Magi3 (membrane associated guanylate kinase, WW and PDZ domain containing 3) - Rat Genome Database

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Pathways
Gene: Magi3 (membrane associated guanylate kinase, WW and PDZ domain containing 3) Rattus norvegicus
Analyze
Symbol: Magi3
Name: membrane associated guanylate kinase, WW and PDZ domain containing 3
RGD ID: 621362
Description: Enables protein phosphatase binding activity. Predicted to be involved in signal transduction. Predicted to be located in bicellular tight junction; nucleus; and plasma membrane. Predicted to be active in cell-cell junction and cytoplasm. Orthologous to human MAGI3 (membrane associated guanylate kinase, WW and PDZ domain containing 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MAGI-3; membrane-associated guanylate kinase inverted 3; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3; membrane-associated guanylate kinase-related (MAGI-3); scaffolding protein SLIPR; scaffolding-like protein; Slipr
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82194,206,587 - 194,405,468 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2194,206,934 - 194,405,157 (-)EnsemblGRCr8
mRatBN7.22191,514,726 - 191,717,048 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2191,518,506 - 191,716,735 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2199,115,106 - 199,312,451 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02196,987,842 - 197,185,182 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02191,804,807 - 192,002,144 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02206,499,467 - 206,699,105 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2206,499,463 - 206,699,105 (-)Ensemblrn6Rnor6.0
Rnor_5.02225,922,923 - 226,123,408 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42199,247,907 - 199,448,518 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2183,989,608 - 184,187,750 (-)NCBICelera
RGSC_v3.12199,210,660 - 199,411,272 (-)NCBI
Cytogenetic Map2q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Junctional protein MAGI-3 interacts with receptor tyrosine phosphatase beta (RPTPbeta) and tyrosine-phosphorylated proteins. Adamsky K, etal., J Cell Sci 2003 Apr 1;116(Pt 7):1279-89.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Proteomic analysis of beta1-adrenergic receptor interactions with PDZ scaffold proteins. He J, etal., J Biol Chem. 2006 Feb 3;281(5):2820-7. Epub 2005 Nov 29.
4. Combined genealogical, mapping, and expression approaches to identify spontaneously hypertensive rat hypertension candidate genes. Hinojos CA, etal., Hypertension 2005 Apr;45(4):698-704. Epub 2005 Feb 14.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases. Valiente M, etal., J Biol Chem. 2005 Aug 12;280(32):28936-43. Epub 2005 Jun 10.
Additional References at PubMed
PMID:15195140   PMID:15458844   PMID:34985721  


Genomics

Comparative Map Data
Magi3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82194,206,587 - 194,405,468 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2194,206,934 - 194,405,157 (-)EnsemblGRCr8
mRatBN7.22191,514,726 - 191,717,048 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2191,518,506 - 191,716,735 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2199,115,106 - 199,312,451 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02196,987,842 - 197,185,182 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02191,804,807 - 192,002,144 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02206,499,467 - 206,699,105 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2206,499,463 - 206,699,105 (-)Ensemblrn6Rnor6.0
Rnor_5.02225,922,923 - 226,123,408 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42199,247,907 - 199,448,518 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2183,989,608 - 184,187,750 (-)NCBICelera
RGSC_v3.12199,210,660 - 199,411,272 (-)NCBI
Cytogenetic Map2q34NCBI
MAGI3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381113,390,515 - 113,685,923 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1113,390,501 - 113,685,923 (+)Ensemblhg38GRCh38
GRCh371113,933,137 - 114,228,545 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361113,734,998 - 114,030,068 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1112,163,278 - 112,457,777 (+)NCBICelera
Cytogenetic Map1p13.2NCBI
HuRef1111,790,744 - 112,086,122 (+)NCBIHuRef
CHM1_11114,048,332 - 114,343,392 (+)NCBICHM1_1
T2T-CHM13v2.01113,401,966 - 113,697,567 (+)NCBIT2T-CHM13v2.0
Magi3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393103,920,575 - 104,127,722 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3103,920,575 - 104,127,690 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm383104,013,259 - 104,220,406 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3104,013,259 - 104,220,374 (-)Ensemblmm10GRCm38
MGSCv373103,817,182 - 104,024,329 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv363104,144,322 - 104,349,088 (-)NCBIMGSCv36mm8
Celera3106,215,763 - 106,425,761 (-)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map345.52NCBI
Magi3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543516,735,598 - 16,972,204 (+)Ensembl
ChiLan1.0NW_00495543516,735,598 - 16,974,005 (+)NCBIChiLan1.0ChiLan1.0
MAGI3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21106,059,475 - 106,345,340 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11105,652,908 - 105,938,949 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0188,873,080 - 88,914,647 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11123,917,788 - 123,954,130 (-)NCBIPanPan1.1PanPan1.1panPan2
MAGI3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11762,055,705 - 62,290,808 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1762,057,610 - 62,291,157 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1761,570,381 - 61,805,404 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01763,222,635 - 63,464,371 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1763,223,299 - 63,464,446 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11761,959,312 - 62,200,517 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01762,023,101 - 62,258,082 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01762,782,483 - 63,017,543 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
MAGI3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4106,882,435 - 107,120,035 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.14106,880,617 - 107,120,043 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24117,027,271 - 117,265,990 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAGI3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12019,980,543 - 20,265,612 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2019,978,673 - 20,108,628 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603822,753,124 - 23,045,924 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Magi3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247729,108,294 - 9,371,724 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247729,108,214 - 9,375,367 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Magi3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1353,888,398 - 54,066,814 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Magi3
1293 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:195
Count of miRNA genes:135
Interacting mature miRNAs:171
Transcripts:ENSRNOT00000026952
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2191709311217961898Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2171994826205135428Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2188565047233565047Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2192287802229609668Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2184856304229856304Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2184856304229856304Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2159440760195313808Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2191709311217961898Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2192287802221089121Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2184856304229856304Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2192287802237287802Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2182024327227024327Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2184482291229482291Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
7488929Bp366Blood pressure QTL 3660.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2187663373195783351Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2186850607231850607Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2192287802237287802Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2182635347227635347Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2184856304229856304Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat

Markers in Region
D2Wox34  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22191,624,814 - 191,624,907 (+)MAPPERmRatBN7.2
Rnor_6.02206,607,173 - 206,607,265NCBIRnor6.0
Rnor_5.02226,030,883 - 226,030,975UniSTSRnor5.0
RGSC_v3.42199,355,340 - 199,355,432UniSTSRGSC3.4
RGSC_v3.42199,355,339 - 199,355,432RGDRGSC3.4
Celera2184,097,009 - 184,097,101UniSTS
RGSC_v3.12199,318,094 - 199,318,186RGD
RH 3.4 Map21331.9UniSTS
RH 3.4 Map21331.9RGD
RH 2.0 Map21009.8RGD
Cytogenetic Map2q34UniSTS
BE098226  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22191,718,454 - 191,718,606 (+)MAPPERmRatBN7.2
Rnor_6.02206,700,500 - 206,700,651NCBIRnor6.0
Rnor_5.02226,124,803 - 226,124,954UniSTSRnor5.0
RGSC_v3.42199,450,286 - 199,450,437UniSTSRGSC3.4
Celera2184,189,760 - 184,189,911UniSTS
RH 3.4 Map21342.5UniSTS
Cytogenetic Map2q34UniSTS
AA859339  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22191,555,197 - 191,555,387 (+)MAPPERmRatBN7.2
Rnor_6.02206,536,155 - 206,536,344NCBIRnor6.0
Rnor_5.02225,959,962 - 225,960,151UniSTSRnor5.0
RGSC_v3.42199,284,496 - 199,284,685UniSTSRGSC3.4
Celera2184,026,278 - 184,026,467UniSTS
RH 3.4 Map21343.8UniSTS
Cytogenetic Map2q34UniSTS
BE115259  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22191,528,530 - 191,528,697 (+)MAPPERmRatBN7.2
Rnor_6.02206,509,488 - 206,509,654NCBIRnor6.0
Rnor_5.02225,933,295 - 225,933,461UniSTSRnor5.0
RGSC_v3.42199,257,928 - 199,258,094UniSTSRGSC3.4
Celera2183,999,629 - 183,999,795UniSTS
RH 3.4 Map21342.7UniSTS
Cytogenetic Map2q34UniSTS
RH135900  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82194,207,540 - 194,207,640 (+)Marker Load Pipeline
mRatBN7.22191,519,111 - 191,519,212 (+)MAPPERmRatBN7.2
Rnor_6.02206,500,069 - 206,500,169NCBIRnor6.0
Rnor_5.02225,923,876 - 225,923,976UniSTSRnor5.0
RGSC_v3.42199,248,509 - 199,248,609UniSTSRGSC3.4
Celera2183,990,210 - 183,990,310UniSTS
Cytogenetic Map2q34UniSTS
RH124573  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22191,520,236 - 191,520,343 (+)MAPPERmRatBN7.2
Rnor_6.02206,501,194 - 206,501,300NCBIRnor6.0
Rnor_5.02225,925,001 - 225,925,107UniSTSRnor5.0
RGSC_v3.42199,249,634 - 199,249,740UniSTSRGSC3.4
Celera2183,991,335 - 183,991,441UniSTS
Cytogenetic Map2q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
23 13 84 213 91 90 59 155 59 6 481 282 22 191 109 124 31 34 34

Sequence


Ensembl Acc Id: ENSRNOT00000026952   ⟹   ENSRNOP00000026952
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2194,206,934 - 194,405,157 (-)Ensembl
mRatBN7.2 Ensembl2191,518,506 - 191,716,735 (-)Ensembl
Rnor_6.0 Ensembl2206,499,467 - 206,699,105 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000088095   ⟹   ENSRNOP00000069270
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2194,206,934 - 194,405,157 (-)Ensembl
mRatBN7.2 Ensembl2191,518,506 - 191,716,735 (-)Ensembl
Rnor_6.0 Ensembl2206,499,463 - 206,699,105 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098245   ⟹   ENSRNOP00000090602
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2194,209,891 - 194,405,157 (-)Ensembl
mRatBN7.2 Ensembl2191,520,423 - 191,716,735 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000149807   ⟹   ENSRNOP00000103617
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2194,206,934 - 194,405,157 (-)Ensembl
RefSeq Acc Id: NM_139084   ⟹   NP_620784
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82194,206,938 - 194,405,147 (-)NCBI
mRatBN7.22191,518,510 - 191,716,725 (-)NCBI
Rnor_6.02206,499,467 - 206,699,105 (-)NCBI
Rnor_5.02225,922,923 - 226,123,408 (-)NCBI
RGSC_v3.42199,247,907 - 199,448,518 (-)RGD
Celera2183,989,608 - 184,187,750 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008761367   ⟹   XP_008759589
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82194,209,202 - 194,405,468 (-)NCBI
mRatBN7.22191,520,776 - 191,717,048 (-)NCBI
Rnor_6.02206,501,734 - 206,699,092 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039101721   ⟹   XP_038957649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82194,206,587 - 194,405,468 (-)NCBI
mRatBN7.22191,514,726 - 191,717,048 (-)NCBI
Protein Sequences
Protein RefSeqs NP_620784 (Get FASTA)   NCBI Sequence Viewer  
  XP_008759589 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957649 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF66069 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026952
  ENSRNOP00000090602
GenBank Protein Q9JK71 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_620784   ⟸   NM_139084
- UniProtKB: Q9JK71 (UniProtKB/Swiss-Prot),   F1M7S0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759589   ⟸   XM_008761367
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AE46 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026952   ⟸   ENSRNOT00000026952
Ensembl Acc Id: ENSRNOP00000069270   ⟸   ENSRNOT00000088095
RefSeq Acc Id: XP_038957649   ⟸   XM_039101721
- Peptide Label: isoform X1
- UniProtKB: Q9JK71 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000090602   ⟸   ENSRNOT00000098245
Ensembl Acc Id: ENSRNOP00000103617   ⟸   ENSRNOT00000149807
Protein Domains
Guanylate kinase-like   PDZ   WW

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JK71-F1-model_v2 AlphaFold Q9JK71 1-1470 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621362 AgrOrtholog
BioCyc Gene G2FUF-51787 BioCyc
Ensembl Genes ENSRNOG00000019885 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000026952 ENTREZGENE
  ENSRNOT00000098245 ENTREZGENE
Gene3D-CATH 2.20.70.10 UniProtKB/Swiss-Prot
  2.30.42.10 UniProtKB/Swiss-Prot
  Guanylate Kinase phosphate binding domain UniProtKB/Swiss-Prot
InterPro GK/Ca_channel_bsu UniProtKB/Swiss-Prot
  Guanylate_kin-like_dom UniProtKB/Swiss-Prot
  Guanylate_kinase_CS UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  PDZ_sf UniProtKB/Swiss-Prot
  WW_dom UniProtKB/Swiss-Prot
  WW_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:245903 UniProtKB/Swiss-Prot
NCBI Gene 245903 ENTREZGENE
PANTHER MEMBRANE ASSOCIATED GUANYLATE KINASE-RELATED UniProtKB/Swiss-Prot
  PTHR10316:SF10 UniProtKB/Swiss-Prot
Pfam Guanylate_kin UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  PF00397 UniProtKB/Swiss-Prot
PhenoGen Magi3 PhenoGen
PROSITE GUANYLATE_KINASE_1 UniProtKB/Swiss-Prot
  GUANYLATE_KINASE_2 UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  WW_DOMAIN_1 UniProtKB/Swiss-Prot
  WW_DOMAIN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019885 RatGTEx
SMART GuKc UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  SM00456 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50156 UniProtKB/Swiss-Prot
  SSF51045 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
UniProt A0A0G2JUX7_RAT UniProtKB/TrEMBL
  A0A8I6AE46 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LQY9_RAT UniProtKB/TrEMBL
  F1M7S0 ENTREZGENE, UniProtKB/TrEMBL
  MAGI3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Magi3  membrane associated guanylate kinase, WW and PDZ domain containing 3    membrane-associated guanylate kinase-related (MAGI-3)  Name updated 1299863 APPROVED
2005-01-20 Magi3  membrane-associated guanylate kinase-related (MAGI-3)  Slipr  scaffolding protein SLIPR  Symbol and Name updated 1299863 APPROVED
2002-08-07 Slipr  scaffolding protein SLIPR      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a guanylate-kinase-like region, six PDZ and two WW domains 634198
gene_expression expression is increased 2.5 fold in SHR compared with WKY rats 1357414
gene_process acts as a as a scaffolding molecule to mediate cell-cell and cell-matrix interactions 634198