Enpep (glutamyl aminopeptidase) - Rat Genome Database

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Gene: Enpep (glutamyl aminopeptidase) Rattus norvegicus
Analyze
Symbol: Enpep
Name: glutamyl aminopeptidase
RGD ID: 621228
Description: Enables aminopeptidase activity and peptide binding activity. Involved in peptide catabolic process and protein processing. Located in brush border membrane. Orthologous to human ENPEP (glutamyl aminopeptidase); PARTICIPATES IN angiotensin III signaling pathway; renin-angiotensin cascade pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: aminopeptidase A; AP-A; EAP; glutamyl aminopeptidase-like; LOC100910501
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82220,456,258 - 220,526,218 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2220,456,278 - 220,526,218 (-)EnsemblGRCr8
mRatBN7.22217,781,985 - 217,851,947 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2217,782,005 - 217,851,947 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2225,456,243 - 225,526,211 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02223,355,888 - 223,425,871 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02218,213,588 - 218,283,553 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02233,667,253 - 233,743,866 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2233,667,254 - 233,743,866 (-)Ensemblrn6Rnor6.0
Rnor_5.02252,991,592 - 253,066,142 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42226,731,079 - 226,732,069 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2210,077,457 - 210,147,068 (-)NCBICelera
RGSC_v3.12226,717,758 - 226,718,749 (-)NCBI
Cytogenetic Map2q42NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-naphthylamine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buspirone  (EXP)
Butylbenzyl phthalate  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
cyclosporin A  (EXP,ISO)
dextran sulfate  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
erianin  (ISO)
felbamate  (EXP)
flutamide  (EXP)
fulvestrant  (ISO)
fumonisin B1  (ISO)
glafenine  (EXP)
indole-3-methanol  (EXP)
inulin  (ISO)
L-ethionine  (EXP)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N(4)-hydroxycytidine  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nimesulide  (EXP)
omeprazole  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
phenytoin  (EXP)
pirinixic acid  (EXP,ISO)
progesterone  (ISO)
resveratrol  (EXP)
rotenone  (EXP)
S-nitrosoglutathione  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
toluene  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (EXP)
undecane  (EXP)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Renin-angiotensin system-regulating aminopeptidase activities are modified in the pineal gland of rats with breast cancer induced by N-methyl-nitrosourea. Carrera MP, etal., Cancer Invest. 2006 Mar;24(2):149-53.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Targeting the renin-angiotensin system: what's new? Leckie BJ Curr Med Chem Cardiovasc Hematol Agents. 2005 Jan;3(1):23-32.
5. Molecular cloning and expression of aminopeptidase A isoforms from rat hippocampus. Lee HJ, etal., Biochim Biophys Acta 2000 Sep 7;1493(1-2):273-8.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. The luminal membrane of rat thick limb expresses AT1 receptor and aminopeptidase activities. Poumarat JS, etal., Kidney Int. 2002 Aug;62(2):434-45.
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Rat kidney glutamyl aminopeptidase (aminopeptidase A): molecular identity and cellular localization. Song L, etal., Am J Physiol 1994 Oct;267(4 Pt 2):F546-57.
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15. Expression of aminopeptidase A, an angiotensinase, in glomerular mesangial cells. Troyanovskaya M, etal., Hypertension 1996 Mar;27(3 Pt 2):518-22.
Additional References at PubMed
PMID:7795661   PMID:8244382   PMID:8346219   PMID:10692253   PMID:14998491   PMID:15489334   PMID:15682487   PMID:16286663   PMID:16790432   PMID:17519555   PMID:17897319   PMID:19056867  
PMID:19608358   PMID:22206666   PMID:23376485   PMID:23533145   PMID:23888046   PMID:25960007   PMID:33161775  


Genomics

Comparative Map Data
Enpep
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82220,456,258 - 220,526,218 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2220,456,278 - 220,526,218 (-)EnsemblGRCr8
mRatBN7.22217,781,985 - 217,851,947 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2217,782,005 - 217,851,947 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2225,456,243 - 225,526,211 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02223,355,888 - 223,425,871 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02218,213,588 - 218,283,553 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02233,667,253 - 233,743,866 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2233,667,254 - 233,743,866 (-)Ensemblrn6Rnor6.0
Rnor_5.02252,991,592 - 253,066,142 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42226,731,079 - 226,732,069 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2210,077,457 - 210,147,068 (-)NCBICelera
RGSC_v3.12226,717,758 - 226,718,749 (-)NCBI
Cytogenetic Map2q42NCBI
ENPEP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384110,476,155 - 110,565,285 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4110,365,733 - 110,565,285 (+)Ensemblhg38GRCh38
GRCh374111,397,311 - 111,486,441 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364111,616,678 - 111,703,942 (+)NCBIBuild 36Build 36hg18NCBI36
Build 344111,754,928 - 111,841,027NCBI
Celera4108,691,011 - 108,778,278 (+)NCBICelera
Cytogenetic Map4q25NCBI
HuRef4107,128,917 - 107,216,191 (+)NCBIHuRef
CHM1_14111,373,917 - 111,461,184 (+)NCBICHM1_1
T2T-CHM13v2.04113,778,214 - 113,867,343 (+)NCBIT2T-CHM13v2.0
Enpep
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393129,062,826 - 129,126,398 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3129,062,824 - 129,126,369 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm383129,269,177 - 129,332,749 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3129,269,175 - 129,332,720 (-)Ensemblmm10GRCm38
MGSCv373128,972,095 - 129,035,667 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv363129,261,642 - 129,324,742 (-)NCBIMGSCv36mm8
Celera3135,776,158 - 135,839,883 (-)NCBICelera
Cytogenetic Map3G3NCBI
cM Map357.92NCBI
Enpep
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545715,863,881 - 15,943,074 (-)NCBIChiLan1.0ChiLan1.0
ENPEP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23108,564,622 - 108,650,616 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14108,857,811 - 108,943,716 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04102,969,397 - 103,056,978 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14113,534,565 - 113,620,654 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4113,532,126 - 113,620,654 (+)EnsemblpanPan2panpan1.1
ENPEP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13230,553,055 - 30,639,790 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3230,553,182 - 30,638,522 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3211,396,688 - 11,483,396 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03230,773,999 - 30,860,935 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3230,774,117 - 30,859,344 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13230,760,121 - 30,846,715 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03230,511,400 - 30,597,700 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0329,256,791 - 9,343,499 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Enpep
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530110,285,323 - 10,365,581 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365631,585,471 - 1,665,677 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365631,585,450 - 1,665,663 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ENPEP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8111,748,514 - 111,858,510 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.18111,765,839 - 111,858,349 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28119,968,866 - 120,060,970 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ENPEP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1758,363,816 - 58,448,231 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl758,364,445 - 58,447,574 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603737,045,128 - 37,128,693 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Enpep
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248384,742,794 - 4,828,724 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248384,742,841 - 4,826,767 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Enpep
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1329,982,786 - 30,054,398 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Enpep
676 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:335
Count of miRNA genes:186
Interacting mature miRNAs:205
Transcripts:ENSRNOT00000074879
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631563Hcuc3Hepatic copper content QTL 33.87liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2212145502231732847Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2214404877251712708Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2204795005249795005Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
1302789Stl26Serum triglyceride level QTL 263.10.0035blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)2206613059226891081Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2196140964251540988Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2214404877251712708Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2205135267250135267Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2188565047233565047Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2192287802229609668Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2184856304229856304Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2184856304229856304Rat
631203Gluco14Glucose level QTL 140.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)2209350500221678003Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2214404877251712708Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2192287802221089121Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2184856304229856304Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2192287802237287802Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2182024327227024327Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2184482291229482291Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2202029709236904960Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2210956252251712708Rat
8693697Alc36Alcohol consumption QTL 3620.592drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2219814164239320906Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2205135267225627153Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2214404877251712708Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2218051934251712708Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2186850607231850607Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2192287802237287802Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2214404877251712708Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2182635347227635347Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2220274283249795005Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2184856304229856304Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2203664411248664411Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2220274283249795005Rat

Markers in Region
D2Wox67  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22217,853,183 - 217,853,423 (+)MAPPERmRatBN7.2
Rnor_6.02233,984,120 - 233,984,359NCBIRnor6.0
Rnor_6.02233,745,103 - 233,745,342NCBIRnor6.0
Rnor_5.02253,067,379 - 253,067,618UniSTSRnor5.0
Rnor_5.02253,306,223 - 253,306,462UniSTSRnor5.0
RGSC_v3.42226,734,175 - 226,734,414UniSTSRGSC3.4
Celera2210,148,305 - 210,148,544UniSTS
Cytogenetic Map2q42UniSTS
RH133895  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22217,782,221 - 217,782,439 (+)MAPPERmRatBN7.2
Rnor_6.02233,667,471 - 233,667,688NCBIRnor6.0
Rnor_5.02252,991,810 - 252,992,027UniSTSRnor5.0
Celera2210,077,694 - 210,077,911UniSTS
RH 3.4 Map21557.4UniSTS
Cytogenetic Map2q42UniSTS
BE111146  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22217,819,206 - 217,819,402 (+)MAPPERmRatBN7.2
Rnor_6.02233,704,485 - 233,704,680NCBIRnor6.0
Rnor_5.02253,028,989 - 253,029,184UniSTSRnor5.0
Celera2210,114,297 - 210,114,492UniSTS
RH 3.4 Map21546.7UniSTS
Cytogenetic Map2q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 60 59 6 324 160 11 139 81 92 31 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000087062   ⟹   ENSRNOP00000068728
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2220,456,278 - 220,526,218 (-)Ensembl
mRatBN7.2 Ensembl2217,782,005 - 217,851,947 (-)Ensembl
Rnor_6.0 Ensembl2233,667,254 - 233,743,866 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107896   ⟹   ENSRNOP00000085978
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2220,456,278 - 220,526,218 (-)Ensembl
mRatBN7.2 Ensembl2217,782,005 - 217,851,947 (-)Ensembl
RefSeq Acc Id: NM_022251   ⟹   NP_071587
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82220,456,258 - 220,526,218 (-)NCBI
mRatBN7.22217,781,985 - 217,851,947 (-)NCBI
Rnor_6.02233,667,253 - 233,743,866 (-)NCBI
Rnor_5.02252,991,592 - 253,066,142 (-)NCBI
RGSC_v3.42226,731,079 - 226,732,069 (-)RGD
Celera2210,077,457 - 210,147,068 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_071587 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF37622 (Get FASTA)   NCBI Sequence Viewer  
  AAF66710 (Get FASTA)   NCBI Sequence Viewer  
  AAH66663 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000068728
GenBank Protein P50123 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_071587   ⟸   NM_022251
- UniProtKB: Q9QV24 (UniProtKB/Swiss-Prot),   Q9JLQ9 (UniProtKB/Swiss-Prot),   Q9JLQ7 (UniProtKB/Swiss-Prot),   Q64200 (UniProtKB/Swiss-Prot),   P50123 (UniProtKB/Swiss-Prot),   A0A0G2JTI8 (UniProtKB/TrEMBL),   A6HVN5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068728   ⟸   ENSRNOT00000087062
Ensembl Acc Id: ENSRNOP00000085978   ⟸   ENSRNOT00000107896
Protein Domains
Aminopeptidase N-like N-terminal   ERAP1-like C-terminal   Peptidase M1 membrane alanine aminopeptidase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P50123-F1-model_v2 AlphaFold P50123 1-945 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691746
Promoter ID:EPDNEW_R2271
Type:multiple initiation site
Name:Enpep_1
Description:glutamyl aminopeptidase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02233,743,698 - 233,743,758EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621228 AgrOrtholog
BioCyc Gene G2FUF-51247 BioCyc
Ensembl Genes ENSRNOG00000051854 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000087062 ENTREZGENE
Gene3D-CATH 1.10.390.10 UniProtKB/Swiss-Prot
  1.25.50.20 UniProtKB/Swiss-Prot
  2.60.40.1730 UniProtKB/Swiss-Prot
  2.60.40.1910 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5623429 IMAGE-MGC_LOAD
InterPro Aminopeptidase_N-like_N UniProtKB/Swiss-Prot
  Aminopeptidase_N-like_N UniProtKB/Swiss-Prot
  ERAP1-like_C_dom UniProtKB/Swiss-Prot
  M1_APN-typ UniProtKB/Swiss-Prot
  Peptidase_M1 UniProtKB/Swiss-Prot
  Peptidase_M1_aminopeptidases UniProtKB/Swiss-Prot
  Peptidase_M1_dom UniProtKB/Swiss-Prot
  Peptidase_M4/M1_CTD_sf UniProtKB/Swiss-Prot
KEGG Report rno:64017 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72453 IMAGE-MGC_LOAD
NCBI Gene 64017 ENTREZGENE
PANTHER GLUTAMYL AMINOPEPTIDASE UniProtKB/Swiss-Prot
  PROTEASE M1 ZINC METALLOPROTEASE UniProtKB/Swiss-Prot
Pfam ERAP1_C UniProtKB/Swiss-Prot
  Peptidase_M1 UniProtKB/Swiss-Prot
  Peptidase_M1_N UniProtKB/Swiss-Prot
PhenoGen Enpep PhenoGen
PRINTS ALADIPTASE UniProtKB/Swiss-Prot
PROSITE ZINC_PROTEASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000051854 RatGTEx
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot
  SSF63737 UniProtKB/Swiss-Prot
UniProt A0A0G2JTI8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A4U4_RAT UniProtKB/TrEMBL
  A6HVN5 ENTREZGENE, UniProtKB/TrEMBL
  AMPE_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q64200 ENTREZGENE
  Q9JLQ7 ENTREZGENE
  Q9JLQ9 ENTREZGENE
  Q9QV24 ENTREZGENE
UniProt Secondary Q64200 UniProtKB/Swiss-Prot
  Q9JLQ7 UniProtKB/Swiss-Prot
  Q9JLQ9 UniProtKB/Swiss-Prot
  Q9QV24 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Enpep  glutamyl aminopeptidase  LOC100910501  glutamyl aminopeptidase-like  Data merged from RGD:6498411 737654 PROVISIONAL
2012-07-05 LOC100910501  glutamyl aminopeptidase-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 Enpep  glutamyl aminopeptidase    aminopeptidase A  Name updated 1299863 APPROVED
2002-08-07 Enpep  aminopeptidase A      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the glomerular mesangial cells 631868
gene_process may play a role in modulating the activity of intrarenal angiotensin II  
gene_process minimizes the contraction due to angiotensin II in stimulated mesangial cells 631868