Il24 (interleukin 24) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Il24 (interleukin 24) Rattus norvegicus
Analyze
Symbol: Il24
Name: interleukin 24
RGD ID: 621484
Description: Predicted to enable cytokine activity. Involved in several processes, including cellular response to interleukin-4; cellular response to lipopolysaccharide; and negative regulation of cell migration. Located in extracellular space. Biomarker of periodontal disease. Orthologous to human IL24 (interleukin 24); PARTICIPATES IN interleukin-23 signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 2-methoxyethanol; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cytokine-like protein Mob-5; If2e; IL-24; interferon 2e; interleukin-24; Mda-7; Mda7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81344,905,362 - 44,910,760 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1344,905,363 - 44,910,760 (-)EnsemblGRCr8
mRatBN7.21342,353,089 - 42,358,487 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1342,353,090 - 42,358,487 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1344,959,629 - 44,965,001 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01346,247,762 - 46,253,134 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01343,502,896 - 43,508,291 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01347,618,451 - 47,623,849 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1347,618,452 - 47,623,849 (-)Ensemblrn6Rnor6.0
Rnor_5.01352,707,115 - 52,712,513 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41343,831,510 - 43,836,908 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1342,702,558 - 42,707,956 (-)NCBICelera
RGSC_v3.11343,845,553 - 43,850,951 (-)NCBI
Cytogenetic Map13q13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-phenyl-1-cyclopentanecarboxylic acid 2-[2-(diethylamino)ethoxy]ethyl ester  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxyethanol  (EXP)
3',4'-dimethoxyflavone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-phenylprop-2-enal  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-aminosalicylic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitroquinoline N-oxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
9-cis-retinoic acid  (ISO)
acetylsalicylic acid  (ISO)
acyclovir  (ISO)
alatrofloxacin  (ISO)
albuterol  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
alpidem  (ISO)
amikacin  (ISO)
ammonium chloride  (EXP)
aripiprazole  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzalkonium chloride  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
biperiden  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP)
bongkrekic acid  (ISO)
Brevetoxin B  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chromium(6+)  (ISO)
clavulanic acid  (ISO)
copper(II) chloride  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
didanosine  (ISO)
Didecyldimethylammonium  (ISO)
dihydroergotamine  (ISO)
dimethylarsinic acid  (ISO)
dimethylarsinous acid  (ISO)
diphenhydramine  (ISO)
doxorubicin  (ISO)
Doxylamine succinate  (ISO)
esmolol  (ISO)
ethanol  (ISO)
etodolac  (ISO)
flutamide  (ISO)
formaldehyde  (ISO)
fucoxanthin  (ISO)
fulvestrant  (ISO)
furan  (EXP)
geldanamycin  (ISO)
gentamycin  (EXP)
glucose  (ISO)
hydroxyzine  (ISO)
Iproniazid  (ISO)
iron(III) nitrilotriacetate  (EXP)
isobutanol  (ISO)
isoniazide  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
ketoconazole  (ISO)
ketorolac tromethamine  (ISO)
lead diacetate  (ISO)
levofloxacin  (ISO)
lipopolysaccharide  (ISO)
lovastatin  (ISO)
lucanthone  (ISO)
lumiracoxib  (ISO)
malathion  (ISO)
mebendazole  (ISO)
medroxyprogesterone acetate  (ISO)
methoxychlor  (EXP)
methylisothiazolinone  (ISO)
methylparaben  (ISO)
metronidazole  (ISO)
minoxidil  (ISO)
N-acetyl-L-cysteine  (ISO)
nefazodone  (ISO)
nevirapine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nimesulide  (ISO)
nomifensine  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
oxybutynin  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paliperidone palmitate  (ISO)
paracetamol  (EXP)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
penbutolol  (ISO)
pentanal  (ISO)
pentane-2,3-dione  (EXP)
perfluorobutyric acid  (ISO)
perfluorooctanoic acid  (ISO)
Phenoxybenzamine  (ISO)
phentolamine  (ISO)
phenylarsine oxide  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pioglitazone  (ISO)
pirprofen  (ISO)
PK-11195  (ISO)
potassium bromate  (EXP)
primaquine  (ISO)
primidone  (ISO)
Primycin  (ISO)
procyclidine  (ISO)
progesterone  (ISO)
protriptyline  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
Rutecarpine  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sodium hypochlorite  (ISO)
sulindac  (ISO)
sulindac sulfone  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
terazosin  (ISO)
thiram  (ISO)
Tiron  (ISO)
titanium dioxide  (EXP,ISO)
tolcapone  (ISO)
toluene 2,4-diisocyanate  (ISO)
trazodone  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
Trihexyphenidyl  (ISO)
triprolidine  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
zafirlukast  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)
zolpidem  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular region  (IEA,ISO)
extracellular space  (IBA,IDA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. New microbicidal functions of tracheal glands: defective anti-infectious response to Pseudomonas aeruginosa in cystic fibrosis. Bastonero S, etal., PLoS One. 2009;4(4):e5357. Epub 2009 Apr 28.
2. IL-24 is expressed by rat and human macrophages. Garn H, etal., Immunobiology. 2002 Jul;205(3):321-34.
3. Adaptive immune response in osteoclastic bone resorption induced by orally administered Aggregatibacter actinomycetemcomitans in a rat model of periodontal disease. Li Y, etal., Mol Oral Microbiol. 2010 Aug;25(4):275-92.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Interleukin 24 is induced by the RET/PTC3 oncoprotein and is an autocrine growth factor for epithelial cells. Shinohara S and Rothstein JL, Oncogene. 2004 Sep 30;23(45):7571-9.
12. Cutaneous rat wounds express c49a, a novel gene with homology to the human melanoma differentiation associated gene, mda-7. Soo C, etal., J Cell Biochem 1999 Jul 1;74(1):1-10.
13. Interleukin-24 induces expression of beta4 integrin but suppresses anchorage-independent growth of rat mammary tumor cells by a mechanism that is independent of beta4. Xuan W, etal., Mol Cancer Res. 2009 Mar;7(3):433-42. Epub 2009 Mar 3.
14. Identification of a novel ligand-receptor pair constitutively activated by ras oncogenes. Zhang R, etal., J Biol Chem 2000 Aug 11;275(32):24436-43.
Additional References at PubMed
PMID:11342597   PMID:18708357   PMID:23869901   PMID:28253513   PMID:33683657  


Genomics

Comparative Map Data
Il24
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81344,905,362 - 44,910,760 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1344,905,363 - 44,910,760 (-)EnsemblGRCr8
mRatBN7.21342,353,089 - 42,358,487 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1342,353,090 - 42,358,487 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1344,959,629 - 44,965,001 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01346,247,762 - 46,253,134 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01343,502,896 - 43,508,291 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01347,618,451 - 47,623,849 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1347,618,452 - 47,623,849 (-)Ensemblrn6Rnor6.0
Rnor_5.01352,707,115 - 52,712,513 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41343,831,510 - 43,836,908 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1342,702,558 - 42,707,956 (-)NCBICelera
RGSC_v3.11343,845,553 - 43,850,951 (-)NCBI
Cytogenetic Map13q13NCBI
IL24
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381206,897,443 - 206,904,139 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1206,897,443 - 206,904,139 (+)Ensemblhg38GRCh38
GRCh371207,070,788 - 207,077,484 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361205,137,412 - 205,144,107 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1180,322,323 - 180,329,018 (+)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1177,769,060 - 177,775,758 (+)NCBIHuRef
CHM1_11208,343,358 - 208,350,049 (+)NCBICHM1_1
T2T-CHM13v2.01206,160,421 - 206,168,444 (+)NCBIT2T-CHM13v2.0
Il24
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391130,809,801 - 130,815,153 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1130,809,811 - 130,815,191 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381130,882,074 - 130,887,411 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1130,882,074 - 130,887,454 (-)Ensemblmm10GRCm38
MGSCv371132,778,651 - 132,783,988 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361132,709,620 - 132,713,542 (-)NCBIMGSCv36mm8
Celera1133,505,154 - 133,510,492 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map156.89NCBI
Il24
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540642,432,795 - 42,437,016 (+)Ensembl
ChiLan1.0NW_00495540642,431,845 - 42,437,392 (+)NCBIChiLan1.0ChiLan1.0
IL24
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2142,471,582 - 42,476,937 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1142,436,439 - 42,443,132 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01182,500,680 - 182,507,098 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11186,779,207 - 186,785,928 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1186,779,207 - 186,785,928 (+)EnsemblpanPan2panpan1.1
IL24
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.176,043,249 - 6,047,097 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl76,041,625 - 6,047,097 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha75,604,056 - 5,611,189 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.075,729,222 - 5,736,484 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl75,730,965 - 5,736,902 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.175,663,760 - 5,670,885 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.075,768,112 - 5,771,954 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.075,804,402 - 5,811,774 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Il24
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934468,479,166 - 68,486,831 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365575,719,592 - 5,727,113 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365575,719,592 - 5,727,113 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL24
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl967,525,557 - 67,530,738 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1967,525,246 - 67,532,407 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2974,001,424 - 74,009,553 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL24
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12522,453,579 - 22,460,361 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2522,454,382 - 22,459,757 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605523,124,189 - 23,131,659 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il24
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248074,581,731 - 4,585,010 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248074,581,805 - 4,586,808 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Il24
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1104,918,568 - 4,924,083 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Il24
13 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:39
Interacting mature miRNAs:40
Transcripts:ENSRNOT00000006106
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)131186625456866254Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132485392569853925Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133996821183286298Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131244842147969993Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131238432057384320Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131746828262468282Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131238432057384320Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13600200847359539Rat
2303032Bp328Blood pressure QTL 328arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134373632747969993Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)132433543255601132Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133708798382087983Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131244842148744906Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132624480871244808Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133379409678794096Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133483494779834947Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133379409660914504Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)13308875548088755Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132624480871244808Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)133828629883286298Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131771133662711336Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)131186625456866254Rat

Markers in Region
D13Rat21  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21342,356,636 - 42,356,786 (+)MAPPERmRatBN7.2
Rnor_6.01347,621,999 - 47,622,148NCBIRnor6.0
Rnor_5.01352,710,663 - 52,710,812UniSTSRnor5.0
RGSC_v3.41343,835,058 - 43,835,207UniSTSRGSC3.4
RGSC_v3.41343,835,057 - 43,835,207RGDRGSC3.4
Celera1342,706,106 - 42,706,255UniSTS
RGSC_v3.11343,849,101 - 43,849,250RGD
RH 3.4 Map13112.4UniSTS
RH 3.4 Map13112.4RGD
RH 2.0 Map13306.3RGD
SHRSP x BN Map1310.2499RGD
Cytogenetic Map13q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
7 11 15 58 38 42 13 89 13 3 207 128 8 35 51 59 29 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000006106   ⟹   ENSRNOP00000006106
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1344,905,363 - 44,910,760 (-)Ensembl
mRatBN7.2 Ensembl1342,353,090 - 42,358,487 (-)Ensembl
Rnor_6.0 Ensembl1347,618,452 - 47,623,849 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095701   ⟹   ENSRNOP00000097653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1344,905,363 - 44,908,867 (-)Ensembl
mRatBN7.2 Ensembl1342,353,090 - 42,356,594 (-)Ensembl
RefSeq Acc Id: NM_133311   ⟹   NP_579845
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,905,362 - 44,910,760 (-)NCBI
mRatBN7.21342,353,089 - 42,358,487 (-)NCBI
Rnor_6.01347,618,451 - 47,623,849 (-)NCBI
Rnor_5.01352,707,115 - 52,712,513 (-)NCBI
RGSC_v3.41343,831,510 - 43,836,908 (-)RGD
Celera1342,702,558 - 42,707,956 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_579845 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB69171 (Get FASTA)   NCBI Sequence Viewer  
  AAF75553 (Get FASTA)   NCBI Sequence Viewer  
  CAB0000205 (Get FASTA)   NCBI Sequence Viewer  
  EDM09839 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006106
  ENSRNOP00000006106.2
GenBank Protein Q9JI24 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_579845   ⟸   NM_133311
- Peptide Label: precursor
- UniProtKB: Q9JI24 (UniProtKB/Swiss-Prot),   A6IC08 (UniProtKB/TrEMBL),   A0A7R8C3K9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006106   ⟸   ENSRNOT00000006106
Ensembl Acc Id: ENSRNOP00000097653   ⟸   ENSRNOT00000095701

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JI24-F1-model_v2 AlphaFold Q9JI24 1-183 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621484 AgrOrtholog
BioCyc Gene G2FUF-18363 BioCyc
Ensembl Genes ENSRNOG00000004470 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006106 ENTREZGENE
  ENSRNOT00000006106.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot
  IL-10/19/20/24/26 UniProtKB/Swiss-Prot
  IL-10_CS UniProtKB/Swiss-Prot
  IL-24 UniProtKB/Swiss-Prot
KEGG Report rno:170819 UniProtKB/Swiss-Prot
NCBI Gene 170819 ENTREZGENE
PANTHER INTERLEUKIN-19-RELATED UniProtKB/Swiss-Prot
  INTERLEUKIN-24 UniProtKB/Swiss-Prot
PhenoGen Il24 PhenoGen
PRINTS INTRLEUKIN24 UniProtKB/Swiss-Prot
PROSITE INTERLEUKIN_10 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004470 RatGTEx
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot
UniProt A0A7R8C3K9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GM58_RAT UniProtKB/TrEMBL
  A6IC08 ENTREZGENE, UniProtKB/TrEMBL
  IL24_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Il24  interleukin 24      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Il24  interleukin 24      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the fibroblast-like cells at the wound edge and base 633079
gene_homology 78% homologous to the human MDA-7 633079
gene_regulation expression upregulated during the inflammatory and early granulation tissue phases of wound repair 633079