Pi4ka (phosphatidylinositol 4-kinase alpha) - Rat Genome Database

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Gene: Pi4ka (phosphatidylinositol 4-kinase alpha) Rattus norvegicus
Analyze
Symbol: Pi4ka
Name: phosphatidylinositol 4-kinase alpha
RGD ID: 621213
Description: Enables 1-phosphatidylinositol 4-kinase activity. Predicted to be involved in several processes, including myelination in peripheral nervous system; phosphatidylinositol-mediated signaling; and reorganization of cellular membranes to establish viral sites of replication. Predicted to act upstream of or within Schwann cell migration and actin cytoskeleton organization. Located in Golgi-associated vesicle membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 84. Orthologous to human PI4KA (phosphatidylinositol 4-kinase alpha); PARTICIPATES IN inositol metabolic pathway; phosphoinositide metabolic pathway; inositol phosphate metabolic pathway; INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: leuserpin 2; phosphatidylinositol 4-kinase; phosphatidylinositol 4-kinase a; phosphatidylinositol 4-kinase, catalytic, alpha; phosphatidylinositol 4-kinase, catalytic, alpha polypeptide; PI4-kinase alpha; PI4K-alpha; Pik4ca; ptdIns-4-kinase alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81197,113,390 - 97,234,374 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1197,113,245 - 97,228,315 (+)EnsemblGRCr8
mRatBN7.21183,609,148 - 83,726,876 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1183,609,069 - 83,724,080 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1192,336,920 - 92,454,084 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01184,998,070 - 85,115,233 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01184,051,678 - 84,168,839 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01187,858,323 - 87,975,549 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1187,858,453 - 87,973,422 (+)Ensemblrn6Rnor6.0
Rnor_5.01190,914,592 - 91,028,242 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41185,610,281 - 85,726,603 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1182,373,025 - 82,486,238 (+)NCBICelera
RGSC_v3.11185,650,877 - 85,767,200 (+)NCBI
Cytogenetic Map11q23NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylparaben  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
CGP 52608  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
coumarin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dichlorine  (EXP)
ethanol  (ISO)
finasteride  (EXP)
flutamide  (EXP)
fulvestrant  (ISO)
heptachlor  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
leflunomide  (EXP)
linsidomine  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (EXP)
methoxychlor  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (EXP)
okadaic acid  (ISO)
ozone  (EXP)
p-toluidine  (EXP)
paracetamol  (ISO)
quercetin  (ISO)
rofecoxib  (ISO)
rotenone  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulindac  (EXP)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
thapsigargin  (ISO)
triphenyl phosphate  (EXP)
trovafloxacin  (ISO)
tungsten  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
Golgi-associated vesicle membrane  (IDA)
plasma membrane  (IBA,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
4. Cloning, expression, and localization of 230-kDa phosphatidylinositol 4-kinase. Nakagawa T, etal., J Biol Chem 1996 May 17;271(20):12088-94.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8286422   PMID:17131383   PMID:19211550   PMID:19376974   PMID:19946888   PMID:20458337   PMID:21423176   PMID:23229899   PMID:25327288   PMID:25468996   PMID:29476059   PMID:30053369  
PMID:32357304  


Genomics

Comparative Map Data
Pi4ka
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81197,113,390 - 97,234,374 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1197,113,245 - 97,228,315 (+)EnsemblGRCr8
mRatBN7.21183,609,148 - 83,726,876 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1183,609,069 - 83,724,080 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1192,336,920 - 92,454,084 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01184,998,070 - 85,115,233 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01184,051,678 - 84,168,839 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01187,858,323 - 87,975,549 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1187,858,453 - 87,973,422 (+)Ensemblrn6Rnor6.0
Rnor_5.01190,914,592 - 91,028,242 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41185,610,281 - 85,726,603 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1182,373,025 - 82,486,238 (+)NCBICelera
RGSC_v3.11185,650,877 - 85,767,200 (+)NCBI
Cytogenetic Map11q23NCBI
PI4KA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382220,707,691 - 20,858,811 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2220,707,691 - 20,859,417 (-)Ensemblhg38GRCh38
GRCh372221,061,979 - 21,213,099 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362219,391,979 - 19,543,070 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342219,386,544 - 19,517,555NCBI
Celera225,492,598 - 5,494,284 (+)NCBICelera
Celera224,557,005 - 4,704,409 (-)NCBICelera
Cytogenetic Map22q11.21NCBI
HuRef224,329,838 - 4,481,241 (-)NCBIHuRef
CHM1_12221,062,151 - 21,213,286 (-)NCBICHM1_1
T2T-CHM13v2.02221,116,400 - 21,267,532 (-)NCBIT2T-CHM13v2.0
Pi4ka
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391617,098,215 - 17,224,178 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1617,098,215 - 17,224,178 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381617,280,351 - 17,406,314 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1617,280,351 - 17,406,314 (-)Ensemblmm10GRCm38
MGSCv371617,280,444 - 17,406,407 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361617,193,915 - 17,319,877 (-)NCBIMGSCv36mm8
Celera1617,853,225 - 17,979,271 (-)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1610.71NCBI
Pi4ka
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544219,446,955 - 19,598,725 (+)Ensembl
ChiLan1.0NW_00495544219,446,955 - 19,594,790 (+)NCBIChiLan1.0ChiLan1.0
PI4KA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22330,414,241 - 30,565,263 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12232,963,144 - 33,114,773 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0222,931,523 - 3,082,475 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PI4KA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12630,630,693 - 30,749,158 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2630,630,261 - 30,749,126 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2630,589,065 - 30,707,530 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02632,039,270 - 32,155,774 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2632,038,805 - 32,155,769 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12630,085,016 - 30,204,201 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02629,709,699 - 29,828,234 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02630,798,988 - 30,918,013 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pi4ka
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118140,376,969 - 140,513,432 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366192,240,266 - 2,377,093 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366192,240,641 - 2,377,088 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PI4KA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1450,390,410 - 50,491,944 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11450,390,416 - 50,491,983 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21453,838,856 - 53,940,687 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PI4KA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,648,184 - 4,797,573 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl194,648,183 - 4,797,396 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660852,209,589 - 2,351,629 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pi4ka
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624945837,864 - 1,014,684 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624945837,877 - 1,016,041 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pi4ka
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v142,550,135 - 2,662,882 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:207
Count of miRNA genes:157
Interacting mature miRNAs:169
Transcripts:ENSRNOT00000065378
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)117385089499753367Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)117330831599753367Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)117961851999753367Rat

Markers in Region
D11Wox17  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21183,674,893 - 83,675,061 (+)MAPPERmRatBN7.2
Rnor_6.01187,924,191 - 87,924,358NCBIRnor6.0
Rnor_5.01190,979,890 - 90,980,057UniSTSRnor5.0
RGSC_v3.41185,677,091 - 85,677,258UniSTSRGSC3.4
Celera1182,438,485 - 82,438,652UniSTS
Cytogenetic Map11q23UniSTS
MHAa22f12.seq  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21183,670,701 - 83,670,897 (+)MAPPERmRatBN7.2
Rnor_6.01187,919,999 - 87,920,194NCBIRnor6.0
Rnor_5.01190,975,698 - 90,975,893UniSTSRnor5.0
RGSC_v3.41185,672,899 - 85,673,094UniSTSRGSC3.4
Celera1182,434,293 - 82,434,488UniSTS
Cytogenetic Map11q23UniSTS
RH130116  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21183,664,552 - 83,664,737 (+)MAPPERmRatBN7.2
Rnor_6.01187,913,850 - 87,914,034NCBIRnor6.0
Rnor_5.01190,969,549 - 90,969,733UniSTSRnor5.0
RGSC_v3.41185,666,750 - 85,666,934UniSTSRGSC3.4
Celera1182,428,144 - 82,428,328UniSTS
RH 3.4 Map11722.22UniSTS
Cytogenetic Map11q23UniSTS
BE105289  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21183,678,275 - 83,678,481 (+)MAPPERmRatBN7.2
Rnor_6.01187,927,573 - 87,927,778NCBIRnor6.0
Rnor_5.01190,983,040 - 90,983,245UniSTSRnor5.0
RGSC_v3.41185,680,918 - 85,681,123UniSTSRGSC3.4
Celera1182,441,976 - 82,442,181UniSTS
RH 3.4 Map11719.91UniSTS
Cytogenetic Map11q23UniSTS
MARC_2765-2766:991933387:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81197,226,275 - 97,226,593 (+)Marker Load Pipeline
mRatBN7.21183,722,040 - 83,722,358 (+)MAPPERmRatBN7.2
Rnor_6.01187,971,383 - 87,971,700NCBIRnor6.0
Rnor_5.01191,026,203 - 91,026,520UniSTSRnor5.0
RGSC_v3.41185,724,564 - 85,724,881UniSTSRGSC3.4
Celera1182,484,199 - 82,484,516UniSTS
Cytogenetic Map11q23UniSTS
D3S1674  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01187,896,898 - 87,896,926NCBIRnor6.0
Rnor_6.0926,106,841 - 26,106,869NCBIRnor6.0
Rnor_5.01190,952,596 - 90,952,624UniSTSRnor5.0
Rnor_5.0924,967,829 - 24,967,857UniSTSRnor5.0
RGSC_v3.4918,768,932 - 18,768,960UniSTSRGSC3.4
RGSC_v3.41185,649,795 - 85,649,823UniSTSRGSC3.4
Celera1182,411,330 - 82,411,358UniSTS
Celera920,069,465 - 20,069,493UniSTS
Cytogenetic Map11q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000091117   ⟹   ENSRNOP00000072265
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1197,113,245 - 97,228,315 (+)Ensembl
mRatBN7.2 Ensembl1183,609,069 - 83,724,080 (+)Ensembl
Rnor_6.0 Ensembl1187,858,453 - 87,973,422 (+)Ensembl
RefSeq Acc Id: NM_001415014   ⟹   NP_001401943
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,113,390 - 97,228,195 (+)NCBI
mRatBN7.21183,609,148 - 83,723,960 (+)NCBI
RefSeq Acc Id: XR_001840421
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,113,390 - 97,234,374 (+)NCBI
mRatBN7.21183,609,202 - 83,726,876 (+)NCBI
Rnor_6.01187,858,323 - 87,975,549 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001840422
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,113,390 - 97,230,341 (+)NCBI
mRatBN7.21183,609,202 - 83,726,108 (+)NCBI
Rnor_6.01187,858,323 - 87,975,457 (+)NCBI
Sequence:
RefSeq Acc Id: XR_010055966
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,113,390 - 97,230,341 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001401943 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD10400 (Get FASTA)   NCBI Sequence Viewer  
  BAA19614 (Get FASTA)   NCBI Sequence Viewer  
  EDL77884 (Get FASTA)   NCBI Sequence Viewer  
  EDL77885 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000072265
GenBank Protein O08662 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Acc Id: ENSRNOP00000072265   ⟸   ENSRNOT00000091117
RefSeq Acc Id: NP_001401943   ⟸   NM_001415014
- UniProtKB: O08662 (UniProtKB/Swiss-Prot),   A0A0G2K2J3 (UniProtKB/Swiss-Prot),   A0A140TAJ5 (UniProtKB/TrEMBL)
Protein Domains
PI3K/PI4K catalytic   PIK helical

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08662-F1-model_v2 AlphaFold O08662 1-2096 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621213 AgrOrtholog
BioCyc Gene G2FUF-20586 BioCyc
BioCyc Pathway PWY-6351 [D-myo-inositol (1,4,5)-trisphosphate biosynthesis] BioCyc
  PWY-6352 [3-phosphoinositide biosynthesis] BioCyc
BioCyc Pathway Image PWY-6351 BioCyc
  PWY-6352 BioCyc
Ensembl Genes ENSRNOG00000060045 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000091117 ENTREZGENE
Gene3D-CATH 1.10.1070.11 UniProtKB/Swiss-Prot
  1.25.40.70 UniProtKB/Swiss-Prot
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4 UniProtKB/Swiss-Prot
InterPro ARM-type_fold UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  PI3/4_kinase_cat_dom UniProtKB/Swiss-Prot
  PI3/4_kinase_cat_sf UniProtKB/Swiss-Prot
  PI3/4_kinase_CS UniProtKB/Swiss-Prot
  PI3K_accessory_sf UniProtKB/Swiss-Prot
  PI4K_N UniProtKB/Swiss-Prot
  PI_Kinase UniProtKB/Swiss-Prot
  PInositide-3_kin_accessory_dom UniProtKB/Swiss-Prot
NCBI Gene 64161 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL 4-KINASE ALPHA UniProtKB/Swiss-Prot
  PTHR10048 UniProtKB/Swiss-Prot
Pfam PI3_PI4_kinase UniProtKB/Swiss-Prot
  PI3Ka UniProtKB/Swiss-Prot
  PI4K_N UniProtKB/Swiss-Prot
PhenoGen Pi4ka PhenoGen
PROSITE PI3_4_KINASE_1 UniProtKB/Swiss-Prot
  PI3_4_KINASE_2 UniProtKB/Swiss-Prot
  PI3_4_KINASE_3 UniProtKB/Swiss-Prot
  PIK_HELICAL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000060045 RatGTEx
SMART PI3Ka UniProtKB/Swiss-Prot
  PI3Kc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt A0A0G2K2J3 ENTREZGENE
  A0A140TAJ5 ENTREZGENE, UniProtKB/TrEMBL
  O08662 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A0A0G2K2J3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Pi4ka  phosphatidylinositol 4-kinase alpha  Pi4ka  phosphatidylinositol 4-kinase, catalytic, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-19 Pi4ka  phosphatidylinositol 4-kinase, catalytic, alpha  Pik4ca  phosphatidylinositol 4-kinase, catalytic, alpha polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Pik4ca  phosphatidylinositol 4-kinase, catalytic, alpha polypeptide    phosphatidylinositol 4-kinase  Name updated 1299863 APPROVED
2002-08-07 Pik4ca  phosphatidylinositol 4-kinase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization associated with the membrane 633726
gene_domains contains ankyrin repeat domain, lipid kinase unique domain, pleckstrin homology domain, presumed lipid kinase/protein kinase homology domain, proline-rich region, and SH3 domain 633726
gene_expression expressed widely in the gray matter of the brain; enriched in the fetal brain 633726
gene_process may mediate neuronal differentiation and maturation including the synaptogenesis and synaptic plasticity 633726
gene_protein 2041 amino acids; 231.3 kDa 633726