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Gene: Usf2 (upstream transcription factor 2, c-fos interacting) Rattus norvegicus

Analyze

Symbol:

Usf2

Name:

upstream transcription factor 2, c-fos interacting

RGD ID:

620975

Description:

Enables DNA-binding transcription factor activity; E-box binding activity; and identical protein binding activity. Contributes to DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human USF2 (upstream transcription factor 2, c-fos interacting); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

major late transcription factor 2; transcription factor USF2; upstream stimulatory factor 2; upstream transcription factor 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	95,302,109 - 95,321,334 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	95,302,105 - 95,313,119 (-)	Ensembl				GRCr8
mRatBN7.2	1	86,174,703 - 86,185,942 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	86,174,703 - 86,185,617 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	91,594,835 - 91,606,038 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	100,060,999 - 100,072,201 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	93,353,133 - 93,364,336 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	89,371,798 - 89,383,005 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	89,371,794 - 89,382,463 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	90,527,311 - 90,538,532 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	85,981,897 - 85,993,346 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	80,543,548 - 80,554,594 (-)	NCBI		Celera
RGSC_v3.1	1	86,060,007 - 86,071,457 (-)	NCBI
Cytogenetic Map	1	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

prostate cancer (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,3',4,4'-tetrachlorobiphenyl (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxynon-2-enal (ISO)

aldehydo-D-glucose (ISO)

ammonium chloride (EXP)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

C60 fullerene (EXP)

carbon nanotube (ISO)

CGP 52608 (ISO)

choline (ISO)

chromium(6+) (EXP)

ciguatoxin CTX1B (ISO)

clofibrate (ISO)

cobalt dichloride (ISO)

crocidolite asbestos (ISO)

D-glucose (ISO)

diarsenic trioxide (ISO)

dimethylarsinic acid (EXP)

dioxygen (ISO)

elemental selenium (ISO)

ethanol (ISO)

flutamide (EXP)

folic acid (ISO)

FR900359 (ISO)

furan (ISO)

glucose (ISO)

L-methionine (ISO)

lead diacetate (ISO)

leflunomide (EXP)

metoprolol (EXP)

nitrates (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

Pf-06840003 (ISO)

phenobarbital (ISO)

propiconazole (ISO)

resveratrol (ISO)

selenium atom (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

thiram (ISO)

titanium dioxide (ISO)

Tributyltin oxide (EXP)

trichostatin A (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

valproic acid (ISO)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to glucose stimulus (ISO)

DNA-templated transcription (IEA)

glucose mediated signaling pathway (ISO,ISS)

lactation (ISO)

lipid homeostasis (ISO)

positive regulation of DNA-templated transcription (ISO)

positive regulation of transcription by RNA polymerase II (IEA,IMP,ISO,ISS)

regulation of transcription by RNA polymerase II (IBA,ISO)

Cellular Component

nucleoplasm (ISO)

nucleus (IEA,ISO)

Molecular Function

bHLH transcription factor binding (ISO)

DNA binding (IEA,ISO)

DNA-binding transcription activator activity, RNA polymerase II-specific (ISO,ISS)

DNA-binding transcription factor activity (IEA,IMP)

DNA-binding transcription factor activity, RNA polymerase II-specific (IDA,ISO)

double-stranded DNA binding (IDA)

E-box binding (IDA,IMP,ISO)

identical protein binding (IMP)

protein binding (ISO)

protein dimerization activity (IEA)

protein heterodimerization activity (ISO)

protein homodimerization activity (ISO)

protein-containing complex binding (IMP)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,IDA)

sequence-specific DNA binding (IDA)

sequence-specific double-stranded DNA binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transcriptional regulation of the distal promoter of the rat pyruvate carboxylase gene by hepatocyte nuclear factor 3beta/Foxa2 and upstream stimulatory factors in insulinoma cells.	Boonsaen T, etal., Biochem J. 2007 Jul 15;405(2):359-67.
2.	Essential role in vivo of upstream stimulatory factors for a normal dietary response of the fatty acid synthase gene in the liver.	Casado M, etal., J Biol Chem. 1999 Jan 22;274(4):2009-13. doi: 10.1074/jbc.274.4.2009.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	Molecular cloning and functional expression of a fifth-type alpha 2,3-sialyltransferase (mST3Gal V: GM3 synthase).	Kono M, etal., Biochem Biophys Res Commun 1998 Dec 9;253(1):170-5.
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms.	Viollet B, etal., J Biol Chem 1996 Jan 19;271(3):1405-15.

Additional References at PubMed

PMID:7523363	PMID:7852331	PMID:11272846	PMID:11319134	PMID:12477932	PMID:12907752	PMID:15184388	PMID:15187018	PMID:15358760	PMID:15466854	PMID:15661922	PMID:17955499
PMID:18167349	PMID:18955796	PMID:20410211	PMID:21734262

Genomics

Comparative Map Data

Usf2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	95,302,109 - 95,321,334 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	95,302,105 - 95,313,119 (-)	Ensembl				GRCr8
mRatBN7.2	1	86,174,703 - 86,185,942 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	86,174,703 - 86,185,617 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	91,594,835 - 91,606,038 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	100,060,999 - 100,072,201 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	93,353,133 - 93,364,336 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	89,371,798 - 89,383,005 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	89,371,794 - 89,382,463 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	90,527,311 - 90,538,532 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	85,981,897 - 85,993,346 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	80,543,548 - 80,554,594 (-)	NCBI		Celera
RGSC_v3.1	1	86,060,007 - 86,071,457 (-)	NCBI
Cytogenetic Map	1	q21	NCBI

USF2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	35,268,962 - 35,279,821 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	35,268,962 - 35,279,821 (+)	Ensembl			hg38	GRCh38
GRCh37	19	35,759,865 - 35,770,724 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	40,451,736 - 40,462,558 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	19	40,451,735 - 40,462,558	NCBI
Celera	19	32,473,334 - 32,484,156 (+)	NCBI		Celera
Cytogenetic Map	19	q13.12	NCBI
HuRef	19	32,268,608 - 32,279,346 (+)	NCBI		HuRef
CHM1_1	19	35,761,601 - 35,772,338 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	37,813,633 - 37,824,489 (+)	NCBI		T2T-CHM13v2.0

Usf2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	30,645,421 - 30,656,288 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	30,644,673 - 30,656,228 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	7	30,945,248 - 30,956,951 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	30,945,248 - 30,956,803 (-)	Ensembl			mm10	GRCm38
MGSCv37	7	31,730,267 - 31,741,822 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	7	30,654,756 - 30,665,539 (-)	NCBI		MGSCv36	mm8
Celera	7	25,511,313 - 25,522,504 (-)	NCBI		Celera
Cytogenetic Map	7	B1	NCBI
cM Map	7	19.27	NCBI

Usf2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955468	4,565,025 - 4,574,619 (+)	Ensembl
ChiLan1.0	NW_004955468	4,565,089 - 4,574,294 (+)	NCBI	ChiLan1.0	ChiLan1.0

USF2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	41,281,473 - 41,292,355 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	43,264,861 - 43,275,723 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	32,215,305 - 32,226,172 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	40,954,115 - 40,963,542 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2

USF2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	117,308,882 - 117,319,397 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	117,309,222 - 117,367,616 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	116,711,852 - 116,721,252 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	117,908,795 - 117,918,184 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	117,908,795 - 117,918,329 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	117,471,547 - 117,480,906 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	117,097,401 - 117,106,770 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	118,152,947 - 118,162,349 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Usf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	10,621,639 - 10,633,186 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936570	1,012,654 - 1,024,288 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936570	1,012,696 - 1,024,243 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

USF2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	44,774,008 - 44,783,592 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	44,774,417 - 44,783,594 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	40,194,539 - 40,203,590 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

USF2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	30,202,224 - 30,212,783 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	30,202,375 - 30,213,058 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666073	7,976,409 - 7,987,328 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Usf2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624794	8,261,561 - 8,270,527 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624794	8,261,078 - 8,270,527 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Usf2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	165,082,555 - 165,093,652 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Usf2
47 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	313
Count of miRNA genes:	133
Interacting mature miRNAs:	152
Transcripts:	ENSRNOT00000028548, ENSRNOT00000028550, ENSRNOT00000041809
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578649	Bmd8	Bone mineral density QTL 8	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	51940904	101229020	Rat
1582234	Gluco18	Glucose level QTL 18	3.4	0.0003	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	87889942	132889942	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	51941022	208479811	Rat
1358359	Sradr1	Stress Responsive Adrenal Weight QTL 1	4.74		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	39728272	132889942	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	51940904	168768703	Rat
2300324	Fetw1	Fetal weight QTL 1	12.1	0.005	fetal growth trait (VT:0004201)	fetal body weight (CMO:0002080)	1	92963855	109494029	Rat
1331800	Scl25	Serum cholesterol level QTL 25	3.013		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	87785026	142582336	Rat
7421628	Bp361	Blood pressure QTL 361		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	83019780	128019780	Rat
631495	Bp96	Blood pressure QTL 96	4.52		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	66404680	111404680	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34184556	172281316	Rat
631512	Scl6	Serum cholesterol level QTL 6	9.6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	81269860	99645535	Rat
2298545	Neuinf8	Neuroinflammation QTL 8	4.6		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	1	66009857	160501508	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34565911	208798288	Rat
631519	Pia11	Pristane induced arthritis QTL 11	5.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	93903998	191260518	Rat
1302788	Scl19	Serum cholesterol QTL 19	4.6	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	66400974	132889942	Rat
1549903	Bp267	Blood pressure QTL 267			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	84107164	115183752	Rat
2313083	Bmd74	Bone mineral density QTL 74	4	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	1	91302413	136302413	Rat
2313402	Anxrr24	Anxiety related response QTL 24			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	1	51511344	153680016	Rat
61342	Bp27	Blood pressure QTL 27	3.4	0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	65405637	96805205	Rat
1358192	Ept13	Estrogen-induced pituitary tumorigenesis QTL 13	3.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	1	86622262	131622262	Rat
6903308	Scl36	Serum cholesterol QTL 36	2	0.0125	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	58769992	103769992	Rat
2300164	Bmd44	Bone mineral density QTL 44	5.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	1	66077886	111077886	Rat
738022	Anxrr13	Anxiety related response QTL 13	4.6	0.00039	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)	1	92683681	137683681	Rat
10054135	Gmadr2	Adrenal mass QTL 2	1.97	0.0129	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	86993904	131993904	Rat
152025249	Scl82	Serum cholesterol level QTL 82	4.77		blood cholesterol amount (VT:0000180)		1	52891222	109116986	Rat
1331749	Hrtrt11	Heart rate QTL 11	2.973		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	92683681	137683681	Rat
7411712	Strs4	Sensitivity to stroke QTL 4	8.7		cerebrum integrity trait (VT:0010549)	percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)	1	87558587	132558587	Rat

Markers in Region

U01663

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	86,175,004 - 86,175,179 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	89,372,100 - 89,372,274	NCBI	Rnor6.0
Rnor_5.0	1	90,527,613 - 90,527,787	UniSTS	Rnor5.0
RGSC_v3.4	1	85,982,199 - 85,982,373	UniSTS	RGSC3.4
Celera	1	80,543,850 - 80,544,024	UniSTS
Cytogenetic Map	1	q21	UniSTS

BF406210

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	86,176,463 - 86,176,660 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	89,373,559 - 89,373,755	NCBI	Rnor6.0
Rnor_5.0	1	90,529,072 - 90,529,268	UniSTS	Rnor5.0
RGSC_v3.4	1	85,983,658 - 85,983,854	UniSTS	RGSC3.4
Celera	1	80,545,309 - 80,545,505	UniSTS
RH 3.4 Map	1	845.3	UniSTS
Cytogenetic Map	1	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	163	91	90	59	92	59	6	356	192	11	142	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031139	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039092335	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB035647	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB035648	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB035649	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB035650	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB035651	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB047556	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC111870	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC128735	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473979	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X90823	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000087381 ⟹ ENSRNOP00000072660

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	95,302,109 - 95,313,021 (-)	Ensembl
mRatBN7.2 Ensembl	1	86,174,703 - 86,185,617 (-)	Ensembl
Rnor_6.0 Ensembl	1	89,371,794 - 89,382,463 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000103509 ⟹ ENSRNOP00000094253

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	95,302,109 - 95,313,021 (-)	Ensembl
mRatBN7.2 Ensembl	1	86,174,703 - 86,185,617 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000122374 ⟹ ENSRNOP00000098697

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	95,302,105 - 95,313,119 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000136984 ⟹ ENSRNOP00000101519

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	95,311,383 - 95,312,795 (-)	Ensembl

RefSeq Acc Id:

NM_031139 ⟹ NP_112401

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	95,302,109 - 95,313,318 (-)	NCBI
mRatBN7.2	1	86,174,703 - 86,185,915 (-)	NCBI
Rnor_6.0	1	89,371,798 - 89,383,005 (-)	NCBI
Rnor_5.0	1	90,527,311 - 90,538,532 (-)	NCBI
RGSC_v3.4	1	85,981,897 - 85,993,346 (-)	RGD
Celera	1	80,543,548 - 80,554,594 (-)	RGD

Sequence:

show sequence

TAGAAAGCGGCGGCAGCTGCAGCCACGATCCGCCGCCGAACCGGGCCAGGCCGGGCGGCGGACG
CGAGAACCGAGGATCTGGGAAACAGGGCGGCCGCCATCCGGGCAGGGCCGAGTTATAAAAAAAA
ATTAAAAAAAAAGGAAGGCTCAAGTCTCGGCGGCGGCGGCGGCAAGCACTCAGGGAAGCAGGCC
CCAGGCGTGCGGCGGCGGGGCGGCGGGCGGCGAGCCGGCCGGCGGGCGGGCGGGGGGCATCTGA
ACTGTGGCCCGGAGCCTCGCGCCGCCCGGAACTGGCGGCGGGCGGAGCGGATGGAAGAGGCGGC
AGCTGCAGGAGTAGCGGCGGCGGCGGCGGCGGCATCTCCTCCTCACATGACCCACTGTTTGTCC
CCGTGATCAGCGCGAGGCTCCCGTGTCTCCTCCGTCCCCTCCTGCCGAGCGGGTGAGCGCCGGG
CTCGGGCCCCCCCGGCCGCCCTCTCCCTCCCCTCCCTCCCCTCCCCTCCCCCCCGCCCCCCCCA
TGGACATGCTGGACCCGGGTCTGGATCCCGCTTCCTCGGCCACCGCTGCTGCCGCCGCCAGCCA
CGACAAGGGACCCGAGGCCGAGGAGGGCGTTGAGCTGCAGGAAGGCGGGGACGGCCCGGGGGCT
GAGGAGCAGACGGCGGTGGCCATCGCCAGCGTCCAGCAGGCGGCGTTCGGCGACCATAATATCC
AGTACCAGTTCCGCACAGAGAGTAATGGAGGCCAGGTGACATACCGCGTAGTCCAGGTGACTGA
TGGTCAGCTGGACGGCCAGGGCGACGCGGCTGGCGCCGTCAGCGTCGTGTCCACCGCTGCCTTC
GCAGGGGGGCAGCAGGCTGTGACCCAGGTGGGTGTGGACGGGGCAGCCCAGCGCCCCGGCCCTG
CCGCTGCCTCTGTACCCACAGGTCCCGCAGCACCCTTCCCGCTGGCTGTAATTCAAAATCCATT
CAGCAATGGTGGCAGCCCAGCAGCCGAAGCTGTCAGCGGGGAGGCACGGTTTGCTTATTTTCCA
GCATCCAGTGTCGGCGATACCACAGCTGTGTCTGTTCAAACTACAGACCAGAGCCTACAGGCCG
GAGGCCAGTTCTATGTCATGATGACACCCCAGGATGTGCTTCAAACAGGAACACAGAGGACAAT
TGCACCCCGGACACACCCCTATTCTCCGAAAATTGATGGAACCAGAACTCCTCGAGATGAGAGA
AGAAGAGCTCAGCACAATGAAGTGGAGCGGAGAAGGAGGGACAAGATCAACAACTGGATTGTCC
AGCTTTCAAAAATCATTCCAGATTGTCATGCAGACAACAGCAAGACAGGGGCGAGTAAAGGGGG
CATCCTGTCCAAGGCTTGCGATTACATCCGGGAGCTACGCCAGACCAACCAGCGTATGCAGGAG
ACCTTCAAGGAGGCAGAGCGGCTGCAAATGGACAATGAGCTCCTGAGGCAGCAGATCGAGGAGC
TGAAGAACGAGAACGCCCTGCTTCGAGCCCAACTGCAGCAGCACAACCTGGAAATGGTGGGCGA
GAGCACCCGGCAGTGATGCCCGCTGGCTCACCCTTCAGCTGCTGCCGGCCTTTGCTGCCCCTCC
CCCAGCCCTTAGCACAGAGAGGGAGATGCCCCTCCCCAAGCTGCGTTTTTTATAGTAGATTTTT
AACAAAAACAAGGAGACATAATGCATTTCTGTTGATACATTGCCCACTACCCTCCCCCATGCGG
AAATGATGTCCACCTGCCCATCTGTCCGTCAGCCTCCCTTCTCGGCCCTCACCAGCCCATCACT
TATAGTGGGCTCATCGGGAGGAGCGAGGGAGGAGGACAGAGGCCCCGCTGCCCGCTGCCTCCTT
GGTCTCTAGAGGTATTGAGACAGGGTGCTTATGGGAAGGAGGGAGCTTTGGGGATGGGGGCCTT
CCCTGGGGCCTGGACCTATGCAGGGAGGCCAAGCCCCCCCACCCCTCTTGTTTCTGGATCCCTG
CTCCCCTCTGGGTGTGTGGGTGTGTATGTGTGTGTGTGTGTGCGCGTGTGTATGTGTGCGTGTG
TGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTTTAATTTTCTTTATGGAAAATGGACAAAAAAT
AGAGAGAGAGGTATTTAACTGCAATAAACTGGCCAGTGTGGCCCCGCCTAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039092335 ⟹ XP_038948263

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	95,302,109 - 95,321,334 (-)	NCBI
mRatBN7.2	1	86,175,066 - 86,185,942 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_112401	(Get FASTA)	NCBI Sequence Viewer
	XP_038948263	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI28736	(Get FASTA)	NCBI Sequence Viewer
	BAB19964	(Get FASTA)	NCBI Sequence Viewer
	BAB19965	(Get FASTA)	NCBI Sequence Viewer
	BAB19966	(Get FASTA)	NCBI Sequence Viewer
	BAB19967	(Get FASTA)	NCBI Sequence Viewer
	BAB19968	(Get FASTA)	NCBI Sequence Viewer
	BAB20993	(Get FASTA)	NCBI Sequence Viewer
	CAA62338	(Get FASTA)	NCBI Sequence Viewer
	EDM07695	(Get FASTA)	NCBI Sequence Viewer
	EDM07696	(Get FASTA)	NCBI Sequence Viewer
	EDM07697	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000072660
	ENSRNOP00000094253
	ENSRNOP00000094253.1
GenBank Protein	Q63665	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_112401 ⟸ NM_031139

- UniProtKB:

Q9EQX2 (UniProtKB/Swiss-Prot), Q9EQX1 (UniProtKB/Swiss-Prot), Q76MU2 (UniProtKB/Swiss-Prot), Q76MJ1 (UniProtKB/Swiss-Prot), Q9EQX3 (UniProtKB/Swiss-Prot), Q63665 (UniProtKB/Swiss-Prot), A2VCW7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDMLDPGLDPASSATAAAAASHDKGPEAEEGVELQEGGDGPGAEEQTAVAIASVQQAAFGDHNI
QYQFRTESNGGQVTYRVVQVTDGQLDGQGDAAGAVSVVSTAAFAGGQQAVTQVGVDGAAQRPGP
AAASVPTGPAAPFPLAVIQNPFSNGGSPAAEAVSGEARFAYFPASSVGDTTAVSVQTTDQSLQA
GGQFYVMMTPQDVLQTGTQRTIAPRTHPYSPKIDGTRTPRDERRRAQHNEVERRRRDKINNWIV
QLSKIIPDCHADNSKTGASKGGILSKACDYIRELRQTNQRMQETFKEAERLQMDNELLRQQIEE
LKNENALLRAQLQQHNLEMVGESTRQ

hide sequence

Ensembl Acc Id:

ENSRNOP00000072660 ⟸ ENSRNOT00000087381

RefSeq Acc Id:	XP_038948263 ⟸ XM_039092335
- Peptide Label:	isoform X1
- UniProtKB:	A2VCW7 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000094253 ⟸ ENSRNOT00000103509

Ensembl Acc Id:

ENSRNOP00000098697 ⟸ ENSRNOT00000122374

Ensembl Acc Id:

ENSRNOP00000101519 ⟸ ENSRNOT00000136984

Protein Domains

bHLH

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q63665-F1-model_v2	AlphaFold	Q63665	1-346	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13689937

Promoter ID:

EPDNEW_R461

Type:

single initiation site

Name:

Usf2_1

Description:

upstream transcription factor 2, c-fos interacting

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	89,382,446 - 89,382,506	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620975	AgrOrtholog
BioCyc Gene	G2FUF-60054	BioCyc
Ensembl Genes	ENSRNOG00000053725	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000087381	ENTREZGENE
	ENSRNOT00000103509	ENTREZGENE
	ENSRNOT00000103509.1	UniProtKB/Swiss-Prot
Gene3D-CATH	4.10.280.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7190049	IMAGE-MGC_LOAD
InterPro	bHLH_dom	UniProtKB/Swiss-Prot
	HLH_DNA-bd_sf	UniProtKB/Swiss-Prot
	USF	UniProtKB/Swiss-Prot
KEGG Report	rno:81817	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:156629	IMAGE-MGC_LOAD
NCBI Gene	81817	ENTREZGENE
PANTHER	FI24210P1	UniProtKB/Swiss-Prot
	UPSTREAM STIMULATORY FACTOR 2	UniProtKB/Swiss-Prot
Pfam	HLH	UniProtKB/Swiss-Prot
PhenoGen	Usf2	PhenoGen
PROSITE	BHLH	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000053725	RatGTEx
SMART	HLH	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF47459	UniProtKB/Swiss-Prot
UniProt	A0A0G2K3J3_RAT	UniProtKB/TrEMBL
	A0ABK0L7Z9_RAT	UniProtKB/TrEMBL
	A2VCW7	ENTREZGENE, UniProtKB/TrEMBL
	A6JA37_RAT	UniProtKB/TrEMBL
	Q63665	ENTREZGENE
	Q76MJ1	ENTREZGENE
	Q76MU2	ENTREZGENE
	Q9EQX1	ENTREZGENE
	Q9EQX2	ENTREZGENE
	Q9EQX3	ENTREZGENE
	USF2_RAT	UniProtKB/Swiss-Prot
UniProt Secondary	Q76MJ1	UniProtKB/Swiss-Prot
	Q76MU2	UniProtKB/Swiss-Prot
	Q9EQX1	UniProtKB/Swiss-Prot
	Q9EQX2	UniProtKB/Swiss-Prot
	Q9EQX3	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2010-05-25	Usf2	upstream transcription factor 2, c-fos interacting	Usf2	upstream transcription factor 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	Usf2	upstream transcription factor 2		transcription factor USF2	Name updated	1299863	APPROVED
2002-08-07	Usf2	transcription factor USF2			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_protein	two isoforms originated by differential splicing, corresponding to 44-kDa subunit, USF2a, and 38-kDa subunit, USF2b	634234

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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