Secisbp2 (SECIS binding protein 2) - Rat Genome Database

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Gene: Secisbp2 (SECIS binding protein 2) Rattus norvegicus
Analyze
Symbol: Secisbp2
Name: SECIS binding protein 2
RGD ID: 620991
Description: Enables mRNA 3'-UTR binding activity and selenocysteine insertion sequence binding activity. Involved in positive regulation of selenocysteine incorporation and selenocysteine incorporation. Predicted to be located in cytosol. Predicted to be part of ribonucleoprotein complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in thyroid gland disease. Orthologous to human SECISBP2 (SECIS binding protein 2); INTERACTS WITH 2,4-dinitrotoluene; ammonium chloride; atrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Sbp2; SECIS-binding protein 2; selenocysteine insertion sequence-binding protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81713,690,263 - 13,721,303 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1713,690,264 - 13,721,250 (-)EnsemblGRCr8
mRatBN7.21713,538,513 - 13,569,573 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1713,538,513 - 13,569,523 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1713,467,413 - 13,498,425 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01715,078,169 - 15,109,291 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01713,394,206 - 13,425,222 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01713,555,348 - 13,586,595 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1713,555,349 - 13,586,554 (-)Ensemblrn6Rnor6.0
Rnor_5.01715,630,050 - 15,661,255 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41719,391,401 - 19,422,392 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1713,294,292 - 13,325,279 (-)NCBICelera
RGSC_v3.11719,391,400 - 19,422,392 (-)NCBI
Cytogenetic Map17p14NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (TAS)
mitochondrion  (IBA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA)
ribonucleoprotein complex  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Ribosomal protein L30 is a component of the UGA-selenocysteine recoding machinery in eukaryotes. Chavatte L, etal., Nat Struct Mol Biol. 2005 May;12(5):408-16. Epub 2005 Apr 10.
2. Purification, redox sensitivity, and RNA binding properties of SECIS-binding protein 2, a protein involved in selenoprotein biosynthesis. Copeland PR and Driscoll DM, J Biol Chem. 1999 Sep 3;274(36):25447-54. doi: 10.1074/jbc.274.36.25447.
3. A novel RNA binding protein, SBP2, is required for the translation of mammalian selenoprotein mRNAs. Copeland PR, etal., EMBO J 2000 Jan 17;19(2):306-14.
4. Insight into mammalian selenocysteine insertion: domain structure and ribosome binding properties of Sec insertion sequence binding protein 2. Copeland PR, etal., Mol Cell Biol 2001 Mar;21(5):1491-8.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16962588   PMID:17332014   PMID:17636016   PMID:17901054   PMID:18614015   PMID:19106619   PMID:19467292   PMID:19716792   PMID:22658674   PMID:22992746   PMID:23777426   PMID:24274065  
PMID:24844465   PMID:25692238  


Genomics

Comparative Map Data
Secisbp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81713,690,263 - 13,721,303 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1713,690,264 - 13,721,250 (-)EnsemblGRCr8
mRatBN7.21713,538,513 - 13,569,573 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1713,538,513 - 13,569,523 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1713,467,413 - 13,498,425 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01715,078,169 - 15,109,291 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01713,394,206 - 13,425,222 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01713,555,348 - 13,586,595 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1713,555,349 - 13,586,554 (-)Ensemblrn6Rnor6.0
Rnor_5.01715,630,050 - 15,661,255 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41719,391,401 - 19,422,392 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1713,294,292 - 13,325,279 (-)NCBICelera
RGSC_v3.11719,391,400 - 19,422,392 (-)NCBI
Cytogenetic Map17p14NCBI
SECISBP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38989,318,500 - 89,367,117 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl989,318,460 - 89,363,633 (+)Ensemblhg38GRCh38
GRCh37991,933,415 - 91,974,578 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36991,123,232 - 91,164,381 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34989,162,989 - 89,204,108NCBI
Celera962,515,571 - 62,559,423 (+)NCBICelera
Cytogenetic Map9q22.2NCBI
HuRef961,766,313 - 61,808,504 (+)NCBIHuRef
CHM1_1992,082,239 - 92,123,388 (+)NCBICHM1_1
T2T-CHM13v2.09101,482,274 - 101,530,894 (+)NCBIT2T-CHM13v2.0
Secisbp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391351,805,721 - 51,838,080 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1351,805,733 - 51,838,080 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381351,651,682 - 51,684,044 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1351,651,697 - 51,684,044 (+)Ensemblmm10GRCm38
MGSCv371351,747,083 - 51,779,015 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361351,664,193 - 51,696,853 (+)NCBIMGSCv36mm8
Celera1352,724,612 - 52,756,453 (+)NCBICelera
Cytogenetic Map13A5NCBI
cM Map1326.12NCBI
Secisbp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555152,698,075 - 2,730,074 (-)Ensembl
ChiLan1.0NW_0049555152,697,370 - 2,729,425 (-)NCBIChiLan1.0ChiLan1.0
SECISBP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21150,094,103 - 50,144,381 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1950,096,491 - 50,145,164 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0960,408,272 - 60,456,945 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1988,454,427 - 88,503,051 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl988,454,531 - 88,498,095 (+)EnsemblpanPan2panpan1.1
SECISBP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1196,879,840 - 96,927,583 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl196,880,369 - 96,933,862 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha197,342,988 - 97,390,342 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0197,491,659 - 97,539,348 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl197,491,665 - 97,539,349 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1197,119,771 - 97,167,142 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0196,838,962 - 96,886,290 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0197,597,325 - 97,644,687 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Secisbp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494411,119,725 - 11,156,389 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936780264,329 - 301,091 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936780264,366 - 300,999 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SECISBP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14912,015 - 955,974 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.114911,985 - 955,978 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214933,804 - 957,382 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SECISBP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11299,813,954 - 99,855,682 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1299,814,043 - 99,854,852 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603888,135,100 - 88,184,768 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Secisbp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476523,247,135 - 23,296,465 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476523,246,342 - 23,296,071 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Secisbp2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11470,023,516 - 70,054,639 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Secisbp2
207 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:89
Count of miRNA genes:68
Interacting mature miRNAs:80
Transcripts:ENSRNOT00000041371
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17926675540968173Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17436005727233623Rat
8552966Pigfal18Plasma insulin-like growth factor 1 level QTL 188.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)171286094257860942Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
1582224Epfw4Epididymal fat weight QTL 43.50.0058epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)17920650523859062Rat
1582225Bw67Body weight QTL 676.20.0001body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
1582226Bw64Body weight QTL 644.20.0017body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
9589151Insul30Insulin level QTL 308.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)171286094257860942Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131706603Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
9589057Scfw6Subcutaneous fat weight QTL 68.620.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)171286094257860942Rat
1582208Kidm32Kidney mass QTL 323.90.0018kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17920650523859062Rat
9590154Scort9Serum corticosterone level QTL 923.570.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)171286094257860942Rat
9590088Insglur7Insulin/glucose ratio QTL 720.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)171286094257860942Rat
1549900Iddm20Insulin dependent diabetes mellitus QTL 203.7pancreas integrity trait (VT:0010560)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)17122181410Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)171060469455604694Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
7411666Foco31Food consumption QTL 3111.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)171286094257860942Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17121499218Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
1581553Pur14Proteinuria QTL 145.30.0001urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)17798524316523460Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17857434232199534Rat
1582258Bw76Body weight QTL 764.60.0005body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat
1582199Insul5Insulin level QTL 53.40.0119blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)17920650523859062Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17436005727233623Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17212084322087569Rat
1582241Bw70Body weight QTL 704.60.0003body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
1582245Bw73Body weight QTL 734.60.0004body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122877318Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000041371   ⟹   ENSRNOP00000039532
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1713,690,264 - 13,721,250 (-)Ensembl
mRatBN7.2 Ensembl1713,538,513 - 13,569,523 (-)Ensembl
Rnor_6.0 Ensembl1713,555,349 - 13,586,554 (-)Ensembl
RefSeq Acc Id: NM_024002   ⟹   NP_076492
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81713,690,264 - 13,721,250 (-)NCBI
mRatBN7.21713,538,514 - 13,569,501 (-)NCBI
Rnor_6.01713,555,349 - 13,586,554 (-)NCBI
Rnor_5.01715,630,050 - 15,661,255 (-)NCBI
RGSC_v3.41719,391,401 - 19,422,392 (-)RGD
Celera1713,294,292 - 13,325,279 (-)RGD
Sequence:
RefSeq Acc Id: XM_008771506   ⟹   XP_008769728
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81713,690,263 - 13,721,303 (-)NCBI
mRatBN7.21713,538,513 - 13,569,573 (-)NCBI
Rnor_6.01713,555,348 - 13,586,595 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039096098   ⟹   XP_038952026
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81713,694,347 - 13,721,303 (-)NCBI
mRatBN7.21713,542,549 - 13,569,573 (-)NCBI
RefSeq Acc Id: XM_039096099   ⟹   XP_038952027
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81713,690,263 - 13,717,926 (-)NCBI
mRatBN7.21713,538,513 - 13,569,518 (-)NCBI
RefSeq Acc Id: XM_039096100   ⟹   XP_038952028
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81713,690,263 - 13,717,926 (-)NCBI
mRatBN7.21713,538,513 - 13,566,177 (-)NCBI
RefSeq Acc Id: XM_063276769   ⟹   XP_063132839
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81713,695,325 - 13,721,303 (-)NCBI
RefSeq Acc Id: XR_005495337
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81713,691,984 - 13,721,303 (-)NCBI
mRatBN7.21713,538,513 - 13,569,573 (-)NCBI
RefSeq Acc Id: NP_076492   ⟸   NM_024002
- UniProtKB: Q9QX72 (UniProtKB/Swiss-Prot),   A6J6T6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769728   ⟸   XM_008771506
- Peptide Label: isoform X1
- UniProtKB: F1LPQ8 (UniProtKB/TrEMBL),   A6J6T6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000039532   ⟸   ENSRNOT00000041371
RefSeq Acc Id: XP_038952027   ⟸   XM_039096099
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038952028   ⟸   XM_039096100
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038952026   ⟸   XM_039096098
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063132839   ⟸   XM_063276769
- Peptide Label: isoform X2
Protein Domains
Ribosomal protein eL8/eL30/eS12/Gadd45

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QX72-F1-model_v2 AlphaFold Q9QX72 1-846 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700338
Promoter ID:EPDNEW_R10861
Type:initiation region
Name:Secisbp2_1
Description:SECIS binding protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01713,586,559 - 13,586,619EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620991 AgrOrtholog
BioCyc Gene G2FUF-10074 BioCyc
Ensembl Genes ENSRNOG00000013773 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000041371 ENTREZGENE
Gene3D-CATH 3.30.1330.30 UniProtKB/Swiss-Prot
InterPro L30e-like UniProtKB/Swiss-Prot
  Ribosomal_L7Ae/L30e/S12e/Gad45 UniProtKB/Swiss-Prot
  SECISBP2 UniProtKB/Swiss-Prot
KEGG Report rno:79049 UniProtKB/Swiss-Prot
NCBI Gene 79049 ENTREZGENE
PANTHER PTHR13284 UniProtKB/Swiss-Prot
  SELENOCYSTEINE INSERTION SEQUENCE-BINDING PROTEIN 2 UniProtKB/Swiss-Prot
Pfam Ribosomal_L7Ae UniProtKB/Swiss-Prot
PhenoGen Secisbp2 PhenoGen
RatGTEx ENSRNOG00000013773 RatGTEx
Superfamily-SCOP SSF55315 UniProtKB/Swiss-Prot
UniProt A6J6T6 ENTREZGENE, UniProtKB/TrEMBL
  A6J6T7_RAT UniProtKB/TrEMBL
  F1LPQ8 ENTREZGENE, UniProtKB/TrEMBL
  Q9QX72 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Secisbp2  SECIS binding protein 2  Sbp2    Symbol updated 1299863 APPROVED
2002-08-07 Sbp2  SECIS binding protein 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains an RNA binding domain found in ribosomal proteins and a yeast suppressor of translation termination 633967
gene_domains contains a conserved 32 amino-acid domain, L30 RNA binding domain, which is required for RNA binding activity and function 628439
gene_function binds to the Sec insertion sequence (SECIS) element of selenoprotein 3 UTRs 628439
gene_physical_interaction stably associates with ribosomes via 28S rRNA and interacts with Sec-specific elongation factor (eEFsec) 628439
gene_process plays a role in selenocysteine (Sec)- mediated translational regualtion 628439
gene_protein 94 kDa 628439