Cript (CXXC repeat containing interactor of PDZ3 domain) - Rat Genome Database

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Pathways
Gene: Cript (CXXC repeat containing interactor of PDZ3 domain) Rattus norvegicus
Analyze
Symbol: Cript
Name: CXXC repeat containing interactor of PDZ3 domain
RGD ID: 621545
Description: Enables PDZ domain binding activity and microtubule binding activity. Involved in cytoplasmic microtubule organization; protein localization to microtubule; and regulation of postsynaptic density organization. Located in dendritic shaft; dendritic spine; and neuronal cell body. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Human ortholog(s) of this gene implicated in Rothmund-Thomson syndrome. Orthologous to human CRIPT (CXXC repeat containing interactor of PDZ3 domain); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cysteine-rich interactor of PDZ three; cysteine-rich interactor of PDZ3; cysteine-rich PDZ-binding protein; postsynaptic protein Cript
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8613,334,978 - 13,342,934 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl613,334,954 - 13,345,044 (-)EnsemblGRCr8
mRatBN7.267,581,428 - 7,589,384 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl67,580,703 - 7,589,399 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx67,859,902 - 7,867,890 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.068,169,313 - 8,177,303 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.067,696,427 - 7,704,417 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0610,594,147 - 10,602,103 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl610,594,122 - 10,602,085 (+)Ensemblrn6Rnor6.0
Rnor_5.0620,582,664 - 20,590,620 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4610,475,037 - 10,482,993 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera67,316,891 - 7,324,847 (-)NCBICelera
RGSC_v3.1610,475,036 - 10,482,992 (+)NCBI
Cytogenetic Map6q12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
3. CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90. Niethammer M, etal., Neuron 1998 Apr;20(4):693-707.
4. Microtubule binding by CRIPT and its potential role in the synaptic clustering of PSD-95. Passafaro M, etal., Nat Neurosci. 1999 Dec;2(12):1063-9.
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
8. Laminar organization of the NMDA receptor complex within the postsynaptic density. Valtschanoff JG and Weinberg RJ, J Neurosci. 2001 Feb 15;21(4):1211-7.
Additional References at PubMed
PMID:9786987   PMID:17474715   PMID:32157575  


Genomics

Comparative Map Data
Cript
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8613,334,978 - 13,342,934 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl613,334,954 - 13,345,044 (-)EnsemblGRCr8
mRatBN7.267,581,428 - 7,589,384 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl67,580,703 - 7,589,399 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx67,859,902 - 7,867,890 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.068,169,313 - 8,177,303 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.067,696,427 - 7,704,417 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0610,594,147 - 10,602,103 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl610,594,122 - 10,602,085 (+)Ensemblrn6Rnor6.0
Rnor_5.0620,582,664 - 20,590,620 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4610,475,037 - 10,482,993 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera67,316,891 - 7,324,847 (-)NCBICelera
RGSC_v3.1610,475,036 - 10,482,992 (+)NCBI
Cytogenetic Map6q12NCBI
CRIPT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38246,617,215 - 46,630,176 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl246,616,416 - 46,685,037 (+)Ensemblhg38GRCh38
GRCh37246,844,354 - 46,857,315 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36246,697,812 - 46,705,690 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34246,755,958 - 46,763,834NCBI
Celera246,683,006 - 46,691,562 (+)NCBICelera
Cytogenetic Map2p21NCBI
HuRef246,581,752 - 46,590,308 (+)NCBIHuRef
CHM1_1246,774,619 - 46,783,172 (+)NCBICHM1_1
T2T-CHM13v2.0246,622,209 - 46,635,170 (+)NCBIT2T-CHM13v2.0
Cript
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391787,332,989 - 87,343,236 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1787,332,978 - 87,343,238 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381787,025,561 - 87,035,808 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1787,025,550 - 87,035,810 (+)Ensemblmm10GRCm38
MGSCv371787,424,901 - 87,435,148 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361786,933,922 - 86,944,136 (+)NCBIMGSCv36mm8
Celera1791,403,072 - 91,413,302 (+)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1756.9NCBI
Cript
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544113,525,686 - 13,533,458 (+)Ensembl
ChiLan1.0NW_00495544113,525,686 - 13,533,458 (+)NCBIChiLan1.0ChiLan1.0
CRIPT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21279,765,138 - 79,773,168 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A79,769,117 - 79,777,125 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A46,732,683 - 46,740,589 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A47,663,304 - 47,671,463 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A47,663,304 - 47,671,463 (+)EnsemblpanPan2panpan1.1
CRIPT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11048,840,243 - 48,851,461 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1048,839,509 - 48,851,258 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1048,694,222 - 48,705,439 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01049,711,249 - 49,722,470 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1049,710,515 - 49,722,470 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11049,419,142 - 49,430,374 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01049,709,293 - 49,720,507 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01049,892,428 - 49,903,655 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cript
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629234,220,855 - 34,230,384 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365085,650,057 - 5,658,950 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365085,650,057 - 5,658,966 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRIPT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1393,911,425 - 93,925,916 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23100,002,179 - 100,010,007 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CRIPT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11460,564,994 - 60,572,929 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604551,272,528 - 51,280,174 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cript
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473828,067,616 - 28,077,238 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473828,067,615 - 28,079,593 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Cript
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v175,953,126 - 5,961,389 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cript
128 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:123
Count of miRNA genes:94
Interacting mature miRNAs:109
Transcripts:ENSRNOT00000020534
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6197587946975879Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6197587946975879Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6144788383Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6197587946975879Rat
2293706Bmd20Bone mineral density QTL 204.30.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6125740059Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6197587946975879Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6323998948239989Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6323998948239989Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6140163351Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6120510098Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6323998948239989Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6323998948239989Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6197587946975879Rat

Markers in Region
RH141427  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.267,581,554 - 7,581,769 (-)MAPPERmRatBN7.2
Rnor_6.0610,601,762 - 10,601,976NCBIRnor6.0
Rnor_5.0620,590,279 - 20,590,493UniSTSRnor5.0
RGSC_v3.4610,482,652 - 10,482,866UniSTSRGSC3.4
Celera67,317,018 - 7,317,232UniSTS
Cytogenetic Map6q12UniSTS
RH132997  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.267,586,602 - 7,586,783 (-)MAPPERmRatBN7.2
Rnor_6.0610,596,748 - 10,596,928NCBIRnor6.0
Rnor_5.0620,585,265 - 20,585,445UniSTSRnor5.0
RGSC_v3.4610,477,638 - 10,477,818UniSTSRGSC3.4
Celera67,322,066 - 7,322,246UniSTS
Cytogenetic Map6q12UniSTS
RH138667  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.267,582,227 - 7,582,373 (-)MAPPERmRatBN7.2
Rnor_6.0610,601,158 - 10,601,303NCBIRnor6.0
Rnor_5.0620,589,675 - 20,589,820UniSTSRnor5.0
RGSC_v3.4610,482,048 - 10,482,193UniSTSRGSC3.4
Celera67,317,691 - 7,317,836UniSTS
Cytogenetic Map6q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000020534   ⟹   ENSRNOP00000020534
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl613,334,954 - 13,345,044 (-)Ensembl
mRatBN7.2 Ensembl67,580,703 - 7,589,399 (-)Ensembl
Rnor_6.0 Ensembl610,594,122 - 10,602,085 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113445   ⟹   ENSRNOP00000097693
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl613,334,954 - 13,340,667 (-)Ensembl
mRatBN7.2 Ensembl67,580,703 - 7,587,117 (-)Ensembl
RefSeq Acc Id: NM_019907   ⟹   NP_063972
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8613,334,978 - 13,342,934 (-)NCBI
mRatBN7.267,581,428 - 7,589,384 (-)NCBI
Rnor_6.0610,594,147 - 10,602,103 (+)NCBI
Rnor_5.0620,582,664 - 20,590,620 (+)NCBI
RGSC_v3.4610,475,037 - 10,482,993 (+)RGD
Celera67,316,891 - 7,324,847 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_063972 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC40102 (Get FASTA)   NCBI Sequence Viewer  
  EDM02654 (Get FASTA)   NCBI Sequence Viewer  
  EDM02655 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000020534.5
  ENSRNOP00000097693
GenBank Protein Q792Q4 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_063972   ⟸   NM_019907
- UniProtKB: Q792Q4 (UniProtKB/Swiss-Prot),   A6H9E9 (UniProtKB/TrEMBL),   A0A8I6AVC2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020534   ⟸   ENSRNOT00000020534
Ensembl Acc Id: ENSRNOP00000097693   ⟸   ENSRNOT00000113445

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q792Q4-F1-model_v2 AlphaFold Q792Q4 1-101 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694389
Promoter ID:EPDNEW_R4914
Type:initiation region
Name:Cript_1
Description:CXXC repeat containing interactor of PDZ3 domain
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0610,594,140 - 10,594,200EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621545 AgrOrtholog
BioCyc Gene G2FUF-38711 BioCyc
Ensembl Genes ENSRNOG00000015215 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000020534.7 UniProtKB/Swiss-Prot
  ENSRNOT00000113445 ENTREZGENE
InterPro PDZ-binding_CRIPT UniProtKB/Swiss-Prot
KEGG Report rno:56725 UniProtKB/Swiss-Prot
NCBI Gene 56725 ENTREZGENE
PANTHER CYSTEINE-RICH PDZ-BINDING PROTEIN UniProtKB/Swiss-Prot
  PTHR11805 UniProtKB/Swiss-Prot
Pfam Cript UniProtKB/Swiss-Prot
PhenoGen Cript PhenoGen
RatGTEx ENSRNOG00000015215 RatGTEx
UniProt A0A8I6AVC2 ENTREZGENE, UniProtKB/TrEMBL
  A6H9E9 ENTREZGENE, UniProtKB/TrEMBL
  A6H9F0_RAT UniProtKB/TrEMBL
  CRIPT_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Cript  CXXC repeat containing interactor of PDZ3 domain  Cript  cysteine-rich PDZ-binding protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-25 Cript  cysteine-rich PDZ-binding protein  Cript  postsynaptic protein Cript  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Cript  postsynaptic protein Cript      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Cript        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the postsynaptic density 632510
gene_physical_interaction binds to the third PDZ domain of PSD-95 via its C terminus 632510