RGD Reference Report - Localization and regional distribution of p23/TMP21 in the brain. - Rat Genome Database

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Localization and regional distribution of p23/TMP21 in the brain.

Authors: Vetrivel, KS  Kodam, A  Gong, P  Chen, Y  Parent, AT  Kar, S  Thinakaran, G 
Citation: Vetrivel KS, etal., Neurobiol Dis. 2008 Oct;32(1):37-49. Epub 2008 Jul 3.
RGD ID: 2317276
Pubmed: PMID:18652896   (View Abstract at PubMed)
PMCID: PMC2639720   (View Article at PubMed Central)
DOI: DOI:10.1016/j.nbd.2008.06.012   (Journal Full-text)

Sequential processing of amyloid precursor protein by beta- and gamma-secretases generates Alzheimer's disease (AD)-associated beta-amyloid peptides. Recently it was reported that the transmembrane protein p23/TMP21 associates with gamma-secretase, and negatively regulates beta-amyloid production. Despite the link between p23 function and AD pathogenesis, the expression of p23 has not been examined in the brain. Here, we describe the detailed immunohistochemical characterization of p23 expression in rodent and human brain. We report that p23 is co-expressed with gamma-secretase subunits in select neuronal cell populations in rodent brain. Interestingly, the steady-state level of p23 in the brain is high during embryonic development and then declines after birth. Furthermore, the steady-state p23 levels are reduced in the brains of individuals with AD. We conclude that p23 is expressed in neurons throughout the brain and the decline in p23 expression during postnatal development may significantly contribute to enhanced beta-amyloid production in the adult brain.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Alzheimer's disease  IEP 2317276protein:decreased expression:brain cortex (human)RGD 
Alzheimer's disease  ISOTMED10 (Homo sapiens)2317276; 2317276protein:decreased expression:brain cortex (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tmed10  (transmembrane p24 trafficking protein 10)

Genes (Mus musculus)
Tmed10  (transmembrane p24 trafficking protein 10)

Genes (Homo sapiens)
TMED10  (transmembrane p24 trafficking protein 10)


Additional Information