Kcnt1 (potassium sodium-activated channel subfamily T member 1) - Rat Genome Database

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Gene: Kcnt1 (potassium sodium-activated channel subfamily T member 1) Rattus norvegicus
Analyze
Symbol: Kcnt1
Name: potassium sodium-activated channel subfamily T member 1
RGD ID: 621106
Description: Enables chloride-activated potassium channel activity; intracellular sodium-activated potassium channel activity; and outward rectifier potassium channel activity. Involved in potassium ion transmembrane transport. Located in plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 5 and developmental and epileptic encephalopathy 14. Orthologous to human KCNT1 (potassium sodium-activated channel subfamily T member 1); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: potassium channel subfamily T member 1; potassium channel subunit (Slack); potassium channel, sodium-activated subfamily T, member 1; potassium channel, subfamily T, member 1; rSlo2; sequence like a calcium-activated potassium channel subunit; Slack
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8329,081,071 - 29,136,902 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl329,081,321 - 29,134,768 (+)EnsemblGRCr8
mRatBN7.238,682,964 - 8,736,615 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,682,113 - 8,736,667 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx311,752,260 - 11,789,926 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0320,335,474 - 20,373,140 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0318,590,792 - 18,628,457 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.033,310,641 - 3,366,558 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl33,310,954 - 3,365,340 (+)Ensemblrn6Rnor6.0
Rnor_5.038,673,033 - 8,726,493 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.434,050,340 - 4,088,029 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera33,521,129 - 3,558,818 (+)NCBICelera
RGSC_v3.134,050,339 - 4,088,029 (+)NCBI
Cytogenetic Map3p13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Localization of the Slack potassium channel in the rat central nervous system. Bhattacharjee A, etal., J Comp Neurol 2002 Dec 16;454(3):241-54.
2. Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP. Bhattacharjee A, etal., J Neurosci 2003 Dec 17;23(37):11681-91.
3. Na+-activated K+ channels express a large delayed outward current in neurons during normal physiology. Budelli G, etal., Nat Neurosci. 2009 Jun;12(6):745-50. doi: 10.1038/nn.2313. Epub 2009 May 3.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. The sodium-activated potassium channel is encoded by a member of the Slo gene family. Yuan A, etal., Neuron 2003 Mar 6;37(5):765-73.
Additional References at PubMed
PMID:10196543   PMID:18082331   PMID:18664322   PMID:19403831   PMID:19540251   PMID:25347289   PMID:26721627   PMID:28222129   PMID:28366665   PMID:30860870   PMID:36898835   PMID:37889366  


Genomics

Comparative Map Data
Kcnt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8329,081,071 - 29,136,902 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl329,081,321 - 29,134,768 (+)EnsemblGRCr8
mRatBN7.238,682,964 - 8,736,615 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,682,113 - 8,736,667 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx311,752,260 - 11,789,926 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0320,335,474 - 20,373,140 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0318,590,792 - 18,628,457 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.033,310,641 - 3,366,558 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl33,310,954 - 3,365,340 (+)Ensemblrn6Rnor6.0
Rnor_5.038,673,033 - 8,726,493 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.434,050,340 - 4,088,029 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera33,521,129 - 3,558,818 (+)NCBICelera
RGSC_v3.134,050,339 - 4,088,029 (+)NCBI
Cytogenetic Map3p13NCBI
KCNT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389135,702,185 - 135,795,502 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9135,702,185 - 135,795,508 (+)Ensemblhg38GRCh38
GRCh379138,594,031 - 138,687,348 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369137,733,859 - 137,824,813 (+)NCBIBuild 36Build 36hg18NCBI36
Build 349135,819,982 - 135,904,199NCBI
Celera9109,111,863 - 109,202,929 (+)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9108,055,583 - 108,146,760 (+)NCBIHuRef
CHM1_19138,742,378 - 138,833,497 (+)NCBICHM1_1
T2T-CHM13v2.09147,929,033 - 148,022,602 (+)NCBIT2T-CHM13v2.0
Kcnt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39225,753,807 - 25,808,285 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl225,753,746 - 25,808,285 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38225,863,791 - 25,918,273 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,863,734 - 25,918,273 (+)Ensemblmm10GRCm38
MGSCv37225,719,374 - 25,773,793 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36225,699,870 - 25,740,282 (+)NCBIMGSCv36mm8
Celera225,584,088 - 25,640,454 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map218.27NCBI
Kcnt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555134,712,516 - 4,765,657 (-)Ensembl
ChiLan1.0NW_0049555134,712,772 - 4,765,657 (-)NCBIChiLan1.0ChiLan1.0
KCNT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2113,589,397 - 3,685,539 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan193,591,730 - 3,687,241 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09106,773,184 - 106,867,490 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19135,813,431 - 135,853,461 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9135,763,956 - 135,852,482 (+)EnsemblpanPan2panpan1.1
KCNT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1949,532,073 - 49,581,332 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl949,532,922 - 49,593,633 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha948,784,630 - 48,845,057 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0950,411,434 - 50,471,850 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl950,411,452 - 50,472,234 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1949,191,495 - 49,251,818 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0949,485,623 - 49,546,068 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0949,533,803 - 49,594,207 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Kcnt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947201,507,793 - 201,540,179 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366691,834,582 - 1,871,791 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366691,834,879 - 1,867,572 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.21308,727,206 - 308,790,168 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCNT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1122,410,520 - 2,502,176 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl122,408,751 - 2,486,858 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660582,716,197 - 2,752,847 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247601,167,641 - 1,209,802 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247601,167,489 - 1,209,155 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Kcnt1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1511,169,421 - 11,222,230 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Kcnt1
229 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:180
Count of miRNA genes:78
Interacting mature miRNAs:81
Transcripts:ENSRNOT00000023542, ENSRNOT00000061773
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32905627547904329Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3612543751125437Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3136721849Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)32905627547904329Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat

Markers in Region
D3Rat57  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8329,115,463 - 29,115,662 (+)Marker Load Pipeline
mRatBN7.238,717,349 - 8,717,520 (+)MAPPERmRatBN7.2
Rnor_6.033,345,114 - 3,345,312NCBIRnor6.0
Rnor_5.038,707,196 - 8,707,394UniSTSRnor5.0
RGSC_v3.434,069,684 - 4,069,882UniSTSRGSC3.4
RGSC_v3.434,069,683 - 4,069,882RGDRGSC3.4
Celera33,540,473 - 3,540,671UniSTS
RGSC_v3.134,069,464 - 4,069,918RGD
SHRSP x BN Map32.4499RGD
SHRSP x BN Map32.4499UniSTS
Cytogenetic Map3p13UniSTS
RH138010  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.238,735,810 - 8,735,947 (+)MAPPERmRatBN7.2
Rnor_6.033,363,603 - 3,363,739NCBIRnor6.0
Rnor_5.038,725,685 - 8,725,821UniSTSRnor5.0
RGSC_v3.434,088,173 - 4,088,309UniSTSRGSC3.4
Celera33,558,962 - 3,559,098UniSTS
Cytogenetic Map3p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 12 47 150 91 90 59 39 59 6 277 119 11 129 81 92 31 15 15

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001413123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_021853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005501975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF089730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY884213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000023542   ⟹   ENSRNOP00000023542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl329,096,109 - 29,134,768 (+)Ensembl
mRatBN7.2 Ensembl38,698,005 - 8,736,667 (+)Ensembl
Rnor_6.0 Ensembl33,325,770 - 3,363,459 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000061773   ⟹   ENSRNOP00000058487
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl329,081,321 - 29,134,755 (+)Ensembl
mRatBN7.2 Ensembl38,682,113 - 8,736,667 (+)Ensembl
Rnor_6.0 Ensembl33,310,954 - 3,365,340 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104747   ⟹   ENSRNOP00000089937
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl329,096,120 - 29,134,757 (+)Ensembl
mRatBN7.2 Ensembl38,698,005 - 8,736,667 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110074   ⟹   ENSRNOP00000096324
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl329,081,458 - 29,134,768 (+)Ensembl
mRatBN7.2 Ensembl38,683,345 - 8,736,667 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000130387   ⟹   ENSRNOP00000103835
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl329,081,321 - 29,134,755 (+)Ensembl
RefSeq Acc Id: NM_001413123   ⟹   NP_001400052
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,081,339 - 29,134,757 (+)NCBI
mRatBN7.238,683,226 - 8,736,615 (+)NCBI
RefSeq Acc Id: NM_021853   ⟹   NP_068625
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,096,096 - 29,134,757 (+)NCBI
mRatBN7.238,697,981 - 8,736,615 (+)NCBI
Rnor_6.033,325,770 - 3,363,459 (+)NCBI
Rnor_5.038,673,033 - 8,726,493 (+)NCBI
RGSC_v3.434,050,340 - 4,088,029 (+)RGD
Celera33,521,129 - 3,558,818 (+)RGD
Sequence:
RefSeq Acc Id: XM_006233697   ⟹   XP_006233759
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,095,847 - 29,136,902 (+)NCBI
mRatBN7.238,696,856 - 8,736,615 (+)NCBI
Rnor_6.033,325,462 - 3,366,558 (+)NCBI
Rnor_5.038,673,033 - 8,726,493 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233698   ⟹   XP_006233760
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,095,846 - 29,136,902 (+)NCBI
mRatBN7.238,696,856 - 8,736,615 (+)NCBI
Rnor_6.033,325,462 - 3,366,558 (+)NCBI
Rnor_5.038,673,033 - 8,726,493 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233699   ⟹   XP_006233761
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,095,849 - 29,136,902 (+)NCBI
mRatBN7.238,696,858 - 8,736,615 (+)NCBI
Rnor_6.033,325,462 - 3,366,558 (+)NCBI
Rnor_5.038,673,033 - 8,726,493 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233700   ⟹   XP_006233762
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,095,847 - 29,136,902 (+)NCBI
mRatBN7.238,696,857 - 8,736,615 (+)NCBI
Rnor_6.033,325,462 - 3,366,558 (+)NCBI
Rnor_5.038,673,033 - 8,726,493 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233701   ⟹   XP_006233763
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,095,847 - 29,136,902 (+)NCBI
mRatBN7.238,696,856 - 8,736,615 (+)NCBI
Rnor_6.033,325,462 - 3,366,558 (+)NCBI
Rnor_5.038,673,033 - 8,726,493 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233702   ⟹   XP_006233764
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,095,850 - 29,136,902 (+)NCBI
mRatBN7.238,696,859 - 8,736,615 (+)NCBI
Rnor_6.033,325,462 - 3,366,558 (+)NCBI
Rnor_5.038,673,033 - 8,726,493 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233703   ⟹   XP_006233765
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,095,850 - 29,136,902 (+)NCBI
mRatBN7.238,696,858 - 8,736,615 (+)NCBI
Rnor_6.033,325,462 - 3,366,558 (+)NCBI
Rnor_5.038,673,033 - 8,726,493 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233704   ⟹   XP_006233766
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,081,071 - 29,136,902 (+)NCBI
mRatBN7.238,682,964 - 8,736,615 (+)NCBI
Rnor_6.033,310,641 - 3,366,558 (+)NCBI
Rnor_5.038,673,033 - 8,726,493 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233706   ⟹   XP_006233768
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,095,843 - 29,133,596 (+)NCBI
mRatBN7.238,696,854 - 8,735,450 (+)NCBI
Rnor_6.033,325,462 - 3,363,177 (+)NCBI
Rnor_5.038,673,033 - 8,726,493 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233707   ⟹   XP_006233769
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,081,076 - 29,136,902 (+)NCBI
mRatBN7.238,682,968 - 8,736,615 (+)NCBI
Rnor_6.033,310,643 - 3,366,558 (+)NCBI
Rnor_5.038,673,033 - 8,726,493 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008761624   ⟹   XP_008759846
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,081,073 - 29,136,902 (+)NCBI
mRatBN7.238,682,968 - 8,736,615 (+)NCBI
Rnor_6.033,310,641 - 3,366,558 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039105771   ⟹   XP_038961699
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,117,020 - 29,136,902 (+)NCBI
mRatBN7.238,718,882 - 8,736,615 (+)NCBI
RefSeq Acc Id: XM_063284465   ⟹   XP_063140535
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,095,843 - 29,133,596 (+)NCBI
RefSeq Acc Id: XR_005501975
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,095,838 - 29,125,391 (+)NCBI
mRatBN7.238,696,851 - 8,727,246 (+)NCBI
RefSeq Acc Id: NP_068625   ⟸   NM_021853
- Peptide Label: isoform 1
- UniProtKB: A0A8I6A9R0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233766   ⟸   XM_006233704
- Peptide Label: isoform X8
- UniProtKB: A6JTB4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233769   ⟸   XM_006233707
- Peptide Label: isoform X10
- UniProtKB: D3ZNI9 (UniProtKB/TrEMBL),   A6JTB4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233768   ⟸   XM_006233706
- Peptide Label: isoform X9
- UniProtKB: A6JTB5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233759   ⟸   XM_006233697
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A9R0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233763   ⟸   XM_006233701
- Peptide Label: isoform X5
- UniProtKB: A0A8I6A9R0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233761   ⟸   XM_006233699
- Peptide Label: isoform X3
- UniProtKB: Q9Z258 (UniProtKB/Swiss-Prot),   Q5D6C6 (UniProtKB/Swiss-Prot),   F1LSG1 (UniProtKB/TrEMBL),   A0A8I6A9R0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233765   ⟸   XM_006233703
- Peptide Label: isoform X7
- UniProtKB: A0A8I6A9R0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233760   ⟸   XM_006233698
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A9R0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233762   ⟸   XM_006233700
- Peptide Label: isoform X4
- UniProtKB: A0A8I6A9R0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233764   ⟸   XM_006233702
- Peptide Label: isoform X6
- UniProtKB: A0A8I6A9R0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759846   ⟸   XM_008761624
- Peptide Label: isoform X13
- UniProtKB: A0A8I6ALJ8 (UniProtKB/TrEMBL),   A6JTB4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023542   ⟸   ENSRNOT00000023542
Ensembl Acc Id: ENSRNOP00000058487   ⟸   ENSRNOT00000061773
RefSeq Acc Id: XP_038961699   ⟸   XM_039105771
- Peptide Label: isoform X12
Ensembl Acc Id: ENSRNOP00000096324   ⟸   ENSRNOT00000110074
Ensembl Acc Id: ENSRNOP00000089937   ⟸   ENSRNOT00000104747
RefSeq Acc Id: NP_001400052   ⟸   NM_001413123
- Peptide Label: isoform 2
- UniProtKB: A6JTB4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140535   ⟸   XM_063284465
- Peptide Label: isoform X11
- UniProtKB: A6JTB5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000103835   ⟸   ENSRNOT00000130387
Protein Domains
RCK N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z258-F1-model_v2 AlphaFold Q9Z258 1-1237 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621106 AgrOrtholog
BioCyc Gene G2FUF-50409 BioCyc
Ensembl Genes ENSRNOG00000017283 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055000527 UniProtKB/Swiss-Prot
  ENSRNOG00060031801 UniProtKB/Swiss-Prot
  ENSRNOG00065026234 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023542 ENTREZGENE
  ENSRNOT00000023542.6 UniProtKB/Swiss-Prot
  ENSRNOT00000061773 ENTREZGENE
  ENSRNOT00000104747 ENTREZGENE
  ENSRNOT00000110074 ENTREZGENE
  ENSRNOT00000130387 ENTREZGENE
  ENSRNOT00055000913 UniProtKB/Swiss-Prot
  ENSRNOT00060055395 UniProtKB/Swiss-Prot
  ENSRNOT00065046477 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot
InterPro K_chnl_BK_asu UniProtKB/Swiss-Prot
  K_chnl_dom UniProtKB/Swiss-Prot
  K_chnl_Slo-like UniProtKB/Swiss-Prot
  RCK_N UniProtKB/Swiss-Prot
KEGG Report rno:60444 UniProtKB/Swiss-Prot
NCBI Gene 60444 ENTREZGENE
PANTHER CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN UniProtKB/Swiss-Prot
  POTASSIUM CHANNEL SUBFAMILY T MEMBER 1 UniProtKB/Swiss-Prot
Pfam BK_channel_a UniProtKB/Swiss-Prot
  Ion_trans_2 UniProtKB/Swiss-Prot
  Slo-like_RCK UniProtKB/Swiss-Prot
PhenoGen Kcnt1 PhenoGen
PROSITE RCK_N UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017283 RatGTEx
  ENSRNOG00055000527 RatGTEx
  ENSRNOG00060031801 RatGTEx
  ENSRNOG00065026234 RatGTEx
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/Swiss-Prot
UniProt A0A8I6A9R0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ALJ8 ENTREZGENE, UniProtKB/TrEMBL
  A6JTB4 ENTREZGENE, UniProtKB/TrEMBL
  A6JTB5 ENTREZGENE, UniProtKB/TrEMBL
  D3ZNI9 ENTREZGENE, UniProtKB/TrEMBL
  F1LSG1 ENTREZGENE
  KCNT1_RAT UniProtKB/Swiss-Prot
  Q5D6C6 ENTREZGENE
  Q9Z258 ENTREZGENE
UniProt Secondary F1LSG1 UniProtKB/Swiss-Prot
  Q5D6C6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnt1  potassium sodium-activated channel subfamily T member 1  Kcnt1  potassium channel, sodium-activated subfamily T, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnt1  potassium channel, sodium-activated subfamily T, member 1  Kcnt1  potassium channel, subfamily T, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Kcnt1  potassium channel, subfamily T, member 1  Slack  potassium channel subunit (Slack)  Symbol and Name updated 1299863 APPROVED
2002-08-07 Slack  potassium channel subunit (Slack)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation activated by intracellular Na(+), high conductance, and prominent subconductance states 633994