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Gene: Frk (fyn-related Src family tyrosine kinase) Rattus norvegicus

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Symbol:

Frk

Name:

fyn-related Src family tyrosine kinase

RGD ID:

621423

Description:

Enables protein tyrosine kinase activity. Involved in cell differentiation. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human FRK (fyn related Src family tyrosine kinase); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

fyn-related kinase; GASK; gastrointestinal-associated kinase; gastrointestinal-associated tyrosine kinase; GTK; src related tyrosine kinase; tyrosine-protein kinase FRK

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FRK (fyn related Src family tyrosine kinase)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB
Mus musculus (house mouse):	Frk (fyn-related kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Frk (fyn related Src family tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	FRK (fyn related Src family tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FRK (fyn related Src family tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Frk (fyn related Src family tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FRK (fyn related Src family tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	FRK (fyn related Src family tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Frk (fyn related Src family tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Frk (fyn related Src family tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	MRS2 (magnesium transporter MRS2)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	FRK (fyn related Src family tyrosine kinase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Frk (fyn-related kinase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	frk (fyn-related Src family tyrosine kinase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Src42A	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Src42A	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	src-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	src-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	frk	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	39,820,441 - 39,926,065 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	20	39,820,295 - 39,926,362 (+)	Ensembl				GRCr8
mRatBN7.2	20	38,265,416 - 38,371,038 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	38,265,280 - 38,371,114 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	20	39,982,683 - 40,087,947 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	39,641,813 - 39,747,077 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	40,361,387 - 40,454,796 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	41,266,408 - 41,383,731 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	41,266,566 - 41,383,424 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	20	42,996,389 - 43,115,825 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	20	38,882,048 - 38,909,179 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	20	39,046,328 - 39,149,411 (+)	NCBI		Celera
RGSC_v3.1	20	38,905,058 - 38,932,186 (+)	NCBI
Cytogenetic Map	20	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

glucose intolerance (ISO)

Goldenhar syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

3-chloropropane-1,2-diol (EXP)

3H-1,2-dithiole-3-thione (EXP)

acetamide (EXP)

afimoxifene (ISO)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (EXP,ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

bisphenol F (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

CGP 52608 (ISO)

chloroprene (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

cycloheximide (ISO)

cyclosporin A (ISO)

D-glucose (ISO)

diarsenic trioxide (ISO)

diethyl phthalate (EXP)

doxorubicin (ISO)

flutamide (EXP)

genistein (EXP)

glucose (ISO)

glycidyl methacrylate (ISO)

graphite (EXP)

irinotecan (EXP)

lead diacetate (EXP)

leflunomide (ISO)

N-acetyl-1,4-benzoquinone imine (ISO)

N-nitrosodiethylamine (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

ponatinib (ISO)

potassium dichromate (ISO)

quercetin (ISO)

quinolin-8-ol (ISO)

resorcinol (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

triphenyl phosphate (EXP)

troglitazone (ISO)

urethane (ISO)

valproic acid (ISO)

vancomycin (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell differentiation (IBA,IEP)

cell surface receptor protein tyrosine kinase signaling pathway (IBA)

negative regulation of transcription by RNA polymerase II (IEA,ISO)

Cellular Component

cytoplasm (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IEA)

plasma membrane (IBA)

Molecular Function

ATP binding (IEA)

kinase activity (IEA)

non-membrane spanning protein tyrosine kinase activity (IBA,IEA)

nucleotide binding (IEA)

protein binding (ISO)

protein kinase activity (IEA)

protein tyrosine kinase activity (IDA,IEA,ISO)

signaling receptor binding (IBA)

transferase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	A newly identified tyrosine kinase is preferentially expressed in the gastrointestinal tract.	Sunitha I and Avigan MI, Biochim Biophys Acta 1994 Apr 28;1221(3):348-52.
8.	The apical membranes of maturing gut columnar epithelial cells contain the enzymatically active form of a newly identified fyn-related tyrosine kinase.	Sunitha I and Avigan MI, Oncogene 1996 Aug 1;13(3):547-59.

Additional References at PubMed

PMID:12725532	PMID:12837246	PMID:17959796	PMID:19056867	PMID:19345329	PMID:23376485	PMID:23533145

Genomics

Comparative Map Data

Frk
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	39,820,441 - 39,926,065 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	20	39,820,295 - 39,926,362 (+)	Ensembl				GRCr8
mRatBN7.2	20	38,265,416 - 38,371,038 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	38,265,280 - 38,371,114 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	20	39,982,683 - 40,087,947 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	39,641,813 - 39,747,077 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	40,361,387 - 40,454,796 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	41,266,408 - 41,383,731 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	41,266,566 - 41,383,424 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	20	42,996,389 - 43,115,825 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	20	38,882,048 - 38,909,179 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	20	39,046,328 - 39,149,411 (+)	NCBI		Celera
RGSC_v3.1	20	38,905,058 - 38,932,186 (+)	NCBI
Cytogenetic Map	20	q12	NCBI

FRK
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	115,931,149 - 116,100,725 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	115,931,149 - 116,061,093 (-)	Ensembl			hg38	GRCh38
GRCh37	6	116,252,312 - 116,382,054 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	116,369,386 - 116,488,614 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	6	116,369,386 - 116,488,614	NCBI
Celera	6	117,005,260 - 117,124,941 (-)	NCBI		Celera
Cytogenetic Map	6	q22.1	NCBI
HuRef	6	113,842,168 - 113,962,110 (-)	NCBI		HuRef
CHM1_1	6	116,525,566 - 116,645,735 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	117,114,676 - 117,284,719 (-)	NCBI		T2T-CHM13v2.0

Frk
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	34,359,396 - 34,487,530 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	34,359,395 - 34,487,274 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	10	34,483,400 - 34,611,232 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	34,483,399 - 34,611,278 (+)	Ensembl			mm10	GRCm38
MGSCv37	10	34,203,206 - 34,331,038 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	10	34,172,815 - 34,299,745 (+)	NCBI		MGSCv36	mm8
Celera	10	35,388,501 - 35,517,021 (+)	NCBI		Celera
Cytogenetic Map	10	B1	NCBI
cM Map	10	18.85	NCBI

Frk
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955526	736,116 - 895,170 (+)	Ensembl
ChiLan1.0	NW_004955526	736,446 - 892,331 (+)	NCBI	ChiLan1.0	ChiLan1.0

FRK
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	135,942,035 - 136,069,526 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	133,834,844 - 133,962,488 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	113,748,464 - 113,903,350 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	117,894,974 - 118,049,161 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	117,894,974 - 118,009,497 (-)	Ensembl			panPan2	panpan1.1

FRK
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	71,659,397 - 71,756,213 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	71,660,978 - 71,756,705 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	71,420,739 - 71,517,543 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	72,542,156 - 72,639,028 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	72,543,526 - 72,639,435 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	71,894,237 - 71,990,956 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	71,736,303 - 71,832,807 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	72,125,285 - 72,221,594 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Frk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	106,846,026 - 106,953,104 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936824	575,642 - 678,129 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936824	575,618 - 677,775 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FRK
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	81,605,700 - 81,714,250 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	81,606,599 - 81,714,543 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	91,721,749 - 91,829,785 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FRK
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	57,749,406 - 57,874,948 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	13	57,755,840 - 57,875,024 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666040	30,038,022 - 30,192,716 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Frk
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624856	2,489,898 - 2,575,101 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624856	2,485,044 - 2,580,784 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Frk
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	18	35,859,903 - 35,956,920 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Frk
895 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	597
Count of miRNA genes:	266
Interacting mature miRNAs:	337
Transcripts:	ENSRNOT00000000653
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4889610	Pancm3	Pancreatic morphology QTL 3	3.75	0.001	pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	20	4189476	49189476	Rat
2303587	Bw93	Body weight QTL 93	13		body mass (VT:0001259)	body weight (CMO:0000012)	20	26689362	56021148	Rat
1598858	Cm61	Cardiac mass QTL 61	3.6		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	20	8216359	53216359	Rat
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1533083	46533083	Rat
1331747	Hrtrt16	Heart rate QTL 16	3.163		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	20	26792353	56021148	Rat
1598816	Memor12	Memory QTL 12	2.4		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	20	12243242	49189476	Rat
2303626	Vencon10	Ventilatory control QTL 10		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	20	20745585	56021148	Rat
2303578	Gluco50	Glucose level QTL 50	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	20	26689362	56021148	Rat
1598869	Memor6	Memory QTL 6	3.1		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	20	26689362	56021148	Rat
1598870	Bp289	Blood pressure QTL 289	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	20	8216359	53216359	Rat
2300188	Bmd68	Bone mineral density QTL 68	6.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	20	26689362	56021148	Rat
70158	Bp60	Blood pressure QTL 60	3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	20	32156967	45978663	Rat

Markers in Region

RH131763

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	38,371,046 - 38,371,202 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	41,383,443 - 41,383,598	NCBI	Rnor6.0
Rnor_5.0	20	43,115,537 - 43,115,692	UniSTS	Rnor5.0
RGSC_v3.4	20	38,909,188 - 38,909,343	UniSTS	RGSC3.4
Celera	20	39,149,420 - 39,149,575	UniSTS
RH 3.4 Map	20	411.3	UniSTS
Cytogenetic Map	20	q12	UniSTS

RH132991

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	38,265,670 - 38,265,889 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	41,266,821 - 41,267,039	NCBI	Rnor6.0
Rnor_5.0	20	42,996,758 - 42,996,976	UniSTS	Rnor5.0
Celera	20	39,046,583 - 39,046,801	UniSTS
RH 3.4 Map	20	404.42	UniSTS
Cytogenetic Map	20	q12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	158	91	90	59	41	59	6	305	141	11	137	81	92	31	15	15

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_024368	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006256517	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474051	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U09583	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000000653 ⟹ ENSRNOP00000000653

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	20	39,820,295 - 39,926,362 (+)	Ensembl
mRatBN7.2 Ensembl	20	38,265,280 - 38,371,114 (+)	Ensembl
Rnor_6.0 Ensembl	20	41,266,566 - 41,383,424 (+)	Ensembl

RefSeq Acc Id:

NM_024368 ⟹ NP_077344

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	39,820,441 - 39,926,065 (+)	NCBI
mRatBN7.2	20	38,265,416 - 38,371,038 (+)	NCBI
Rnor_6.0	20	41,266,566 - 41,383,434 (+)	NCBI
Rnor_5.0	20	42,996,389 - 43,115,825 (+)	NCBI
RGSC_v3.4	20	38,882,048 - 38,909,179 (+)	RGD
Celera	20	39,046,328 - 39,149,411 (+)	RGD

Sequence:

show sequence

GGCACGAGCAGCTGCAGGTTTGAAGCTGGGTGAGAGCAGCTGCAGCAGGCCAGGCTGGGACGTT
TCGCCTGGAGTTAGTCTCTCCGTAACTTTTTCCTGGGACAGAGGGAGAGGTGGCTGTTCTTTGT
TCTCAGATGTCCCTCTAAATAAAACCTTTTTTATTTTATTTATTGTTGGGTGCCCAGGCAGTCA
GGAAGAAGCACTTTCCCACTGGACCTCCTTCTCAGTCCCCCTCTTGATTTTGCCCCAGGGCAGC
AGCTACAAACAGAAAGCCAGCTGTGAGTGTCTTCTTGCCAAGCCCAGATCTGCGAGAGATCCGA
AGCAGGACTTTATAGCTCTTCTCAGTATGGTGAGTTGTAGCTGATTTGGAAGCTGGTGGAGGAG
GACAGTGGCTCTGTACAGCTTGTGGGGATCTCCCCTGCTACTACCACCAGCCGGAACACCATGG
GCAGCGTCTGTATGAGGCTTTGGGCATACCTTCAGCCTTTTCTCCCCTGCTGGTCCCAAGAAGC
AGACAAATCAGTGGTGATTGAGAATCCAGGGGCCTACTGTCCTCCAGAGGCCAATCGAAGCCAA
GGCCAGTATTTTGTGGCTCTGTTTGATTACGAAGCTCGTACTGCAGAGGACCTGAGCTTCCATG
CCGGCGACAAGCTCCAAGTCTTGGACACTTCTCATGAGGGCTGGTGGTTGGCCAGACATTTGGA
AAAGAAGGGACCCGGCTTAGGTCAGCAGCTGCAGGGCTACATTCCTTCCAATTACGTGGCAGAG
GACCGGAGTCTCCAGGCAGAACCGTGGTTTTTCGGAGCAATCAAAAGAGCAGATGCAGAAAAGC
AACTTCTGTATTCAGAAAACCAGACGGGCGCCTTTCTAATCAGAGAGAGTGAGAGCCAGAAGGG
TGACTTCTCCCTCTCAGTTTTAGATGAAGGTGTTGTGAAACACTACAGGATAAGAAGGTTGGAT
GAAGGTGGCTTCTTCCTCACCAGGAGAAAAACTTTTTCAACCTTGAATGAATTTGTGAACTACT
ACACCACAACAAGTGATGGGCTGTGTGTCAAGCTGGAGAAGCCATGCTTAAAGATTCAGGTACC
GACCCCTTTTGATTTGTCATATAAAACTGTGGACCAGTGGGAGATAGACCGCAACTCCATACAG
CTTCTCAAGCGACTGGGATCTGGTCAGTTTGGAGAAGTTTGGGAAGGTCTGTGGAATAATACCA
CTCCAGTGGCTGTGAAAACGTTAAAACCAGGTTCAATGGATCCAAATGACTTCCTCAGGGAGGC
ACAGATAATGAAGAGCCTAAGACACCCCAAGCTCATCCAGCTCTATGCTGTTTGCACATTAGAA
GATCCAATTTATATTATTACAGAATTGATGAGACATGGAAGTCTGCAAGAATATCTCCAAAATG
ATGGTGGGTCGAAAATCCGTTTGACTCAACAGGTGGACATGGCTGCACAGGTAGCTTCTGGAAT
GGCCTATTTGGAGTCCCAGAACTATATCCACAGAGATCTGGCTGCAAGAAATGTCCTTGTTGGT
GAACATAATATCTATAAAGTAGCAGATTTTGGACTTGCAAGAGTTTTTAAGGTGGATAATGAAG
ACATCTATGAATCTAAACACGAAATAAAGCTGCCAGTGAAGTGGACTGCACCCGAAGCCATTCG
TACTAATAAATTCAGCATTAAGTCTGATGTGTGGTCTTTTGGAATCCTGCTCTATGAAATCATT
ACTTATGGCAAAATGCCTTACAGCGGGATGACAGGTGCTCAAGTAATTCATATGTTGGGTCAAA
ACTACAGACTACCACAGCCATCTAACTGTCCAGAGCAATTCTATAGCATCATGATGGAATGCTG
GAATGTAGAGCCCAAGCAACGACCAACGTTCGAGACCCTGCACTGGAAACTTGAAGACTACTTT
GAACCAGACTCTTCCTATTCTGATACAAACAACTTCATAAACTAAACAACAAGGAAAAAGAAGA
AATATAATTAAGATGTGAAAACGCGGAACTCACCAGTCCAGAAATATCGTCTTCTCAACCAACT
GTGAAATCAGCTTATTTTGACATATTCAGGTGGTAGGATGAACTCAACCATGCATTCTGTATCA
AAAAGATCATCTGTGTATTCTATTGAGTAGGAAACGCTGCAGGACAGTATAAGATGATGTGTCA
TTTTTCCCTCACTGCCTGGTAAAATCAATCACACTAAATGAAGTTATTTTTCTTCCTTTTAAGA
ACTCCTCACATTTCTATTTATTGTTTGAAATGCCGATCAAGAGAATCAACAGATGACGGTGTTT
ACTCTGTTACTGTTGTGGGCATTTTCCTGTTTACTGATTAGACTGGTTATTCATTATTCCTCAA
ATTGCTGAATCCCATCAGGCTGTTATTATGAAGGAATTTGATTGCTTTGCTGCACAGCAGGACC
TGTGCTTTGAGATATTTTTTTCCCTCTCTTTTAAAATATCTTGTAACTACAATGATGGCAAAGC
ATGCTAAATGACTCGATTGTACTTGAAGTAATTGCACGTATTTTTCCTGTGCATAAGAAAGCGC
AAGGCTGTTGAGAAAAAGAATTAAAATCTTCCTCATTTTGTAGGAGGAAATGATGGAGTTTGCT
CTATACCTCAGTATGTGTCATCAGAGAATCATCTGCATTAGTTTTAATCTCTTAATGTCAGGAA
TCAGATTGCAAAGCCGAGTAATTGTTATGTGTGGGAATATAAGGGAACTACCACACTGCCTACC
AGGTCTGAGAAATAGATATTAAAGTGGCTTAGGGAAGCTAACAGAGAGCTGGAGGATTGCTGCA
GCTTTCTAAGTAATAATAAAAAGTTCCTTTGGCACACTGGCCGATTTTAAATTGGCTGCAAGAC
AGGCCAAGCCATGCTTCAGCTCTTGAGGCTAGGAATAATGTCTAAACATGGTTATGAAATGTAG
CTTTCGTCTGTTAAGACTGGATGCTTTTAGTCTCTTCATTTTTTTCCTCACCTTGGTAAGAACT
TCCCTGTTTTCTTAGGCAATGAGTGTATCGAATGTTCTGCCTCATTGGATAGTTAGCAATACTT
CTCTAAAGTCAGCTCCATATATTCCATGATCTTCTAATGTGCAGTGCTGAATGAATGTTCCAAA
AGGAACATTCATCCTCCTATAGGACAGAAGAGAATATCTAGATGGTCACAAGGATCCCCTGGGA
ATTGAAAAACATGTCAGTTCTTTCAACTAGGAACTAGGAGGCAAGGCATCAGGGATTAACTTTT
ACCAGTTCAGTGATGTCAGGACCCTAGCTGCATTTCTGTTGCCATGGTGAAAATCCTGACAAAA
AGCAACTTAGAAGAGGCAAGGTTTATTTTAGCTTACAATCCCATGTCATTGTATCACAGCAGGA
AGTCACTGTGACAAGATCTTGAAGCTGATTACACCACATCCACATTCTAAGAGGAGAGAGACAT
TCACGGATAGCTTGCTTCCTGATTTGTGCTCAGGTCAATTTCTACACTCTTAAAAAGTTTGGGA
CAGCTTTGCCTAGGTAATAGCATGACACACAATAGGCTGGACTTTCCAGGATCAATTAACGTAA
TTAAGACAATCTCTACAGACATGTCCAAAAGGCCAGTATAATATAGAGAATCATTTTCAACTCT
TTGCAACTCTCTTTCTGGGTTATTCTAGGTACTGACAAATTGGATCACTTAAGCTAGCCATTAG
ACCACTAAGACTCAAACTTTCCCATCTATAGCAAGCATTGTCTGTGTTCAACTGGTCACAGGTA
ACCACCAGTGGTAAGTGAGGCTCCTTGTTACCTTTATATTCAAGAAGATAAAATGGGCAACTTA
ACCCCTTAGACCATTATCCTAAGCCTAAACACACACACGCACGCACGCACGCACGCACGCACAC
ACACACGCACACGTGCATGCACACACACTCACCTCATTCCCATTTTGGGGGATAAGCAGGTGGC
AAACACAATCCCGTGACCAGTGAACAACAATCAGCACAGTGAATGTAAATGCAAAGTGTTGATT
GGCTTGGAAGAAAGTCTGCACTGAAGCTGCGAATATAAACTTCTCCAAGACAAGTTTCTTATTT
GAAAAAAAAAATTGAGAGATTGATTCCTGAGTTGGTGTCCAATCACAGAACTATTAAAGATGAA
TTAACTGTTGGAATTAATCTATGTACATGTAAGCATTCATTTATCATCTCAAACATGTCTGAAC
TGACTTGAATCTGAATCATGTGTGAAGACCACAGAGAAGGAAAAGCATTTGTAAGATAAAGTCG
CCATTAATATTTTAATCAGTTGACAGAGCATGGGGTAGCTTCCGTTGTTTATTTCAGATTGCCT
GGTCAAATGTAACCAAGGAGAAGACATTCAACAACTAGGTGGCTAAAATGAAATTTTTAAAAAA
GGACTCGCTTTTCCTGAGTTCATTTCTTCAGGACAGATTCTACTTGGGGCGTATGTATAAAGGA
GGAGCACTAGTCTCATTTCATTGTACAAATTCAAATGCTTTGCACTTTTATGTGGTAGCTGATA
ATAATAAATTTGTAGTAAGTTCTGGCTTTGAAATATAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_077344	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC52725	(Get FASTA)	NCBI Sequence Viewer
	EDL87787	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000000653
GenBank Protein	Q62662	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_077344 ⟸ NM_024368

- UniProtKB:

Q62662 (UniProtKB/Swiss-Prot), A6KID2 (UniProtKB/TrEMBL), A0A8L2PZJ9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGSVCMRLWAYLQPFLPCWSQEADKSVVIENPGAYCPPEANRSQGQYFVALFDYEARTAEDLSF
HAGDKLQVLDTSHEGWWLARHLEKKGPGLGQQLQGYIPSNYVAEDRSLQAEPWFFGAIKRADAE
KQLLYSENQTGAFLIRESESQKGDFSLSVLDEGVVKHYRIRRLDEGGFFLTRRKTFSTLNEFVN
YYTTTSDGLCVKLEKPCLKIQVPTPFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNN
TTPVAVKTLKPGSMDPNDFLREAQIMKSLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQ
NDGGSKIRLTQQVDMAAQVASGMAYLESQNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDN
EDIYESKHEIKLPVKWTAPEAIRTNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIHMLG
QNYRLPQPSNCPEQFYSIMMECWNVEPKQRPTFETLHWKLEDYFEPDSSYSDTNNFIN

hide sequence

Ensembl Acc Id:

ENSRNOP00000000653 ⟸ ENSRNOT00000000653

Protein Domains

Protein kinase SH2 SH3

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q62662-F1-model_v2	AlphaFold	Q62662	1-506	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701643

Promoter ID:

EPDNEW_R12166

Type:

initiation region

Name:

Frk_1

Description:

fyn-related Src family tyrosine kinase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	20	41,266,567 - 41,266,627	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621423	AgrOrtholog
BioCyc Gene	G2FUF-3545	BioCyc
Ensembl Genes	ENSRNOG00000000543	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000000653	ENTREZGENE
Gene3D-CATH	3.30.505.10	UniProtKB/Swiss-Prot
	Phosphorylase Kinase, domain 1	UniProtKB/Swiss-Prot
	SH3 Domains	UniProtKB/Swiss-Prot
	Transferase(Phosphotransferase) domain 1	UniProtKB/Swiss-Prot
InterPro	Kinase-like_dom_sf	UniProtKB/Swiss-Prot
	Non-receptor_tyrosine_kinases	UniProtKB/Swiss-Prot
	Prot_kinase_dom	UniProtKB/Swiss-Prot
	Protein_kinase_ATP_BS	UniProtKB/Swiss-Prot
	Ser-Thr/Tyr_kinase_cat_dom	UniProtKB/Swiss-Prot
	SH2	UniProtKB/Swiss-Prot
	SH2_dom_sf	UniProtKB/Swiss-Prot
	SH2_Frk	UniProtKB/Swiss-Prot
	SH3-like_dom_sf	UniProtKB/Swiss-Prot
	SH3_domain	UniProtKB/Swiss-Prot
	Tyr_kinase_AS	UniProtKB/Swiss-Prot
	Tyr_kinase_cat_dom	UniProtKB/Swiss-Prot
KEGG Report	rno:79209	UniProtKB/Swiss-Prot
NCBI Gene	79209	ENTREZGENE
PANTHER	TYROSINE-PROTEIN KINASE	UniProtKB/Swiss-Prot
Pfam	Pkinase_Tyr	UniProtKB/Swiss-Prot
	SH2	UniProtKB/Swiss-Prot
	SH3_1	UniProtKB/Swiss-Prot
PharmGKB	FRK	RGD
PhenoGen	Frk	PhenoGen
PRINTS	SH2DOMAIN	UniProtKB/Swiss-Prot
	SH3DOMAIN	UniProtKB/Swiss-Prot
	TYRKINASE	UniProtKB/Swiss-Prot
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_TYR	UniProtKB/Swiss-Prot
	SH2	UniProtKB/Swiss-Prot
	SH3	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000000543	RatGTEx
SMART	SH2	UniProtKB/Swiss-Prot
	SH3	UniProtKB/Swiss-Prot
	TyrKc	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF50044	UniProtKB/Swiss-Prot
	SSF55550	UniProtKB/Swiss-Prot
	SSF56112	UniProtKB/Swiss-Prot
UniProt	A0A8L2PZJ9	ENTREZGENE, UniProtKB/TrEMBL
	A6KID2	ENTREZGENE, UniProtKB/TrEMBL
	FRK_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2014-07-09	Frk	fyn-related Src family tyrosine kinase	Frk	fyn-related kinase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Frk	fyn-related kinase		src related tyrosine kinase	Name updated	1299863	APPROVED
2002-08-07	Frk	src related tyrosine kinase			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	enriched in the brush border membranes of epithelial cells	632737
gene_expression	expressed in columnar epithelium of gut	632737
gene_product	member of frk/rak-a fyn related tyrosine kinase family	632737

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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