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Gene: Ces2c (carboxylesterase 2C) Rattus norvegicus

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Symbol:

Ces2c

Name:

carboxylesterase 2C

RGD ID:

621510

Description:

Enables retinyl-palmitate esterase activity. Predicted to be involved in retinoid metabolic process. Predicted to be located in endoplasmic reticulum. Orthologous to human CES2 (carboxylesterase 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-nitrofluorene; 3,3',4,4',5-pentachlorobiphenyl.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

ACH M1; acylcarnitine hydrolase; acylcarnitine hydrolase-like; carboxylesterase 2 (intestine, liver); carboxylesterase 2-like; carboxylic ester hydrolase; CES RL4; Ces2; Ces2l; CESRL4; LOC108348093; rCES2

RGD Orthologs

Mouse

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Ces2c (carboxylesterase 2C)	RGD	RGD
Other homologs ²
Homo sapiens (human):	CES2 (carboxylesterase 2)	HGNC	Ensembl, OrthoDB, Panther
Homo sapiens (human):	SOST (sclerostin)	HGNC	OMA
Homo sapiens (human):	PANK3 (pantothenate kinase 3)	HGNC	OMA
Homo sapiens (human):	ALOX15 (arachidonate 15-lipoxygenase)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	CES2 (carboxylesterase 2)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Mus musculus (house mouse):	Ces2c (carboxylesterase 2C)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ces3 (carboxylesterase 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ces2 (carboxylesterase 2 (intestine, liver))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ZC376.3	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Caenorhabditis elegans (roundworm):	B0238.1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA)
Caenorhabditis elegans (roundworm):	C52A10.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA)
Drosophila melanogaster (fruit fly):	Est-6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER)
Drosophila melanogaster (fruit fly):	Est-6	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Drosophila melanogaster (fruit fly):	Est-P	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER)
Drosophila melanogaster (fruit fly):	Jhe	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PANTHER)
Drosophila melanogaster (fruit fly):	Jhe	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Drosophila melanogaster (fruit fly):	CG6414	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PANTHER)
Drosophila melanogaster (fruit fly):	CG4382	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|PANTHER)
Caenorhabditis elegans (roundworm):	ges-1	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Drosophila melanogaster (fruit fly):	CG4757	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|PANTHER)
Danio rerio (zebrafish):	ces2b	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ces3.1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ces3.1	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	ces3.4	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ces3.4	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	ces2.8	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ces2.6	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ces2.3	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ces2.7	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ces2.2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ces2.5	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ces2.3	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	270,377,201 - 270,384,768 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	270,374,913 - 270,384,801 (+)	Ensembl				GRCr8
mRatBN7.2	1	260,391,190 - 260,398,757 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	260,388,902 - 260,398,790 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	268,598,492 - 268,606,058 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	275,304,512 - 275,312,078 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	267,958,843 - 267,966,409 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	282,640,752 - 282,648,319 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	282,638,017 - 282,702,424 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	290,007,967 - 290,021,934 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	267,887,420 - 267,894,987 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	256,028,966 - 256,036,533 (+)	NCBI		Celera
RGSC_v3.1	1	268,098,504 - 268,106,072 (+)	NCBI
Cytogenetic Map	1	q55	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthaleneacetic acid (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2-nitrofluorene (EXP)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,3',5-triiodo-L-thyronine (EXP)

4,4'-sulfonyldiphenol (ISO)

4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one (EXP)

5-bromo-2'-deoxyuridine (ISO)

acetylsalicylic acid (ISO)

aflatoxin B1 (EXP,ISO)

Azoxymethane (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

butylated hydroxyanisole (ISO)

Butylbenzyl phthalate (EXP)

captan (ISO)

carbon nanotube (ISO)

choline (ISO)

chrysene (ISO)

clofibrate (EXP)

cyanocob(III)alamin (ISO)

cyproconazole (EXP)

dextran sulfate (ISO)

diallyl trisulfide (EXP)

dichloroacetic acid (ISO)

epoxiconazole (EXP)

ethanol (ISO)

ethoxyquin (ISO)

fentin chloride (EXP)

fipronil (EXP,ISO)

folic acid (ISO)

folpet (ISO)

furan (EXP,ISO)

glycine betaine (ISO)

GW 4064 (ISO)

indole-3-methanol (EXP)

inulin (ISO)

L-methionine (ISO)

lipopolysaccharide (ISO)

N-nitrosodiethylamine (EXP)

N-nitrosomorpholine (EXP)

oltipraz (ISO)

paracetamol (EXP,ISO)

parathion (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenformin (EXP)

phenobarbital (EXP,ISO)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

prochloraz (EXP)

resveratrol (EXP)

rotenone (EXP)

sevoflurane (EXP)

sodium arsenite (ISO)

spironolactone (ISO)

streptozocin (EXP)

tetraphene (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

lipid metabolic process (IEA)

retinoid metabolic process (TAS)

retinol metabolic process (IEA)

Cellular Component

endoplasmic reticulum (IEA)

Molecular Function

acylcarnitine hydrolase activity (IEA,ISO)

all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity (IEA)

carboxylesterase activity (IBA)

carboxylic ester hydrolase activity (IEA)

hydrolase activity (IEA)

retinyl-palmitate esterase activity (IBA,IDA)

References

References - curated

#	Reference Title	Reference Citation
1.	Purification, molecular cloning, and functional expression of inducible liver acylcarnitine hydrolase in C57BL/6 mouse, belonging to the carboxylesterase multigene family.	Furihata T, etal., Arch Biochem Biophys 2003 Aug 1;416(1):101-9.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins.	Holmes RS, etal., Mamm Genome. 2010 Oct;21(9-10):427-41. Epub 2010 Oct 8.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	GOA pipeline	RGD automated data pipeline
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Identification of microsomal rat liver carboxylesterases and their activity with retinyl palmitate.	Sanghani SP, etal., Eur J Biochem 2002 Sep;269(18):4387-98.

Additional References at PubMed

PMID:15632090	PMID:15794950	PMID:16527247	PMID:17392394	PMID:17764701	PMID:19187434

Genomics

Comparative Map Data

Ces2c
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	270,377,201 - 270,384,768 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	270,374,913 - 270,384,801 (+)	Ensembl				GRCr8
mRatBN7.2	1	260,391,190 - 260,398,757 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	260,388,902 - 260,398,790 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	268,598,492 - 268,606,058 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	275,304,512 - 275,312,078 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	267,958,843 - 267,966,409 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	282,640,752 - 282,648,319 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	282,638,017 - 282,702,424 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	290,007,967 - 290,021,934 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	267,887,420 - 267,894,987 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	256,028,966 - 256,036,533 (+)	NCBI		Celera
RGSC_v3.1	1	268,098,504 - 268,106,072 (+)	NCBI
Cytogenetic Map	1	q55	NCBI

Ces2c
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	105,573,700 - 105,581,115 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	105,573,700 - 105,581,115 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	8	104,847,068 - 104,854,483 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	104,847,068 - 104,854,483 (+)	Ensembl			mm10	GRCm38
MGSCv37	8	107,370,968 - 107,378,383 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	8	107,736,215 - 107,743,597 (+)	NCBI		MGSCv36	mm8
Celera	8	109,077,665 - 109,085,082 (+)	NCBI		Celera
Cytogenetic Map	8	D3	NCBI
cM Map	8	53.04	NCBI

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	139
Count of miRNA genes:	88
Interacting mature miRNAs:	90
Transcripts:	ENSRNOT00000045656, ENSRNOT00000073241
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
724552	Glom2	Glomerulus QTL 2	3.3	0.0001	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)	1	232312773	270518180	Rat
631215	Stl8	Serum triglyceride level QTL 8	9.27	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	1	234540191	270518180	Rat
7387289	Uae45	Urinary albumin excretion QTL 45	2.86	0.0021	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	233204160	270518180	Rat
71112	Bw115	Body weight QTL 115	6	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	1	269633753	270518180	Rat
61327	Eae7	Experimental allergic encephalomyelitis QTL 7	5.6		body mass (VT:0001259)	change in body weight (CMO:0002045)	1	226175591	270518180	Rat
1578775	Iddm21	Insulin dependent diabetes mellitus QTL 21	4.13		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	245782829	270518180	Rat
1598839	Rf56	Renal function QTL 56			renal blood flow trait (VT:2000006)	ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)	1	255849111	270518180	Rat
1600397	Edcs4	Endometrial carcinoma susceptibility QTL 4	2.2		uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	1	176288899	270518180	Rat
631836	Stl31	Serum triglyceride level QTL 31	4.64	5e-06	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	1	247133834	270518180	Rat
631536	Lnnr2	Liver neoplastic nodule remodeling QTL 2	2.9	0.0005	liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)	1	243953669	270518180	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	162548015	270518180	Rat
738032	Hcas5	Hepatocarcinoma susceptibility QTL 5	3.12		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	185857683	270518180	Rat
2302040	Pia35	Pristane induced arthritis QTL 35	3.8	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	1	226175591	270518180	Rat
631669	Iddm9	Insulin dependent diabetes mellitus QTL 9	2.8	0.039	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	233349180	270518180	Rat
1598821	Rf55	Renal function QTL 55	6.3		renal blood flow trait (VT:2000006)	ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)	1	228174566	270518180	Rat
1600390	Niddm64	Non-insulin dependent diabetes mellitus QTL 64		0.003	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	257624997	270518180	Rat

Markers in Region

RH131401

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	1	270,383,909 - 270,384,548 (+)	Marker Load Pipeline
mRatBN7.2	1	260,397,898 - 260,398,537 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	282,647,461 - 282,648,099	NCBI	Rnor6.0
Rnor_6.0	1	282,684,859 - 282,685,497	NCBI	Rnor6.0
Rnor_5.0	1	290,021,042 - 290,021,680	UniSTS	Rnor5.0
Rnor_5.0	1	289,983,480 - 289,984,118	UniSTS	Rnor5.0
RGSC_v3.4	1	267,894,129 - 267,894,767	UniSTS	RGSC3.4
Celera	1	256,035,675 - 256,036,313	UniSTS
Cytogenetic Map	1	q55	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system
16	9	20	47	80	80	49	25	49	6	217	68	3	26	77	84	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_133586	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB010570	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB010635	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB191005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473986	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

NM_133586 ⟹ NP_598270

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	270,377,201 - 270,384,768 (+)	NCBI
mRatBN7.2	1	260,391,190 - 260,398,757 (+)	NCBI
Rnor_6.0	1	282,640,752 - 282,648,319 (+)	NCBI
Rnor_5.0	1	290,007,967 - 290,021,934 (+)	NCBI
RGSC_v3.4	1	267,887,420 - 267,894,987 (+)	RGD
Celera	1	256,028,966 - 256,036,533 (+)	RGD

Sequence:

show sequence

TAGCCCGACGAACTGAGAACTGGCCATGGCACGGAAACAACCACATAGCTGGCTGAATGCTGTG
CTCTTTGGGCTCCTGCTTATTCTTATCCATGTGTGGGGTCAGGACTCACCAGAGTCCAGCTCCA
TCAGGACCACACACACGGGCCAGGTCCGAGGAAAGCTTGACCACGTGAGGGACACTAAAGCTGG
TGTCCACACCTTCCTGGGAATTCCCTTTGCCAAGGCTCCTGTAGGACCGCTGCGCTTTGCACCT
CCTGAGGACCCTGAGCCATGGAGTGGTGTGAGAGATGGGACCTCACATCCGGCCATGTGTCTGC
AAAATATTGATATGCTGGATGAAGTAGGCCTGACAGATATGAAAATGATACTGTCTTCCATTCC
TATGTCTGAGGACTGCCTGTATCTCAACATCTATACACCAGCCCATGCCCATGAGGGCTCTAAC
CTGCCTGTGATGGTGTGCATCCACGGAGGTGCACTGGTTATAGGAATGGCTTCCATGTGTGATG
GATCTCTATTGGCAGTCAATGAGGACTTGGTGGTTGTCGCTATCCAGTATCGTCTGGGTGTCCT
GGGCTTTTTCAGCACTGGAGATGAGCATGCCAGAGGCAACTGGGGATACCTGGACCAAGTGGCT
GCCCTGCGATGGGTCCAGCAGAATATCGCCCATTTTGGAGGCAACCCTAACCGGGTCACTATTT
TTGGCGTGTCTGCAGGTGGCACAAGTGTGTCTTCACATGTTATATCCCCCATGTCTCAAGGGCT
CTTCCATGGTGCCATCATGGAGAGTGGAGTGGCCCTGCTGCCTGACCTTATCTCTGAAACCTCT
GAGACGGTCTCCACTACAGTGGCCAAGCTCTCTGGATGTGAGGCCACGGACTCAGAGACCCTGG
TGCGCTGCCTGAGAGCCAAGAGTGGAGCAGAGATTCTGGTCATTAACAAGGTCTTCAAGATGAT
TCCCGCTGTGGTGGATGGAGAGTTCCTACCCAGGCATCCCAAAGAGCTGTTGGCATCTGAGGAT
TTTCGCCCTGTCCCCAGCATCATTGGTGTTAACACTGATGAGTACTGTTGCACCATTCCTATGG
TCATGGGCACTGCTCAAATAATAAAGGAGCTATCCAGAGAGAACCTGCAGGCTGTTCTAAAGGA
TACAGCAGCACAAATGATGCTTCCTCCTGAGTGTGGTGACCTGCTAATGGAAGAGTACATGGGG
AATACTGATGATCCCCAGACCCTACAAATACAGTACGCTGAGATGATGGGAGACTTCCTGTTTG
TGATCCCTGCACTCCAAGTTGCACACTTTCAACGTTCCCATGCCCCTGTCTACTTCTATGAGTT
CCAACATGCACCCAGCTATTTCAAGAATGTCAGGCCACCCCACGTGAAGGCTGACCATGCTGAT
GAGGTTCCTTTTGTCTTTGGGTCCTTCTTCTGGGGCATAAAAGTTGACTTCACTGAGGAGGAGA
AGCTGCTGAGTAGGCGGATGATGAAGTACTGGGCCAATTTTGCAAGACACGGGAACCCCAACAG
CGAGGGTCTACCCTACTGGCCTGTGTTGGACCACGACGAGCAGTACCTGCAGTTGGACACCCAG
CCTGCTGTGGACCGAGCCCTGAAGGCCAGAAGGCTGCAGTTCTGGACCAAGACTCTGCCCCAGA
AGATCCAGGAGCTAAATGGAGCTCAGAAAAACCATGCAGAGCTGTAGTGTCTGGTGAAAGGAAC
AGAGTGTGGGAGTGAGGGCAGGTGGGATCATTCTGAGTTTCAAAGTCTAATTTTCTGTTCCAAC
ACGCAGAATCCTTTCCAACCCCAATATTTTCCCTTTCTGACATGAATGAGAAGCCCTCCGTGTG
TTACTCTTTATTCTTCTGGGCAAAATTTAATTGGACTCAATAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_598270	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAA25690	(Get FASTA)	NCBI Sequence Viewer
	BAA25692	(Get FASTA)	NCBI Sequence Viewer
	BAD77829	(Get FASTA)	NCBI Sequence Viewer
	EDL94590	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000064884
GenBank Protein	O70631	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_598270 ⟸ NM_133586
- Peptide Label:	precursor
- UniProtKB:	O70631 (UniProtKB/Swiss-Prot), G3V9D8 (UniProtKB/Swiss-Prot), A0A0G2K455 (UniProtKB/TrEMBL)
- Sequence:	show sequence MARKQPHSWLNAVLFGLLLILIHVWGQDSPESSSIRTTHTGQVRGKLDHVRDTKAGVHTFLGIP FAKAPVGPLRFAPPEDPEPWSGVRDGTSHPAMCLQNIDMLDEVGLTDMKMILSSIPMSEDCLYL NIYTPAHAHEGSNLPVMVCIHGGALVIGMASMCDGSLLAVNEDLVVVAIQYRLGVLGFFSTGDE HARGNWGYLDQVAALRWVQQNIAHFGGNPNRVTIFGVSAGGTSVSSHVISPMSQGLFHGAIMES GVALLPDLISETSETVSTTVAKLSGCEATDSETLVRCLRAKSGAEILVINKVFKMIPAVVDGEF LPRHPKELLASEDFRPVPSIIGVNTDEYCCTIPMVMGTAQIIKELSRENLQAVLKDTAAQMMLP PECGDLLMEEYMGNTDDPQTLQIQYAEMMGDFLFVIPALQVAHFQRSHAPVYFYEFQHAPSYFK NVRPPHVKADHADEVPFVFGSFFWGIKVDFTEEEKLLSRRMMKYWANFARHGNPNSEGLPYWPV LDHDEQYLQLDTQPAVDRALKARRLQFWTKTLPQKIQELNGAQKNHAEL hide sequence

Protein Domains

Carboxylesterase type B

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O70631-F1-model_v2	AlphaFold	O70631	1-561	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621510	AgrOrtholog
BioCyc Gene	G2FUF-55209	BioCyc
Ensembl Genes	ENSRNOG00000036571	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000074303	ENTREZGENE
Gene3D-CATH	3.40.50.1820	UniProtKB/Swiss-Prot
InterPro	AB_hydrolase	UniProtKB/Swiss-Prot
	CarbesteraseB	UniProtKB/Swiss-Prot
	Carboxylesterase_B_AS	UniProtKB/Swiss-Prot
	Carboxylesterase_B_CS	UniProtKB/Swiss-Prot
	Type-B_Carboxylest/Lipase	UniProtKB/Swiss-Prot
KEGG Report	rno:171118	UniProtKB/Swiss-Prot
NCBI Gene	171118	ENTREZGENE
PANTHER	CARBOXYLESTERASE	UniProtKB/Swiss-Prot
Pfam	COesterase	UniProtKB/Swiss-Prot
PhenoGen	Ces2c	PhenoGen
PROSITE	CARBOXYLESTERASE_B_1	UniProtKB/Swiss-Prot
	CARBOXYLESTERASE_B_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000036571	RatGTEx
Superfamily-SCOP	SSF53474	UniProtKB/Swiss-Prot
UniProt	A0A0G2JV37_RAT	UniProtKB/TrEMBL
	A0A0G2K455	ENTREZGENE, UniProtKB/TrEMBL
	EST2C_RAT	UniProtKB/Swiss-Prot
	G3V9D8	ENTREZGENE
	M0R646_RAT	UniProtKB/TrEMBL
	O70631	ENTREZGENE
UniProt Secondary	G3V9D8	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Ces2c	carboxylesterase 2C	LOC108348093	acylcarnitine hydrolase-like	Data merged from RGD:11416512	737654	PROVISIONAL
2016-08-02	LOC108348093	acylcarnitine hydrolase-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2010-11-18	Ces2c	carboxylesterase 2C	Ces2l	carboxylesterase 2-like	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-23	Ces2l	carboxylesterase 2-like	Ces2	carboxylesterase 2 (intestine, liver)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Ces2	carboxylesterase 2 (intestine, liver)			Symbol and Name status set to approved	1299863	APPROVED
2002-08-07	Ces2	carboxylesterase 2 (intestine, liver)			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_product	member of the carboxylesterase gene family	634722

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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