Map1lc3b (microtubule-associated protein 1 light chain 3 beta) - Rat Genome Database

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Gene: Map1lc3b (microtubule-associated protein 1 light chain 3 beta) Rattus norvegicus
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Symbol: Map1lc3b (Ensembl: Map1lc3b2)
Name: microtubule-associated protein 1 light chain 3 beta (Ensembl:microtubule-associated protein 1 light chain 3 beta 2)
RGD ID: 621315
Description: Enables microtubule binding activity and protein domain specific binding activity. Predicted to be involved in cellular response to nitrogen starvation and macroautophagy. Predicted to act upstream of or within positive regulation of mucus secretion. Located in several cellular components, including autophagosome membrane; dendrite; and neuronal cell body. Part of microtubule associated complex. Is active in presynapse. Orthologous to several human genes including MAP1LC3B (microtubule associated protein 1 light chain 3 beta); PARTICIPATES IN autophagy pathway; INTERACTS WITH 1,3-dichloropropan-2-ol; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: autophagy-related protein LC3 B; autophagy-related ubiquitin-like modifier LC3 B; LC3B; MAP1 light chain 3-like protein 2; MAP1A/1B light chain 3 B; MAP1A/MAP1B LC3 B; MAP1A/MAP1B light chain 3 B; Map1lc3; MGC93422; microtubule-associated proteins 1A/1B light chain 3; microtubule-associated proteins 1A/1B light chain 3B; MPL3; zbs559
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Map1lc3b2  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81966,571,631 - 66,582,270 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1677,696,531 - 77,697,009 (-)EnsemblGRCr8
GRCr8 Ensembl1966,574,407 - 66,584,358 (+)EnsemblGRCr8
mRatBN7.21949,665,795 - 49,673,655 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1670,994,128 - 70,994,606 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl1949,665,791 - 49,677,690 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1956,456,727 - 56,464,411 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01957,140,942 - 57,148,612 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01959,355,262 - 59,362,946 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01953,635,449 - 53,643,970 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1953,629,779 - 53,646,058 (+)Ensemblrn6Rnor6.0
Rnor_5.01964,373,068 - 64,381,400 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41951,847,187 - 51,854,858 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1948,912,797 - 48,920,467 (+)NCBICelera
RGSC_v3.11951,852,067 - 51,859,738 (+)NCBI
Cytogenetic Map19q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dichloropropan-2-ol  (EXP)
1-monopalmitoylglycerol  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-D  (EXP,ISO)
2-(tert-butylimino)-5-phenyl-3-(propan-2-yl)-1,3,5-thiadiazinan-4-one  (ISO)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
2-deoxy-D-glucose  (ISO)
2-hydroxyethyl methacrylate  (ISO)
25-hydroxycholesterol  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3-methyladenine  (EXP,ISO)
3-Nitrofluoranthene  (ISO)
3-nitropropanoic acid  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4,5,6,7-TETRABROMOBENZOTRIAZOLE  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methoxy-TEMPO  (ISO)
4-phenylbutyric acid  (EXP,ISO)
5,7-dihydroxy-4'-methoxyflavone  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7-ketocholesterol  (ISO)
abamectin  (EXP)
Abemaciclib  (ISO)
ABT-737  (ISO)
acadesine  (ISO)
acetaldehyde  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
acrylonitrile  (ISO)
actinomycin D  (ISO)
Aescin  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldrin  (ISO)
alginic acid  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (ISO)
aloxistatin  (ISO)
alpha,alpha-trehalose  (EXP,ISO)
alpha-amanitin  (EXP,ISO)
Alpinetin  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP,ISO)
amphotericin B  (ISO)
amsacrine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimony(0)  (ISO)
antimycin A  (ISO)
apigenin  (ISO)
apocynin  (EXP)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
artesunate  (ISO)
asperuloside  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (EXP)
atrazine  (ISO)
auramine O  (ISO)
AZD4547  (ISO)
AZD8186  (ISO)
azoxystrobin  (ISO)
bafilomycin A1  (EXP,ISO)
Bafilomycin B1  (ISO)
BAPTA  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (EXP,ISO)
beta-ionone  (ISO)
beta-lapachone  (ISO)
betulinic acid  (ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
brefeldin A  (ISO)
buprofezin  (ISO)
buspirone  (EXP)
busulfan  (ISO)
butachlor  (ISO)
butanal  (ISO)
butein  (ISO)
C60 fullerene  (EXP)
cadmium acetate  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calcidiol  (ISO)
calcitriol  (ISO)
calix[6]arene  (ISO)
Calpeptin  (ISO)
canagliflozin  (ISO)
capivasertib  (ISO)
carbamazepine  (EXP)
carbon disulfide  (ISO)
carbon nanotube  (EXP,ISO)
carfilzomib  (ISO)
carglumic acid  (ISO)
carteolol  (ISO)
carvacrol  (EXP)
CCCP  (ISO)
celecoxib  (ISO)
cerium trichloride  (ISO)
CGP 52608  (ISO)
CGS-21680  (ISO)
chenodeoxycholic acid  (ISO)
chloropicrin  (ISO)
chloroquine  (EXP,ISO)
chlorotoluron  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (ISO)
cholic acid  (ISO)
chromium(6+)  (ISO)
chrysin  (EXP)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
Citreoviridin  (EXP,ISO)
clobetasol  (ISO)
clofibrate  (EXP,ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
colistin  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corticosterone  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
crocin-1  (EXP)
Cryptotanshinone  (ISO)
curcumin  (EXP,ISO)
Curcumol  (EXP)
cyanamide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (EXP,ISO)
D-glucose  (EXP,ISO)
D-mannopyranose  (ISO)
dapagliflozin  (EXP)
DDE  (ISO)
deguelin  (ISO)
Dehydroeburicoic acid  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenzofuran  (ISO)
Dibromoacetonitrile  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dideuterium oxide  (ISO)
diethyl malate  (ISO)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
diosgenin  (EXP,ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (ISO)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
EHT 1864  (ISO)
elemental selenium  (EXP)
entinostat  (ISO)
enzalutamide  (ISO)
erastin  (EXP)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
everolimus  (ISO)
fangchinoline  (ISO)
fenofibrate  (ISO)
ferric ammonium citrate  (ISO)
ferric oxide  (ISO)
ferrostatin-1  (EXP)
finasteride  (EXP)
flavokawain B  (ISO)
flavonoids  (EXP)
flutamide  (EXP,ISO)
folic acid  (ISO)
fomepizole  (ISO)
formaldehyde  (EXP,ISO)
Forsythiaside  (ISO)
fructose  (EXP)
fumonisin B1  (ISO)
gamma-hexachlorocyclohexane  (EXP)
Garcinol  (ISO)
gefitinib  (ISO)
gingerol  (ISO)
Ginkgoic acid  (ISO)
ginsenoside Rb1  (EXP,ISO)
ginsenoside Rg2  (ISO)
Ginsenoside Rg5  (ISO)
glafenine  (EXP)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
glycerol 2-phosphate  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhizinic acid  (EXP)
hemin  (ISO)
hesperidin  (EXP)
hexadecanoic acid  (EXP,ISO)
Honokiol  (ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
indoxyl sulfate  (ISO)
inositol  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
Isobavachin  (ISO)
isoliquiritigenin  (ISO)
ivermectin  (ISO)
JTE-013  (EXP)
juglone  (ISO)
Jujuboside A  (ISO)
kainic acid  (EXP)
L-ascorbic acid 2-phosphate  (ISO)
L-leucine  (ISO)
L-serine  (EXP)
lactucin  (ISO)
lactulose  (ISO)
lanthanum trichloride  (EXP,ISO)
lead diacetate  (EXP)
lead nitrate  (ISO)
lead(0)  (EXP,ISO)
leflunomide  (EXP,ISO)
levofloxacin  (ISO)
lipopolysaccharide  (EXP,ISO)
luteolin  (ISO)
LY294002  (EXP,ISO)
lycopene  (EXP,ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
melibiose  (ISO)
menadione  (ISO)
mercury dichloride  (EXP)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylphenidate  (EXP,ISO)
metyrapone  (ISO)
miconazole  (ISO)
Mitoquinone  (ISO)
mitoxantrone  (ISO)
MJN110  (ISO)
MK-2206  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
myriocin  (ISO)
N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-acylsphinganine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
NADP zwitterion  (EXP)
NADP(+)  (EXP)
Naftopidil  (ISO)
nefazodone  (EXP,ISO)
nelfinavir  (ISO)
nickel dichloride  (ISO)
niclosamide  (ISO)
nicotinamide  (ISO)
nimesulide  (EXP)
Nivalenol  (ISO)
nobiletin  (ISO)
Nonylphenol  (EXP)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
octadecanoic acid  (ISO)
octreotide  (ISO)
okadaic acid  (ISO)
olaparib  (EXP,ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
Ophiopogonin D  (ISO)
osthole  (EXP)
oxidopamine  (EXP)
ozone  (ISO)
paclitaxel  (EXP,ISO)
paracetamol  (EXP,ISO)
paraformaldehyde macromolecule  (ISO)
paraquat  (ISO)
parthenolide  (ISO)
PD 0325901  (ISO)
pectolinarigenin  (ISO)
Pentoxifylline  (EXP)
pepstatin A  (ISO)
perfluorobutyric acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (EXP)
permethrin  (ISO)
phenobarbital  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylethanolamine  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
PNU-282987  (EXP)
potassium chromate  (ISO)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
procyanidin B2  (ISO)
propofol  (ISO)
protosappanin A  (EXP)
pterostilbene  (ISO)
puerarin  (EXP)
quercetin  (EXP,ISO)
quetiapine fumarate  (ISO)
rac-1-monopalmitoylglycerol  (ISO)
radon atom  (ISO)
radon(0)  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (ISO)
rotenone  (EXP,ISO)
roxadustat  (EXP)
ruthenium red  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
SCH772984  (ISO)
selenium atom  (EXP)
selenomethionine  (ISO)
sepantronium  (ISO)
serpentine asbestos  (ISO)
sertraline  (ISO)
sevoflurane  (EXP,ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP,ISO)
Soman  (EXP)
sphingosine 1-phosphate  (EXP)
spironolactone  (EXP)
stattic  (ISO)
streptozocin  (EXP)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sulfur dioxide  (EXP)
swainsonine  (EXP,ISO)
T-2 toxin  (EXP,ISO)
tamoxifen  (ISO)
Tartrolon D  (ISO)
taurine  (ISO)
taurocholic acid  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thapsigargin  (EXP,ISO)
Theaflavin 3,3'-digallate  (ISO)
thiabendazole  (ISO)
thiamet G  (EXP)
thiamine(1+) chloride  (EXP,ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
toosendanin  (ISO)
trametinib  (ISO)
tricalcium bis(phosphate)  (ISO)
trichostatin A  (EXP,ISO)
triclosan  (ISO)
trifloxystrobin  (ISO)
trimethyltin  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
trovafloxacin  (ISO)
tunicamycin  (EXP,ISO)
tyloxapol  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vanillin  (ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
vincristine  (EXP,ISO)
vismodegib  (ISO)
vorinostat  (EXP,ISO)
wortmannin  (ISO)
zearalenone  (EXP,ISO)
zinc atom  (EXP,ISO)
zinc oxide  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals. Andres-Alonso M, etal., Nat Commun. 2019 Nov 29;10(1):5448. doi: 10.1038/s41467-019-13224-z.
2. Network organization of the human autophagy system. Behrends C, etal., Nature. 2010 Jul 1;466(7302):68-76. Epub 2010 Jun 20.
3. A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers. Bergman MR, etal., Biochem J 2003 Feb 1;369(Pt 3):485-96.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. Kabeya Y, etal., J Cell Sci. 2004 Jun 1;117(Pt 13):2805-12.
6. Molecular characterization of light chain 3. A microtubule binding subunit of MAP1A and MAP1B. Mann SS and Hammarback JA, J Biol Chem 1994 Apr 15;269(15):11492-7.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Hepatic interferon regulatory factor 8 expression mediates liver ischemia/reperfusion injury in mice. Shi G, etal., Biochem Pharmacol. 2021 Oct;192:114728. doi: 10.1016/j.bcp.2021.114728. Epub 2021 Aug 13.
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
12. LC3 conjugation system in mammalian autophagy. Tanida I, etal., Int J Biochem Cell Biol. 2004 Dec;36(12):2503-18.
13. Molecular cloning and characterization of rat LC3A and LC3B--two novel markers of autophagosome. Wu J, etal., Biochem Biophys Res Commun. 2006 Jan 6;339(1):437-42. Epub 2005 Nov 14.
14. MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint. Yang H, etal., Autophagy. 2020 Feb;16(2):271-288. doi: 10.1080/15548627.2019.1606647. Epub 2019 Apr 21.
Additional References at PubMed
PMID:11060023   PMID:14760703   PMID:15095872   PMID:15489334   PMID:16854843   PMID:19279012   PMID:22783020   PMID:22948227   PMID:23629966   PMID:24089209   PMID:24185898   PMID:24351649  
PMID:24747438   PMID:25127057   PMID:25215947   PMID:25244949   PMID:25494214   PMID:26284655   PMID:27187184   PMID:27442348   PMID:28223137   PMID:29554128   PMID:29901175   PMID:31140414  
PMID:33391467   PMID:38651895  


Genomics

Comparative Map Data
Map1lc3b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81966,571,631 - 66,582,270 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1677,696,531 - 77,697,009 (-)EnsemblGRCr8
GRCr8 Ensembl1966,574,407 - 66,584,358 (+)EnsemblGRCr8
mRatBN7.21949,665,795 - 49,673,655 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1670,994,128 - 70,994,606 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl1949,665,791 - 49,677,690 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1956,456,727 - 56,464,411 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01957,140,942 - 57,148,612 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01959,355,262 - 59,362,946 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01953,635,449 - 53,643,970 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1953,629,779 - 53,646,058 (+)Ensemblrn6Rnor6.0
Rnor_5.01964,373,068 - 64,381,400 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41951,847,187 - 51,854,858 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1948,912,797 - 48,920,467 (+)NCBICelera
RGSC_v3.11951,852,067 - 51,859,738 (+)NCBI
Cytogenetic Map19q12NCBI
MAP1LC3B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381687,392,336 - 87,404,774 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1687,383,953 - 87,405,090 (+)Ensemblhg38GRCh38
GRCh371687,425,942 - 87,438,380 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361685,983,320 - 85,995,881 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341685,983,450 - 85,995,880NCBI
Celera1671,722,569 - 71,735,146 (+)NCBICelera
Cytogenetic Map16q24.2NCBI
HuRef1673,168,889 - 73,180,793 (+)NCBIHuRef
CHM1_11688,837,611 - 88,850,167 (+)NCBICHM1_1
T2T-CHM13v2.01693,463,228 - 93,475,656 (+)NCBIT2T-CHM13v2.0
Map1lc3b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398122,317,177 - 122,325,499 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8122,317,100 - 122,325,499 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm388121,590,438 - 121,598,760 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8121,590,361 - 121,598,760 (+)Ensemblmm10GRCm38
MGSCv378124,114,368 - 124,121,947 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368124,476,528 - 124,484,107 (+)NCBIMGSCv36mm8
Celera8125,811,811 - 125,819,390 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map870.67NCBI
Map1lc3b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555411,852,388 - 1,868,194 (+)Ensembl
ChiLan1.0NW_0049555411,852,388 - 1,868,194 (+)NCBIChiLan1.0ChiLan1.0
MAP1LC3B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21897,140,144 - 97,163,688 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan116103,065,985 - 103,080,043 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01668,063,869 - 68,076,772 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11687,393,976 - 87,399,736 (+)NCBIPanPan1.1PanPan1.1panPan2
MAP1LC3B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1565,669,553 - 65,683,445 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha565,681,248 - 65,695,108 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0565,891,103 - 65,905,466 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.1565,915,961 - 65,929,771 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0565,747,849 - 65,761,805 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0566,161,995 - 66,175,961 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
MAP1LC3B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl61,915,387 - 1,941,069 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.161,919,879 - 1,941,069 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.262,007,809 - 2,029,003 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAP1LC3B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1572,762,428 - 72,774,204 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl572,763,050 - 72,772,770 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660472,921,927 - 2,933,888 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map1lc3b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247463,084,392 - 3,094,250 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247463,084,418 - 3,094,250 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Map1lc3b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11741,253,179 - 41,260,892 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:288
Count of miRNA genes:193
Interacting mature miRNAs:226
Transcripts:ENSRNOT00000051352, ENSRNOT00000067141
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)196124916174246245Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat

Markers in Region
RH128740  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21949,673,499 - 49,673,652 (+)MAPPERmRatBN7.2
Rnor_6.01953,643,815 - 53,643,967NCBIRnor6.0
Rnor_5.01964,381,250 - 64,381,402UniSTSRnor5.0
RGSC_v3.41951,854,708 - 51,854,860UniSTSRGSC3.4
Celera1948,920,317 - 48,920,469UniSTS
RH 3.4 Map19680.7UniSTS
Cytogenetic Map19q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000019033   ⟹   ENSRNOP00000075089
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1677,696,531 - 77,697,009 (-)Ensembl
mRatBN7.2 Ensembl1670,994,128 - 70,994,606 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000051352   ⟹   ENSRNOP00000049421
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1953,629,779 - 53,646,055 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000067141   ⟹   ENSRNOP00000062130
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1949,665,984 - 49,677,690 (+)Ensembl
Rnor_6.0 Ensembl1953,635,688 - 53,643,964 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079382   ⟹   ENSRNOP00000072338
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1966,574,407 - 66,584,358 (+)Ensembl
mRatBN7.2 Ensembl1949,665,791 - 49,675,743 (+)Ensembl
Rnor_6.0 Ensembl1953,635,445 - 53,646,058 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000130178   ⟹   ENSRNOP00000112440
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1966,574,496 - 66,582,269 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000133432   ⟹   ENSRNOP00000100980
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1966,574,584 - 66,582,269 (+)Ensembl
RefSeq Acc Id: NM_022867   ⟹   NP_074058
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81966,574,595 - 66,582,265 (+)NCBI
mRatBN7.21949,665,979 - 49,673,650 (+)NCBI
Rnor_6.01953,635,633 - 53,643,965 (+)NCBI
Rnor_5.01964,373,068 - 64,381,400 (+)NCBI
RGSC_v3.41951,847,187 - 51,854,858 (+)RGD
Celera1948,912,797 - 48,920,467 (+)RGD
Sequence:
RefSeq Acc Id: XM_017601351   ⟹   XP_017456840
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81966,571,631 - 66,582,270 (+)NCBI
mRatBN7.21949,665,795 - 49,673,655 (+)NCBI
Rnor_6.01953,635,449 - 53,643,970 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063278272   ⟹   XP_063134342
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81966,574,599 - 66,582,270 (+)NCBI
RefSeq Acc Id: NP_074058   ⟸   NM_022867
- UniProtKB: A6IZP8 (UniProtKB/TrEMBL),   A0A0G2K9Q7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456840   ⟸   XM_017601351
- Peptide Label: isoform X2
- UniProtKB: Q6XVN7 (UniProtKB/Swiss-Prot),   Q62625 (UniProtKB/Swiss-Prot),   A6IZP7 (UniProtKB/TrEMBL),   A0A0G2K9Q7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072338   ⟸   ENSRNOT00000079382
Ensembl Acc Id: ENSRNOP00000062130   ⟸   ENSRNOT00000067141
Ensembl Acc Id: ENSRNOP00000049421   ⟸   ENSRNOT00000051352
RefSeq Acc Id: XP_063134342   ⟸   XM_063278272
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000075089   ⟸   ENSRNOT00000019033
Ensembl Acc Id: ENSRNOP00000100980   ⟸   ENSRNOT00000133432
Ensembl Acc Id: ENSRNOP00000112440   ⟸   ENSRNOT00000130178

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62625-F1-model_v2 AlphaFold Q62625 1-142 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701192
Promoter ID:EPDNEW_R11715
Type:initiation region
Name:Map1lc3b_1
Description:microtubule-associated protein 1 light chain 3 beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01953,635,650 - 53,635,710EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621315 AgrOrtholog
BioCyc Gene G2FUF-5427 BioCyc
Ensembl Genes ENSRNOG00000017905 Ensembl, ENTREZGENE
  ENSRNOG00000038106 Ensembl
Ensembl Transcript ENSRNOT00000130178 ENTREZGENE
  ENSRNOT00000133432 ENTREZGENE
Gene3D-CATH Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6889616 IMAGE-MGC_LOAD
  IMAGE:7189855 IMAGE-MGC_LOAD
InterPro Atg8-like UniProtKB/Swiss-Prot
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot
KEGG Report rno:64862 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72811 IMAGE-MGC_LOAD
  MGC:93422 IMAGE-MGC_LOAD
NCBI Gene 64862 ENTREZGENE
PANTHER PTHR10969 UniProtKB/Swiss-Prot
Pfam Atg8 UniProtKB/Swiss-Prot
PhenoGen Map1lc3b PhenoGen
RatGTEx ENSRNOG00000017905 RatGTEx
  ENSRNOG00000038106 RatGTEx
Superfamily-SCOP SSF54236 UniProtKB/Swiss-Prot
UniProt A0A0G2K9Q7 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LI38_RAT UniProtKB/TrEMBL
  A6IZP7 ENTREZGENE, UniProtKB/TrEMBL
  A6IZP8 ENTREZGENE, UniProtKB/TrEMBL
  MLP3B_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6XVN7 ENTREZGENE
  Q7TQ75_RAT UniProtKB/TrEMBL
UniProt Secondary Q6XVN7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Map1lc3b  microtubule-associated protein 1 light chain 3 beta    microtubule-associated proteins 1A/1B light chain 3  Name updated 1299863 APPROVED
2004-09-10 Map1lc3b  microtubule-associated proteins 1A/1B light chain 3  MPL3    Symbol and Name updated 1299863 APPROVED
2002-08-07 MPL3  microtubule-associated proteins 1A/1B light chain 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed only in neurons 633201
gene_protein 16.4 kDa 633201