Mug1 (murinoglobulin 1) - Rat Genome Database

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Gene: Mug1 (murinoglobulin 1) Rattus norvegicus
Analyze
Symbol: Mug1
Name: murinoglobulin 1
RGD ID: 621366
Description: Predicted to enable endopeptidase inhibitor activity and protease binding activity. Predicted to be involved in acute-phase response. Predicted to act upstream of or within embryo implantation. Predicted to be located in extracellular space. Orthologous to human PZP (PZP alpha-2-macroglobulin like); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: A1i3; alpha x protein; alpha(1)-inhibitor 3 variant I; alpha(1)-inhibitor 3, variant I; alpha-1 inhibitor 3 variant I; alpha-1-inhibitor III; alpha-X protein; LOC100911784; Murinoglobulin 1 homolog; Murinoglobulin 1 homolog (mouse); murinoglobulin-1; murinoglobulin-1-like; plasma proteinase inhibitor alpha-1-inhibitor III
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84156,748,351 - 156,802,132 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.24155,076,270 - 155,130,051 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4155,076,312 - 155,130,051 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4161,340,322 - 161,393,985 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04157,123,785 - 157,177,448 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04155,766,407 - 155,820,067 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04154,676,382 - 154,729,288 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4154,391,647 - 154,729,310 (+)Ensemblrn6Rnor6.0
Rnor_5.04221,759,519 - 221,812,407 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44158,283,901 - 158,337,639 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4143,909,294 - 143,962,861 (+)NCBICelera
RGSC_v3.14158,528,836 - 158,582,575 (+)NCBI
Cytogenetic Map4q42NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
buspirone  (EXP)
buta-1,3-diene  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
carnosic acid  (ISO)
chloroform  (EXP)
clofibrate  (EXP,ISO)
Cuprizon  (EXP)
cyproconazole  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP)
dibenzofurans  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
dioxygen  (ISO)
doxorubicin  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
finasteride  (EXP)
flutamide  (EXP)
furan  (EXP)
gefitinib  (ISO)
genistein  (ISO)
inulin  (ISO)
lead diacetate  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosomorpholine  (EXP)
naloxone  (EXP)
naphthalene  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
ozone  (EXP)
paracetamol  (EXP)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
permethrin  (EXP)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
propiconazole  (ISO)
quercetin  (EXP)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sulindac  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
theophylline  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP,ISO)
Triptolide  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Sequence and acute phase regulation of rat alpha 1-inhibitor III messenger RNA. Braciak TA, etal., J Biol Chem 1988 Mar 15;263(8):3999-4012.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. Differential regulation of the two mRNA species of the rodent negative acute phase protein alpha 1-inhibitor 3. Regler R, etal., FEBS Lett 1991 May 6;282(2):368-72.
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Identification and sequencing of cDNA clones for the rodent negative acute-phase protein alpha 1-inhibitor 3. Schweizer M, etal., Eur J Biochem 1987 Apr 15;164(2):375-81.
Additional References at PubMed
PMID:2511184   PMID:14580373   PMID:21362503   PMID:22206666   PMID:22516433   PMID:23533145   PMID:32325114  


Genomics

Comparative Map Data
Mug1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84156,748,351 - 156,802,132 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.24155,076,270 - 155,130,051 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4155,076,312 - 155,130,051 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4161,340,322 - 161,393,985 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04157,123,785 - 157,177,448 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04155,766,407 - 155,820,067 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04154,676,382 - 154,729,288 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4154,391,647 - 154,729,310 (+)Ensemblrn6Rnor6.0
Rnor_5.04221,759,519 - 221,812,407 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44158,283,901 - 158,337,639 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4143,909,294 - 143,962,861 (+)NCBICelera
RGSC_v3.14158,528,836 - 158,582,575 (+)NCBI
Cytogenetic Map4q42NCBI
Mug1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396121,815,455 - 121,866,016 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6121,815,500 - 121,866,016 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm386121,838,496 - 121,889,057 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6121,838,541 - 121,889,057 (+)Ensemblmm10GRCm38
MGSCv376121,788,559 - 121,839,075 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv366121,804,160 - 121,854,676 (+)NCBIMGSCv36mm8
Celera6123,675,203 - 123,725,690 (+)NCBICelera
Cytogenetic Map6F1NCBI
cM Map657.52NCBI

Variants

.
Variants in Mug1
302 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:20
Count of miRNA genes:20
Interacting mature miRNAs:20
Transcripts:ENSRNOT00000019969
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4146370897184426481Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4134095016179095016Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4149763204169799698Rat
61446Coreg2Compensatory renal growth QTL 23.5kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)4150095743159267220Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4146370897184426481Rat
6478757Anxrr44Anxiety related response QTL 440.01087locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
1358364Sradr4Stress Responsive Adrenal Weight QTL 44.92adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)4131384565176384565Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4123870974168870974Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4117559384162559384Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4140059299181024663Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4127263297172263297Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4126334185171334185Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4147299608184426481Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
6478782Anxrr52Anxiety related response QTL 520.02091locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4124700988169700988Rat
6478720Alc23Alcohol consumption QTL 230.00509drinking behavior trait (VT:0001422)ethanol drink intake rate to body weight ratio (CMO:0001616)4155834926184426481Rat
6478785Anxrr53Anxiety related response QTL 530.01397locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4137447185182447185Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4137430611182430611Rat
6478728Anxrr36Anxiety related response QTL 360.01061locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4134199006168870974Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4148121375176967367Rat
6478733Anxrr37Anxiety related response QTL 370.00095locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
6478737Anxrr38Anxiety related response QTL 380.00159locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4116184844161184844Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4148834094168870974Rat

Markers in Region
D4Rat65  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr84156,694,947 - 156,695,075 (+)Marker Load Pipeline
mRatBN7.24155,022,860 - 155,022,988 (+)MAPPERmRatBN7.2
Rnor_6.04154,548,343 - 154,548,470NCBIRnor6.0
Rnor_5.04221,631,462 - 221,631,589UniSTSRnor5.0
RGSC_v3.44158,230,218 - 158,230,345UniSTSRGSC3.4
RGSC_v3.44158,230,217 - 158,230,345RGDRGSC3.4
Celera4143,855,885 - 143,856,024UniSTS
RGSC_v3.14158,475,154 - 158,475,281RGD
RH 3.4 Map4995.11UniSTS
RH 3.4 Map4995.11RGD
SHRSP x BN Map478.1999RGD
SHRSP x BN Map478.1999UniSTS
Cytogenetic Map4q42UniSTS
D4Won45  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24155,097,857 - 155,098,120 (+)MAPPERmRatBN7.2
Rnor_6.04154,697,097 - 154,697,357NCBIRnor6.0
Rnor_6.04154,618,941 - 154,619,199NCBIRnor6.0
Rnor_5.04221,702,060 - 221,702,318UniSTSRnor5.0
Rnor_5.04221,780,216 - 221,780,476UniSTSRnor5.0
RGSC_v3.44158,305,447 - 158,305,707UniSTSRGSC3.4
Celera4143,930,710 - 143,930,930UniSTS
Cytogenetic Map4q42UniSTS
RH143613  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map4997.7UniSTS
Cytogenetic Map4q42UniSTS
AU047685  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24154,993,866 - 154,994,029 (+)MAPPERmRatBN7.2
Rnor_6.04154,519,665 - 154,519,827NCBIRnor6.0
Rnor_5.04221,602,784 - 221,602,946UniSTSRnor5.0
RGSC_v3.44158,201,202 - 158,201,364UniSTSRGSC3.4
Celera4143,826,931 - 143,827,093UniSTS
Cytogenetic Map4q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
6 9 14 62 85 81 53 24 53 6 157 68 9 33 22 41 28 2 2

Sequence


Ensembl Acc Id: ENSRNOT00000019969   ⟹   ENSRNOP00000019969
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4155,076,312 - 155,130,051 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079192   ⟹   ENSRNOP00000069175
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4155,076,312 - 155,129,655 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108828   ⟹   ENSRNOP00000082949
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4155,076,312 - 155,129,655 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119571   ⟹   ENSRNOP00000093643
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4155,076,312 - 155,129,655 (+)Ensembl
RefSeq Acc Id: NM_023103   ⟹   NP_075591
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84156,748,395 - 156,802,132 (+)NCBI
mRatBN7.24155,076,312 - 155,130,051 (+)NCBI
Rnor_6.04154,676,427 - 154,729,288 (+)NCBI
Rnor_5.04221,759,519 - 221,812,407 (+)NCBI
RGSC_v3.44158,283,901 - 158,337,639 (+)RGD
Celera4143,909,294 - 143,962,861 (+)RGD
Sequence:
RefSeq Acc Id: XM_006237282   ⟹   XP_006237344
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84156,748,351 - 156,801,751 (+)NCBI
mRatBN7.24155,076,270 - 155,129,670 (+)NCBI
Rnor_6.04154,676,382 - 154,728,907 (+)NCBI
Rnor_5.04221,759,519 - 221,812,407 (+)NCBI
Sequence:
RefSeq Acc Id: NP_075591   ⟸   NM_023103
- Peptide Label: precursor
- UniProtKB: Q9JMK7 (UniProtKB/Swiss-Prot),   Q78DZ4 (UniProtKB/Swiss-Prot),   Q63023 (UniProtKB/Swiss-Prot),   Q63020 (UniProtKB/Swiss-Prot),   Q63018 (UniProtKB/Swiss-Prot),   Q03626 (UniProtKB/Swiss-Prot),   Q03310 (UniProtKB/Swiss-Prot),   D4A6E3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237344   ⟸   XM_006237282
- Peptide Label: isoform X1
- UniProtKB: D4A6E3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069175   ⟸   ENSRNOT00000079192
Ensembl Acc Id: ENSRNOP00000093643   ⟸   ENSRNOT00000119571
Ensembl Acc Id: ENSRNOP00000019969   ⟸   ENSRNOT00000019969
Ensembl Acc Id: ENSRNOP00000082949   ⟸   ENSRNOT00000108828
Protein Domains
Alpha-2-macroglobulin   Alpha-2-macroglobulin bait region   Alpha-macroglobulin receptor-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q03626-F1-model_v2 AlphaFold Q03626 1-1487 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693369
Promoter ID:EPDNEW_R3892
Type:multiple initiation site
Name:LOC297568_1
Description:alpha-1-inhibitor III
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R3891  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04154,676,399 - 154,676,459EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621366 AgrOrtholog
BioCyc Gene G2FUF-43169 BioCyc
Ensembl Genes ENSRNOG00000037188 Ensembl
  ENSRNOG00000067685 Ensembl
  ENSRNOG00000091232 ENTREZGENE
Ensembl Transcript ENSRNOT00000019969 ENTREZGENE
  ENSRNOT00000079192 ENTREZGENE
Gene3D-CATH 1.50.10.20 UniProtKB/Swiss-Prot
  2.20.130.20 UniProtKB/Swiss-Prot
  2.60.120.1540 UniProtKB/Swiss-Prot
  2.60.40.10 UniProtKB/Swiss-Prot
  2.60.40.1930 UniProtKB/Swiss-Prot
  2.60.40.1940 UniProtKB/Swiss-Prot
  2.60.40.690 UniProtKB/Swiss-Prot
  6.20.50.160 UniProtKB/Swiss-Prot
InterPro A-macroglobulin_rcpt-bd UniProtKB/Swiss-Prot
  A-macroglobulin_rcpt-bd_sf UniProtKB/Swiss-Prot
  A2M/Complement_sys UniProtKB/Swiss-Prot
  A2M_N_BRD UniProtKB/Swiss-Prot
  A2M_TED UniProtKB/Swiss-Prot
  Alpha-macroglob_thiol-ester_cl UniProtKB/Swiss-Prot
  Alpha-macroglobulin_TED UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_E-set UniProtKB/Swiss-Prot
  Macroglobln_a2 UniProtKB/Swiss-Prot
  MacrogloblnA2_CS UniProtKB/Swiss-Prot
  MG2 UniProtKB/Swiss-Prot
  MG3 UniProtKB/Swiss-Prot
  MG4 UniProtKB/Swiss-Prot
  Terpenoid_cyclase/PrenylTrfase UniProtKB/Swiss-Prot
  TonB_box_CS UniProtKB/Swiss-Prot
KEGG Report rno:497794 UniProtKB/Swiss-Prot
NCBI Gene Mug1 ENTREZGENE
PANTHER MACROGLOBULIN / COMPLEMENT UniProtKB/Swiss-Prot
  MURINOGLOBULIN-1-RELATED UniProtKB/Swiss-Prot
Pfam A2M UniProtKB/Swiss-Prot
  A2M_BRD UniProtKB/Swiss-Prot
  A2M_recep UniProtKB/Swiss-Prot
  MG2 UniProtKB/Swiss-Prot
  MG3 UniProtKB/Swiss-Prot
  MG4 UniProtKB/Swiss-Prot
  TED_complement UniProtKB/Swiss-Prot
PhenoGen Mug1 PhenoGen
PROSITE ALPHA_2_MACROGLOBULIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000037188 RatGTEx
  ENSRNOG00000067685 RatGTEx
  ENSRNOG00000091232 RatGTEx
SMART A2M UniProtKB/Swiss-Prot
  A2M_N_2 UniProtKB/Swiss-Prot
  A2M_recep UniProtKB/Swiss-Prot
  Thiol-ester_cl UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48239 UniProtKB/Swiss-Prot
  SSF49410 UniProtKB/Swiss-Prot
  SSF81296 UniProtKB/Swiss-Prot
UniProt A0A0G2JUP5_RAT UniProtKB/TrEMBL
  D4A6E3 ENTREZGENE, UniProtKB/TrEMBL
  MUG1_RAT UniProtKB/Swiss-Prot
  Q03310 ENTREZGENE
  Q03626 ENTREZGENE
  Q63018 ENTREZGENE
  Q63020 ENTREZGENE
  Q63023 ENTREZGENE
  Q78DZ4 ENTREZGENE
  Q9JMK7 ENTREZGENE
UniProt Secondary Q03310 UniProtKB/Swiss-Prot
  Q63018 UniProtKB/Swiss-Prot
  Q63020 UniProtKB/Swiss-Prot
  Q63023 UniProtKB/Swiss-Prot
  Q78DZ4 UniProtKB/Swiss-Prot
  Q9JMK7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-03-31 Mug1  murinoglobulin 1  Mug5  murinoglobulin 5  Name and Symbol changed 629549 APPROVED
2025-03-31 Mug5  murinoglobulin 5  Mug1  murinoglobulin 1  Name and Symbol changed 629549 APPROVED
2021-03-09 Mug1  murinoglobulin 1  LOC100911784  murinoglobulin-1-like  Data merged from RGD:6491022 737654 PROVISIONAL
2012-07-05 LOC100911784  murinoglobulin-1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-02-22 Mug1  murinoglobulin 1  Mug1  Murinoglobulin 1 homolog (mouse)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Mug1  Murinoglobulin 1 homolog (mouse)    alpha(1)-inhibitor 3, variant I  Name updated 1299863 APPROVED
2002-08-07 Mug1  alpha(1)-inhibitor 3, variant I      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_homology shows 58% overall sequence identity with rat alpha 2-macroglobulin  
gene_protein 1477-amino acid precursor polypeptide