Gene: Nova1 (NOVA alternative splicing regulator 1) Rattus norvegicus
Analyze
Symbol:
Nova1
Name:
NOVA alternative splicing regulator 1
RGD ID:
621345
Description:
Predicted to enable mRNA 3'-UTR binding activity and sequence-specific mRNA binding activity. Involved in regulation of mRNA processing and spinal cord development. Predicted to be active in cytoplasm and nucleus. Orthologous to human NOVA1 (NOVA alternative splicing regulator 1); INTERACTS WITH (+)-pilocarpine; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
neuro-oncological ventral antigen 1; Nova-1; RNA-binding protein Nova-1
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 6 69,506,983 - 69,632,437 (-) NCBI GRCr8 GRCr8 GRCr8 GRCr8 Ensembl 6 69,506,983 - 69,632,437 (-) Ensembl GRCr8 mRatBN7.2 6 63,780,105 - 63,905,567 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 6 63,783,489 - 63,906,289 (-) Ensembl mRatBN7.2 UTH_Rnor_SHR_Utx 6 64,171,614 - 64,293,460 (-) NCBI UTH_Rnor_SHR_Utx UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 6 64,486,772 - 64,608,608 (-) NCBI UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 6 63,933,525 - 64,055,455 (-) NCBI UTH_Rnor_WKY_Bbb_1.0 UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 6 66,960,126 - 67,085,836 (-) NCBI Rnor_6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 6 66,963,510 - 67,085,390 (-) Ensembl rn6 Rnor6.0 Rnor_5.0 6 76,535,375 - 76,660,962 (-) NCBI Rnor_5.0 Rnor_5.0 rn5 RGSC_v3.4 6 66,193,472 - 66,320,240 (-) NCBI RGSC_v3.4 RGSC_v3.4 rn4 Celera 6 62,747,220 - 62,869,241 (-) NCBI Celera RGSC_v3.1 6 66,202,073 - 66,323,082 (-) NCBI Cytogenetic Map 6 q21 NCBI
JBrowse:
Only show annotations with direct experimental evidence (0 objects hidden)
Nova1 Rat (+)-pilocarpine increases expression EXP 6480464 Pilocarpine results in increased expression of NOVA1 mRNA CTD PMID:20470870 Nova1 Rat (+)-pilocarpine multiple interactions EXP 6480464 Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NOVA1 mRNA] CTD PMID:20470870 Nova1 Rat 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactions ISO Nova1 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Nova1 Rat 17beta-estradiol decreases expression ISO NOVA1 (Homo sapiens) 6480464 Estradiol results in decreased expression of NOVA1 mRNA CTD PMID:18692832 Nova1 Rat 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Nova1 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Nova1 Rat 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO Nova1 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Nova1 Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO NOVA1 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in increased expression of NOVA1 mRNA CTD PMID:21296121 Nova1 Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of NOVA1 mRNA CTD PMID:32109520|PMID:33387578 Nova1 Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of NOVA1 mRNA CTD PMID:22298810 Nova1 Rat 2,3,7,8-Tetrachlorodibenzofuran decreases expression EXP 6480464 2,3,7,8-tetrachlorodibenzofuran results in decreased expression of NOVA1 mRNA CTD PMID:32109520 Nova1 Rat 2,4,4'-trichlorobiphenyl multiple interactions ISO Nova1 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Nova1 Rat 3,4-methylenedioxymethamphetamine increases expression ISO Nova1 (Mus musculus) 6480464 N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of NOVA1 mRNA CTD PMID:20188158 Nova1 Rat 4-hydroxyphenyl retinamide decreases expression ISO Nova1 (Mus musculus) 6480464 Fenretinide results in decreased expression of NOVA1 mRNA CTD PMID:28973697 Nova1 Rat aflatoxin B1 increases expression ISO NOVA1 (Homo sapiens) 6480464 Aflatoxin B1 results in increased expression of NOVA1 mRNA CTD PMID:27153756 Nova1 Rat aflatoxin B1 decreases methylation ISO NOVA1 (Homo sapiens) 6480464 Aflatoxin B1 results in decreased methylation of NOVA1 promoter CTD PMID:30157460 Nova1 Rat ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of NOVA1 mRNA CTD PMID:16483693 Nova1 Rat antirheumatic drug increases expression ISO NOVA1 (Homo sapiens) 6480464 Antirheumatic Agents results in increased expression of NOVA1 mRNA CTD PMID:24449571 Nova1 Rat aristolochic acid A decreases expression ISO NOVA1 (Homo sapiens) 6480464 aristolochic acid I results in decreased expression of NOVA1 mRNA CTD PMID:33212167 Nova1 Rat arsenite(3-) increases methylation ISO NOVA1 (Homo sapiens) 6480464 arsenite results in increased methylation of NOVA1 promoter CTD PMID:23974009 Nova1 Rat arsenous acid decreases expression ISO NOVA1 (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of NOVA1 mRNA CTD PMID:20458559 Nova1 Rat benzo[a]pyrene increases methylation ISO NOVA1 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of NOVA1 5' UTR; Benzo(a)pyrene results in increased methylation of more ... CTD PMID:27901495 Nova1 Rat benzo[a]pyrene decreases methylation ISO NOVA1 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased methylation of NOVA1 3' UTR CTD PMID:27901495 Nova1 Rat benzo[a]pyrene affects methylation ISO NOVA1 (Homo sapiens) 6480464 Benzo(a)pyrene affects the methylation of NOVA1 promoter CTD PMID:27901495 Nova1 Rat beryllium sulfate increases expression ISO NOVA1 (Homo sapiens) 6480464 beryllium sulfate results in increased expression of NOVA1 mRNA CTD PMID:16314022 Nova1 Rat bis(2-ethylhexyl) phthalate decreases expression ISO NOVA1 (Homo sapiens) 6480464 Diethylhexyl Phthalate results in decreased expression of NOVA1 mRNA CTD PMID:31163220 Nova1 Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of NOVA1 mRNA CTD PMID:25181051 Nova1 Rat bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with Genistein] results in increased methylation of NOVA1 gene CTD PMID:28505145 Nova1 Rat butanal decreases expression ISO NOVA1 (Homo sapiens) 6480464 butyraldehyde results in decreased expression of NOVA1 mRNA CTD PMID:26079696 Nova1 Rat cadmium atom multiple interactions ISO NOVA1 (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of NOVA1 more ... CTD PMID:35301059 Nova1 Rat cadmium atom multiple interactions EXP 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of NOVA1 more ... CTD PMID:39012411 Nova1 Rat cadmium dichloride increases expression ISO NOVA1 (Homo sapiens) 6480464 Cadmium Chloride results in increased expression of NOVA1 mRNA CTD PMID:38382870 Nova1 Rat cadmium dichloride multiple interactions EXP 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of NOVA1 more ... CTD PMID:39012411 Nova1 Rat cadmium dichloride multiple interactions ISO NOVA1 (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of NOVA1 more ... CTD PMID:35301059 Nova1 Rat cisplatin multiple interactions ISO NOVA1 (Homo sapiens) 6480464 [Cisplatin co-treated with jinfukang] results in decreased expression of NOVA1 mRNA CTD PMID:27392435 Nova1 Rat clobetasol decreases expression ISO Nova1 (Mus musculus) 6480464 Clobetasol results in decreased expression of NOVA1 mRNA CTD PMID:27462272 Nova1 Rat copper(II) sulfate increases expression ISO NOVA1 (Homo sapiens) 6480464 Copper Sulfate results in increased expression of NOVA1 mRNA CTD PMID:19549813 Nova1 Rat cytarabine increases expression ISO NOVA1 (Homo sapiens) 6480464 Cytarabine results in increased expression of NOVA1 mRNA CTD PMID:21198554 Nova1 Rat dexamethasone increases expression ISO NOVA1 (Homo sapiens) 6480464 Dexamethasone results in increased expression of NOVA1 mRNA CTD PMID:25047013 Nova1 Rat diarsenic trioxide decreases expression ISO NOVA1 (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of NOVA1 mRNA CTD PMID:20458559 Nova1 Rat diclofenac decreases expression ISO Nova1 (Mus musculus) 6480464 Diclofenac results in decreased expression of NOVA1 mRNA CTD PMID:26934552 Nova1 Rat dorsomorphin multiple interactions ISO NOVA1 (Homo sapiens) 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression more ... CTD PMID:27188386 Nova1 Rat entinostat decreases expression ISO NOVA1 (Homo sapiens) 6480464 entinostat results in decreased expression of NOVA1 mRNA CTD PMID:26272509 Nova1 Rat entinostat multiple interactions ISO NOVA1 (Homo sapiens) 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression more ... CTD PMID:27188386 Nova1 Rat ethanol affects splicing ISO Nova1 (Mus musculus) 6480464 Ethanol affects the splicing of NOVA1 mRNA CTD PMID:30319688 Nova1 Rat folic acid decreases expression ISO Nova1 (Mus musculus) 6480464 Folic Acid results in decreased expression of NOVA1 mRNA CTD PMID:25629700 Nova1 Rat genistein multiple interactions EXP 6480464 [bisphenol A co-treated with Genistein] results in increased methylation of NOVA1 gene CTD PMID:28505145 Nova1 Rat gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of NOVA1 mRNA CTD PMID:33387578 Nova1 Rat hydralazine multiple interactions ISO NOVA1 (Homo sapiens) 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of NOVA1 mRNA CTD PMID:17183730 Nova1 Rat lead(0) decreases expression ISO NOVA1 (Homo sapiens) 6480464 Lead results in decreased expression of NOVA1 mRNA CTD PMID:19921347 Nova1 Rat lead(0) affects splicing ISO NOVA1 (Homo sapiens) 6480464 Lead affects the splicing of NOVA1 mRNA CTD PMID:28903495 Nova1 Rat maneb multiple interactions ISO Nova1 (Mus musculus) 6480464 [Maneb co-treated with Paraquat] results in decreased expression of NOVA1 mRNA CTD PMID:36117858 Nova1 Rat miconazole decreases expression ISO Nova1 (Mus musculus) 6480464 Miconazole results in decreased expression of NOVA1 mRNA CTD PMID:27462272 Nova1 Rat mifepristone increases expression ISO NOVA1 (Homo sapiens) 6480464 Mifepristone results in increased expression of NOVA1 mRNA CTD PMID:17584828 Nova1 Rat Muraglitazar increases expression EXP 6480464 muraglitazar results in increased expression of NOVA1 mRNA CTD PMID:21515302 Nova1 Rat N-methyl-4-phenylpyridinium decreases expression ISO NOVA1 (Homo sapiens) 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of NOVA1 mRNA CTD PMID:24810058 Nova1 Rat nickel sulfate decreases expression ISO NOVA1 (Homo sapiens) 6480464 nickel sulfate results in decreased expression of NOVA1 mRNA CTD PMID:22714537 Nova1 Rat ozone multiple interactions ISO Nova1 (Mus musculus) 6480464 [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of NOVA1 more ... CTD PMID:34911549 Nova1 Rat paracetamol decreases expression ISO NOVA1 (Homo sapiens) 6480464 Acetaminophen results in decreased expression of NOVA1 mRNA CTD PMID:22230336 Nova1 Rat paraquat multiple interactions ISO Nova1 (Mus musculus) 6480464 [Maneb co-treated with Paraquat] results in decreased expression of NOVA1 mRNA CTD PMID:36117858 Nova1 Rat PCB138 multiple interactions ISO Nova1 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Nova1 Rat pirinixic acid increases expression ISO Nova1 (Mus musculus) 6480464 pirinixic acid results in increased expression of NOVA1 mRNA CTD PMID:20813756 Nova1 Rat rotenone decreases expression ISO NOVA1 (Homo sapiens) 6480464 Rotenone results in decreased expression of NOVA1 protein CTD PMID:39603559 Nova1 Rat SB 431542 multiple interactions ISO NOVA1 (Homo sapiens) 6480464 [LDN 193189 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein] results in increased expression of NOVA1 more ... CTD PMID:27188386|PMID:37664457 Nova1 Rat scopolamine multiple interactions EXP 6480464 Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NOVA1 mRNA] CTD PMID:20470870 Nova1 Rat sevoflurane increases expression EXP 6480464 Sevoflurane results in increased expression of NOVA1 mRNA; Sevoflurane results in increased expression of NOVA1 more ... CTD PMID:35110470 Nova1 Rat silicon dioxide decreases expression ISO NOVA1 (Homo sapiens) 6480464 Silicon Dioxide analog results in decreased expression of NOVA1 mRNA CTD PMID:25895662 Nova1 Rat Soman decreases expression EXP 6480464 Soman results in decreased expression of NOVA1 mRNA CTD PMID:19281266 Nova1 Rat tamoxifen decreases expression ISO NOVA1 (Homo sapiens) 6480464 Tamoxifen results in decreased expression of NOVA1 mRNA CTD PMID:15590111 Nova1 Rat temozolomide decreases expression ISO NOVA1 (Homo sapiens) 6480464 Temozolomide results in decreased expression of NOVA1 mRNA CTD PMID:31758290 Nova1 Rat Tesaglitazar increases expression EXP 6480464 tesaglitazar results in increased expression of NOVA1 mRNA CTD PMID:21515302 Nova1 Rat testosterone decreases expression ISO NOVA1 (Homo sapiens) 6480464 Testosterone results in decreased expression of NOVA1 mRNA CTD PMID:33359661 Nova1 Rat trichostatin A decreases expression ISO NOVA1 (Homo sapiens) 6480464 trichostatin A results in decreased expression of NOVA1 mRNA CTD PMID:24935251|PMID:26272509 Nova1 Rat trichostatin A multiple interactions ISO NOVA1 (Homo sapiens) 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... CTD PMID:27188386 Nova1 Rat troglitazone increases expression EXP 6480464 troglitazone results in increased expression of NOVA1 mRNA CTD PMID:21515302 Nova1 Rat valproic acid decreases methylation ISO NOVA1 (Homo sapiens) 6480464 Valproic Acid results in decreased methylation of NOVA1 gene CTD PMID:29154799 Nova1 Rat valproic acid multiple interactions ISO NOVA1 (Homo sapiens) 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of NOVA1 mRNA; [NOG protein co-treated more ... CTD PMID:17183730|PMID:27188386 Nova1 Rat valproic acid affects expression ISO NOVA1 (Homo sapiens) 6480464 Valproic Acid affects the expression of NOVA1 mRNA CTD PMID:25979313 Nova1 Rat valproic acid decreases expression ISO NOVA1 (Homo sapiens) 6480464 Valproic Acid results in decreased expression of NOVA1 mRNA CTD PMID:23179753|PMID:24383497|PMID:24935251|PMID:26272509|PMID:28001369 Nova1 Rat vitamin E decreases expression ISO NOVA1 (Homo sapiens) 6480464 Vitamin E results in decreased expression of NOVA1 mRNA CTD PMID:19244175
Biological Process
Only show annotations with direct experimental evidence (0 objects hidden)
Nova1 Rat mRNA processing involved_in IEA UniProtKB-KW:KW-0507 1600115 GO_REF:0000043 UniProt GO_REF:0000043 Nova1 Rat mRNA splicing, via spliceosome acts_upstream_of_or_within ISO RGD:1550966,MGI:104297 1624291 MGI:2386947 PMID:10719891 RGD PMID:10719891 Nova1 Rat mRNA splicing, via spliceosome involved_in IBA MGI:104297|PANTHER:PTN000815734 1600115 GO_REF:0000033 GO_Central GO_REF:0000033 Nova1 Rat negative regulation of cold-induced thermogenesis involved_in ISS UniProtKB:Q9JKN6 13673747 PMID:27635635 YuBioLab Nova1 Rat negative regulation of cold-induced thermogenesis involved_in ISO RGD:1550966,MGI:104297 1624291 UniProtKB:A0A1W2P872 PMID:27635635 RGD PMID:27635635 Nova1 Rat nervous system development involved_in IEA UniProtKB-KW:KW-0524 1600115 GO_REF:0000043 UniProt GO_REF:0000043 Nova1 Rat nervous system development involved_in IBA PANTHER:PTN002568539|RGD:621345 1600115 GO_REF:0000033 GO_Central GO_REF:0000033 Nova1 Rat regulation of alternative mRNA splicing, via spliceosome involved_in ISS UniProtKB:Q9JKN6 1600115 GO_REF:0000024 UniProt GO_REF:0000024 Nova1 Rat regulation of alternative mRNA splicing, via spliceosome involved_in IBA FB:FBgn0261552|MGI:104296|MGI:104297|PANTHER:PTN000815734|UniProtKB:Q9UNW9 1600115 GO_REF:0000033 GO_Central GO_REF:0000033 Nova1 Rat regulation of alternative mRNA splicing, via spliceosome involved_in ISO RGD:1550966,MGI:104297 1624291 PMID:14615540, PMID:17065982, PMID:27223325 RGD PMID:14615540|PMID:17065982|PMID:27223325 Nova1 Rat regulation of mRNA processing IMP 708602 RGD Nova1 Rat regulation of mRNA processing involved_in IEA ARBA:ARBA00026423 1600115 GO_REF:0000117 UniProt GO_REF:0000117 Nova1 Rat regulation of RNA metabolic process acts_upstream_of_or_within ISO RGD:1550966,MGI:104297 1624291 MGI:104296 PMID:23359859 RGD PMID:23359859 Nova1 Rat RNA splicing involved_in IEA UniProtKB-KW:KW-0508 1600115 GO_REF:0000043 UniProt GO_REF:0000043 Nova1 Rat spinal cord development IEP 708602 RGD