Symbol:
Hes3
Name:
hes family bHLH transcription factor 3
RGD ID:
621339
Description:
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of DNA-templated transcription. Predicted to be active in nucleus. Orthologous to human HES3 (hes family bHLH transcription factor 3); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 6-propyl-2-thiouracil; all-trans-retinoic acid.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
hairy and enhancer of split 3; hairy and enhancer of split 3 (Drosophila); transcription factor HES-3
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 5 168,076,337 - 168,082,270 (-) NCBI GRCr8 GRCr8 GRCr8 GRCr8 Ensembl 5 168,077,093 - 168,078,987 (-) Ensembl GRCr8 mRatBN7.2 5 162,793,611 - 162,799,578 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 5 162,794,367 - 162,796,261 (-) Ensembl mRatBN7.2 UTH_Rnor_SHR_Utx 5 165,497,390 - 165,499,284 (-) NCBI UTH_Rnor_SHR_Utx UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 5 167,318,992 - 167,320,886 (-) NCBI UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 5 167,281,192 - 167,283,086 (-) NCBI UTH_Rnor_WKY_Bbb_1.0 UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 5 169,463,196 - 169,469,795 (-) NCBI Rnor_6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 5 169,464,989 - 169,467,153 (-) Ensembl rn6 Rnor6.0 Rnor_5.0 5 173,017,857 - 173,020,507 (-) NCBI Rnor_5.0 Rnor_5.0 rn5 RGSC_v3.4 5 169,516,965 - 169,518,859 (-) NCBI RGSC_v3.4 RGSC_v3.4 rn4 Celera 5 161,025,648 - 161,027,542 (-) NCBI Celera RGSC_v3.1 5 169,527,152 - 169,529,047 (-) NCBI Cytogenetic Map 5 q36 NCBI
JBrowse:
Only show annotations with direct experimental evidence (0 objects hidden)
Hes3 Rat 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactions ISO Hes3 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Hes3 Rat 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Hes3 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Hes3 Rat 2,2',5,5'-tetrachlorobiphenyl increases expression EXP 6480464 2,5,2',5'-tetrachlorobiphenyl results in increased expression of HES3 mRNA CTD PMID:23829299 Hes3 Rat 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO Hes3 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Hes3 Rat 2,4,4'-trichlorobiphenyl multiple interactions ISO Hes3 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Hes3 Rat 3',5'-cyclic AMP multiple interactions ISO HES3 (Homo sapiens) 6480464 [BDNF protein co-treated with GDNF protein co-treated with Cyclic AMP co-treated with TGFB3 protein co-treated more ... CTD PMID:33713149 Hes3 Rat 3,3',5,5'-tetrabromobisphenol A decreases expression ISO HES3 (Homo sapiens) 6480464 tetrabromobisphenol A results in decreased expression of HES3 mRNA CTD PMID:31326446 Hes3 Rat 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of HES3 mRNA CTD PMID:24780913 Hes3 Rat all-trans-retinoic acid decreases expression EXP 6480464 Tretinoin results in decreased expression of HES3 mRNA CTD PMID:20488242 Hes3 Rat ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of HES3 mRNA CTD PMID:16483693 Hes3 Rat benzo[a]pyrene increases methylation ISO HES3 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of HES3 5' UTR; Benzo(a)pyrene results in increased methylation of more ... CTD PMID:27901495 Hes3 Rat benzo[a]pyrene affects methylation ISO HES3 (Homo sapiens) 6480464 Benzo(a)pyrene affects the methylation of HES3 promoter CTD PMID:27901495 Hes3 Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of HES3 mRNA CTD PMID:25181051|PMID:41034487 Hes3 Rat Butylbenzyl phthalate increases methylation ISO Hes3 (Mus musculus) 6480464 butylbenzyl phthalate results in increased methylation of HES3 promoter CTD PMID:28392331 Hes3 Rat C60 fullerene decreases expression EXP 6480464 fullerene C60 results in decreased expression of HES3 mRNA CTD PMID:19167457 Hes3 Rat cadmium atom increases expression ISO HES3 (Homo sapiens) 6480464 Cadmium results in increased expression of HES3 mRNA CTD PMID:24376830 Hes3 Rat decabromodiphenyl ether decreases expression ISO HES3 (Homo sapiens) 6480464 decabromobiphenyl ether results in decreased expression of HES3 mRNA CTD PMID:31326446 Hes3 Rat ethylparaben decreases expression ISO HES3 (Homo sapiens) 6480464 ethyl-p-hydroxybenzoate results in decreased expression of HES3 mRNA CTD PMID:37690743 Hes3 Rat hexaconazole decreases expression ISO Hes3 (Mus musculus) 6480464 hexaconazole results in decreased expression of HES3 mRNA CTD PMID:22045034 Hes3 Rat L-ascorbic acid multiple interactions ISO HES3 (Homo sapiens) 6480464 [BDNF protein co-treated with GDNF protein co-treated with Cyclic AMP co-treated with TGFB3 protein co-treated more ... CTD PMID:33713149 Hes3 Rat maneb multiple interactions ISO Hes3 (Mus musculus) 6480464 [Paraquat co-treated with Maneb] affects the expression of HES3 mRNA CTD PMID:22563483 Hes3 Rat methylmercury chloride affects expression EXP 6480464 methylmercuric chloride affects the expression of HES3 mRNA CTD PMID:20864626 Hes3 Rat N-ethyl-N-nitrosourea increases mutagenesis ISO Hes3 (Mus musculus) 6480464 Ethylnitrosourea results in increased mutagenesis of HES3 mRNA CTD PMID:27776689 Hes3 Rat N-methyl-4-phenylpyridinium decreases expression ISO HES3 (Homo sapiens) 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of HES3 mRNA CTD PMID:24810058 Hes3 Rat paraquat multiple interactions ISO Hes3 (Mus musculus) 6480464 [Paraquat co-treated with Maneb] affects the expression of HES3 mRNA CTD PMID:22563483 Hes3 Rat PCB138 multiple interactions ISO Hes3 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Hes3 Rat pirinixic acid increases expression ISO Hes3 (Mus musculus) 6480464 pirinixic acid results in increased expression of HES3 mRNA CTD PMID:20813756 Hes3 Rat potassium dichromate decreases expression ISO Hes3 (Mus musculus) 6480464 Potassium Dichromate results in decreased expression of HES3 mRNA CTD PMID:23608068 Hes3 Rat sodium fluoride decreases expression ISO Hes3 (Mus musculus) 6480464 Sodium Fluoride results in decreased expression of HES3 mRNA CTD PMID:27862939 Hes3 Rat Tetrachlorobisphenol A decreases expression ISO HES3 (Homo sapiens) 6480464 tetrachlorodian results in decreased expression of HES3 mRNA CTD PMID:31326446 Hes3 Rat thimerosal decreases expression ISO Hes3 (Mus musculus) 6480464 Thimerosal results in decreased expression of HES3 mRNA CTD PMID:24675092 Hes3 Rat titanium dioxide decreases methylation ISO Hes3 (Mus musculus) 6480464 titanium dioxide results in decreased methylation of HES3 gene CTD PMID:35295148 Hes3 Rat titanium dioxide increases expression ISO Hes3 (Mus musculus) 6480464 titanium dioxide results in increased expression of HES3 mRNA CTD PMID:35295148 Hes3 Rat triptonide increases expression ISO Hes3 (Mus musculus) 6480464 triptonide results in increased expression of HES3 mRNA CTD PMID:33045310 Hes3 Rat valproic acid decreases expression ISO Hes3 (Mus musculus) 6480464 Valproic Acid results in decreased expression of HES3 mRNA CTD PMID:22045034