Hes3 (hes family bHLH transcription factor 3) - Rat Genome Database

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Pathways
Gene: Hes3 (hes family bHLH transcription factor 3) Rattus norvegicus
Analyze
Symbol: Hes3
Name: hes family bHLH transcription factor 3
RGD ID: 621339
Description: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of DNA-templated transcription. Predicted to be active in nucleus. Orthologous to human HES3 (hes family bHLH transcription factor 3); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 6-propyl-2-thiouracil; all-trans-retinoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hairy and enhancer of split 3; hairy and enhancer of split 3 (Drosophila); transcription factor HES-3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85168,076,337 - 168,082,270 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5168,077,093 - 168,078,987 (-)EnsemblGRCr8
mRatBN7.25162,793,611 - 162,799,578 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5162,794,367 - 162,796,261 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5165,497,390 - 165,499,284 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05167,318,992 - 167,320,886 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05167,281,192 - 167,283,086 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05169,463,196 - 169,469,795 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5169,464,989 - 169,467,153 (-)Ensemblrn6Rnor6.0
Rnor_5.05173,017,857 - 173,020,507 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45169,516,965 - 169,518,859 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5161,025,648 - 161,027,542 (-)NCBICelera
RGSC_v3.15169,527,152 - 169,529,047 (-)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split. Sasai Y, etal., Genes Dev 1992 Dec;6(12B):2620-34.
Additional References at PubMed
PMID:10858455   PMID:11500373   PMID:11522634   PMID:19050759  


Genomics

Comparative Map Data
Hes3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85168,076,337 - 168,082,270 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5168,077,093 - 168,078,987 (-)EnsemblGRCr8
mRatBN7.25162,793,611 - 162,799,578 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5162,794,367 - 162,796,261 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5165,497,390 - 165,499,284 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05167,318,992 - 167,320,886 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05167,281,192 - 167,283,086 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05169,463,196 - 169,469,795 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5169,464,989 - 169,467,153 (-)Ensemblrn6Rnor6.0
Rnor_5.05173,017,857 - 173,020,507 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45169,516,965 - 169,518,859 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5161,025,648 - 161,027,542 (-)NCBICelera
RGSC_v3.15169,527,152 - 169,529,047 (-)NCBI
Cytogenetic Map5q36NCBI
HES3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3816,244,179 - 6,245,578 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl16,244,179 - 6,245,578 (+)Ensemblhg38GRCh38
GRCh3716,304,239 - 6,305,638 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3616,226,849 - 6,228,225 (+)NCBIBuild 36Build 36hg18NCBI36
Celera15,418,756 - 5,420,142 (+)NCBICelera
Cytogenetic Map1p36.31NCBI
HuRef15,452,365 - 5,454,401 (+)NCBIHuRef
CHM1_116,292,896 - 6,294,282 (+)NCBICHM1_1
T2T-CHM13v2.015,769,823 - 5,771,222 (+)NCBIT2T-CHM13v2.0
Hes3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394152,369,707 - 152,376,133 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4152,370,429 - 152,376,119 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm384152,285,250 - 152,291,911 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4152,285,972 - 152,291,662 (-)Ensemblmm10GRCm38
MGSCv374151,660,081 - 151,665,771 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364151,129,772 - 151,135,462 (-)NCBIMGSCv36mm8
Celera4154,572,853 - 154,579,001 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map483.01NCBI
Hes3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554866,272,757 - 6,273,721 (-)Ensembl
ChiLan1.0NW_0049554866,272,757 - 6,273,721 (-)NCBIChiLan1.0ChiLan1.0
HES3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21221,977,474 - 221,981,958 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11220,618,837 - 220,623,273 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v015,008,155 - 5,012,868 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.116,264,032 - 6,268,002 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl16,265,738 - 6,266,937 (+)EnsemblpanPan2panpan1.1
HES3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1560,134,351 - 60,136,924 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl560,135,918 - 60,136,924 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha560,145,732 - 60,146,738 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0560,351,678 - 60,353,519 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl560,351,678 - 60,352,684 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1560,351,013 - 60,352,019 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0560,217,827 - 60,219,665 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0560,619,280 - 60,620,286 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hes3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505830,607,847 - 30,613,685 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366231,096,870 - 1,097,858 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366231,096,519 - 1,098,175 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HES3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl667,133,482 - 67,135,292 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1667,134,259 - 67,138,639 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2662,038,600 - 62,042,601 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HES3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120125,493,703 - 125,500,577 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605429,600,131 - 29,601,550 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hes3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248185,153,717 - 5,161,026 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248185,156,428 - 5,160,858 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Hes3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v118,452,034 - 8,457,280 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:63
Count of miRNA genes:56
Interacting mature miRNAs:61
Transcripts:ENSRNOT00000014536
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5149642129171146538Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5160111176171146538Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5156396728172190305Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5156289283171137955Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5160071170172129029Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
1 1 23 89 18 18 11 14 11 4 67 48 8 76 7 32 7 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000014536   ⟹   ENSRNOP00000014535
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5168,077,093 - 168,078,987 (-)Ensembl
mRatBN7.2 Ensembl5162,794,367 - 162,796,261 (-)Ensembl
Rnor_6.0 Ensembl5169,464,989 - 169,467,153 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118276   ⟹   ENSRNOP00000088398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5168,077,093 - 168,078,462 (-)Ensembl
mRatBN7.2 Ensembl5162,794,367 - 162,795,698 (-)Ensembl
RefSeq Acc Id: NM_022687   ⟹   NP_073178
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85168,077,093 - 168,078,987 (-)NCBI
mRatBN7.25162,794,367 - 162,796,261 (-)NCBI
Rnor_6.05169,465,274 - 169,467,168 (-)NCBI
Rnor_5.05173,017,857 - 173,020,507 (-)NCBI
RGSC_v3.45169,516,965 - 169,518,859 (-)RGD
Celera5161,025,648 - 161,027,542 (-)RGD
Sequence:
RefSeq Acc Id: XM_008764381   ⟹   XP_008762603
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85168,076,337 - 168,082,270 (-)NCBI
mRatBN7.25162,793,611 - 162,799,578 (-)NCBI
Rnor_6.05169,463,196 - 169,469,774 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017593612   ⟹   XP_017449101
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85168,076,337 - 168,081,470 (-)NCBI
mRatBN7.25162,793,611 - 162,798,650 (-)NCBI
Rnor_6.05169,463,196 - 169,469,656 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017593614   ⟹   XP_017449103
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85168,076,337 - 168,081,470 (-)NCBI
mRatBN7.25162,793,611 - 162,798,650 (-)NCBI
Rnor_6.05169,463,196 - 169,469,656 (-)NCBI
Sequence:
RefSeq Acc Id: NP_073178   ⟸   NM_022687
- UniProtKB: Q04667 (UniProtKB/Swiss-Prot),   A6IUH9 (UniProtKB/TrEMBL),   A0A8I6AIT4 (UniProtKB/TrEMBL),   A6IUH8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008762603   ⟸   XM_008764381
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017449103   ⟸   XM_017593614
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017449101   ⟸   XM_017593612
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000014535   ⟸   ENSRNOT00000014536
Ensembl Acc Id: ENSRNOP00000088398   ⟸   ENSRNOT00000118276
Protein Domains
bHLH   Orange

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q04667-F1-model_v2 AlphaFold Q04667 1-175 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621339 AgrOrtholog
BioCyc Gene G2FUF-39016 BioCyc
Ensembl Genes ENSRNOG00000010893 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014536 ENTREZGENE
  ENSRNOT00000014536.4 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot
InterPro bHLH_dom UniProtKB/Swiss-Prot
  HES_HEY UniProtKB/Swiss-Prot
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot
  Orange_dom UniProtKB/Swiss-Prot
KEGG Report rno:64628 UniProtKB/Swiss-Prot
NCBI Gene 64628 ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED UniProtKB/Swiss-Prot
Pfam HLH UniProtKB/Swiss-Prot
PhenoGen Hes3 PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot
  ORANGE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010893 RatGTEx
SMART HLH UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot
UniProt A0A8I6AIT4 ENTREZGENE, UniProtKB/TrEMBL
  A6IUH8 ENTREZGENE, UniProtKB/TrEMBL
  A6IUH9 ENTREZGENE, UniProtKB/TrEMBL
  HES3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-11 Hes3  hes family bHLH transcription factor 3  Hes3  hairy and enhancer of split 3 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Hes3  hairy and enhancer of split 3 (Drosophila)    transcription factor HES-3  Name updated 1299863 APPROVED
2002-08-07 Hes3  transcription factor HES-3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed only in cerebellar Purkinje cells 61625