Cdc25a (cell division cycle 25A) - Rat Genome Database

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Gene: Cdc25a (cell division cycle 25A) Rattus norvegicus
Analyze
Symbol: Cdc25a
Name: cell division cycle 25A
RGD ID: 621498
Description: Enables phosphoprotein phosphatase activity. Involved in G1/S transition of mitotic cell cycle and positive regulation of cholangiocyte proliferation. Predicted to be active in cytoplasm and nucleus. Used to study autosomal recessive polycystic kidney disease. Biomarker of autosomal recessive polycystic kidney disease. Human ortholog(s) of this gene implicated in cervical cancer; prostate cancer; and urinary bladder cancer. Orthologous to human CDC25A (cell division cycle 25A); PARTICIPATES IN cell cycle pathway, mitotic; INTERACTS WITH (+)-schisandrin B; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cell division cycle 25 homolog A (S. cerevisiae); cell division cycle 25 homolog A (S. pombe); dual specificity phosphatase Cdc25A; M-phase inducer phosphatase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88118,742,824 - 118,761,190 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8118,742,426 - 118,761,188 (+)EnsemblGRCr8
mRatBN7.28109,864,356 - 109,882,734 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,864,478 - 109,882,701 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8115,480,079 - 115,498,174 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08113,679,257 - 113,697,352 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08111,522,054 - 111,540,149 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08117,953,223 - 117,971,552 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,953,444 - 117,971,519 (+)Ensemblrn6Rnor6.0
Rnor_5.08117,305,748 - 117,324,074 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48114,237,704 - 114,255,971 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8109,154,287 - 109,172,351 (+)NCBICelera
RGSC_v3.18114,257,158 - 114,275,426 (+)NCBI
Cytogenetic Map8q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(+)-taxifolin  (ISO)
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(20R)-protopanaxadiol  (ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (ISO)
adenine  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
aniline  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
bazedoxifene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bosutinib  (ISO)
Bufotalin  (ISO)
Butylparaben  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
chromium(3+) trichloride  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coptisine  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
daunorubicin  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (ISO)
dichlorvos  (EXP)
diethyl maleate  (EXP)
diminazene diaceturate  (ISO)
dioxygen  (ISO)
doxorubicin  (EXP,ISO)
Enterolactone  (ISO)
entinostat  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fenhexamid  (ISO)
fenofibrate  (EXP)
folic acid  (ISO)
furan  (EXP)
gentamycin  (EXP)
geraniol  (ISO)
glyphosate  (ISO)
GSK-J4  (ISO)
GW 3965  (ISO)
harmine  (ISO)
hydrogen peroxide  (ISO)
hydroxytyrosol  (ISO)
hydroxyurea  (ISO)
isosilybin A  (ISO)
Lasiocarpine  (ISO)
leptomycin B  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
metformin  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
monocrotaline  (ISO)
Muraglitazar  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
n-propyl gallate  (EXP)
nelfinavir  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
nicotine  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pifithrin-alpha hydrobromide  (ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
propylparaben  (ISO)
resveratrol  (EXP,ISO)
riddelliine  (ISO)
rotenone  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
teriflunomide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thioridazine  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
toosendanin  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
Tylophorine  (ISO)
valproic acid  (ISO)
vemurafenib  (ISO)
VX nerve agent  (ISO)
wortmannin  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
nucleus  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Plumbagin, a medicinal plant-derived naphthoquinone, is a novel inhibitor of the growth and invasion of hormone-refractory prostate cancer. Aziz MH, etal., Cancer Res. 2008 Nov 1;68(21):9024-32.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. p27Kip1 repression of ErbB2-induced mammary tumor growth in transgenic mice involves Skp2 and Wnt/beta-catenin signaling. Hulit J, etal., Cancer Res. 2006 Sep 1;66(17):8529-41.
5. Cdc25A is a novel phosphatase functioning early in the cell cycle. Jinno S, etal., EMBO J 1994 Apr 1;13(7):1549-56.
6. HYAL1-v1, an alternatively spliced variant of HYAL1 hyaluronidase: a negative regulator of bladder cancer. Lokeshwar VB, etal., Cancer Res. 2006 Dec 1;66(23):11219-27.
7. Inhibition of Cdc25A suppresses hepato-renal cystogenesis in rodent models of polycystic kidney and liver disease. Masyuk TV, etal., Gastroenterology. 2012 Mar;142(3):622-633.e4. doi: 10.1053/j.gastro.2011.11.036. Epub 2011 Dec 7.
8. Prognostic implication of CDC25A and cyclin E expression on primary breast cancer patients. Mehdipour P, etal., Cell Biol Int. 2009 Oct;33(10):1050-6. Epub 2009 Jun 23.
9. Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1-mediated activation of the c-Myc signaling pathway. Mochizuki T, etal., J Biol Chem 1999 Jun 25;274(26):18659-66.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. Deregulated CDC25A expression promotes mammary tumorigenesis with genomic instability. Ray D, etal., Cancer Res. 2007 Feb 1;67(3):984-91.
13. Hemizygous disruption of Cdc25A inhibits cellular transformation and mammary tumorigenesis in mice. Ray D, etal., Cancer Res. 2007 Jul 15;67(14):6605-11.
14. GOA pipeline RGD automated data pipeline
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Activation of cell cycle regulatory proteins in the apoptosis of terminally differentiated oligodendrocytes. Strazza M, etal., Neurochem Res. 2004 May;29(5):923-31.
17. Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malignant features and aggressive cancer phenotypes. Wang Z, etal., BMC Cancer. 2010 May 25;10:233.
18. Changes in gene expression induced by chemoradiation in advanced cervical carcinoma: a microarray study of RTOG C-0128. Zempolich K, etal., Gynecol Oncol. 2008 May;109(2):275-9. Epub 2008 Mar 4.
Additional References at PubMed
PMID:11981756   PMID:14742443   PMID:18949056   PMID:19966869   PMID:20813185   PMID:21376736   PMID:22843495   PMID:22899714   PMID:24211536   PMID:39305937  


Genomics

Comparative Map Data
Cdc25a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88118,742,824 - 118,761,190 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8118,742,426 - 118,761,188 (+)EnsemblGRCr8
mRatBN7.28109,864,356 - 109,882,734 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,864,478 - 109,882,701 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8115,480,079 - 115,498,174 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08113,679,257 - 113,697,352 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08111,522,054 - 111,540,149 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08117,953,223 - 117,971,552 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,953,444 - 117,971,519 (+)Ensemblrn6Rnor6.0
Rnor_5.08117,305,748 - 117,324,074 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48114,237,704 - 114,255,971 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8109,154,287 - 109,172,351 (+)NCBICelera
RGSC_v3.18114,257,158 - 114,275,426 (+)NCBI
Cytogenetic Map8q32NCBI
CDC25A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38348,157,146 - 48,188,417 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl348,157,146 - 48,188,417 (-)Ensemblhg38GRCh38
GRCh37348,198,636 - 48,229,907 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36348,173,672 - 48,204,805 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34348,173,671 - 48,204,805NCBI
Celera348,147,668 - 48,178,797 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef348,253,008 - 48,284,141 (-)NCBIHuRef
CHM1_1348,150,488 - 48,181,619 (-)NCBICHM1_1
T2T-CHM13v2.0348,184,306 - 48,215,830 (-)NCBIT2T-CHM13v2.0
Cdc25a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399109,704,545 - 109,722,963 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9109,704,647 - 109,722,963 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm389109,875,518 - 109,893,895 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9109,875,579 - 109,893,895 (+)Ensemblmm10GRCm38
MGSCv379109,778,083 - 109,796,394 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369109,733,366 - 109,751,296 (+)NCBIMGSCv36mm8
Celera9109,601,935 - 109,621,511 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map959.81NCBI
Cdc25a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542024,344,388 - 24,362,596 (+)Ensembl
ChiLan1.0NW_00495542024,345,002 - 24,361,802 (+)NCBIChiLan1.0ChiLan1.0
CDC25A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2248,121,554 - 48,152,273 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1348,126,322 - 48,157,503 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0348,068,601 - 48,099,806 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1349,154,307 - 49,186,115 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl349,154,307 - 49,186,115 (-)EnsemblpanPan2panpan1.1
CDC25A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12040,823,683 - 40,849,113 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2040,823,459 - 40,847,608 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2040,741,248 - 40,764,940 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02041,309,415 - 41,334,896 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2041,309,419 - 41,334,893 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12040,549,928 - 40,573,619 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02040,951,503 - 40,974,658 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02041,231,962 - 41,255,400 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cdc25a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118202,108,272 - 202,130,970 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365961,659,159 - 1,678,788 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365961,657,411 - 1,680,109 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDC25A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.21334,164,323 - 34,190,078 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CDC25A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1229,534,114 - 9,564,927 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl229,534,053 - 9,564,741 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041157,537,318 - 157,569,097 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdc25a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473073,443,731 - 73,464,486 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473073,443,895 - 73,463,979 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Cdc25a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v18100,486,063 - 100,504,445 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cdc25a
72 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:458
Count of miRNA genes:230
Interacting mature miRNAs:279
Transcripts:ENSRNOT00000028141
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)898145073122898010Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat

Markers in Region
RH142287  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8q32UniSTS
BF386976  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28109,879,927 - 109,880,082 (+)MAPPERmRatBN7.2
Rnor_6.08117,968,743 - 117,968,897NCBIRnor6.0
Rnor_5.08117,321,265 - 117,321,419UniSTSRnor5.0
RGSC_v3.48114,253,197 - 114,253,351UniSTSRGSC3.4
Celera8109,169,597 - 109,169,751UniSTS
RH 3.4 Map81115.79UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000028141   ⟹   ENSRNOP00000028141
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8118,743,048 - 118,761,157 (+)Ensembl
mRatBN7.2 Ensembl8109,864,758 - 109,882,701 (+)Ensembl
Rnor_6.0 Ensembl8117,953,444 - 117,971,519 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116348   ⟹   ENSRNOP00000082319
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8118,743,048 - 118,759,559 (+)Ensembl
mRatBN7.2 Ensembl8109,864,478 - 109,881,103 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000131172   ⟹   ENSRNOP00000102326
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8118,742,935 - 118,761,186 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000137536   ⟹   ENSRNOP00000102479
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8118,743,242 - 118,759,235 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000167389   ⟹   ENSRNOP00000101754
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8118,742,426 - 118,761,188 (+)Ensembl
RefSeq Acc Id: NM_133571   ⟹   NP_598255
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,743,048 - 118,761,157 (+)NCBI
mRatBN7.28109,864,591 - 109,882,701 (+)NCBI
Rnor_6.08117,953,444 - 117,971,519 (+)NCBI
Rnor_5.08117,305,748 - 117,324,074 (+)NCBI
RGSC_v3.48114,237,704 - 114,255,971 (+)RGD
Celera8109,154,287 - 109,172,351 (+)RGD
Sequence:
RefSeq Acc Id: XM_006243702   ⟹   XP_006243764
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,742,829 - 118,761,190 (+)NCBI
mRatBN7.28109,864,356 - 109,882,734 (+)NCBI
Rnor_6.08117,953,223 - 117,971,552 (+)NCBI
Rnor_5.08117,305,748 - 117,324,074 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243703   ⟹   XP_006243765
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,743,322 - 118,761,190 (+)NCBI
mRatBN7.28109,864,862 - 109,882,734 (+)NCBI
Rnor_6.08117,953,764 - 117,971,552 (+)NCBI
Rnor_5.08117,305,748 - 117,324,074 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063264813   ⟹   XP_063120883
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,742,824 - 118,759,479 (+)NCBI
RefSeq Acc Id: NP_598255   ⟸   NM_133571
- UniProtKB: P48965 (UniProtKB/Swiss-Prot),   G3V8T0 (UniProtKB/TrEMBL),   A6I3C9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243764   ⟸   XM_006243702
- Peptide Label: isoform X1
- UniProtKB: P48965 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006243765   ⟸   XM_006243703
- Peptide Label: isoform X2
- UniProtKB: P48965 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028141   ⟸   ENSRNOT00000028141
Ensembl Acc Id: ENSRNOP00000082319   ⟸   ENSRNOT00000116348
RefSeq Acc Id: XP_063120883   ⟸   XM_063264813
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZUR1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000102326   ⟸   ENSRNOT00000131172
Ensembl Acc Id: ENSRNOP00000102479   ⟸   ENSRNOT00000137536
Ensembl Acc Id: ENSRNOP00000101754   ⟸   ENSRNOT00000167389
Protein Domains
Rhodanese

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P48965-F1-model_v2 AlphaFold P48965 1-525 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621498 AgrOrtholog
BioCyc Gene G2FUF-29084 BioCyc
Ensembl Genes ENSRNOG00000020737 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000028141 ENTREZGENE
  ENSRNOT00000116348 ENTREZGENE
  ENSRNOT00000137536 ENTREZGENE
Gene3D-CATH 3.40.250.10 UniProtKB/Swiss-Prot
InterPro MPI_Phosphatase UniProtKB/Swiss-Prot
  Rhodanese-like_dom UniProtKB/Swiss-Prot
  Rhodanese-like_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:171102 UniProtKB/Swiss-Prot
NCBI Gene 171102 ENTREZGENE
PANTHER M-PHASE INDUCER PHOSPHATASE 1 UniProtKB/Swiss-Prot
  M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25 UniProtKB/Swiss-Prot
Pfam M-inducer_phosp UniProtKB/Swiss-Prot
  Rhodanese UniProtKB/Swiss-Prot
PhenoGen Cdc25a PhenoGen
PRINTS MPIPHPHTASE UniProtKB/Swiss-Prot
PROSITE RHODANESE_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020737 RatGTEx
SMART RHOD UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52821 UniProtKB/Swiss-Prot
UniProt A0A8I5ZUR1 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L1T1_RAT UniProtKB/TrEMBL
  A0ABK0LB72_RAT UniProtKB/TrEMBL
  A0ABK0LJM7_RAT UniProtKB/TrEMBL
  A6I3C8_RAT UniProtKB/TrEMBL
  A6I3C9 ENTREZGENE, UniProtKB/TrEMBL
  G3V8T0 ENTREZGENE, UniProtKB/TrEMBL
  MPIP1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-23 Cdc25a  cell division cycle 25A  Cdc25a  cell division cycle 25 homolog A (S. pombe)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-01-29 Bsnd  cell division cycle 25 homolog A (S. pombe)  Cdc25a  cell division cycle 25 homolog A (S. cerevisiae)  Name updated 1299863 APPROVED
2005-01-20 Cdc25a  cell division cycle 25 homolog A (S. cerevisiae)    cell division cycle 25A  Name updated 1299863 APPROVED
2002-08-07 Cdc25a  cell division cycle 25A      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process immunodepletion inhibits cell cycle progression from G1 into the S phase 724653