGTACAGCCACCATCGAGTGGCATCTACAGCGCCAC
CTACCTAGAGGCCAGCCCCTTGGGCAGTGCCTTCTTTCGGCTCATCGTGCGAGGCTGTGAGGCT
GGACGCTGGGGGCCGGGATGTGTCAAGGATTGCCCAGGCTGCCTGCATGGAGGTGTCTGTCATG
ACCACGATGGCGAATGTGTGTGCCCCCCTGGATTCACTGGCACCCGCTGTGAGCAGGCCTGCAG
AGAAGGTCGTTTTGGACAGAGCTGCCAGGAACAGTGCCCAGGCACAGCAGGCTGTCGGGGTCTC
ACCTTCTGCCTCCCAGATCCCTATGGCTGTTCTTGTGGATCTGGCTGGAGGGGAAGCCAGTGCC
AGGAAGCATGTGCACCTGGTCATTTTGGGGCAGATTGTCGCCTCCAGTGTCAGTGTCAAAATGG
TGGTACTTGTGATCGGTTCAGCGGCTGCGTCTGCCCCTCCGGGTGGCATGGAGTCCACTGTGAA
AAGTCAGACCGGATCCCCCAGATCCTCAATGTGGCCACAGAGCTGGAGTTCAACTTAGGGACAA
TGCCCCGGATCAACTGTGCAGCTGCCGGGAATCCCTTCCCAGTACGGGGCAGCATGGAACTCCG
CAAGCCAGACGGCACCATGCTCCTGTCTACCAAAGCCATTGTGGAGCCAGATAGGACCACAGCT
GAGTTCGAGGTGCCCCGTTTGACTCTTGGGGACAGCGGGTTCTGGGAATGCCGTGTATCGACGT
CTGGTGGCCAAGATAGCCGGCGCTTCAAGGTCAATGTCAAAGTACCCCCAGTGCCTCTGACTGC
ACCTCGGCTCCTGGCCAAGCAGAGCCGCCAGCTTGTGGTCTCCCCACTGGTCTCCTTCGGTGGG
GATGGACCCATCTCCTCTGTCCGCCTGCACTACCGGCCCCAGGACAGCATGATTACCTGGTCTG
CCATTGTGGTGGATCCCAGTGAGAATGTGACATTAATGAACCTGAAGCCAAGGACAGGATACAA
CGTTCGGGTGCAGCTGAGCCGGCCAGGGGAAGGAGGAGAAGGAGCCTGGGGTCCTTCGACTCTC
ATGACTACGGACTGTCCTGAGCCTTTGCTGCAGCCGTGGGTAGAGAGCTGGAACGTGGAGGGTC
CTGACAGGCTACGGGTGAGCTGGTCTCTACCCTCGGTGCCACTGTCTGGGGATGGTTTCCTGCT
GCGTCTGTGGGATGGGGCCCGGGGACAGGAGAGGCGGGAGAACATCTCATCCCCCCAGGCCCGC
ACTGCCCTCCTGACTGGACTCACGCCTGGCACGCACTACCAACTGGATGTGCGGCTGTATCACT
GCACCCTCCTGGGCCCTGCCTCACCCTCTGCGCATGTGCACCTGCCCCTCAGCGGGCCTCCAGC
TCCCCGCCACCTCCGTGCCCAGGCCCTCTCAGACTCTGAGATCCGTCTGATGTGGCAGCATCCT
GAGGCTCCGCCTGGACCTATATCCAAGTACATTGTGGAGATTCAGGTGGCCGGGGGCTCAGGAG
ACCCTCAGTGGATGGATGTAGACAAACCCGAGGAGACGAGCACCACCGTCCGTGGTCTCAATGC
CAGCACACGCTACCTCTTCCGTGTGCGGGCCAGTGTGCAGGGTCTCGGCGACTGGAGCAACACA
GTGGAAGAGACCACGCTGGGTAATGGGCTGCAGAGTGCGAGCCCAGTCCAAGAGAGCCGGGTGG
CTGAAGACGGTCTGGATCAGCAGCTGGTCCTGGCTGTGGTAGGCTCCGTCTCTGCCACCTGCCT
CACCATCCTGGCTGCCCTTTTAGCCCTGGTGTGTATCCGAAGAAGCTGCCTACATCGGAGACAT
ACCTTCACCTACCAGTCAGGATCGGGTGAAGAGACCATCCTGCAGTTCAGCTCAGGGACCTTGA
CATTGACCCGACGGCCAAAGCCACAGCCTGAGCCTTTGAGTTACCCTGTGCTGGAGTGGGAGGA
CATCACCTTTGAGGACCTCATCGGGGAGGGGAACTTCGGCCAAGTGATCCGGGCCATGATCAAG
AAGGACGGACTCAAGATGAACGCAGCCATCAAGATGCTGAAAGAGTATGCGTCTGAAAATGACC
ACCGAGACTTTGCAGGGGAACTAGAAGTTCTGTGCAAACTAGGACACCACCCCAATATTATCAA
CCTCTTGGGGGCCTGTGAGAACCGAGGCTACTTGTATATTGCGATCGAATATGCCCCGTATGGA
AACCTGCTAGATTTCCTGAGAAAGAGCAGGGTCCTGGAGACTGATCCAGCTTTTGCTCGAGAGC
ATGGAACAGCCTCCACACTCAGCTCCCGGCAGCTGCTGCGCTTTGCCAGTGATGCAGCCAACGG
GATGCAGTACCTTAGTGAGAAGCAGTTCATTCACAGGGACCTGGCTGCCCGAAATGTTCTGGTC
GGAGAGAACCTGGCCTCCAAGATTGCAGACTTTGGCCTTTCTCGGGGGGAGGAAGTATATGTGA
AGAAGACGATGGGCCGTCTTCCTGTGCGTTGGATGGCCATTGAGTCCCTCAACTACAGCGTCTA
CACTACCAAGAGTGACGTCTGGTCATTTGGGGTCCTCCTCTGGGAGATAGTGAGCCTTGGAGGC
ACGCCCTACTGTGGCATGACCTGTGCTGAGCTCTACGAGAAACTGCCTCAAGGCTATCGCATGG
AGCAGCCTCGAAACTGTGATGATGAAGTGTACGAGCTGATGCGGCAGTGCTGGCGGGACCGTCC
CTATGAGCGCCCCCCTTTTGCCCAGATTGCACTACAGTTGGGCCGCATGCTGGAAGCCAGGAAG
GCCTACGTGAACATGTCACTGTTTGAGAACTTTACCTATGCAGGCATCGATGCCACAGCTGAGG
AGGCCTAGGCTGCCCCCCACCAGAACCTGGCTCTGCTGGCCGGAGCAAACTGCTTCCACCTGTG
ACTCTGAACCCTTCCAACCTCTGACCCAAGCTGTCTCAAGAAAGTCTTTTAATTTAAAGGAGAA
AGGAAAGGATCCAGGAAACATGGGGTGGAGGGAAACGGGGATCCCCATTTTTGGCAGCTGCTCC
TATAGCTACCCCTTCATATTCTTCCTTCTACAAATGTGTTCCCCACTCTGATGCTGCCCAAACC
CAAACCCCACTTCTGATCCTCTACCAAAAGCAGCATGCATGTTACTAACACCCCGTTTAGCTAC
CCTACTCTCTGCTCGTACTCAAAAAATAAATGCTTGGAACAGCAAAAAAAAAAAAAAAAAAAAA
AAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006238720 ⟹ XP_006238782

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	137,285,408 - 137,305,047 (-)	NCBI
mRatBN7.2	5	132,000,013 - 132,019,658 (-)	NCBI
Rnor_6.0	5	137,294,544 - 137,321,116 (-)	NCBI
Rnor_5.0	5	141,084,008 - 141,111,659 (-)	NCBI

Sequence:

show sequence

TTCCTCTTCCTCCCCAGCACCGAGGTGCACTGAGCCGAACAGGCTGAACCCTCAGACCCGCAGC
AACTGACCCCGGGCCCAGCCGGCCTCGGCTGGCCCAGGTCAGCCTCCGGAGTATGGTCTGGTGG
GGATCCCCTTTCCTGCTCCCCATTCTTTTTCTGGCCTCTCATGTTGGTGCATCCGTGGATTTAA
CACTGCTGGCCAATCTGCGTATCACCGAACCCCAGCGTTTCTTCCTGACCTGTGTGTCTGGTGA
GGCGGGAGCAGGGAGGAGCTCCGACGTCTGGGGCCCGCCCCTGCTGCTGGAAAAGGATGATCGC
ATAGTGCGCACCTTCCCACCCGGGCAGCCCCTGCACCTCACTCGCAACGGTTCACACCAGGTCA
CGCTGCGGGGCTTCTCCAAGCCCTCGGATTTAGTAGGCGTCTTCTCCTGCGTGGGTGGAGCTGG
CACGAGGCGCACTCGAGTCCTCTATGTGCACAACAGCCCGGGGGCACACCTGTTTCCAGACAAG
GTCACACACACGGTGAACAAAGGTGATACCGCTGTGCTTTCTGCACGAGTGCACAAGGAAAAGC
AGACTGATGTGATTTGGAAGAACAATGGATCCTACTTCCATACCCTAGACTGGCATGAGGCCCA
TGATGGGCGGTTTCAACTGCAGCTCCAAAATGTACAGCCACCATCGAGTGGCATCTACAGCGCC
ACCTACCTAGAGGCCAGCCCCTTGGGCAGTGCCTTCTTTCGGCTCATCGTGCGAGGCTGTGAGG
CTGGACGCTGGGGGCCGGGATGTGTCAAGGATTGCCCAGGCTGCCTGCATGGAGGTGTCTGTCA
TGACCACGATGGCGAATGTGTGTGCCCCCCTGGATTCACTGGCACCCGCTGTGAGCAGGCCTGC
AGAGAAGGTCGTTTTGGACAGAGCTGCCAGGAACAGTGCCCAGGCACAGCAGGCTGTCGGGGTC
TCACCTTCTGCCTCCCAGATCCCTATGGCTGTTCTTGTGGATCTGGCTGGAGGGGAAGCCAGTG
CCAGGAAGCATGTGCACCTGGTCATTTTGGGGCAGATTGTCGCCTCCAGTGTCAGTGTCAAAAT
GGTGGTACTTGTGATCGGTTCAGCGGCTGCGTCTGCCCCTCCGGGTGGCATGGAGTCCACTGTG
AAAAGTCAGACCGGATCCCCCAGATCCTCAATGTGGCCACAGAGCTGGAGTTCAACTTAGGGAC
AATGCCCCGGATCAACTGTGCAGCTGCCGGGAATCCCTTCCCAGTACGGGGCAGCATGGAACTC
CGCAAGCCAGACGGCACCATGCTCCTGTCTACCAAAGCCATTGTGGAGCCAGATAGGACCACAG
CTGAGTTCGAGGTGCCCCGTTTGACTCTTGGGGACAGCGGGTTCTGGGAATGCCGTGTATCGAC
GTCTGGTGGCCAAGATAGCCGGCGCTTCAAGGTCAATGTCAAAGTACCCCCAGTGCCTCTGACT
GCACCTCGGCTCCTGGCCAAGCAGAGCCGCCAGCTTGTGGTCTCCCCACTGGTCTCCTTCGGTG
GGGATGGACCCATCTCCTCTGTCCGCCTGCACTACCGGCCCCAGGACAGCATGATTACCTGGTC
TGCCATTGTGGTGGATCCCAGTGAGAATGTGACATTAATGAACCTGAAGCCAAGGACAGGATAC
AACGTTCGGGTGCAGCTGAGCCGGCCAGGGGAAGGAGGAGAAGGAGCCTGGGGTCCTTCGACTC
TCATGACTACGGACTGTCCTGAGCCTTTGCTGCAGCCGTGGGTAGAGAGCTGGAACGTGGAGGG
TCCTGACAGGCTACGGGTGAGCTGGTCTCTACCCTCGGTGCCACTGTCTGGGGATGGTTTCCTG
CTGCGTCTGTGGGATGGGGCCCGGGGACAGGAGAGGCGGGAGAACATCTCATCCCCCCAGGCCC
GCACTGCCCTCCTGACTGGACTCACGCCTGGCACGCACTACCAACTGGATGTGCGGCTGTATCA
CTGCACCCTCCTGGGCCCTGCCTCACCCTCTGCGCATGTGCACCTGCCCCTCAGCGGGCCTCCA
GCTCCCCGCCACCTCCGTGCCCAGGCCCTCTCAGACTCTGAGATCCGTCTGATGTGGCAGCATC
CTGAGGCTCCGCCTGGACCTATATCCAAGTACATTGTGGAGATTCAGGTGGCCGGGGGCTCAGG
AGACCCTCAGTGGATGGATGTAGACAAACCCGAGGAGACGAGCACCACCGTCCGTGGTCTCAAT
GCCAGCACACGCTACCTCTTCCGTGTGCGGGCCAGTGTGCAGGGTCTCGGCGACTGGAGCAACA
CAGTGGAAGAGACCACGCTGGGGCTGCAGAGTGCGAGCCCAGTCCAAGAGAGCCGGGTGGCTGA
AGACGGTCTGGATCAGCAGCTGGTCCTGGCTGTGGTAGGCTCCGTCTCTGCCACCTGCCTCACC
ATCCTGGCTGCCCTTTTAGCCCTGGTGTGTATCCGAAGAAGCTGCCTACATCGGAGACATACCT
TCACCTACCAGTCAGGATCGGGTGAAGAGACCATCCTGCAGTTCAGCTCAGGGACCTTGACATT
GACCCGACGGCCAAAGCCACAGCCTGAGCCTTTGAGTTACCCTGTGCTGGAGTGGGAGGACATC
ACCTTTGAGGACCTCATCGGGGAGGGGAACTTCGGCCAAGTGATCCGGGCCATGATCAAGAAGG
ACGGACTCAAGATGAACGCAGCCATCAAGATGCTGAAAGAGTATGCGTCTGAAAATGACCACCG
AGACTTTGCAGGGGAACTAGAAGTTCTGTGCAAACTAGGACACCACCCCAATATTATCAACCTC
TTGGGGGCCTGTGAGAACCGAGGCTACTTGTATATTGCGATCGAATATGCCCCGTATGGAAACC
TGCTAGATTTCCTGAGAAAGAGCAGGGTCCTGGAGACTGATCCAGCTTTTGCTCGAGAGCATGG
AACAGCCTCCACACTCAGCTCCCGGCAGCTGCTGCGCTTTGCCAGTGATGCAGCCAACGGGATG
CAGTACCTTAGTGAGAAGCAGTTCATTCACAGGGACCTGGCTGCCCGAAATGTTCTGGTCGGAG
AGAACCTGGCCTCCAAGATTGCAGACTTTGGCCTTTCTCGGGGGGAGGAAGTATATGTGAAGAA
GACGATGGGCCGTCTTCCTGTGCGTTGGATGGCCATTGAGTCCCTCAACTACAGCGTCTACACT
ACCAAGAGTGACGTCTGGTCATTTGGGGTCCTCCTCTGGGAGATAGTGAGCCTTGGAGGCACGC
CCTACTGTGGCATGACCTGTGCTGAGCTCTACGAGAAACTGCCTCAAGGCTATCGCATGGAGCA
GCCTCGAAACTGTGATGATGAAGTGTACGAGCTGATGCGGCAGTGCTGGCGGGACCGTCCCTAT
GAGCGCCCCCCTTTTGCCCAGATTGCACTACAGTTGGGCCGCATGCTGGAAGCCAGGAAGGCCT
ACGTGAACATGTCACTGTTTGAGAACTTTACCTATGCAGGCATCGATGCCACAGCTGAGGAGGC
CTAGGCTGCCCCCCACCAGAACCTGGCTCTGCTGGCCGGAGCAAACTGCTTCCACCTGTGACTC
TGAACCCTTCCAACCTCTGACCCAAGCTGTCTCAAGAAAGTCTTTTAATTTAAAGGAGAAAGGA
AAGGATCCAGGAAACATGGGGTGGAGGGAAACGGGGATCCCCATTTTTGGCAGCTGCTCCTATA
GCTACCCCTTCATATTCTTCCTTCTACAAATGTGTTCCCCACTCTGATGCTGCCCAAACCCAAA
CCCCACTTCTGATCCTCTACCAAAAGCAGCATGCATGTTACTAACACCCCGTTTAGCTACCCTA
CTCTCTGCTCGTACTCAAAAAATAAATGCTTGGAACAGCCA

hide sequence

Protein Sequences


Protein RefSeqs	NP_445997	(Get FASTA)	NCBI Sequence Viewer
	XP_006238782	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB84296	(Get FASTA)	NCBI Sequence Viewer
	AAI69020	(Get FASTA)	NCBI Sequence Viewer
	EDL90165	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000027414
	ENSRNOP00000027414.5
	ENSRNOP00000106828.1
	ENSRNOP00000107274.1

RefSeq Acc Id:	NP_445997 ⟸ NM_053545
- Peptide Label:	precursor
- UniProtKB:	B5DFD6 (UniProtKB/TrEMBL), A6JZI8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MVWWGSPFLLPILFLASHVGASVDLTLLANLRITEPQRFFLTCVSGEAGAGRSSDVWGPPLLLE KDDRIVRTFPPGQPLHLTRNGSHQVTLRGFSKPSDLVGVFSCVGGAGTRRTRVLYVHNSPGAHL FPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKNNGSYFHTLDWHEAHDGRFQLQLQNVQPPSSG IYSATYLEASPLGSAFFRLIVRGCEAGRWGPGCVKDCPGCLHGGVCHDHDGECVCPPGFTGTRC EQACREGRFGQSCQEQCPGTAGCRGLTFCLPDPYGCSCGSGWRGSQCQEACAPGHFGADCRLQC QCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQILNVATELEFNLGTMPRINCAAAGNPFPVRG SMELRKPDGTMLLSTKAIVEPDRTTAEFEVPRLTLGDSGFWECRVSTSGGQDSRRFKVNVKVPP VPLTAPRLLAKQSRQLVVSPLVSFGGDGPISSVRLHYRPQDSMITWSAIVVDPSENVTLMNLKP RTGYNVRVQLSRPGEGGEGAWGPSTLMTTDCPEPLLQPWVESWNVEGPDRLRVSWSLPSVPLSG DGFLLRLWDGARGQERRENISSPQARTALLTGLTPGTHYQLDVRLYHCTLLGPASPSAHVHLPL SGPPAPRHLRAQALSDSEIRLMWQHPEAPPGPISKYIVEIQVAGGSGDPQWMDVDKPEETSTTV RGLNASTRYLFRVRASVQGLGDWSNTVEETTLGNGLQSASPVQESRVAEDGLDQQLVLAVVGSV SATCLTILAALLALVCIRRSCLHRRHTFTYQSGSGEETILQFSSGTLTLTRRPKPQPEPLSYPV LEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHH PNIINLLGACENRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFAS DAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESL NYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQC WRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFENFTYAGIDATAEEA hide sequence

RefSeq Acc Id:	XP_006238782 ⟸ XM_006238720
- Peptide Label:	isoform X1
- UniProtKB:	A6JZI8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MVWWGSPFLLPILFLASHVGASVDLTLLANLRITEPQRFFLTCVSGEAGAGRSSDVWGPPLLLE KDDRIVRTFPPGQPLHLTRNGSHQVTLRGFSKPSDLVGVFSCVGGAGTRRTRVLYVHNSPGAHL FPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKNNGSYFHTLDWHEAHDGRFQLQLQNVQPPSSG IYSATYLEASPLGSAFFRLIVRGCEAGRWGPGCVKDCPGCLHGGVCHDHDGECVCPPGFTGTRC EQACREGRFGQSCQEQCPGTAGCRGLTFCLPDPYGCSCGSGWRGSQCQEACAPGHFGADCRLQC QCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQILNVATELEFNLGTMPRINCAAAGNPFPVRG SMELRKPDGTMLLSTKAIVEPDRTTAEFEVPRLTLGDSGFWECRVSTSGGQDSRRFKVNVKVPP VPLTAPRLLAKQSRQLVVSPLVSFGGDGPISSVRLHYRPQDSMITWSAIVVDPSENVTLMNLKP RTGYNVRVQLSRPGEGGEGAWGPSTLMTTDCPEPLLQPWVESWNVEGPDRLRVSWSLPSVPLSG DGFLLRLWDGARGQERRENISSPQARTALLTGLTPGTHYQLDVRLYHCTLLGPASPSAHVHLPL SGPPAPRHLRAQALSDSEIRLMWQHPEAPPGPISKYIVEIQVAGGSGDPQWMDVDKPEETSTTV RGLNASTRYLFRVRASVQGLGDWSNTVEETTLGLQSASPVQESRVAEDGLDQQLVLAVVGSVSA TCLTILAALLALVCIRRSCLHRRHTFTYQSGSGEETILQFSSGTLTLTRRPKPQPEPLSYPVLE WEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPN IINLLGACENRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDA ANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNY SVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWR DRPYERPPFAQIALQLGRMLEARKAYVNMSLFENFTYAGIDATAEEA hide sequence

Ensembl Acc Id:

ENSRNOP00000027414 ⟸ ENSRNOT00000027414

Ensembl Acc Id:

ENSRNOP00000107274 ⟸ ENSRNOT00000156581

Ensembl Acc Id:

ENSRNOP00000106828 ⟸ ENSRNOT00000137312

Protein Domains

EGF-like Fibronectin type-III Ig-like Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B5DFD6-F1-model_v2	AlphaFold	B5DFD6	1-1137	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693970

Promoter ID:

EPDNEW_R4491

Type:

multiple initiation site

Name:

Tie1_1

Description:

tyrosine kinase with immunoglobulin-like and EGF-like domains1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	137,321,063 - 137,321,123	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621642	AgrOrtholog
BioCyc Gene	G2FUF-40143	BioCyc
Ensembl Genes	ENSRNOG00000020173	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000027414	ENTREZGENE
	ENSRNOT00000027414.9	UniProtKB/TrEMBL
	ENSRNOT00000137312.1	UniProtKB/TrEMBL
	ENSRNOT00000156581.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.10	UniProtKB/TrEMBL
	Phosphorylase Kinase, domain 1	UniProtKB/TrEMBL
	Tie2 ligand-binding domain superfamily	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7098279	IMAGE-MGC_LOAD
InterPro	EG-like_dom	UniProtKB/TrEMBL
	FN3_sf	UniProtKB/TrEMBL
	FN_III	UniProtKB/TrEMBL
	Ig-like_dom	UniProtKB/TrEMBL
	Ig-like_dom_sf	UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/TrEMBL
	Ig_sub	UniProtKB/TrEMBL
	Immunoglobulin	UniProtKB/TrEMBL
	Kinase-like_dom	UniProtKB/TrEMBL
	LE_dom	UniProtKB/TrEMBL
	Prot_kinase_cat_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	RTK	UniProtKB/TrEMBL
	Ser-Thr/Tyr_kinase_cat_dom	UniProtKB/TrEMBL
	Tyr_kinase_AS	UniProtKB/TrEMBL
	Tyr_kinase_cat_dom	UniProtKB/TrEMBL
KEGG Report	rno:89806	UniProtKB/TrEMBL
MGC_CLONE	MGC:94770	IMAGE-MGC_LOAD
NCBI Gene	89806	ENTREZGENE
PANTHER	TYROSINE-PROTEIN KINASE RECEPTOR	UniProtKB/TrEMBL
	TYROSINE-PROTEIN KINASE RECEPTOR TIE-1	UniProtKB/TrEMBL
Pfam	fn3	UniProtKB/TrEMBL
	PF00047	UniProtKB/TrEMBL
	Pkinase_Tyr	UniProtKB/TrEMBL
PhenoGen	Tie1	PhenoGen
PRINTS	TYRKINASE	UniProtKB/TrEMBL
PROSITE	EGF_1	UniProtKB/TrEMBL
	EGF_2	UniProtKB/TrEMBL
	EGF_3	UniProtKB/TrEMBL
	FN3	UniProtKB/TrEMBL
	IG_LIKE	UniProtKB/TrEMBL
	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_TYR	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000020173	RatGTEx
SMART	EGF	UniProtKB/TrEMBL
	FN3	UniProtKB/TrEMBL
	SM00409	UniProtKB/TrEMBL
	TyrKc	UniProtKB/TrEMBL
Superfamily-SCOP	FN_III-like	UniProtKB/TrEMBL
	Kinase_like	UniProtKB/TrEMBL
	SSF48726	UniProtKB/TrEMBL
UniProt	A0ABK0LPM6_RAT	UniProtKB/TrEMBL
	A0ABK0LZA8_RAT	UniProtKB/TrEMBL
	A6JZI8	ENTREZGENE, UniProtKB/TrEMBL
	B5DFD6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Description	Reference	Status
2005-11-17	Tie1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	Name updated	1299863	APPROVED
2005-01-20	Tie1	tyrosine kinase receptor 1	Symbol and Name status set to approved	1299863	APPROVED
2002-08-07	Tie1	tyrosine kinase receptor 1	Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	protein expression increased with higher cell density	724771

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM