Tmed10 (transmembrane p24 trafficking protein 10) - Rat Genome Database

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Gene: Tmed10 (transmembrane p24 trafficking protein 10) Rattus norvegicus
Analyze
Symbol: Tmed10
Name: transmembrane p24 trafficking protein 10
RGD ID: 620970
Description: Predicted to enable protein transmembrane transporter activity and syntaxin binding activity. Involved in several processes, including Golgi organization; response to alkaloid; and vesicle targeting, to, from or within Golgi. Located in several cellular components, including Golgi apparatus; cytoplasmic vesicle; and endoplasmic reticulum-Golgi intermediate compartment. Part of gamma-secretase complex. Orthologous to human TMED10 (transmembrane p24 trafficking protein 10); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 21 kDa transmembrane-trafficking protein; integral membrane protein Tmp21-I (p23); p24 family protein delta-1; p24delta1; Tmp21; transmembrane emp24 domain-containing protein 10; transmembrane emp24-like trafficking protein 10; transmembrane emp24-like trafficking protein 10 (yeast); transmembrane protein Tmp21; transmembrane trafficking protein 21
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86110,722,887 - 110,757,743 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6110,722,889 - 110,757,777 (-)EnsemblGRCr8
mRatBN7.26104,991,843 - 105,026,705 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6104,991,838 - 105,026,753 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6105,161,423 - 105,196,288 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06105,460,299 - 105,495,169 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06104,829,957 - 104,864,825 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06109,169,739 - 109,205,004 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6109,169,741 - 109,205,004 (-)Ensemblrn6Rnor6.0
Rnor_5.06116,347,952 - 116,383,217 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46109,396,504 - 109,411,292 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6102,814,696 - 102,848,831 (-)NCBICelera
RGSC_v3.16109,399,961 - 109,414,748 (-)NCBI
Cytogenetic Map6q31NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
ampicillin  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP)
calyculin A  (ISO)
cannabidiol  (ISO)
captan  (ISO)
clofibrate  (ISO)
clozapine  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
disodium selenite  (ISO)
diuron  (ISO)
epoxiconazole  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furfural  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
menadione  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
metronidazole  (EXP)
neomycin  (EXP)
okadaic acid  (ISO)
orotic acid  (EXP)
paracetamol  (EXP,ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
sarin  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
succimer  (ISO)
temozolomide  (ISO)
thapsigargin  (EXP,ISO)
tolcapone  (EXP)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Tmp21-I, a vesicular trafficking protein, is differentially expressed during induction of the ureter and metanephros. Baker LA and Gomez RA, J Urol. 2000 Aug;164(2):562-6.
2. Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus. Barr FA, etal., J Cell Biol. 2001 Dec 10;155(6):885-91. Epub 2001 Dec 10.
3. The luminal domain of p23 (Tmp21) plays a critical role in p23 cell surface trafficking. Blum R and Lepier A, Traffic. 2008 Sep;9(9):1530-50. doi: 10.1111/j.1600-0854.2008.00784.x. Epub 2008 Jul 11.
4. Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking. Blum R, etal., J Biol Chem 1996 Jul 19;271(29):17183-9.
5. Intracellular localization and in vivo trafficking of p24A and p23. Blum R, etal., J Cell Sci. 1999 Feb;112 ( Pt 4):537-48.
6. RAB21 interacts with TMED10 and modulates its localization and abundance. Del Olmo T, etal., Biol Open. 2019 Sep 9;8(9). pii: bio.045336. doi: 10.1242/bio.045336.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. p24 and p23, the major transmembrane proteins of COPI-coated transport vesicles, form hetero-oligomeric complexes and cycle between the organelles of the early secretory pathway. Gommel D, etal., FEBS Lett. 1999 Mar 26;447(2-3):179-85.
9. A comparative study of rat and human Tmp21 (p23) reveals the pseudogene-like features of human Tmp21-II. Horer J, etal., DNA Seq 1999;10(2):121-6.
10. A subset of p23 localized on secretory granules in pancreatic beta-cells. Hosaka M, etal., J Histochem Cytochem. 2007 Mar;55(3):235-45. Epub 2006 Nov 13.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Cloning and characterization of rat neuronal apoptosis inhibitory protein cDNA. Shin SW, etal., Neurochem Int 2003 May;42(6):481-91.
16. Affinity pulldown of gamma-secretase and associated proteins from human and rat brain. Teranishi Y, etal., J Cell Mol Med. 2009 Sep 14.
17. Localization and regional distribution of p23/TMP21 in the brain. Vetrivel KS, etal., Neurobiol Dis. 2008 Oct;32(1):37-49. Epub 2008 Jul 3.
18. Elevation of neuronal expression of NAIP reduces ischemic damage in the rat hippocampus. Xu DG, etal., Nat Med. 1997 Sep;3(9):997-1004.
Additional References at PubMed
PMID:9472029   PMID:10052452   PMID:10660306   PMID:12237308   PMID:15047867   PMID:16641999   PMID:18504258   PMID:20427317   PMID:21545355   PMID:23376485   PMID:24271503  


Genomics

Comparative Map Data
Tmed10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86110,722,887 - 110,757,743 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6110,722,889 - 110,757,777 (-)EnsemblGRCr8
mRatBN7.26104,991,843 - 105,026,705 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6104,991,838 - 105,026,753 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6105,161,423 - 105,196,288 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06105,460,299 - 105,495,169 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06104,829,957 - 104,864,825 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06109,169,739 - 109,205,004 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6109,169,741 - 109,205,004 (-)Ensemblrn6Rnor6.0
Rnor_5.06116,347,952 - 116,383,217 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46109,396,504 - 109,411,292 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6102,814,696 - 102,848,831 (-)NCBICelera
RGSC_v3.16109,399,961 - 109,414,748 (-)NCBI
Cytogenetic Map6q31NCBI
TMED10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381475,131,469 - 75,176,612 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1475,131,443 - 75,176,652 (-)Ensemblhg38GRCh38
GRCh371475,598,172 - 75,643,315 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361474,667,924 - 74,713,102 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341474,667,925 - 74,713,045NCBI
Celera1455,635,795 - 55,680,950 (-)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1455,766,322 - 55,811,787 (-)NCBIHuRef
CHM1_11475,535,938 - 75,581,127 (-)NCBICHM1_1
T2T-CHM13v2.01469,340,853 - 69,385,990 (-)NCBIT2T-CHM13v2.0
Tmed10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391285,387,388 - 85,421,491 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1285,387,388 - 85,421,621 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381285,340,614 - 85,374,717 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1285,340,614 - 85,374,847 (-)Ensemblmm10GRCm38
MGSCv371286,681,564 - 86,715,667 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361286,229,717 - 86,263,826 (-)NCBIMGSCv36mm8
Celera1286,798,198 - 86,832,321 (-)NCBICelera
Cytogenetic Map12D2NCBI
cM Map1239.65NCBI
Tmed10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955523393,706 - 436,583 (+)Ensembl
ChiLan1.0NW_004955523393,632 - 438,114 (+)NCBIChiLan1.0ChiLan1.0
TMED10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21576,213,773 - 76,259,034 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11475,430,277 - 75,475,523 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01455,683,121 - 55,728,365 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11474,526,733 - 74,572,000 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1474,526,733 - 74,572,000 (-)EnsemblpanPan2panpan1.1
TMED10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1848,221,372 - 48,257,242 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha847,905,475 - 47,941,324 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0848,449,034 - 48,484,899 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl848,448,864 - 48,484,870 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1848,119,735 - 48,155,593 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0848,141,008 - 48,176,865 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0848,539,708 - 48,575,575 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tmed10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864027,765,073 - 27,803,237 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364884,265,731 - 4,303,948 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364884,265,731 - 4,303,895 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMED10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl798,327,408 - 98,362,606 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1798,327,402 - 98,362,652 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27104,171,513 - 104,206,745 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMED10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12452,349,869 - 52,392,436 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2452,346,815 - 52,392,525 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605340,577,148 - 40,620,562 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmed10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473426,514,594 - 26,549,374 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473426,514,594 - 26,551,361 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Tmed10
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1799,450,248 - 99,486,441 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tmed10
81 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:452
Count of miRNA genes:227
Interacting mature miRNAs:280
Transcripts:ENSRNOT00000010512
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)671278722116278722Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)678204640123204640Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)676937178121937178Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)686494122112380234Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)699437079125323237Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)699708426112483760Rat

Markers in Region
RH130037  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr86110,722,942 - 110,723,329 (+)Marker Load Pipeline
mRatBN7.26104,991,898 - 104,992,285 (+)MAPPERmRatBN7.2
Rnor_6.06109,169,795 - 109,170,181NCBIRnor6.0
Rnor_5.06116,382,775 - 116,383,161UniSTSRnor5.0
RGSC_v3.46109,396,560 - 109,396,946UniSTSRGSC3.4
Celera6102,814,752 - 102,815,138UniSTS
RH 3.4 Map6732.29UniSTS
Cytogenetic Map6q31UniSTS
RH139915  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26104,996,361 - 104,996,551 (+)MAPPERmRatBN7.2
Rnor_6.06109,174,257 - 109,174,446NCBIRnor6.0
Rnor_5.06116,378,510 - 116,378,699UniSTSRnor5.0
RGSC_v3.46109,401,022 - 109,401,211UniSTSRGSC3.4
Celera6102,819,214 - 102,819,403UniSTS
RH 3.4 Map6732.59UniSTS
Cytogenetic Map6q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000010512   ⟹   ENSRNOP00000010512
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6110,722,889 - 110,757,777 (-)Ensembl
mRatBN7.2 Ensembl6104,991,843 - 105,026,753 (-)Ensembl
Rnor_6.0 Ensembl6109,169,741 - 109,205,004 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119556   ⟹   ENSRNOP00000092591
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6110,723,413 - 110,757,777 (-)Ensembl
mRatBN7.2 Ensembl6104,991,838 - 105,026,736 (-)Ensembl
RefSeq Acc Id: NM_053467   ⟹   NP_445919
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86110,722,887 - 110,757,743 (-)NCBI
mRatBN7.26104,991,843 - 105,026,705 (-)NCBI
Rnor_6.06109,169,739 - 109,205,004 (-)NCBI
Rnor_5.06116,347,952 - 116,383,217 (+)NCBI
RGSC_v3.46109,396,504 - 109,411,292 (-)RGD
Celera6102,814,696 - 102,848,831 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_445919 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA06212 (Get FASTA)   NCBI Sequence Viewer  
  CAA66072 (Get FASTA)   NCBI Sequence Viewer  
  EDL81569 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010512
GenBank Protein Q63584 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_445919   ⟸   NM_053467
- Peptide Label: precursor
- UniProtKB: Q9R0W6 (UniProtKB/Swiss-Prot),   Q63584 (UniProtKB/Swiss-Prot),   A6JE25 (UniProtKB/TrEMBL),   A0A8L2Q4S6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010512   ⟸   ENSRNOT00000010512
Ensembl Acc Id: ENSRNOP00000092591   ⟸   ENSRNOT00000119556
Protein Domains
GOLD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63584-F1-model_v2 AlphaFold Q63584 1-219 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694741
Promoter ID:EPDNEW_R5266
Type:initiation region
Name:Tmed10_1
Description:transmembrane p24 trafficking protein 10
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06109,205,038 - 109,205,098EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620970 AgrOrtholog
BioCyc Gene G2FUF-36782 BioCyc
Ensembl Genes ENSRNOG00000007901 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000010512 ENTREZGENE
InterPro GOLD_dom UniProtKB/Swiss-Prot
  TMP21-related UniProtKB/Swiss-Prot
KEGG Report rno:84599 UniProtKB/Swiss-Prot
NCBI Gene 84599 ENTREZGENE
PANTHER PTHR22811 UniProtKB/Swiss-Prot
Pfam EMP24_GP25L UniProtKB/Swiss-Prot
PharmGKB TMED10 RGD
PhenoGen Tmed10 PhenoGen
PROSITE GOLD UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007901 RatGTEx
SMART EMP24_GP25L UniProtKB/Swiss-Prot
UniProt A0A8I6AIG7_RAT UniProtKB/TrEMBL
  A0A8L2Q4S6 ENTREZGENE, UniProtKB/TrEMBL
  A6JE25 ENTREZGENE, UniProtKB/TrEMBL
  Q63584 ENTREZGENE
  Q9R0W6 ENTREZGENE
  TMEDA_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q9R0W6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-19 Tmed10  transmembrane p24 trafficking protein 10  Tmed10  transmembrane emp24-like trafficking protein 10 (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Tmed10  transmembrane emp24-like trafficking protein 10 (yeast)  Tmp21  transmembrane trafficking protein 21  Symbol and Name updated 1299863 APPROVED
2005-01-20 Tmp21  transmembrane trafficking protein 21    integral membrane protein Tmp21-I (p23)  Name updated 1299863 APPROVED
2002-08-07 Tmp21  integral membrane protein Tmp21-I (p23)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains carboxy-terminal tail contains a motif related to the endoplasmic reticulum retention and retrieval consensus sequence KKXX 68840