Ctcf (CCCTC-binding factor) - Rat Genome Database

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Gene: Ctcf (CCCTC-binding factor) Rattus norvegicus
Analyze
Symbol: Ctcf
Name: CCCTC-binding factor
RGD ID: 621344
Description: Enables DNA-binding transcription factor binding activity. Involved in positive regulation of miRNA transcription. Located in dense fibrillar component and granular component. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 21; basal cell carcinoma; female breast cancer; skin melanoma; and skin squamous cell carcinoma. Orthologous to human CTCF (CCCTC-binding factor); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 5-aza-2'-deoxycytidine; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 11-zinc finger protein; CCCTC-binding factor (zinc finger protein); CTCFL paralog; transcriptional repressor CTCF
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81950,431,478 - 50,481,013 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1950,431,689 - 50,481,012 (+)EnsemblGRCr8
mRatBN7.21933,521,726 - 33,571,124 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1933,529,319 - 33,571,123 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1940,337,528 - 40,386,695 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01940,990,859 - 41,040,027 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01943,288,547 - 43,337,784 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01937,600,151 - 37,649,674 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1937,600,148 - 37,649,673 (+)Ensemblrn6Rnor6.0
Rnor_5.01948,467,547 - 48,516,378 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41935,461,942 - 35,514,934 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1932,950,156 - 32,999,072 (+)NCBICelera
RGSC_v3.11935,466,822 - 35,519,814 (+)NCBI
Cytogenetic Map19q12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Association of mutation and low expression of the CTCF gene with breast cancer progression. Akhtar MS, etal., Saudi Pharm J. 2020 May;28(5):607-614. doi: 10.1016/j.jsps.2020.03.013. Epub 2020 Apr 2.
2. Decreased poly(ADP-ribosyl)ation of CTCF, a transcription factor, is associated with breast cancer phenotype and cell proliferation. Docquier F, etal., Clin Cancer Res. 2009 Sep 15;15(18):5762-71. doi: 10.1158/1078-0432.CCR-09-0329. Epub 2009 Sep 8.
3. Transgenic RNAi reveals essential function for CTCF in H19 gene imprinting. Fedoriw AM, etal., Science 2004 Jan 9;303(5655):238-40.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. PARP1 Stabilizes CTCF Binding and Chromatin Structure To Maintain Epstein-Barr Virus Latency Type. Lupey-Green LN, etal., J Virol. 2018 Aug 29;92(18). pii: JVI.00755-18. doi: 10.1128/JVI.00755-18. Print 2018 Sep 15.
7. Changes in the DNA methylation profile of the rat H19 gene upstream region during development and transgenic hepatocarcinogenesis and its role in the imprinted transcriptional regulation of the H19 gene. Manoharan H, etal., Mol Carcinog 2004 Sep;41(1):1-16.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. Identification of miR-34 regulatory networks in settings of disease and antimiR-therapy: Implications for treating cardiac pathology and other diseases. Ooi JY, etal., RNA Biol. 2016 Apr 28:1-14.
12. Functional Mutations Form at CTCF-Cohesin Binding Sites in Melanoma Due to Uneven Nucleotide Excision Repair across the Motif. Poulos RC, etal., Cell Rep. 2016 Dec 13;17(11):2865-2872. doi: 10.1016/j.celrep.2016.11.055.
13. Expression of the transcription factor CTCF in invasive breast cancer: a candidate gene located at 16q22.1. Rakha EA, etal., Br J Cancer. 2004 Oct 18;91(8):1591-6. doi: 10.1038/sj.bjc.6602144.
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Restraint of angiogenesis by zinc finger transcription factor CTCF-dependent chromatin insulation. Tang M, etal., Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15231-6. doi: 10.1073/pnas.1104662108. Epub 2011 Sep 6.
18. Targeting of CTCF to the nucleolus inhibits nucleolar transcription through a poly(ADP-ribosyl)ation-dependent mechanism. Torrano V, etal., J Cell Sci. 2006 May 1;119(Pt 9):1746-59. doi: 10.1242/jcs.02890. Epub 2006 Apr 4.
19. Interactive actions of Bdnf methylation and cell metabolism for building neural resilience under the influence of diet. Tyagi E, etal., Neurobiol Dis. 2015 Jan;73:307-18. doi: 10.1016/j.nbd.2014.09.014. Epub 2014 Oct 2.
20. CTCF is essential for up-regulating expression from the amyloid precursor protein promoter during differentiation of primary hippocampal neurons. Yang Y, etal., J Neurochem 1999 Dec;73(6):2286-98.
21. NF-kappa B mediated up-regulation of CCCTC-binding factor in pediatric acute lymphoblastic leukemia. Zhang H, etal., Mol Cancer. 2014 Jan 7;13:5. doi: 10.1186/1476-4598-13-5.
Additional References at PubMed
PMID:8649389   PMID:9407128   PMID:9591631   PMID:11743158   PMID:12011441   PMID:12075007   PMID:12461525   PMID:15143173   PMID:15340049   PMID:15572351   PMID:16107875   PMID:16815976  
PMID:16951251   PMID:17827499   PMID:18347100   PMID:18413740   PMID:18550811   PMID:18614575   PMID:18654629   PMID:19322193   PMID:22780989   PMID:23804403   PMID:24105743   PMID:26321640  
PMID:28319062   PMID:29712779   PMID:32125046   PMID:35927544   PMID:38774923  


Genomics

Comparative Map Data
Ctcf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81950,431,478 - 50,481,013 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1950,431,689 - 50,481,012 (+)EnsemblGRCr8
mRatBN7.21933,521,726 - 33,571,124 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1933,529,319 - 33,571,123 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1940,337,528 - 40,386,695 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01940,990,859 - 41,040,027 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01943,288,547 - 43,337,784 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01937,600,151 - 37,649,674 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1937,600,148 - 37,649,673 (+)Ensemblrn6Rnor6.0
Rnor_5.01948,467,547 - 48,516,378 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41935,461,942 - 35,514,934 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1932,950,156 - 32,999,072 (+)NCBICelera
RGSC_v3.11935,466,822 - 35,519,814 (+)NCBI
Cytogenetic Map19q12NCBI
CTCF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381667,562,526 - 67,639,177 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1667,561,831 - 67,639,189 (+)Ensemblhg38GRCh38
GRCh371667,596,429 - 67,673,088 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361666,153,965 - 66,230,589 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341666,153,963 - 66,230,580NCBI
Celera1652,104,229 - 52,181,578 (+)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1653,469,579 - 53,546,004 (+)NCBIHuRef
CHM1_11669,003,654 - 69,080,781 (+)NCBICHM1_1
T2T-CHM13v2.01673,357,293 - 73,433,946 (+)NCBIT2T-CHM13v2.0
Ctcf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398106,351,135 - 106,409,554 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8106,363,200 - 106,409,554 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm388105,636,474 - 105,682,922 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8105,636,568 - 105,682,922 (+)Ensemblmm10GRCm38
MGSCv378108,160,438 - 108,206,822 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368108,525,670 - 108,572,051 (+)NCBIMGSCv36mm8
Celera8109,860,822 - 109,907,765 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.04NCBI
Ctcf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554849,042,524 - 9,064,927 (-)Ensembl
ChiLan1.0NW_0049554849,041,226 - 9,092,924 (-)NCBIChiLan1.0ChiLan1.0
CTCF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21877,090,712 - 77,167,572 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11683,003,393 - 83,080,048 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01647,906,503 - 47,983,271 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11667,302,952 - 67,372,041 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1667,302,952 - 67,372,041 (+)EnsemblpanPan2panpan1.1
CTCF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1581,808,512 - 81,863,811 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl581,809,393 - 81,858,655 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha581,798,220 - 81,853,471 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0582,243,654 - 82,298,999 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl582,243,653 - 82,298,955 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1582,069,946 - 82,125,241 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0581,751,450 - 81,806,353 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0582,394,029 - 82,449,348 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ctcf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934941,557,377 - 41,601,957 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647517,987,156 - 18,031,760 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647517,987,137 - 18,031,733 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTCF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl628,195,647 - 28,261,009 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1628,188,002 - 28,261,009 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2625,467,984 - 25,508,432 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CTCF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1559,806,753 - 59,889,534 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl559,806,551 - 59,880,049 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604722,559,050 - 22,640,771 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ctcf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474618,706,663 - 18,760,203 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474618,705,017 - 18,760,345 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ctcf
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11725,368,857 - 25,417,192 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ctcf
264 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:182
Count of miRNA genes:133
Interacting mature miRNAs:167
Transcripts:ENSRNOT00000023853
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)191922068964220689Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19799775052997750Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)193128753251431640Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19799775052997750Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)194072709254856850Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19799775052997750Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)19574806450748064Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19799775052997750Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)194072709254856850Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)194072709254856850Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat

Markers in Region
D19Got22  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21933,533,967 - 33,534,109 (+)MAPPERmRatBN7.2
Rnor_6.01937,612,505 - 37,612,646NCBIRnor6.0
Rnor_5.01948,479,438 - 48,479,579UniSTSRnor5.0
RGSC_v3.41935,478,000 - 35,478,142RGDRGSC3.4
RGSC_v3.41935,478,001 - 35,478,142UniSTSRGSC3.4
Celera1932,962,063 - 32,962,204UniSTS
RGSC_v3.11935,482,882 - 35,483,023RGD
RH 3.4 Map19342.5RGD
RH 3.4 Map19342.5UniSTS
Cytogenetic Map19q12UniSTS
U51037  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81950,479,794 - 50,479,968 (+)Marker Load Pipeline
mRatBN7.21933,569,905 - 33,570,078 (+)MAPPERmRatBN7.2
Rnor_6.01937,648,456 - 37,648,628NCBIRnor6.0
Rnor_5.01948,515,160 - 48,515,332UniSTSRnor5.0
RGSC_v3.41935,513,716 - 35,513,888UniSTSRGSC3.4
Celera1932,997,854 - 32,998,026UniSTS
Cytogenetic Map19q12UniSTS
WI-21064  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21933,570,330 - 33,570,615 (+)MAPPERmRatBN7.2
Rnor_6.01937,648,881 - 37,649,165NCBIRnor6.0
Rnor_5.01948,515,585 - 48,515,869UniSTSRnor5.0
RGSC_v3.41935,514,141 - 35,514,425UniSTSRGSC3.4
Celera1932,998,279 - 32,998,563UniSTS
Cytogenetic Map19q12UniSTS
Ctcf  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21933,570,970 - 33,571,093 (+)MAPPERmRatBN7.2
Rnor_6.01937,649,521 - 37,649,643NCBIRnor6.0
Rnor_5.01948,516,225 - 48,516,347UniSTSRnor5.0
RGSC_v3.41935,514,781 - 35,514,903UniSTSRGSC3.4
Celera1932,998,919 - 32,999,041UniSTS
Cytogenetic Map19q12UniSTS
BF389170  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81950,474,395 - 50,474,992 (+)Marker Load Pipeline
mRatBN7.21933,564,506 - 33,565,103 (+)MAPPERmRatBN7.2
Rnor_6.01937,643,057 - 37,643,653NCBIRnor6.0
Rnor_5.01948,509,761 - 48,510,357UniSTSRnor5.0
RGSC_v3.41935,508,317 - 35,508,913UniSTSRGSC3.4
Celera1932,992,455 - 32,993,051UniSTS
RH 3.4 Map19331.5UniSTS
Cytogenetic Map19q12UniSTS
MARC_20750-20751:1025022208:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21933,569,658 - 33,570,173 (+)MAPPERmRatBN7.2
Rnor_6.01937,648,209 - 37,648,723NCBIRnor6.0
Rnor_5.01948,514,913 - 48,515,427UniSTSRnor5.0
RGSC_v3.41935,513,469 - 35,513,983UniSTSRGSC3.4
Celera1932,997,607 - 32,998,121UniSTS
Cytogenetic Map19q12UniSTS
CTCF_3772  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21933,570,396 - 33,571,121 (+)MAPPERmRatBN7.2
Rnor_6.01937,648,947 - 37,649,671NCBIRnor6.0
Rnor_5.01948,515,651 - 48,516,375UniSTSRnor5.0
RGSC_v3.41935,514,207 - 35,514,931UniSTSRGSC3.4
Celera1932,998,345 - 32,999,069UniSTS
Cytogenetic Map19q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000023853   ⟹   ENSRNOP00000023851
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1950,431,689 - 50,481,012 (+)Ensembl
mRatBN7.2 Ensembl1933,529,319 - 33,571,123 (+)Ensembl
Rnor_6.0 Ensembl1937,600,148 - 37,649,673 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119214   ⟹   ENSRNOP00000079098
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1933,549,556 - 33,571,123 (+)Ensembl
RefSeq Acc Id: NM_031824   ⟹   NP_114012
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,431,845 - 50,481,013 (+)NCBI
mRatBN7.21933,521,948 - 33,571,124 (+)NCBI
Rnor_6.01937,600,377 - 37,649,674 (+)NCBI
Rnor_5.01948,467,547 - 48,516,378 (+)NCBI
RGSC_v3.41935,461,942 - 35,514,934 (+)RGD
Celera1932,950,156 - 32,999,072 (+)RGD
Sequence:
RefSeq Acc Id: XM_006255536   ⟹   XP_006255598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,431,478 - 50,481,013 (+)NCBI
mRatBN7.21933,521,729 - 33,571,124 (+)NCBI
Rnor_6.01937,600,151 - 37,649,674 (+)NCBI
Rnor_5.01948,467,547 - 48,516,378 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039098033   ⟹   XP_038953961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,431,478 - 50,481,013 (+)NCBI
mRatBN7.21933,521,726 - 33,571,124 (+)NCBI
RefSeq Acc Id: XM_039098034   ⟹   XP_038953962
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,431,478 - 50,481,013 (+)NCBI
mRatBN7.21933,521,727 - 33,571,124 (+)NCBI
RefSeq Acc Id: XM_063278318   ⟹   XP_063134388
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,431,478 - 50,476,798 (+)NCBI
RefSeq Acc Id: NP_114012   ⟸   NM_031824
- UniProtKB: Q9R1D1 (UniProtKB/Swiss-Prot),   A0A8I5ZMQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255598   ⟸   XM_006255536
- Peptide Label: isoform X1
- UniProtKB: A0A0H2UHP0 (UniProtKB/TrEMBL),   A6IYR1 (UniProtKB/TrEMBL),   A0A8I5ZMQ8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023851   ⟸   ENSRNOT00000023853
RefSeq Acc Id: XP_038953961   ⟸   XM_039098033
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZMQ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953962   ⟸   XM_039098034
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZMQ8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000079098   ⟸   ENSRNOT00000119214
RefSeq Acc Id: XP_063134388   ⟸   XM_063278318
- Peptide Label: isoform X4
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R1D1-F1-model_v2 AlphaFold Q9R1D1 1-737 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701081
Promoter ID:EPDNEW_R11605
Type:initiation region
Name:Ctcf_1
Description:CCCTC-binding factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01937,600,220 - 37,600,280EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621344 AgrOrtholog
BioCyc Gene G2FUF-5820 BioCyc
Ensembl Genes ENSRNOG00000017674 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000023853 ENTREZGENE
Gene3D-CATH Classic Zinc Finger UniProtKB/Swiss-Prot
InterPro Zinc_finger UniProtKB/Swiss-Prot
  Znf-C2H2_CTCF UniProtKB/Swiss-Prot
  Znf_C2H2_sf UniProtKB/Swiss-Prot
  Znf_C2H2_type UniProtKB/Swiss-Prot
KEGG Report rno:83726 UniProtKB/Swiss-Prot
NCBI Gene 83726 ENTREZGENE
PANTHER GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED UniProtKB/Swiss-Prot
  PR DOMAIN ZINC FINGER PROTEIN UniProtKB/Swiss-Prot
Pfam zf-C2H2 UniProtKB/Swiss-Prot
  zf-C2H2_16 UniProtKB/Swiss-Prot
PhenoGen Ctcf PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017674 RatGTEx
SMART ZnF_C2H2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot
UniProt A0A0H2UHP0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZMQ8 ENTREZGENE
  A6IYR1 ENTREZGENE, UniProtKB/TrEMBL
  CTCF_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Ctcf  CCCTC-binding factor  Ctcf  CCCTC-binding factor (zinc finger protein)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Ctcf  CCCTC-binding factor (zinc finger protein)  Ctcf  CCCTC-binding factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Ctcf  CCCTC-binding factor    CCCTC-binding factor (zinc finger protein)  Name updated 1299863 APPROVED
2002-08-07 Ctcf  CCCTC-binding factor (zinc finger protein)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process required for normal preimplantation development 1302226