Slco1a4 (solute carrier organic anion transporter family, member 1a4) - Rat Genome Database

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Gene: Slco1a4 (solute carrier organic anion transporter family, member 1a4) Rattus norvegicus
Analyze
Symbol: Slco1a4 (Ensembl: Slco1a5)
Name: solute carrier organic anion transporter family, member 1a4 (Ensembl:solute carrier organic anion transporter family, member 1A5)
RGD ID: 621389
Description: Enables bile acid transmembrane transporter activity. Involved in cellular response to xenobiotic stimulus; response to estrogen; and sodium-independent organic anion transport. Located in basal plasma membrane. Biomarker of Dubin-Johnson syndrome; cholestasis; and steatotic liver disease. Orthologous to human SLCO1A2 (solute carrier organic anion transporter family member 1A2); PARTICIPATES IN multispecific organic anion transporter mediated transport pathway; bile acid transport pathway; INTERACTS WITH (+)-pilocarpine; 1-benzylpiperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: brain digoxin carrier protein; brain-specific organic anion transporter; OATP-B1; Oatp2; organic anion transporter 2; Slc21a5; Slco1a2; sodium-independent organic anion-transporting polypeptide 2; solute carrier family 21 (organic anion transporter), member 5; solute carrier family 21 member 5; solute carrier organic anion transporter family member 1A4; solute carrier organic anion transporter family, member 1A2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84176,441,104 - 176,495,846 (-)NCBIGRCr8
mRatBN7.24174,710,004 - 174,764,810 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4174,710,004 - 175,254,573 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4181,004,901 - 181,059,637 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04176,789,179 - 176,843,919 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04175,409,707 - 175,464,446 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04175,969,549 - 176,026,227 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4175,969,549 - 176,026,163 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04240,194,947 - 240,251,561 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera4163,247,039 - 163,301,862 (-)NCBICelera
Cytogenetic Map4q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (ISO)
(+)-pilocarpine  (EXP)
1-benzylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
17beta-estradiol 17-glucosiduronic acid  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4,6-trinitrotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-acetamidofluorene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-iodothyronamine  (ISO)
3-methyl-2-oxobutanoic acid  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-methyl-2-oxopentanoic acid  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (EXP)
7-Hydroxymethotrexate  (ISO)
8-(4-chlorophenylthio)-cAMP  (ISO)
8-Epidiosbulbin E acetate  (ISO)
[2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol  (ISO)
acadesine  (EXP)
aconitic acid  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (EXP)
all-trans-retinoic acid  (ISO)
allyl alcohol  (ISO)
amiodarone  (EXP)
amitriptyline  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
atorvastatin calcium  (EXP,ISO)
atrazine  (EXP)
Azoxymethane  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
bromobenzene  (EXP)
bromosulfophthalein  (ISO)
buspirone  (EXP)
cadmium dichloride  (EXP)
calciol  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
chenodeoxycholic acid  (EXP)
chloroquine  (ISO)
cholic acid  (ISO)
choline  (EXP,ISO)
ciguatoxin CTX1B  (ISO)
citric acid  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
clomipramine  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
DDT  (EXP)
deoxycholic acid  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
dichlorine  (EXP)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
difenoconazole  (ISO)
digitonin  (ISO)
digoxin  (EXP,ISO)
dioscin  (EXP)
diosmetin  (ISO)
dorsomorphin  (EXP,ISO)
DPDPE  (EXP,ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
epyrifenacil  (EXP,ISO)
erythromycin estolate  (EXP)
estrone 3-sulfate  (ISO)
ethanol  (EXP,ISO)
finasteride  (EXP)
fipronil  (EXP,ISO)
fluconazole  (ISO)
fulvestrant  (EXP)
furan  (EXP)
fusidic acid  (EXP)
genistein  (ISO)
glafenine  (EXP)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (EXP)
GW 4064  (EXP)
hydroxyurea  (ISO)
icariside II  (ISO)
imidazopyrazole  (ISO)
imipenem hydrate  (ISO)
imipramine  (EXP)
isethionic acid  (ISO)
ketoconazole  (EXP)
L-methionine  (EXP,ISO)
lipopolysaccharide  (EXP)
lithium atom  (EXP)
lithium hydride  (EXP)
lithocholic acid  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
mefloquine  (ISO)
mercury dichloride  (EXP)
metacetamol  (ISO)
metformin  (EXP,ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
Muraglitazar  (EXP)
N-methylnicotinamide  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
naringin  (ISO)
nefazodone  (EXP)
nicotinamide  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
oleanolic acid  (ISO)
omeprazole  (ISO)
ozone  (EXP)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (ISO)
PCB138  (EXP)
perfluorodecanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
procymidone  (EXP)
propiconazole  (EXP,ISO)
pyrazinecarboxamide  (EXP)
pyrimethamine  (ISO)
quercetin  (ISO)
quinine  (EXP,ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rifampicin  (EXP,ISO)
rifamycin SV  (ISO)
rosuvastatin calcium  (EXP,ISO)
saquinavir  (ISO)
SB 431542  (ISO)
senecionine  (EXP)
serpentine asbestos  (ISO)
silicon dioxide  (EXP)
sirolimus  (EXP)
sodium arsenite  (ISO)
Soman  (EXP)
spironolactone  (ISO)
succinic acid  (ISO)
sulindac  (EXP)
taurine  (ISO)
taurocholic acid  (EXP,ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
triadimefon  (EXP,ISO)
trichloroethene  (ISO)
trimethylamine  (ISO)
trimethylamine N-oxide  (ISO)
Triptolide  (ISO)
troglitazone  (EXP)
trospium chloride  (ISO)
trovafloxacin  (EXP)
ursodeoxycholic acid  (EXP,ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
verapamil  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2. Abe T, etal., J Biol Chem 1998 Aug 28;273(35):22395-401.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Characterization of organic anion transporter regulation, glutathione metabolism and bile formation in the obese Zucker rat. Geier A, etal., J Hepatol. 2005 Dec;43(6):1021-30. Epub 2005 Jul 1.
4. Increased hepatic and renal expressions of multidrug resistance-associated protein 3 in Eisai hyperbilirubinuria rats. Kuroda M, etal., J Gastroenterol Hepatol. 2004 Feb;19(2):146-53.
5. Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters. Leuthold S, etal., Am J Physiol Cell Physiol. 2009 Mar;296(3):C570-82. doi: 10.1152/ajpcell.00436.2008. Epub 2009 Jan 7.
6. Role of AMP-activated protein kinase α1 in 17α-ethinylestradiol-induced cholestasis in rats. Li X, etal., Arch Toxicol. 2017 Jan;91(1):481-494. doi: 10.1007/s00204-016-1697-8. Epub 2016 Apr 18.
7. Transport of the sulfated, amidated bile acid, sulfolithocholyltaurine, into rat hepatocytes is mediated by Oatp1 and Oatp2. Meng LJ, etal., Hepatology 2002 May;35(5):1031-40.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain. Noe B, etal., Proc Natl Acad Sci U S A 1997 Sep 16;94(19):10346-50.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation. Roberts LM, etal., Neuroscience. 2008 Aug 13;155(2):423-38. Epub 2008 Jun 13.
Additional References at PubMed
PMID:11279518   PMID:12101011   PMID:17640976   PMID:17845533   PMID:17868302   PMID:17891554   PMID:18500364   PMID:19570321   PMID:21131267   PMID:22015764   PMID:22998451   PMID:26254357  
PMID:27156567   PMID:28084414   PMID:30208928   PMID:30262595   PMID:30977661   PMID:31102415   PMID:31174976   PMID:31746415   PMID:33779805  


Genomics

Comparative Map Data
Slco1a4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84176,441,104 - 176,495,846 (-)NCBIGRCr8
mRatBN7.24174,710,004 - 174,764,810 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4174,710,004 - 175,254,573 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4181,004,901 - 181,059,637 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04176,789,179 - 176,843,919 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04175,409,707 - 175,464,446 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04175,969,549 - 176,026,227 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4175,969,549 - 176,026,163 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04240,194,947 - 240,251,561 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera4163,247,039 - 163,301,862 (-)NCBICelera
Cytogenetic Map4q44NCBI
SLCO1A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381221,264,600 - 21,419,634 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1221,264,600 - 21,419,594 (-)EnsemblGRCh38hg38GRCh38
GRCh371221,417,534 - 21,572,568 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361221,311,651 - 21,439,638 (-)NCBINCBI36Build 36hg18NCBI36
Celera1226,572,933 - 26,703,770 (-)NCBICelera
Cytogenetic Map12p12.1NCBI
HuRef1221,191,506 - 21,322,480 (-)NCBIHuRef
CHM1_11221,383,004 - 21,513,840 (-)NCBICHM1_1
T2T-CHM13v2.01221,143,252 - 21,298,332 (-)NCBIT2T-CHM13v2.0
Slco1a4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396141,751,164 - 141,802,011 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6141,751,166 - 141,801,925 (-)EnsemblGRCm39 Ensembl
GRCm386141,805,438 - 141,856,284 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6141,805,440 - 141,856,199 (-)EnsemblGRCm38mm10GRCm38
MGSCv376141,753,961 - 141,804,692 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366141,767,846 - 141,818,577 (-)NCBIMGSCv36mm8
Celera6144,866,113 - 144,916,846 (-)NCBICelera
Cytogenetic Map6G2NCBI
cM Map672.9NCBI
Slco1a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541316,821,791 - 16,912,903 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541316,821,808 - 16,910,511 (+)NCBIChiLan1.0ChiLan1.0
SLCO1A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21075,401,236 - 75,536,815 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11275,397,631 - 75,533,213 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01264,963,090 - 65,029,673 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11267,566,060 - 67,632,608 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1267,566,066 - 67,632,608 (+)Ensemblpanpan1.1panPan2
SLCO1A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12726,279,654 - 26,398,000 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2726,279,547 - 26,425,818 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2720,058,574 - 20,176,858 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02726,605,157 - 26,724,035 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2726,605,242 - 26,759,510 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12726,468,383 - 26,586,911 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02726,446,981 - 26,565,625 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02719,763,081 - 19,881,755 (-)NCBIUU_Cfam_GSD_1.0
Slco1a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494587,520,070 - 87,639,751 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365485,507,085 - 5,562,624 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLCO1A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl552,049,443 - 52,129,730 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1552,020,303 - 52,133,132 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2555,357,986 - 55,403,096 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLCO1A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11121,125,711 - 21,283,748 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1121,128,062 - 21,283,796 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606913,956,025 - 14,016,125 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slco1a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475217,495,717 - 17,606,838 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475217,496,923 - 17,606,726 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slco1a4
255 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:519
Count of miRNA genes:234
Interacting mature miRNAs:271
Transcripts:ENSRNOT00000043374, ENSRNOT00000046598
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 22 95 73 72 41 22 41 6 170 67 75 45 54 31

Sequence


Ensembl Acc Id: ENSRNOT00000015112   ⟹   ENSRNOP00000015112
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4175,172,907 - 175,206,896 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000043374   ⟹   ENSRNOP00000042595
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4174,710,906 - 174,764,725 (-)Ensembl
Rnor_6.0 Ensembl4175,970,451 - 176,026,133 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000046598   ⟹   ENSRNOP00000040237
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4174,710,004 - 174,749,214 (-)Ensembl
Rnor_6.0 Ensembl4175,969,549 - 176,026,163 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000049569   ⟹   ENSRNOP00000048288
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4175,172,500 - 175,254,573 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110298   ⟹   ENSRNOP00000094123
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4174,710,004 - 175,254,573 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113317   ⟹   ENSRNOP00000090137
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4174,710,004 - 174,748,899 (-)Ensembl
RefSeq Acc Id: NM_131906   ⟹   NP_571981
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84176,441,104 - 176,495,846 (-)NCBI
mRatBN7.24174,710,004 - 174,764,755 (-)NCBI
Rnor_6.04175,969,549 - 176,026,163 (-)NCBI
Rnor_5.04240,194,947 - 240,251,561 (-)NCBI
Celera4163,247,039 - 163,301,862 (-)RGD
Sequence:
RefSeq Acc Id: NP_571981   ⟸   NM_131906
- UniProtKB: O55224 (UniProtKB/Swiss-Prot),   O35913 (UniProtKB/Swiss-Prot),   A6IMP7 (UniProtKB/TrEMBL),   A0A8I6GHY6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000042595   ⟸   ENSRNOT00000043374
Ensembl Acc Id: ENSRNOP00000040237   ⟸   ENSRNOT00000046598
Ensembl Acc Id: ENSRNOP00000015112   ⟸   ENSRNOT00000015112
Ensembl Acc Id: ENSRNOP00000048288   ⟸   ENSRNOT00000049569
Ensembl Acc Id: ENSRNOP00000094123   ⟸   ENSRNOT00000110298
Ensembl Acc Id: ENSRNOP00000090137   ⟸   ENSRNOT00000113317
Protein Domains
Kazal-like   Major facilitator superfamily (MFS) profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35913-F1-model_v2 AlphaFold O35913 1-661 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693481
Promoter ID:EPDNEW_R4004
Type:initiation region
Name:Slco1a4_1
Description:solute carrier organic anion transporter family, member 1a4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04176,026,174 - 176,026,234EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621389 AgrOrtholog
BioCyc Gene G2FUF-42512 BioCyc
Ensembl Genes ENSRNOG00000047493 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055010096 UniProtKB/Swiss-Prot
  ENSRNOG00060008044 UniProtKB/Swiss-Prot
  ENSRNOG00065005585 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015112.7 UniProtKB/TrEMBL
  ENSRNOT00000043374.4 UniProtKB/Swiss-Prot
  ENSRNOT00000046598.7 UniProtKB/TrEMBL
  ENSRNOT00000110298.1 UniProtKB/TrEMBL
  ENSRNOT00000113317.1 UniProtKB/TrEMBL
  ENSRNOT00055017045 UniProtKB/Swiss-Prot
  ENSRNOT00060013325 UniProtKB/Swiss-Prot
  ENSRNOT00065008301 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kazal_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kazal_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:170698 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 170698 ENTREZGENE
PANTHER PTHR11388 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 1A2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER-RELATED UniProtKB/TrEMBL
Pfam Kazal_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB SLCO1A2 RGD
PhenoGen Slco1a4 PhenoGen
PROSITE KAZAL_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000047493 RatGTEx
  ENSRNOG00055010096 RatGTEx
  ENSRNOG00060008044 RatGTEx
  ENSRNOG00065005585 RatGTEx
Superfamily-SCOP SSF100895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF103473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AKX8_RAT UniProtKB/TrEMBL
  A0A8I6GHY6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q774_RAT UniProtKB/TrEMBL
  A0A8L2QJT4_RAT UniProtKB/TrEMBL
  A6IMP7 ENTREZGENE, UniProtKB/TrEMBL
  O35913 ENTREZGENE
  O55224 ENTREZGENE
  SO1A4_RAT UniProtKB/Swiss-Prot
UniProt Secondary O55224 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-16 Slco1a4  solute carrier organic anion transporter family, member 1a4  Slco1a2  solute carrier organic anion transporter family, member 1A2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-02-02 Slco1a2  solute carrier organic anion transporter family, member 1A2  Slco1a4  solute carrier organic anion transporter family, member 1a4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Slco1a4  solute carrier organic anion transporter family, member 1a4  Slc21a5  solute carrier family 21 (organic anion transporter), member 5  Symbol and Name updated 1299863 APPROVED
2002-08-07 Slc21a5  solute carrier family 21 (organic anion transporter), member 5      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in brain, liver, and kidney 729806