Mlnr (motilin receptor) - Rat Genome Database

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Gene: Mlnr (motilin receptor) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Mlnr
Name: motilin receptor
RGD ID: 621262
Description: Enables thyrotropin-releasing hormone receptor activity. Predicted to be involved in phospholipase C-activating G protein-coupled receptor signaling pathway. Located in neuronal cell body; PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: thyrotropin releasing hormone receptor 2; Trhr2
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81967,317,269 - 67,340,508 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1967,322,133 - 67,327,323 (-)EnsemblGRCr8
mRatBN7.21950,413,570 - 50,422,842 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1950,413,580 - 50,418,770 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1957,210,325 - 57,214,254 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01957,889,579 - 57,893,508 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01960,108,943 - 60,112,872 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01955,176,617 - 55,183,562 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1955,176,258 - 55,183,557 (-)Ensemblrn6Rnor6.0
Rnor_5.01965,888,496 - 65,892,205 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41952,624,099 - 52,627,808 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1949,654,323 - 49,658,096 (-)NCBICelera
RGSC_v3.11952,627,916 - 52,632,887 (-)NCBI
Cytogenetic Map19q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cloning and characterization of a cDNA encoding a novel subtype of rat thyrotropin-releasing hormone receptor. Cao J, etal., J Biol Chem 1998 Nov 27;273(48):32281-7.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Hypothalamic neuronal histamine mediates the thyrotropin-releasing hormone-induced suppression of food intake. Gotoh K, etal., J Neurochem. 2007 Nov;103(3):1102-10. Epub 2007 Aug 30.
4. Cloning and characterization of a new subtype of thyrotropin-releasing hormone receptors. Itadani H, etal., Biochem Biophys Res Commun 1998 Sep 8;250(1):68-71.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12393857   PMID:15944919   PMID:18795335  


Genomics

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:192
Count of miRNA genes:138
Interacting mature miRNAs:158
Transcripts:ENSRNOT00000017317
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)196124916174246245Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
4 6 19 73 17 19 12 26 12 5 89 54 6 63 15 32 7 6 6

Sequence


Ensembl Acc Id: ENSRNOT00000017317   ⟹   ENSRNOP00000017317
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1967,322,133 - 67,327,323 (-)Ensembl
mRatBN7.2 Ensembl1950,413,580 - 50,418,770 (-)Ensembl
Rnor_6.0 Ensembl1955,176,258 - 55,183,557 (-)Ensembl
RefSeq Acc Id: NM_181364   ⟹   NP_852029
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81967,323,196 - 67,327,125 (-)NCBI
mRatBN7.21950,414,643 - 50,418,572 (-)NCBI
Rnor_6.01955,177,690 - 55,181,399 (-)NCBI
Rnor_5.01965,888,496 - 65,892,205 (-)NCBI
RGSC_v3.41952,624,099 - 52,627,808 (-)RGD
Celera1949,654,323 - 49,658,096 (-)RGD
Sequence:
RefSeq Acc Id: XM_017601176   ⟹   XP_017456665
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81967,317,269 - 67,340,508 (-)NCBI
mRatBN7.21950,413,570 - 50,422,842 (-)NCBI
Rnor_6.01955,176,617 - 55,183,562 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063277788   ⟹   XP_063133858
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81967,317,269 - 67,340,508 (-)NCBI
RefSeq Acc Id: XR_010059959
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81967,317,269 - 67,340,508 (-)NCBI
RefSeq Acc Id: NP_852029   ⟸   NM_181364
- UniProtKB: Q9R297 (UniProtKB/TrEMBL),   A6IZR3 (UniProtKB/TrEMBL),   O88820 (UniProtKB/TrEMBL),   Q9QWW3 (UniProtKB/TrEMBL),   F7ER42 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456665   ⟸   XM_017601176
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000017317   ⟸   ENSRNOT00000017317
RefSeq Acc Id: XP_063133858   ⟸   XM_063277788
- Peptide Label: isoform X1
- UniProtKB: A6IZR3 (UniProtKB/TrEMBL),   F7ER42 (UniProtKB/TrEMBL),   Q9R297 (UniProtKB/TrEMBL),   O88820 (UniProtKB/TrEMBL),   Q9QWW3 (UniProtKB/TrEMBL)
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R297-F1-model_v2 AlphaFold Q9R297 1-352 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621262 AgrOrtholog
BioCyc Gene G2FUF-5401 BioCyc
Ensembl Genes ENSRNOG00000012789 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017317 ENTREZGENE
  ENSRNOT00000017317.6 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
  TRH_rcpt_1 UniProtKB/TrEMBL
KEGG Report rno:252859 UniProtKB/TrEMBL
NCBI Gene 252859 ENTREZGENE
PANTHER PTHR46061 UniProtKB/TrEMBL
  THYROLIBERIN RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PhenoGen Mlnr PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  TRHRECEPTOR2 UniProtKB/TrEMBL
  TRHRFAMILY UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012789 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A6IZR3 ENTREZGENE, UniProtKB/TrEMBL
  F7ER42 ENTREZGENE, UniProtKB/TrEMBL
  O88820 ENTREZGENE, UniProtKB/TrEMBL
  Q9QWW3 ENTREZGENE, UniProtKB/TrEMBL
  Q9R297 ENTREZGENE
UniProt Secondary Q9R297 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-18 Mlnr  motilin receptor  Trhr2  thyrotropin releasing hormone receptor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-03-17 Trhr2  thyrotropin releasing hormone receptor 2  Mlnr  motilin receptor  Name and Symbol changed 629549 APPROVED
2014-12-11 Mlnr  motilin receptor  Trhr2  thyrotropin releasing hormone receptor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Trhr2  thyrotropin releasing hormone receptor 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Trhr2  thyrotropin releasing hormone receptor 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expression is brain-specific 634429